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| 1 | Repress,on of MYBL2 by Both microRNA858a and HY5 Leads to the Activation of Anthocyanin Biosynthetic Pathway in Arabidopsis显示文摘 | Yulong Wang Yiqing Wang Zhaoqing Song Huiyong Zhang | 2016 | Molecular Plant2016，9，10： | 27 |
| 2 | Effects of the dispatch modes of the Three Gorges Reservoir on the water regimes in the Dongting Lake area in typical years显示文摘在典型的年里基于地调查原型水文学数据,效果在在东廷·莱克区域的水政体上的三座峡水库的不同派遣模式的跑的时期期间是比较地分析了。结果如下被显示出。(1 ) 影响时期从 5 月 25 日到 6 月 10 日,从 7 月 1 日到 8 月 31 日,从 9 月 15 日到 10 月 31 日并且从 12 月到下一 4 月,在旱季的水补充派遣的影响不在之中是很敏感的。(2 ) 在在预先解除下面的时期期间派遣,流量体积稍微在平常的年里象平均的水水平和高水位线水平上升一样增加。当时在湿、干燥的年里,流量体积的平均增加是 40. | OU Chaomin LI Jingbao ZHANG Zhaoqing LI Xichun YU Guo LIAO Xiaohong | 2012 | Journal of Geographical Sciences2012，22，4： | 12 |
| 3 | Symphony of nanomaterials and immunotherapy based on the cancer-immunity cycle显示文摘The immune system is involved in the initiation and progression of cancer. Research on cancer and immunity has contributed to the development of several clinically successful immunotherapies. These immunotherapies often act on a single step of the cancer-immunity cycle. In recent years, the discovery of new nanomaterials has dramatically expanded the functions and potential applications of nanomaterials. In addition to acting as drug-delivery platforms, some nanomaterials can induce the immunogenic cell death(ICD) of cancer cells or regulate the profile and strength of the immune response as immunomodulators.Based on their versatility, nanomaterials may serve as an integrated platform for multiple drugs or therapeutic strategies, simultaneously targeting several steps of the cancer-immunity cycle to enhance the outcome of anticancer immune response. To illustrate the critical roles of nanomaterials in cancer immunotherapies based on cancer-immunity cycle, this review will comprehensively describe the crosstalk between the immune system and cancer, and the current applications of nanomaterials, including drug carriers, ICD inducers, and immunomodulators. Moreover, this review will provide a detailed discussion of the knowledge regarding developing combinational cancer immunotherapies based on the cancer-immunity cycle, hoping to maximize the efficacy of these treatments assisted by nanomaterials. | Qianqian Li Zhaoqing Shi Fan Zhang Weiwei Zeng Dunwan Zhu Lin Mei | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 4 |
| 4 | Critical function of DNA methyltransferase 1 in tomato development and regulation of the DNA methylome and transcriptome显示文摘DNA methylation confers epigenetic regulation on gene expression and thereby on various biological processes.Tomato has emerged as an excellent system to study the function of DNA methylation in plant development.To date,regulation and function of DNA methylation maintenance remains unclear in tomato plants.Here,we report the critical function of tomato(Solanum lycopersicum)Methyltransferase 1(Sl MET1)in plant development and DNA methylome and transcriptome regulation.Using CRISPR-Cas9 gene editing,we generated slmet1 mutants and observed severe developmental defects with a frame-shift mutation,including small and curly leaves,defective inflorescence,and parthenocarpy.In leaf tissues,mutations in Sl MET1 caused CG hypomethylation and CHH hypermethylationon a whole-genome scale,leading to a disturbed transcriptome including ectopic expression of many RIN target genes such as ACC2 in leaf tissues,which are normally expressed in fruits.Neither the CG hypomethylation nor CHH hypermethylation in the slmet1 mutants is related to tissue culture.Meanwhile,tissue culture induces non-CG hypomethylation,which occurs more frequently at gene regions than at TE regions.Our results depict Sl MET1-and tissue culture-dependent tomato DNA methylomes,and that Sl MET1 is required for maintaining a normal transcriptome and normal development of tomato. | Yu Yang Kai Tang Tatsiana U Datsenka Wenshan Liu Suhui Lv Zhaobo Lang Xingang Wang Jinghui Gao Wei Wang Wenfeng Nie Zhaoqing Chu Heng Zhang Avtar K HANDa Jian-Kang Zhu Huiming Zhang | 2019 | Journal of Integrative Plant Biology2019，61，12： | 3 |
