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| 1 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 7 |
| 2 | Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cancers.Accumulating evidence suggests inherited genetic susceptibility to lung cancer.The present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) patients.Methods: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 mutations.Results: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline BRCA.Conclusions: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC patients.Results suggested a lack of association between germline BRCA status and treatment outcome of EGFR-TKI.In addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 3 | Numerical Simulation of the Solitary Wave Interacting with an Elastic Structure Using MPS-FEM Coupled Method显示文摘Fluid-Structure Interaction(FSI) caused by fluid impacting onto a flexible structure commonly occurs in naval architecture and ocean engineering. Research on the problem of wave-structure interaction is important to ensure the safety of offshore structures. This paper presents the Moving Particle Semi-implicit and Finite Element Coupled Method(MPS-FEM) to simulate FSI problems. The Moving Particle Semi-implicit(MPS) method is used to calculate the fluid domain, while the Finite Element Method(FEM) is used to address the structure domain. The scheme for the coupling of MPS and FEM is introduced first. Then, numerical validation and convergent study are performed to verify the accuracy of the solver for solitary wave generation and FSI problems. The interaction between the solitary wave and an elastic structure is investigated by using the MPS-FEM coupled method. | Chengping Rao Youlin Zhang Decheng Wan | 2017 | Journal of Marine Science and Application2017，16，4： | 2 |
| 4 | Natural infection with torque teno sus virus 1 (TTSuV1) suppresses the immune response to porcine reproductive and respiratory syndrome virus (PRRSV) vaccination显示文摘 | Zhicheng Zhang Yang Wang Hongjie Fan Chengping Lu | 2012 | Archives of Virology2012，，5： | 2 |
| 5 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 6 | Functional analysis of luxS in Streptococcus suis reveals a key role in biofilm formation and virulence显示文摘 | Yang Wang Wei Zhang Zongfu Wu Xianglei Zhu Chengping Lu | 2011 | Veterinary Microbiology2011，，1： | 1 |
| 7 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 8 | Erratum to Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘In the published article1,the affiliation for the first author,Xingshcng Hu,is'Department of Medical Oncology,Cancer Hospital,Chinese Academy of Medical Sciences',we would like to update it to'Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China'.We apologize for the errors and for any confusion it may have caused. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2020 | Cancer Biology & Medicine2020，17，2： | 1 |
| 9 | Construction and Characterization of a Streptococcus suis Serotype 2 Recombinant Expressing Enhanced Green Fluorescent Protein 显示文摘 | Tao Chen QH Zhaolong Li Wei Zhang Chengping Lu Huochun Yao | 2012 | PloS one2012，7，7： | 1 |
| 10 | High-speed 3-D shape measurement based on digital ~ringe projection 显示文摘 | Huang Peisen Zhang Chengping Chiang Fupen | 2003 | Optical Engineering2003，42，1： | 1 |
| 11 | High-speed 3-D shape measurement based on digital fringe projection显示文摘 | Huang Peisen S Zhang Chengping Chiang Fu-Pen | 2003 | Optical Engineering2003，42，1： | 1 |
| 12 | High-speed 3-D shape measurement based on digital fringe projection显示文摘 | Peisen S Huang Chengping Zhang Fu-Pen Chiang | 2003 | Opt Eng2003，42，1： | 1 |
| 13 | Human malignant glioma cells expressing functional formylpeptide receptor recruit endo- thelial progenitor cells for neovascularization 显示文摘 | Chengping Xu Huarong Zhang Feilan Chen | 2010 | Intemational Immu- nopharmacology2010，10，12： | 1 |
| 14 | Natural infection with torque teno sus virus 1 (TTSuV1) suppresses the immune response to porcine reproductive and respiratory syndrome virus (PRRSV) vaccination显示文摘 | Zhicheng Zhang Yang Wang Hongjie Fan Chengping Lu | 2012 | Archives of Virology2012，，5： | 1 |
| 15 | Face stability of shield tunnels considering a kinematically admissible velocity field of soil arching显示文摘Existing mechanism of simulating soil movement at tunnel face is generally based on the translational or rotational velocity field,which is,to some extent,different from the real soil movement in the arching zone.Numerical simulations are carried out first to investigate the characteristics of the velocity distribution at tunnel face and above tunnel vault.Then a new kinematically admissible velocity field is proposed to improve the description of the soil movement according to the results of the numerical simulation.Based on the proposed velocity field,an improved failure mechanism is constructed adopting the spatial discretization technique,which takes into account soil arching effect and plastic deformation within soil mass.Finally,the critical face pressure and the proposed mechanism are compared with the results of the numerical simulation,existing analytical studies and experimental tests to verify the accuracy and improvement of the presented method.The proposed mechanism can serve as an alternative approach for the face stability analysis. | Wei Li Chengping Zhang Dingli Zhang Zijian Ye Zhibiao Tan | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，2： | 1 |
