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| 1 | Extensive translation of circular RNAs driven by N6-methyladenosine显示文摘广泛的 pre-mRNA 拼接背在人的 transcriptome 产生众多的圆形的 RNA (circRNAs ) 。然而,这些 circRNAs 的生物功能仍然保持大部分不清楚。这里,我们报导那 N 6-methyladenosine (m 6 一) , RNA 的最丰富的基础修正,在人的房间从 circRNAs 支持蛋白质翻译的有效开始。我们发现那一致 m 6 A 主题在 circRNAs 和单个 m 6 一个地点是足够的驾驶翻译开始。这 m 6A 驱动的翻译要求开始因素 eIF4G2 和 m 6 读者 YTHDF3,并且被 methyltransferase METTL3/14 提高,在热吃惊之上由 demethylase FTO,和 upregulated 禁止了。通过介绍的 polysome 的进一步的分析,计算预言和集体 spectrometry 揭示那 m 6 circRNAs 的 A 驱动的翻译是普遍的,与有翻译潜力的几百内长的 circRNAs。我们的学习扩展人的 transcriptome 的编码风景,并且在对环境应力的细胞的回答建议导出 circRNA 的蛋白质的一个角色。 | Yun Yang Xiaojuan Fan Miaowei Mao Xiaowei Song Ping Wu6,7 Yang Zhang Yongfeng Jin Yi Yang Ling-Ling Chen Yang Wang Catherine CL Wong Xinshu Xiao Zefeng Wang | 2017 | Cell Research2017，27，5： | 246 |
| 2 | Mixing state of individual carbonaceous particles during a severe haze episode in January 2013,Nanjing,China显示文摘Chemical composition,hourly counts,and sizes of atmospheric carbonaceous particles were measured to investigate their mixing state on clear and hazy days.623,122 carbonaceous particles with sizes0.2-2.0 μm was analyzed using a single-particle aerosol mass spectrometer from 1st to 17 th January2013.Particle types included biomass/biofuel burning particles(biomass),element carbon(EC-dominant)particles that were also mixed with biomass/biofuel burning species(EC-biomass) or secondary species(EC-secondary),organic carbon(OC),internally mixed OC and EC(OCEC),ammonium-containing(ammonium) and sodium-containing(sodium) particles.On clear days the top ranked carbonaceous particle types were biomass(48.2%),EC-biomass(15.7%),OCEC(11.1%),and sodium(9.6%),while on hazy days they were biomass(37.3%),EC-biomass(17.6%),EC-secondary(16.6%),and sodium(12.7%).The fractions of EC-secondary,ammonium(10%),and sodium particle types were elevated on hazy days.Numbers of EC-secondary particles were more than four times those on clear days(4.1%).Thus,carbonaceous particles mixed with ammonium,nitrate and sulfate during aging and transport,enhancing their light extinction effects and hygroscopic growth under high relative humidity on hazy days,further reducing visibility.Our real-time single-particle data showed that changes to mixing state had a significant impact on light extinction during haze events in Nanjing. | Honglei Wang Bin Zhu Zefeng Zhang Junlin An Lijuan Shen | 2015 | Particuology2015，13，3： | 12 |
| 3 | Efficient elimination of multidrug-resistant bacteria using copper sulfide nanozymes anchored to graphene oxide nanosheets显示文摘Antibacterial nanomaterials have attracted growing interest for bacterial infection therapy.However,most nanomaterials eliminate bacteria either physically or chemically,which hampers their efficacy when dealing with multidrug-resistant bacteria.To overcome this,we integrated copper sulfide(CuS)nanoparticles with active graphene oxide nanosheets(GO NSs)to synthesize a superior nanocomposite(CuS/GO NC)that acts both physically and chemically on the bacteria.CuS/GO NC was produced using a facile hydrothermal method,whereby the CuS nanoparticles grew and were uniformly dispersed on the GO NSs in situ.We found that the CuS/GO NC possesses a unique needle-like morphology that physically damages the bacterial cell membrane.CuS/GO NC also exhibits high oxidase-and peroxidase-like activity,ensuring efficient generation of the reactive oxygen species•OH from H2O2,which kills bacteria chemically.These features endow the CuS/GO NC with excellent antibacterial capabilities to kill multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus(MRSA)with only a single dose.Additionally,it was found that the CuS/GO NC accelerated the healing of infected wounds in vivo owing to its good biocompatibility as well as facilitation of cell migration and collagen secretion.This study provides a new strategy to combine the physical and chemical antibacterial modes of nanomaterials to develop more effective therapies to combat multidrug-resistant bacterial infections. | Wanshun Wang Binglin Li Huili Yang Zefeng Lin Lingling Chen Zhan Li Jiayuan Ge Tao Zhang Hong Xia Lihua Li Yao Lu | 2020 | Nano Research2020，13，8： | 8 |
