|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Karyotype Stability and Unbiased Fractionation in the Paleo-Allotetraploid Cucurbita Genomes显示文摘 | Honghe Sun Shan WU Guoyu Zhang Chen Jiao Shaogui Guo Yi Ren Jie Zhang Haiying Zhang Guoyi Gong Zhangcai Jia Fan Zhang Jiaxing Tian William J. Lucas Jeff J. Doyle Haizhen Li Zhangjun Fei Yong Xu | 2017 | Molecular Plant2017，10，10： | 33 |
| 2 | Kiwifruit Genome Database(KGD):a comprehensive resource for kiwifruit genomics显示文摘Kiwifruit(Actinidia spp.)plants produce economically important fruits containing abundant,balanced phytonutrients with extraordinarily high vitamin C contents.Since the release of the first kiwifruit reference genome sequence in 2013,large volumes of genome and transcriptome data have been rapidly accumulated for a handful of kiwifruit species.To efficiently store,analyze,integrate,and disseminate these large-scale datasets to the research community,we constructed the Kiwifruit Genome Database(KGD;http://gffzz6fc08c45f9754a68hnofpvqpbu9up69ux.ffgz.tsg.suse.edu.cn/).The database currently contains all publicly available genome and gene sequences,gene annotations,biochemical pathways,transcriptome profiles derived from public RNA-Seq datasets,and comparative genomic analysis results such as syntenic blocks and homologous gene pairs between different kiwifruit genome assemblies.A set of user-friendly query interfaces,analysis tools and visualization modules have been implemented in KGD to facilitate translational and applied research in kiwifruit,which include JBrowse,a popular genome browser,and the NCBI BLAST sequence search tool.Other notable tools developed within KGD include a genome synteny viewer and tools for differential gene expression analysis as well as gene ontology(GO)term and pathway enrichment analysis. | Junyang Yue Jiacheng Liu Wei Tang Ya Qing Wu Xiaofeng Tang Wei Li Ying Yang Lihuan Wang Shengxiong Huang Congbing Fang Kun Zhao Zhangjun Fei Yongsheng Liu Yi Zheng | 2020 | Horticulture Research2020，7，1： | 6 |
| 3 | Unraveling a genetic roadmap for improved taste in the domesticated apple显示文摘Although taste is an important aspect of fruit quality, an understanding of its genetic control remains elusive in apple and other fruit crops. In this study, we conducted genomic sequence analysis of 497 Malus accessions and revealed erosion of genetic diversity caused by apple breeding and possible independent domestication events of dessert and cider apples. Signatures of selection for fruit acidity and size, but not for fruit sugar content, were detected during the processes of both domestication and improvement. Furthermore, we found that single mutations in major genes affecting fruit taste, including Ma1, MdTDT, and MdSOT2, dramatically decrease malate, citrate, and sorbitol accumulation, respectively, and correspond to important domestication events. Interestingly, Ma1 was identified to have pleiotropic effects on both organic acid content and sugar:acid ratio, suggesting that it plays a vital role in determining fruit taste. Fruit taste is unlikely to have been negatively affected by linkage drag associated with selection for larger fruit that resulted from the pyramiding of multiple genes with minor effects on fruit size. Collectively, our study provides new insights into the genetic basis of fruit quality and its evolutionary roadmap during apple domestication, pinpointing several candidate genes for genetic manipulation of fruit taste in apple. | Liao Liao Weihan Zhang Bo Zhang Ting Fang Xiao-Fei Wang Yarning Cai Collins Ogutu Lei Gao Gang Chen Xiaoqing Nie Jinsheng Xu Quanyan Zhang Yiran Ren Jianqiang Yu Chukun Wang Cecilia H.Deng Baiquan Ma Beibei Zheng Chun-Xiang You Da-Gang Hu Richard Espley Kui Lin-Wang Jia-Long Yao Andrew C.Allan Awais Khan Schuyler S.Korban Zhangjun Fei Ray Ming Yu-Jin Hao Li Li Yuepeng Han | 2021 | Molecular Plant2021，14，9： | 5 |