| 5 | Highly Improved Microstructure and Properties of Poly(p-phenylene terephthalamide) Paper-based Materials via Hot Calendering Process显示文摘In this study,the effect of hot calendering process on the microstructure and properties of poly(p-phenylene terephthalamide)(PPTA) paper-based materials was investigated.The microstructures of the fracture surface,crystalline structure,and single fiber strength of the PPTA paperbased materials as well as the different bonding behaviors between the PPTA fibers and PPTA fibrids obtained before and after the hot calendering process were examined.The results indicated that a high linear pressure would result in a limited improvement of the strength owing to the unimproved paper structure.The optimal values of tensile index and dielectric strength of 56.6 N·m/g and 27.6 kV/mm,respectively,could only be achieved with a synergistic effects of hot calendering temperature and linear pressure(240℃ and 110 k N/m,respectively).This result suggested it was possible to achieve a significant reinforcement and improvement in the interfacial bonding of functional PPTA paper-based materials,and avoid the formation of unexpected pleats and cracks in PPTA paper-based materials during the hot calendering process. | Bin Yang ZhaoQing Lu MeiYun Zhang ShunXi Song RuNan Wang | 2017 | Paper And Biomaterials2017，2，3： | 3 |
| 6 | Association between HER2 status and response to neoadjuvant anthracycline followed by paclitaxel plus carboplatin chemotherapy without trastuzumab in breast cancer显示文摘Background:We recently showed HER2-positive breast cancers are less likely to respond to neoadjuvant anthracycline chemotherapy.Here,we investigated whether HER2-positive breast cancers responded to sequential neoadjuvant anthracycline followed by paclitaxel plus carboplatin regimen in the absence of trastuzumab.Methods:Women(n=372) with operable primary breast cancer initially received two cycles of neoadjuvant anthracyclines,the clinical tumor response was assessed,then patients were received four cycles of paclitaxel plus carboplatin regimen.All the patients did not received trastuzumab treatment in the neoadjuvant setting.HER2 status was determined by immunohistochemistry and/or by fluorescence in situ hybridization in corebiopsy breast cancer tissue obtained before the neoadjuvant chemotherapy.Results:Eighteen percent(67/372) of patients achieved a pathologic complete response(p CR) in their breast.HER2-positive tumors had a significant higher p CR rate than HER2-negative tumors(33.0% versus 13.5%,P<0.001) in this cohort of 372 patients,and positive HER2 status remained an independent favorable predictor of p CR in a multivariate analysis [odds ratio(OR),2.26;95% confidence interval(CI),1.18 to 4.36,P=0.015].Furthermore,patients who responded to initial anthracycline regimens were more likely to respond to paclitaxel plus carboplatin than patients who did not(p CR,27.2% versus 14.6%,P=0.005).Patients with HER2-positive tumors exhibited a significant higher p CR rate than did patients with HER2-negative tumors in both anthracycline response group(40.5% versus 20.0%,P=0.025) and anthracycline non-response group(28.3% versus 11.3%,P=0.002).Conclusions:Under the circumstance of no trastuzumab treatment,women with HER2-positive cancers derive a large benefit from paclitaxel-carboplatin-based neoadjuvant chemotherapy. | Lu Yao Juan Zhang Yiqiang Liu Tao Ouyang Jinfeng Li Tianfeng Wang Zhaoqing Fan Tie Fan Benyao Lin Yuntao Xie | 2015 | Chinese Journal of Cancer Research2015，27，6： | 3 |
| 7 | Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination显示文摘DNA 双海滨裂缝(DSB ) 是高度细胞毒素的损害并且如果,形成主要威胁到染色体稳定性不适当地修理了。我们和其它以前证明了导致 DSB 的小 RNA (diRNAs ) 的一个班在 DSB 地点附近从序列被生产。DiRNAs 与 Argonaute 被联系(以前) 蛋白质和戏在 DSB 修理的一个重要角色,不过,他们通过行动的机制仍然保持不清楚。这里,我们报导在 DSB 修理的 diRNAs 的角色被限制由相应再结合(HR ) 修理并且它明确地在哺乳动物的房间依靠受动器蛋白质 Ago2。有趣地,我们证明 Ago2 与 Rad51 形成建筑群并且相互作用在与电离对待的房间被提高放射。我们证明在 DSB 地点和 HR 修理的 Rad51 累积取决于催化活动和 Ago2 的小 RNA 有约束力的能力。相反,象装载的 RPA 和 Mre11 一样的 DSB 切除术由 Ago2 或 Dicer 弄空是未受影响的,建议 Ago2 很多半在调停直接工作在 DSB 的 Rad51 累积。一起拿,我们的调查结果建议由 diRNAs 指导了那, Ago2 能在 DSB 支持 Rad51 招募或保留由 HR 便于修理。 | Min Gao Wei Wei Ming-Ming Li Yong-Sheng Wu Zhaoqing Ba Kang-Xuan Jin Miao-Miao Li You-Qi Liao Samir Adhikari Zechen Chong Ting Zhang Cai-Xia Guo Tie-shah Tang Bing-Tao Zhu Xing-Zhi Xu Niels Mailand Yun-Gui Yang Yijun Qi Jannie M Rendtlew Danielsen | 2014 | Cell Research2014，24，5： | 3 |