| 4 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders:executive summary and 2019 update on organizational stroke management显示文摘Aim Stroke is characterised by high morbidity,mortality and disability,which seriously affects the health and safety of the people.Stroke has become a serious public health problem in China.Organisational stroke management can significantly reduce the mortality and disability rates of patients with stroke.We provide this evidence-based guideline to present current and comprehensive recommendations for organisational stroke management.Methods A formal literature search of MEDLINE(1 January 1997 through 30 September 2019)was performed.Data were synthesised with the use of evidence tables.Writing group members met by teleconference to discuss data-derived recommendations.The Chinese Stroke Association’s Levels of Evidence grading algorithm was used to grade each recommendation.results Evidence-based guidelines are presented for the organisational management of patients presenting with stroke.The focus of the guideline was subdivided into prehospital first aid system of stroke,rapid diagnosis and treatment of emergency in stroke centre,organisational management of stroke unit and stroke clinic,construction of regional collaborative network among stroke centres and evaluation and continuous improvement of stroke medical quality.Conclusions The guidelines offer an organisational stroke management model for patients with stroke which might help dramatically. | Min Lou Jing Ding Bo Hu Yusheng Zhang Hao Li ZeFeng Tan Yan Wan An-Ding Xu Chinese Stroke Association Stroke Council Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 7 |
| 5 | Splicing dysregulation in cancer: from mechanistic understanding to a new class of therapeutic targets显示文摘RNA splicing dysregulation is widespread in cancer. Accumulating evidence demonstrates that splicing defects resulting from splicing dysregulation play critical roles in cancer pathogenesis and can serve as new biomarkers and therapeutic targets for cancer intervention. These findings have greatly deepened the mechanistic understandings of the regulation of alternative splicing in cancer cells, leading to rapidly growing interests in targeting cancer-related splicing defects as new therapies. Here we summarize the current research progress on splicing dysregulation in cancer and highlight the strategies available or under development for targeting RNA splicing defects in cancer. | Yongbo Wang Yufang Bao Sirui Zhang Zefeng Wang | 2020 | Science China(Life Sciences)2020，63，4： | 5 |
| 6 | Raman micro-spectrometry as a technique for investigating heterogeneous reactions on individual atmospheric particles显示文摘Investigating the heterogeneous reaction on individual atmospheric particles is important because it approximates actual atmospheric conditions and can aid in reducing artifacts in elucidating real mechanisms and processes,and determining real kinetic parameters of the atmosphere relevance.This study developed a Raman microspectrometry method to investigate heterogeneous reactions on individual particles.The method was applied to the reaction of NO2 with individual CaCO3 particles.It was demonstrated that Raman microspectrometry can obtain information on both chemical composition and microscopic morphology at the same time,as well as information on chemical characteristics,such as the phase,which is useful for studying reaction processes.Raman spectra of individual particles deposited on a substrate showed no interference by morphological resonance,which is helpful for obtaining high-quality spectra.Moreover,Raman microspectrometry was compared with other methods for investigating heterogeneous reactions on individual particles and was found to have several advantageous characteristics. | ZHAO DeFeng,ZHU Tong,CHEN Qi,LIU YingJun & ZHANG ZeFeng State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering,Peking University,Beijing 100871,China | 2011 | Science China Chemistry2011，54，1： | 5 |