| 4 | Comparative transcriptome analyses shed light on carotenoid production and plastid development in melon fruit显示文摘Carotenoids,such asβ-carotene,accumulate in chromoplasts of various fleshy fruits,awarding them with colors,aromas,and nutrients.The Orange(CmOr)gene controlsβ-carotene accumulation in melon fruit by posttranslationally enhancing carotenogenesis and repressingβ-carotene turnover in chromoplasts.Carotenoid isomerase(CRTISO)isomerizes yellow prolycopene into red lycopene,a prerequisite for further metabolism intoβ-carotene.We comparatively analyzed the developing fruit transcriptomes of orange-colored melon and its two isogenic EMS-induced mutants,low-β(Cmor)and yofi(Cmcrtiso).The Cmor mutation in low-βcaused a major transcriptomic change in the mature fruit.In contrast,the Cmcrtiso mutation in yofi significantly changed the transcriptome only in early fruit developmental stages.These findings indicate that melon fruit transcriptome is primarily altered by changes in carotenoid metabolic flux and plastid conversion,but minimally by carotenoid composition in the ripe fruit.Clustering of the differentially expressed genes into functional groups revealed an association between fruit carotenoid metabolic flux with the maintenance of the photosynthetic apparatus in fruit chloroplasts.Moreover,large numbers of thylakoid localized photosynthetic genes were differentially expressed in low-β.CmOR family proteins were found to physically interact with light-harvesting chlorophyll a–b binding proteins,suggesting a new role of CmOR for chloroplast maintenance in melon fruit.This study brings more insights into the cellular and metabolic processes associated with fruit carotenoid accumulation in melon fruit and reveals a new maintenance mechanism of the photosynthetic apparatus for plastid development. | Noam Chayut Hui Yuan Yuval Saar Yi Zheng Tianhu Sun Xuesong Zhou Anna Hermanns Elad Oren Adi Faigenboim Maixia Hui Zhangjun Fei Michael Mazourek Joseph Burger Yaakov Tadmor Li Li | 2021 | Horticulture Research2021，8，1： | 3 |
| 5 | A key‘foxy’aroma gene is regulated by homologyinduced promoter indels in the iconic juice grape‘Concord’显示文摘‘Concord’,the most well-known juice grape with a parentage of the North American grape species Vitis labrusca L.,possesses a special‘foxy’aroma predominantly resulted from the accumulation of methyl anthranilate(MA)in berries.This aroma,however,is often perceived as an undesirable attribute by wine consumers and rarely noticeable in the common table and wine grape species V.vinifera.Here we discovered homology-induced promoter indels as a major genetic mechanism for species-specific regulation of a key‘foxy’aroma gene,anthraniloyl-CoA:methanol acyltransferase(AMAT),that is responsible for MA biosynthesis.We found the absence of a 426-bp and/or a 42-bp sequence in AMAT promoters highly associated with high levels of AMAT expression and MA accumulation in‘Concord’and other V.labrusca-derived grapes.These promoter variants,all with direct and inverted repeats,were further confirmed in more than 1,300 Vitis germplasm.Moreover,functional impact of these indels was validated in transgenic Arabidopsis.Superimposed on the promoter regulation,large structural changes including exonic insertion of a retrotransposon were present at the AMAT locus in some V.vinifera grapes.Elucidation of the AMAT genetic regulation advances our understanding of the‘foxy’aroma trait and makes it genetically trackable and amenable in grapevine breeding. | Yingzhen Yang JoséCuenca Nian Wang Zhenchang Liang Honghe Sun Benjamin Gutierrez Xiaojun Xi Jie Arro YiWang Peige Fan Jason Londo Peter Cousins Shaohua Li Zhangjun Fei Gan-Yuan Zhong | 2020 | Horticulture Research2020，7，1： | 3 |
| 6 | Simultaneous evaluation of two branches of a multifunctional integrated optic chip with an ultra-simple dual-channel configuration显示文摘We propose an ultra-simple dual-channel configuration for simultaneously evaluating two branches of a multifunctional integrated optic chip(MFIOC). In the configuration, the MFIOC is employed as a beam splitter to construct the demodulation interferometer together with a 2 × 2 fiber coupler. Interference happens between polarization modes traveling through different channels of the MFIOC. The cross-couplings of each channel are respectively characterized by the interference peaks which distribute on opposite sides of the central interference peak. Temperature responses of the MFIOC are experimentally measured from-40°C to 80°C. Results show that the proposed configuration can achieve simultaneous dual-channel transient measurements with resolution of-90 d B and dynamic range of 90 d B. In addition, the two channels of the configuration have consistent measuring performance, and the two branches of the MFIOC have different responses to temperature variation. | Yonggui Yuan Chuang Li Jun Yang Ai Zhou Shuai Liang Zhangjun Yu Bing Wu Feng Peng Yu Zhang Zhihai Liu Libo Yuan | 2015 | Photonics Research2015，3，4： | 2 |