| 16 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 17 | Highspeed phase shifting profilometry 显示文摘 | Huang Peisen S Chiang Fu Pen | 2001 | Proc SPIE2001，4189，： | 1 |
| 18 | Face stability analysis of a shield tunnel excavated along inclined strata显示文摘The horizontally layered or even inclined strata are often encountered in practical shield tunneling.The influence of inclined strata on face stability of shield tunnels is not fully investigated by the existing studies.This paper adopts both theoretical analysis and numerical simulation to carry out research on face stability in inclined strata.The spatial discretization technique is adopted to construct a threedimensional(3D)kinematic failure mechanism considering intersection between inclined soil interface and tunnel face.An analytical solution for critical support pressure is obtained.Besides,the critical support pressure and 3D kinematic mechanism are compared with numerical results to verify accuracy and effectiveness of analytical model.The influences of dip and position of inclined strata on face stability are thoroughly studied.The proposed failure mechanism can serve as a reference for face stability analysis in inclined strata. | Wei Li Chengping Zhang Shiqin Tu Wen Chen Mengshuo Ma | 2023 | Underground Space2023，，6： | 0 |
| 19 | Discovery of a new nontoxic cuprate superconducting system Ga-Ba-Ca-Cu-O显示文摘Superconductivity is observed in a new nontoxic cuprate system Ga-Ba-Ca-Cu-O,with T_c=82 K for Ga Ba_2Ca_5Cu_6O_(14+δ)(Ga-1256)and T_c=116 K probably for Ga Ba_2Ca_3Cu_4O_(10+δ)(Ga-1234)or Ga Ba_2Ca_2Cu_3O_(8+δ)(Ga-1223),respectively.All compounds are fabricated by solid state reaction method under high pressure and high temperature.Samples are characterized by resistivity,magnetization and X-ray diffraction(XRD)measurements.The temperature dependence of magnetization measured in both zero-field-cooled and field-cooled processes on one sample(S1)shows two superconducting transitions at about 82 K and113 K.The estimated shielding fraction for the phase with T_cof 82 K is about 67%,while the fraction for another phase with T_(c )of 113 K is quite small.The XRD Rietveld refinement for S1 indicates two main phases existing in the sample,Ga-1256 with fraction of about 58%and non-superconducting Ca_(0.85)Cu O_2with fraction of about 42%respectively.Thus,we can conclude the superconducting phase with transition temperature of 82 K is due to Ga-1256.The resistivity measurement also confirms the superconductivity for S1,and the resistivity reaches zero at about 82 K.The temperature dependence of magnetization for another sample(S2)shows much higher superconducting shielding fraction for the phase with T_cof 116 K,which may be a promising prospective for the synthesis of Ga-1234 or Ga-1223 phase. | Yue Zhang Wenhao Liu Jin Si Xiyu Zhu Chengping He Haonan Zhao Hai-Hu Wen | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，9： | 0 |
| 20 | Treatment Effects of Integrated TCM and Western Medicine Treatment Scheme on COVID-19: A Single-armed Clinical Trial显示文摘Backgroud:The outbreak of COVID-19 has brought unprecedented perils to human health and raised public health concerns in more than two hundred countries.Safe and effective treatment scheme is needed urgently.Objective:To evaluate the effects of integratedTCM and western medicine treatment scheme on COVID-19.Methods:A single-armed clinical trial was carried out in Hangzhou Xixi Hospital,an affiliated hospital with Zhejiang Chinese Medical University.102 confirmed cases were screened out from 725 suspected cases and 93 of them were treated with integrated TCM and western medicine treatment scheme.Results:83 cases were cured,5 cases deteriorated,and 5 cases withdrew from the study.No deaths were reported.The mean relief time of fever,cough,diarrhea,and fatigue were(4.78±4.61)days,(7.22±4.99)days,(5.28±3.39)days,and(5.28±3.39)days,respectively.It took(14.84±5.50)days for SARS-CoV-2 by nucleic acid amplification-based testing to turn negative.Multivariable cox regression analysis revealed that age,BMI,PISCT,BPC,AST,CK,BS,and UPRO were independent risk factors for COVID-19 treatment.Conclusion:Our study suggested that integrated TCM and western medicine treatment scheme was effective for COVID-19. | Jianfeng Bao Zhijun Xie Shourong Liu Lin Huang Jing Sun Yujun Tang Haiping Chen Jianjiang Qi Jianchun Guo Liangbin Miao Zhaoyi Li Hui Yang Yi Zhang Zhiyu Li Yuan Xu Shengyou Lin Yunhao Xun Li Zhang Jie Bao Zhaobin Cai Jinsong Huang Chengping Wen | 2021 | Clinical Complementary Medicine and Pharmacology2021，1，1： | 0 |
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