| 7 | Study of Krypton Laser-Induced Choroidal Neovascularization in a Guinea Pig Model of High Anisometropia显示文摘Purpose:To investigate the association between high anisometropia and the area of choroidal neovascularization (CNV) induced by krypton laser in guinea pigs and better understand the pathogenesis and prevention of myopic CNV. Methods:.Nine 3-week old male guinea pigs with anisometropia > 6.00D were randomly assigned to three groups according to examination date after laser photocoagulation (7d, 14d and 28d). All animals underwent refraction. The eye with higher myopia was used as the experimental eye, and the other as the control eye..All eyes received repeated multi-wavelength krypton laser photocoagulation treatments (wavelength: 532 nm; laser power: 400 mW; spot diameter: 50 μm; exposure time: 0.1s). Fundus photography and indocyanine green angiography (ICGA) were performed. Afterwards, the animals were sacrificed immediately,.and the eyes were enucleated and processed for histopathologic examination and flat mounts. Results: CNV appeared at 7d after laser treatment. The area of CNV peaked at 14d, and decrease in area and the presence of scarring was noted at 28 d..CNV was present in 66.7% of eyes by ICGA at 14 d..CNV could be observed under light microscopy at all three time points..At 14 d,.flat mount showed the neovascular plexus around the lesion. Semi-quantitative analysis revealed that the area of CNV in treated eyes was greater than that of control eyes. Conclusion:.Since the mechanism of CNV in this study resembles that of CNV in pathological myopia, this model can be used to investigate the etiology, pathogenesis and treatment of CNV in pathological myopia. | Jianghui Wang Wei Jiang Zefeng Kang Lina Liang Xiaoman Liu Nannan Tian Qing Zhang | 2012 | Eye Science2012，27，2： | 4 |
| 8 | Classification of Imagined Speech EEG Signals with DWT and SVM显示文摘With the development of human-computer interaction technology,brain-computer interface(BCI)has been widely used in medical,entertainment,military,and other fields.Imagined speech is the latest paradigm of BCI and represents the mental process of imagining a word without making a sound or making clear facial movements.Imagined speech allows patients with physical disabilities to communicate with the outside world and use smart devices through imagination.Imagined speech can meet the needs of more complex manipulative tasks considering its more intuitive features.This study proposes a classification method of imagined speech Electroencephalogram(EEG)signals with discrete wavelet transform(DWT)and support vector machine(SVM).An open dataset that consists of 15 subjects imagining speaking six different words,namely,up,down,left,right,backward,and forward,is used.The objective is to improve the classification accuracy of imagined speech BCI system.The features of EEG signals are first extracted by DWT,and the imagined words are clas-sified by SVM with the above features.Experimental results show that the proposed method achieves an average accuracy of 61.69%,which is better than those of existing methods for classifying imagined speech tasks. | ZHANG Lingwei ZHOU Zhengdong XU Yunfei JI Wentao WANG Jiawen SONG Zefeng | 2022 | Instrumentation2022，9，2： | 4 |
