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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Cryptophycin: a new antimicrotubule agent active against drug-resistant cell显示文摘 | Zhang X Mooberry SL | 1994 | Cancer Res1994，54，14： | 1 |
| 3 | Angiotensin Ⅱ-induced superoxide anion generation in human vascular endothelial cells:role of membrane-bound NADH-/NADPH-oxidases显示文摘 | ZHANG H SCR A GARLICHS CD | 1999 | Cardiovasc Res1999，44，1： | 1 |
| 4 | Rapid modification of bacterial artificial chromosomes by ET-recobination 显示文摘 | Muyrers JP Zhang Y Testa G et cd | 1999 | Nucleic Acids Res1999，27，6： | 1 |
| 5 | Clinical value of serum CA 19-9 levels in evaluating respectability of pancreatic carcinoma 显示文摘 | Zhang S Wang YM Sun CD | 2008 | World J Gastroenterol2008，14，23： | 1 |
| 6 | Reduction of serum endothelin1 levels by pneumatic external counterpulsation显示文摘 | Garlichs CD Zhang H Werner D | 1998 | Can J Cardiol1998，14，4： | 1 |
| 7 | Neuroregulative mechanism of hypothalamic paraventricular nucleus on gastric ischemia - reperfusion injury in rats 显示文摘 | Zhang JF Zhang YM Yan CD | 2002 | Life Sci2002，71，13： | 1 |
| 8 | Survival of other fetuses after a fetal death in twin or triplet pregnancies 显示文摘 | Johnson CD Zhang J | 2002 | Obstet Gyneeol2002，99，5： | 1 |
| 9 | Neuroregulative mechanism of hypothalamic paraventricular nucleus on gastric ischemia -reperfusion injury in rats显示文摘 | Zhang JF Zhang YM Yan CD | 2002 | Life Sciences2002，71，13： | 1 |
| 10 | Angiotensin II and potassium regulate human CYP11 B2 transcription through common cis-elements显示文摘 | Clyne CD Zhang Y Slutsker L | 1997 | Mol Endocrinol1997，11，： | 1 |
| 11 | Brain and muscle express a unique alternative transcript of alpha Ⅱ spectrin 显示文摘 | Cianci CD Zhang Z Pradhan D | 1999 | Biochemistry1999，38，15： | 1 |
| 12 | p53 -independent induction of WAF1/cipl in human leukemia cells is correlated with growth arrest accompanying monocyte macrophage differentiation显示文摘 | Zhang W Grasso L McClain CD | 1995 | Cancer Res1995，55，： | 1 |
| 13 | Enhancement of transglutaminase production in Streptomyces mobaraensis as achieved by treatment with excessive MgCl2显示文摘 | Zhang L Zhang L Han X et cd | 2012 | Applied Microbiology and Biotechnology2012，93，6： | 1 |
| 14 | Laparoscopic versus open gastrectomy for early gastric cancer in Asia: a meta-analysis 显示文摘 | Zhang CD Chen SC Feng ZF | 2013 | Surg Laparosc Endosc Pereutan Tech2013，23，4： | 1 |
| 15 | Remodeling in- testinal flora with sleeve gastrectomy in diabetic rats显示文摘 | HUANG X F WENG P ZHANG H X et cd | 2014 | Journal of Diabetes Resem''ch2014，2014，19： | 1 |
| 16 | A homologe of the fungal nuclear migration gene nudc is involved in nomal and malignant human hematopoiesis显示文摘 | Miller BA Zhang MY Gocke CD | 1999 | Exp Hematol1999，27，6： | 1 |
| 17 | Systemic administration of argatroban inhibits protease-activated receptor-1 expression in perihematomal tissue in rats with?intracerebral hemorrhage显示文摘 | Zhou ZH Qu F Zhang CD | 2011 | Brain Res Bull2011，86，： | 1 |
| 18 | Alterations of immune func- tions induced by ^12C^6+ion irradiation in mice 显示文摘 | Zhang H Xie Yi Wang YL et cd | 2007 | Int J Radiat Biol2007，83，9： | 1 |
| 19 | Monocytes coexpress endothelial and macrophagocytic lineage markers and form cord-like structures in Matrigel under angiogenic conditions显示文摘 | Schmeisser A Garlichs CD Zhang H | 2001 | Cardiovasc Res2001，49，： | 1 |
| 20 | HIV protease inhibitors disrupt lipid metabolism by activating endoplasmic reticulum stress and inhibiting autophagy activity in adipocytes显示文摘 | Zha BS Wan X Zhang X et cd | 2013 | PLoS One2013，8，59： | 1 |
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