| 7 | Effect of ALA-PDT on the expressions of MMP-9, MMP-13 and TIMP-1 of hypertrophic scar model in rabbit ears显示文摘Objective: To investigate the effect of 5-aminolevulinic(ALA)-photodynamic therapy(PDT) on the expressions of MMP-9, MMP-13 and TIMP-1 of hypertrophic scar model in rabbit ears, and analyze the possible therapeutic mechanisms of ALA-PDT treatment to hypertrophic scars of rabbit ears. Methods: The experimental animals were randomly divided into normal control, negative control, high concentration of ALA-PDT, low concentration of ALA-PDT and PDT groups. The latter three groups received ALA-PDT treatment or PDT treatment once a week for 3 weeks. The specimens of the rabbits were collected respectively 1, 2 and 3 months after treatment to be used for RT-PCR and Western-blot test. Results: 1, 2 and 3 months after PDT treatment, the expressions of MMP-9 and MMP-13(including mRNA and protein) in hypertrophic scar tissues of three treatment groups were significantly higher than those of the negative control group(P<0.01), and the expression of TIMP-1 mRNA and protein of three treatment groups were significantly lower than that of the negative control group(P<0.01). There were also significant differences between high-concentration ALA-PDT treatment group and the low one(P<0.05). Conclusion: ALA-PDT is effective in treating hypertrophic scars of rabbit ears, and its possible therapeutic mechanisms are that ALA-PDT treatment generates oxidation activation effect to activate the activity of MMPs and induces the photoaging of fibroblasts of hypertrophic scar tissues of rabbit ears to inhibit the activity of TIMPs, which causes the up-regulation of MMPs and the down-regulation of TIMPs. Because of this, the degradation of collagen and ECM is accelerated and the formation of scars is suppressed. | ZHOU Pengjun WANG Qiong LI Zhangjun XIAO Shengxiang XU Lujie | 2013 | Journal of Medical Colleges of PLA(China)2013，28，6： | 2 |
| 8 | The genome and transcriptome analysis of snake gourd provide insights into its evolution and fruit development and ripening显示文摘Snake gourd(Trichosanthes anguina L.),which belongs to the Cucurbitaceae family,is a popular ornamental and food crop species with medicinal value and is grown in many parts of the world.Although progress has been made in its genetic improvement,the organization,composition,and evolution of the snake gourd genome remain largely unknown.Here,we report a high-quality genome assembly for snake gourd,comprising 202 contigs,with a total size of 919.8 Mb and an N50 size of 20.1 Mb.These findings indicate that snake gourd has one of the largest genomes of Cucurbitaceae species sequenced to date.The snake gourd genome assembly harbors 22,874 protein-coding genes and 80.0%of the genome consists of repetitive sequences.Phylogenetic analysis reveals that snake gourd is closely related to sponge gourd but diverged from their common ancestor~33–47 million years ago.The genome sequence reported here serves as a valuable resource for snake gourd genetic research and comparative genomic studies in Cucurbitaceae and other plant species.In addition,fruit transcriptome analysis reveals the candidate genes related to quality traits during snake gourd fruit development and provides a basis for future research on snake gourd fruit development and ripening at the transcript level. | Lili Ma Qing Wang Jianlou Mu Anzhen Fu Changlong Wen Xiaoyan Zhao Lipu Gao Jian Li Kai Shi Yunxiang Wang Xuewen Zhang Xuechuan Zhang Zhangjun Fei Donald Grierson Jinhua Zuo | 2020 | Horticulture Research2020，7，1： | 2 |
| 9 | Orthogonal expansion of ground motion and PDEM-based seismic response analysis of nonlinear structures显示文摘这篇论文为一般随机的过程介绍一个直角的扩大方法。在方法,时间变量 t 的规范的直角的功能首先被介绍执行一个随机的过程然后一种相关矩阵分解技术的分解,它把相关随机的向量转变成标准 uncorrelated 随机变量的向量,被用来完成随机的过程的双直角的分解。就在哈脱利变换和一个真实值的函数的 Fourier 变换之间的关系而言,在上述进程的第一直角的扩大在实际应用程序用哈脱利基础函数被执行而不是三角法的基础函数,这被建议。地震地面运动用上述方法被调查。为了捕获地震地面的主要概率的特征,打手势,直接执行地震排水量的直角的扩大被建议。建议方法是可行的代表地震地面的案例研究表演与仅仅一些随机的变量打手势。在纸的第二部分,概率密度进化方法(PDEM ) 被采用学习受到地震刺激的非线性的结构的随机的反应。在 PDEM,一完全解开了一个维的部分微分方程,概括密度进化方程,在管理非线性的结构的随机的地震回答起一个中央作用。这个方程的答案将产出回答的即时概率密度功能。解决概率密度进化方程的计算算法被描述。一个例子,处理受到随机的地面运动的非线性的框架结构,被说明验证上述途径。 | Li Jie Liu Zhangjun Chen Jianbing | 2009 | Earthquake Engineering and Engineering Vibration2009，8，3： | 2 |