| 9 | A New Cleaner Power Generation System Based on Self-Sustaining Supercritical Water Gasification of Coal显示文摘A new cleaner power generation system(IPGS) is proposed and investigated in this paper. Integrating combined cycle with supercritical water gasification of coal, the thermodynamic energy of the produced syngas is cascade utilized according to its temperature and pressure, both sensible and latent heat of the syngas can be recycled into the system, and thereby the net power efficiency can be about 6.4 percentage points higher than that of the traditional GE gasification based power plant(GEPP). The exergy analysis results show that the exergy efficiency of the proposed system reaches 52.45%, which is 13.94% higher than that of the GEPP, and the improvement in exergy efficiency of the proposed system mainly comes from the exergy destruction decline in the syngas energy recovery process, the condensation process and the syngas purification process. The syngas combustion process is the highest exergy destruction process with a value of 157.84 MW in the proposed system. Further performance improvement of the proposed system lies in the utilization process of syngas. Furthermore, system operation parameters have been examined on the coal mass fraction in the supercritical water gasifier(GF), the gasification temperature, and the gasification pressure. The parametric analysis shows that changes in coal concentration in the GF exert more influence on the exergy efficiency of the system compared with the other two parameters. | LIU Changchun HAN Wei WANG Zefeng ZHANG Na | 2022 | Journal of Thermal Science2022，31，5： | 3 |
| 10 | Electrochemical corrosion behavior of steel wires in a coalmine with a corrosive medium显示文摘6 脳升起电报的 19 点接触被用作我们的研究目标在一个实验室检验钢电线的腐蚀的进步,在 coalmine 模仿实际工作条件。一个电气化学的方法被用来与腐蚀剂酸溶液的不同表面处理调查钢电线的腐蚀行为。在当,赤裸的钢电线的阳极激活过程最快的地方,结果证明钢电线的阳极激活主要发生在腐蚀前期间是他们的相应腐蚀速度,当涂的钢电线和他们的相应腐蚀加速的油的阳极激活过程最低时。在中间、迟了的沉浸时期期间,一部被动电影在钢电线的表面上被产生,它逐渐地与时间的推移被损坏。本地 pitting 腐蚀与一个高极化的潜力在钢电线的表面上容易发生。合适的相等的电路被选择在各种各样的腐蚀剂时间和不同表面处理适合钢电线的电气化学的阻抗光谱学(EIS ) ,它显示好恰当的结果。双电的层费用转移抵抗在顺序增加:赤裸的钢电线,未经治疗的钢电线和油涂的钢电线和他们的腐蚀抵抗接着减少,它与他们的极化曲线一致。油层在未经治疗的钢电线上提供某个保护的效果,但是它的效果不是完全清楚的。 | Wang Songquan Zhang Dekun Wang Dagang Zhang Zefeng | 2011 | Mining Science and Technology2011，21，1： | 3 |
| 11 | Effect of various kinematic parameters of mine hoist on fretting parameters of hoisting rope and a new fretting fatigue test apparatus of steel wires显示文摘 | Dagang Wang Dekun Zhang Zefeng Zhang Shirong Ge | 2012 | Engineering Failure Analysis2012，，： | 2 |
| 12 | Multi-Cluster Feature Selection Based on Isometric Mapping显示文摘Dear editor,This letter presents an unsupervised feature selection method based on machine learning.Feature selection is an important component of artificial intelligence,machine learning,which can effectively solve the curse of dimensionality problem.Since most of the labeled data is expensive to obtain. | Yadi Wang Zefeng Zhang Yinghao Lin | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，3： | 2 |
| 13 | Heterogeneous reaction of NO_2 on the surface of montmorillonite particles显示文摘The studies on heterogeneous reactions over montmorillonite,which is a typical 2:1 layered aluminosilicate,will benefit to the understanding of heterogeneous reactions on clay minerals.Montmorillonite can be classified as sodium montmorillonite or calcium montmorillonite depending on the cation presented between the different layers.Using diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS),the heterogeneous reaction mechanism of NO2 on the surface of montmorillonite was firstly investigated.Results showed that the reaction of NO2 on the surface of sodium and calcium montmorillonite fit a first-order kinetics,and the reaction duration of calcium montmorillonite was longer than that of sodium montmorillonite under the dry condition.For either sodium or calcium montmorillonite,the uptake coefficient decreased as humidity increased. | Zefeng Zhang Jing Shang Tong Zhu Hongjun Li Defeng Zhao Yingju Liu Chunxiang Ye | 2012 | Journal of Environmental Sciences2012，24，10： | 2 |
