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| 1 | clusterProfiler 4.0:A universal enrichment tool for interpreting omics data显示文摘Functional enrichment analysis is pivotal for interpreting highthroughput omics data in life science.It is crucial for this type of tool to use the latest annotation databases for as many organisms as possible.To meet these requirements,we present here an updated version of our popular Bioconductor package,clusterProfiler 4.0.This package has been enhanced considerably compared with its original version published 9 years ago.The new version provides a universal interface for functional enrichment analysis in thousands of organisms based on internally supported ontologies and pathways as well as annotation data provided by users or derived from online databases.It also extends the dplyr and ggplot2 packages to offer tidy interfaces for data operation and visualization.Other new features include gene set enrichment analysis and comparison of enrichment results from multiple gene lists.We anticipate that clusterProfiler 4.0 will be applied to a wide range of scenarios across diverse organisms. | Tianzhi Wu Erqiang Hu Shuangbin Xu Meijun Chen Pingfan Guo Zehan Dai Tingze Feng Lang Zhou Wenli Tang Li Zhan Xiaocong Fu Shanshan Liu Xiaochen Bo Guangchuang Yu | 2021 | The Innovation2021，2，3： | 40 |
| 2 | A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value显示文摘 | Changsong Zou Aojun Chen Lihong Xiao Heike M Muller Peter Ache Georg Haberer Meiling Zhang Wei Jia Ping Deng Ru Huang Daniel Lang Feng Li Dongliang Zhan Xiangyun Wu Hui Zhang Jennifer Bohm Renyi Liu Sergey Shabala Rainer Hedrich Jian-Kang Zhu Heng Zhang | 2017 | Cell Research2017，27，11： | 22 |
| 3 | Large-scale multiferroic complex oxide epitaxy with magnetically switched polarization enabled by solution processing显示文摘Complex oxides with tunable structures have many fascinating properties,though high-quality complex oxide epitaxy with precisely controlled composition is still out of reach.Here we have successfully developed solution-based single-crystalline epitaxy for multiferroic(1-x)BiTi(1-y)/2FeyMg(1-y)/2O3–(x)CaTiO3(BTFM–CTO)solid solution in large area,confirming its ferroelectricity at the atomic scale with strong spontaneous polarization.Careful compositional tuning leads to a bulk magnetization of 0.07±0.035μB/Fe at room temperature,enabling magnetically induced polarization switching exhibiting a large magnetoelectric coefficient of 2.7–3.0×10^-7 s/m.This work demonstrates the great potential of solution processing in large-scale complex oxide epitaxy and establishes novel room-temperature magnetoelectric coupling in epitaxial BTFM–CTO film,making it possible to explore a much wider space of composition,phase,and structure that can be easily scaled up for industrial applications. | Cong Liu Feng An Paria S.M.Gharavi Qinwen Lu Junkun Zha Chao Chen Liming Wang Xiaozhi Zhan Zedong Xu Yuan Zhang Ke Qu Junxiang Yao Yun Ou Zhiming Zhao Xiangli Zhong Dongwen Zhang Nagarajan Valanoor Lang Chen Tao Zhu Deyang Chen Xiaofang Zhai Peng Gao Tingting Jia Shuhong Xie Gaokuo Zhong Jiangyu Li | 2020 | National Science Review2020，7，1： | 2 |
| 4 | Wild type p53 sensitizes soft tissue sarcoma cells to doxorubicin by down-regulating multidrug resistance-1 expression 显示文摘 | Zhan M Yu D Lang A | 2001 | Cancer2001，92，6： | 1 |
| 5 | Samarium triiodide-catalyzed conjugate addition of indoles with electron- deficient olefins显示文摘 | ZHAN Zhuang- Ping YANG Rui- Feng LANG Kai | 2005 | Tetrahedron Letters2005，46，22： | 1 |
| 6 | InvasionDB: A genome and gene database of invasive alien species显示文摘Invasive alien species(IAS) are species whose introduction to areas outside of their native range cause harm to economics, biodiversity, and the environment. Understanding the genetic basis of invasiveness is critical for preventing invasion by an alien species and managing IAS with eco-friendly control methods. In addition, uncovering the genomic features of IAS is essential for accurately predicting invasiveness. However, even though increasing efforts have been devoted to sequencing the genomes of IAS, there is still not an integrated genome database for the invasive biology community. Here, we first determined a list of invasive plants and animals by mining references and databases. Then, we retrieved the genomic and gene data of these IAS, and constructed a database, Invasion DB. Invasion DB encompasses 131 IAS genomes, 76 annotated IAS assemblies, and links these data to conventional functions such as searching for gene coding sequences and Pfam, KEGG, NR annotations, BLAST server, JBrowse, and downloads services. Next, we analyzed 19 invasivenessrelated gene families which confer invasiveness in insects. To study the roles of noncoding RNA in invasiveness, we also annotated 135 494 mi RNAs, 89 294 r RNAs, and 2 671 941 t RNAs from these IAS. In summary, Invasion DB is useful for studying the invasiveness at the genomic level, and thus helps to develop novel management strategies to control IAS. | HUANG Cong LANG Kun QIAN Wan-qiang WANG Shu-ping CAO Xiao-mei HE Rui ZHAN An-ran CHEN Meng-yao YANG Nian-wan LI Fei | 2021 | Journal of Integrative Agriculture2021，20，1： | 1 |