| 8 | A Method to Detect the Abnormal Phenomenonin PVM Program Based on Petri Net | JIANG Chanaiun(Department of Computer Science, Shandong Mining Institute, Tat’an 271019)(Department of Computer Science, Tough University, Shanghai 200092)LI Caiwei(Institute of Automation, Chinese Acadamy of Sciences, Beijing 100080)ZHANG Zhaoqing and QI | 1999 | Systems Science and Systems Engineering1999，9，2： | 2 |
| 9 | A closed-form solution for a double infinite Euler-Bernoulli beam on a viscoelastic foundation subjected to harmonic line load显示文摘The dynamic response of a double infinite beam system connected by a viscoelastic foundation under the harmonic line load is studied. The double infinite beam system consists of two identical and parallel beams, and the two beams are infinite elastic homogeneous and isotropic. A viscoelastic layer connects the two beams continuously. To decouple the two coupled equations governing the response of the double infinite beam system, a variable substitution method is introduced. The frequency domain solutions of the decoupled equations are obtained by using Fourier transforms as well as Laplace transforms successively. The time domain solution in the generalized integral form are then obtained by employing the corresponding inverse transforms, i.e. Fourier transform and inverse Laplace transform. The solution is verified by numerical examples, and the effects of parameters on the response are also investigated. | Li Bing Cheng Yongfeng Zhu Zhaoqing Zhang Fuyou | 2019 | Earthquake Engineering and Engineering Vibration2019，18，1： | 2 |
| 10 | Bismuth-Based Free-Standing Electrodes for Ambient-Condition Ammonia Production in Neutral Media显示文摘Electrocatalytic nitrogen reduction reaction is a carbon-free and energy-saving strategy for efficient synthesis of ammonia under ambient conditions.Here,we report the synthesis of nanosized Bi2O3 particles grown on functionalized exfoliated graphene(Bi2O3/FEG)via a facile electrochemical deposition method.The obtained free-standing Bi2O3/FEG achieves a high Faradaic efficiency of 11.2%and a large NH3 yield of 4.21±0.14μgNH3 h^-1 cm^-2 at-0.5 V versus reversible hydrogen electrode in 0.1 M Na2SO4,better than that in the strong acidic and basic media.Benefiting from its strong interaction of Bi 6p band with the N2p orbitals,binder-free characteristic,and facile electron transfer,Bi2O3/FEG achieves superior catalytic performance and excellent long-term stability as compared with most of the previous reported catalysts.This study is significant to design low-cost,high-efficient Bi-based electrocatalysts for electrochemical ammonia synthesis. | Ying Sun Zizhao Deng Xi‑Ming Song Hui Li Zihang Huang Qin Zhao Daming Feng Wei Zhang Zhaoqing Liu Tianyi Ma | 2020 | Nano-Micro Letters2020，12，10： | 2 |
| 11 | Micrometer-sized ferrosilicon composites wrapped with multi-layered carbon nanosheets as industrialized anodes for high energy lithium-ion batteries显示文摘Various nanostructured architectures have been demonstrated to be effective to address the issues of high capacity Si anodes. However, the scale-up of these nano-Si materials is still a critical obstacle for commercialization. Herein, we use industrial ferrosilicon as low-cost Si source and introduce a facile and scalable method to fabricate a micrometer-sized ferrosilicon/C composite anode, in which ferrosilicon microparticles are wrapped with multi-layered carbon nanosheets. The multi-layered carbon nanosheets could effectively buffer the volume variation of Si as well as create an abundant and reliable conductivity framework, ensuring fast transport of electrons. As a result, the micrometer-sized ferrosilicon/C anode achieves a stable cycling with 805.9 m Ah g-1 over 200 cycles at 500 mA g-1 and a good rate capability of455.6 mAh g-1 at 10 A g-1. Therefore, our approach based on ferrosilicon provides a new opportunity in fabricating cost-effective, pollution-free, and large-scale Si electrode materials for high energy lithium-ion batteries. | Meng Li Jingyi Qiu Songtong Zhang Pengcheng Zhao Zhaoqing Jin Anbang Wang Yue Wang Yusheng Yang Hai Ming | 2020 | Journal of Energy Chemistry2020，29，11： | 2 |