| 14 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 15 | Analysis of the Effect of Optical Properties of Black Carbon on Ozone in an Urban Environment at the Yangtze River Delta,China显示文摘Black carbon(BC)reduces the photolysis coefficient by absorbing solar radiation,thereby affecting the concentration of ozone(O_(3))near the ground.The influence of BC on O_(3)has thus received much attention.In this study,Mie scattering and the tropospheric Ultraviolet and Visible radiation model are used to analyze the effect of BC optical properties on radiation.Combined with data of O_(3)precursors in Nanjing in 2014,an EKMA curve is drawn,and the variations in O_(3)concentration are further investigated using a zero-dimensional box mechanism model(NCAR MM).When O_(3)precursors are unchanged,radiation and O_(3)show a highly similar tendency in response to changing BC optical properties(R=0.997).With the increase of modal radius,the attenuation of fresh BC to radiation and O_(3)first trends upward before decreasing.In the mixing process,the attenuation of BC to radiation and O_(3)presents an upward tendency with the increase of relative humidity but decreases rapidly before increasing slowly with increasing thickness of coating.In addition,mass concentration is another major factor.When the BC to PM_(2.5)ratio increases to 5%in Nanjing,the radiation decreases by approximately 0.13%-3.71%while O_(3)decreases by approximately 8.13%-13.11%.The radiative effect of BC not only reduces O_(3)concentration but also changes the EKMA curve.Compared with the NO_(x)control area,radiation has a significant influence on the VOCs control area.When aerosol optical depth(AOD)increases by 17.15%,the NO_(x)to VOCs ratio decreases by 8.27%,and part of the original NO_(x)control area is transferred to the VOCs control area. | Junlin AN Huan LV Min XUE Zefeng ZHANG Bo HU Junxiu WANG Bin ZHU | 2021 | Advances in Atmospheric Sciences2021，38，7： | 1 |
| 16 | Contactimpact stress analysis of rail joint region using the dynamic finite element methnd显示文摘 | WEN Zefeng JIN Xuesong ZHANG Weihua | 2005 | Wear2005，，258： | 1 |
| 17 | Contact-lmp&ct Stress Analysis of Pu&il Joint P~egion using the Dynamic Finite Element Method 显示文摘 | Zefeng WEN Xuesong JIN Weihua ZHANG | 2005 | Wear2005，258，： | 1 |
| 18 | The Effects of Increased Expression of DLK1 Gene on the Pathogenesis of Myelodysplastic Syndromes显示文摘 | Xiaotang Ma Yue Zhang Lin Yang Zefeng Xu Zhijian Xiao | 2012 | Clinical Lymphoma Myeloma and Leukemia2012，，4： | 1 |
| 19 | Heterogeneous reaction of NO_2 with sea salt particles显示文摘To understand how NO2 reacts with sea salt particles in the atmosphere of Mega-cities in coastal zones,the heterogeneous reaction of NO2 on the surface of wet sea salt was investigated with diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) and ion chromatography (IC).Kinetic measurements indicated that nitrate formation on sea salt was second order in NO 2 concentration and reactive uptake coefficients were (5.51 ± 0.19) × 10-7 and 1.26 × 10-6 respectively under 0% and 20% relative humidity (RH) at NO 2 molecular concentration of 1.96 × 1015 mol/cm3.The results showed that liquid water was formed at the site of MgCl2·6H2O,CaCl2·2H2O on the surface of sea salt and made the reaction more sustainable by releasing hydrated water and absorbing water from air even under a low RH (30%).Therefore,pure NaCl particles should not be used to represent sea salt in studies of the heterogeneous reaction with NO2. | YE ChunXiang 1,LI HongJun 1,ZHU Tong 1,SHANG Jing 1,ZHANG ZeFeng 1,2 & ZHAO DeFeng 1 1 State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering,Peking University,Beijing 100871,China 2 College of Atmospheric Physics,Nanjing University of Information Science and Technology,Nanjing 210044,China | 2010 | Science China Chemistry2010，53，12： | 1 |
| 20 | Effect of various kinematic parameters of mine hoist on fretting parameters of hoisting rope and a new fretting fatigue test apparatus of steel wires显示文摘 | Dagang Wang Dekun Zhang Zefeng Zhang | 2012 | Engineering Failure Analysis2012，，22： | 1 |
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