| 7 | Effect of Ti dopant on shrinkage and performance of MCMB-derived carbon laminations显示文摘 | Zhan Jun Liu Quan Gui Guo Jin Ren Song Lang Liu | 2006 | Carbon2006，，1： | 1 |
| 8 | Characterization of reservoir heterogeneity through fluid movement monitoring with deep electromagnetic and pressure measurements显示文摘 | Ma S M Zhan Lang Kuchuk J F | | 0，，： | 1 |
| 9 | Samarium triiodide-cata- lyzed conjugate addition of indoles with electron-deficient olefins 显示文摘 | Zhan Z P Yang R F Lang K | 2005 | Tetrahedron Lett2005，46，22： | 1 |
| 10 | Modeling hydraulic fracturing induced fracture networks in shale gas reservoirs as a dual porosity system显示文摘 | Changan M Du Xu Zhang Lang Zhan | 2010 | SPE 1321802010，，： | 1 |
| 11 | Wild type p53 sensitizes soft tissue sarcoma cells to doxorubicin by down-regulating multidrug resistance-1 expression显示文摘 | Zhan M Yu D Lang A | 2001 | Cancer2001，92，6： | 1 |
| 12 | Wild type p53 sensitizes soft tissue sarcoma cells to doxorubicin by down-regulating multidrug resistance-1 expression显示文摘 | Zhan M Yu D Lang A | 2001 | Cancer2001，92，： | 1 |
| 13 | Wild type p53 sensitizes soft tissue sarcoma cells to doxorubicin by down-regulating multidrug resistance-1 expression显示文摘 | Zhan MC Yu DH Lang AQ | 2001 | Cancer2001，92，6： | 1 |
| 14 | Wild type p53 sensitizes soft tissue sarcoma cells to Doxorubicin by down-regulating multidrug resistance-1 expression显示文摘 | Zhan M Yu D Lang A | 2001 | Cancer Res2001，92，： | 1 |
| 15 | An integrated pipe network model for simulation of highly fractured reservoirs显示文摘 | Zhan Lang Ershaghi I | 2001 | Proceedings SPE Annual Technical Conference and Exhibition2001，，： | 1 |
| 16 | Blocking the large extracellular loop (LEL) domain of Fc Tetraspanin-3 could inhibit the infection of white spot syndrome virus (WSSV) in Chinese shrimp, Fenneropenaeus chinensis显示文摘 | Lang Gui Bing Wang Fu-Hua Li Yu-Miao Sun Zhan Luo Jian-Hai Xiang | 2012 | Fish and Shellfish Immunology2012，，6： | 1 |
| 17 | Identification of peptide mimetics of xenoreactive alpha-Galantigenic epitope by phage display 显示文摘 | Lang J Zhan J Xu L | 2006 | Biochem Biophys Res Gommun2006，344，1： | 1 |
| 18 | Wild type p53 sensitizes soft tissue sarcoma cells to doxorubicin by down- regulating multidrug resistance-1 expression 显示文摘 | Zhan M Yu D Lang A | 2001 | Cancer2001，92，6： | 1 |
| 19 | 射孔新技术--高性能射孔模型显示文摘爆炸聚能射孔是一种在油气井中射穿套管来形成井筒和套管外岩石之间通道的技术。服务公司通过地面试验,将聚能射孔弹射入无应力水泥靶中,以了解其在已知条件下的射孔性能在认识到模拟程序可能无法正确预测井下聚能射孔弹的性能后,斯伦贝谢的科研人员开发出了可精确计算射孔深度、射孔效率和系统动态响应的软件,并以此来优化在高应力岩石中聚能射孔弹的性能。 | carlos baumann alfredo fayard brenden grove jeremy harvey wenbo yang amit govil andy martin roberto franco mendez garcia arturo ramirez rodriquez jock munro cesar velez terrazas lang zhan | 2017 | 石油工业计算机应用2017，25，3： | 0 |
| 20 | Will the Globe Encounter the Warmest Winter after the Hottest Summer in 2023?显示文摘In the boreal summer and autumn of 2023,the globe experienced an extremely hot period across both oceans and continents.The consecutive record-breaking mean surface temperature has caused many to speculate upon how the global temperature will evolve in the coming 2023/24 boreal winter.In this report,as shown in the multi-model ensemble mean(MME)prediction released by the Institute of Atmospheric Physics at the Chinese Academy of Sciences,a medium-to-strong eastern Pacific El Niño event will reach its mature phase in the following 2−3 months,which tends to excite an anomalous anticyclone over the western North Pacific and the Pacific-North American teleconnection,thus serving to modulate the winter climate in East Asia and North America.Despite some uncertainty due to unpredictable internal atmospheric variability,the global mean surface temperature(GMST)in the 2023/24 winter will likely be the warmest in recorded history as a consequence of both the El Niño event and the long-term global warming trend.Specifically,the middle and low latitudes of Eurasia are expected to experience an anomalously warm winter,and the surface air temperature anomaly in China will likely exceed 2.4 standard deviations above climatology and subsequently be recorded as the warmest winter since 1991.Moreover,the necessary early warnings are still reliable in the timely updated mediumterm numerical weather forecasts and sub-seasonal-to-seasonal prediction. | Fei ZHENG Shuai HU Jiehua MA Lin WANG Kexin LI Bo WU Qing BAO Jingbei PENG Chaofan LI Haifeng ZONG Yao YAO Baoqiang TIAN Hong CHEN Xianmei LANG Fangxing FAN Xiao DONG Yanling ZHAN Tao ZHU Tianjun ZHOU Jiang ZHU | 2024 | Advances in Atmospheric Sciences2024，41，4： | 0 |
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