| 12 | Angiotensin II sustains brain inflammation in mice via TGF-[Beta]显示文摘 | Lanz Tobias V Ding Zhaoqing Ho Peggy P Luo Jian Agrawal Ankur N Srinagesh Hrishikesh Axtell Robert Zhang Hui Platten Michael Wyss-Coray Tony Steinman Lawrence | 2010 | Journal of Clinical Investigation2010，，8： | 1 |
| 13 | Prevalence of Dyslipidemia and Associated Factors Among the Hypertensive Rural Chinese Population显示文摘 | Xingang Zhang Zhaoqing Sun Liqiang Zheng Jue Li Shuangshuang Liu Changlu Xu Jiajin Li Fenfen Zhao Dayi Hu Yingxian Sun | 2007 | Archives of Medical Research2007，，4： | 1 |
| 14 | Effect of PPTA Fiber Morphology on the Performance of Paper-Based Functional Materials 显示文摘 | Zhang Meiyun Huang Rui Lu Zhaoqing | 2011 | Advanced Materials Research2011，23，6238： | 1 |
| 15 | Pulse Pressure and Mean Arterial Pressure in Relation to Ischemic Stroke Among Patients With Uncontrolled Hypertension in Rural Areas of China显示文摘 | Liqiang Zheng Zhaoqing Sun Jue Li Rui Zhang Xingang Zhang Shuangshuang Liu Jiajin Li Changlu Xu Dayi Hu Yingxian Sun | 2008 | Stroke2008，，7： | 1 |
| 16 | Determination of critical micelle concentration of binary surfactant mixtures using UV-VIS spectrophotometry and Gaussian fitting method显示文摘 | LI Xiaoge ZHANG Jianhua LIU Zhaoqing | 2011 | Global Journal of Physical Chemistry2011，2，1： | 1 |
| 17 | Pulse Pressure and Mean Arterial Pressure in Relation to Ischemic Stroke Among Patients With Uncontrolled Hypertension in Rural Areas of China显示文摘 | Liqiang Zheng Zhaoqing Sun Jue Li Rui Zhang Xingang Zhang Shuangshuang Liu Jiajin Li Changlu Xu Dayi Hu Yingxian Sun | 2008 | Stroke2008，，7： | 1 |
| 18 | Large band gaps in elastic phononic crystals with air inclusions 显示文摘 | LAI Yun ZHANG Zhaoqing | 2003 | Applied Physics Letters2003，83，19： | 1 |
| 19 | Predictors ofprogression from prehypertension to hypertension among ruralChinese adults:results from Liaoning Province显示文摘 | Liqiang Zheng Zhaoqing Sun Xingang Zhang al | 2010 | European Journalof Cardiovascular Prevention & Rehabilitation2010，17，2： | 1 |
| 20 | Host protection against Omicron BA.2.2 sublineages by prior vaccination in spring 2022 COVID-19 outbreak in Shanghai显示文摘The Omicron family of SARS-CoV-2 variants are currently driving the COVID-19 pandemic.Here we analyzed the clinical laboratory test results of 9911 Omicron BA.2.2 sublineages-infected symptomatic patients without earlier infection histories during a SARS-CoV-2 outbreak in Shanghai in spring 2022.Compared to an earlier patient cohort infected by SARS-CoV-2 prototype strains in 2020,BA.2.2 infection led to distinct fluctuations of pathophysiological markers in the peripheral blood.In particular,severe/critical cases of COVID19 post BA.2.2 infection were associated with less pro-inflammatory macrophage activation and stronger interferon alpha response in the bronchoalveolar microenvironment.Importantly,the abnormal biomarkers were significantly subdued in individuals who had been immunized by 2 or 3 doses of SARS-CoV-2 prototypeinactivated vaccines,supporting the estimation of an overall 96.02% of protection rate against severe/critical disease in the 4854 cases in our BA.2.2 patient cohort with traceable vaccination records.Furthermore,even though age was a critical risk factor of the severity of COVID-19 post BA.2.2 infection,vaccination-elicited protection against severe/critical COVID-19 reached 90.15% in patients aged≥60 years old.Together,our study delineates the pathophysiological features of Omicron BA.2.2 sublineages and demonstrates significant protection conferred by prior prototype-based inactivated vaccines. | Ziyu Fu Dongguo Liang Wei Zhang Dongling Shi Yuhua Ma Dong Wei Junxiang Xi Sizhe Yang Xiaoguang Xu Di Tian Zhaoqing Zhu Mingquan Guo Lu Jiang Shuting Yu Shuai Wang Fangyin Jiang Yun Ling Shengyue Wang Saijuan Chen Feng Liu Yun Tan Xiaohong Fan | 2023 | Frontiers of Medicine2023，17，3： | 1 |
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