| 10 | Deformation Model Inferred from Focal Mechanisms in the Chinese Mainland and Its Adjacent Areas显示文摘We collect seismic moment tensors of the earthquakes occurring from 1900 to 2013 in and around the Chinese mainland and summarize the surface ruptures and displacements of 70 earthquakes with M S≥7. 0. We divide these large earthquakes into three types. Type A contains earthquakes with surface ruptures and displacements. Type B is earthquakes without displacements and Type C is those without any of this data. We simulate a triangular distribution of displacements for Type B and C. Then,we segment these large earthquakes by using their displacements and surface ruptures. Finally,kinematic models are determined from earthquake data and Bicubic Bessel spline functions. The results show that,first of all,the reasonability and spatial consistency of defined models are advanced.Strain rates have better continuity and are comparable with geologic and geodetic results in Himalaya thrust fault zones. The strain rates decrease in the Tarim basin and the Altun Tagh fault zones because of their low seismicity. The direction of compressional deformation in Gobi-Altay is changed from SE to NE and its extensional direction is changed from NE to NW. The extensional deformation in the Ordos block is diminished obviously. Secondly,earthquakes account for 30- 50% of expected motion of India relative to Eurasia determined from the NUVEL-1A model,with a missing component of 20 mm / a which may contain aseismic deformation such as fault creep and folds,the missing parts of earthquake data and elastic strain energy released by potential earthquakes. | Li Zhangjun Ren Jinwei Zhou Lin Qin Shanlan Chai Xuchao | 2015 | Earthquake Research in China2015，29，2： | 1 |
| 11 | Liver resection versus liver transplantation for hepatocellular carcinoma within the Milan criteria based on estimated microvascular invasion risks显示文摘Background:Preoperative prediction of microvascular invasion(MVI)in hepatocellular carcinoma(HCC)may optimize individualized treatment decision-making.This study aimed to investigate the prognostic differences between HCC patients undergoing liver resection(LR)and liver transplantation(LT)based on predicted MVI risks.Methods:We analysed 905 patients who underwent LR,including 524 who underwent anatomical resection(AR)and 117 who underwent LT for HCC within the Milan criteria using propensity score matching.A nomogram model was used to predict preoperative MVI risk.Results:The concordance indices of the nomogram for predicting MVI were 0.809 and 0.838 in patients undergoing LR and LT,respectively.Based on an optimal cut-off value of 200 points,the nomogram defined patients as high-or low-risk MVI groups.LT resulted in a lower 5-year recurrence rate and higher 5-year overall survival(OS)rate than LR among the high-risk patients(23.6%vs 73.2%,P<0.001;87.8%vs 48.1%,P<0.001)and low-risk patients(19.0%vs 45.7%,P<0.001;86.5%vs 70.0%,P=0.002).The hazard ratios(HRs)of LT vs LR for recurrence and OS were 0.18(95%confidence interval[CI],0.09–0.37)and 0.12(95%CI,0.04–0.37)among the high-risk patients and 0.37(95%CI,0.21–0.66)and 0.36(95%CI,0.17–0.78)among the low-risk patients.LT also provided a lower 5-year recurrence rate and higher 5-year OS rate than AR among the high-risk patients(24.8%vs 63.5%,P=0.001;86.7%vs 65.7%,P=0.004),with HRs of LT vs AR for recurrence and OS being 0.24(95%CI,0.11–0.53)and 0.17(95%CI,0.06–0.52),respectively.The 5-year recurrence and OS rates between patients undergoing LT and AR were not significantly different in the low-risk patients(19.4%vs 28.3%,P=0.129;85.7%vs 77.8%,P=0.161).Conclusions:LT was superior to LR for patients with HCC within the Milan criteria with a predicted high or low risk of MVI.No significant differences in prognosis were found between LT and AR in patients with a low risk of MVI. | Pinghua Yang Fei Teng Shilei Bai Yong Xia Zhihao Xie Zhangjun Cheng Jun Li Zhengqing Lei Kui Wang Baohua Zhang Tian Yang Xuying Wan Hao Yin Hao Shen Timothy M Pawlik Wan Yee Lau Zhiren Fu Feng Shen | 2023 | Gastroenterology Report2023，11，1： | 1 |
| 12 | Cenozoic tectonic evolution of regional fault systems in the SE Tibetan Plateau显示文摘The SE Tibetan Plateau,tectonically situated in the eastern India-Eurasia oblique convergence zone,has experienced multiple stages of deformation since the Cenozoic.Three major tectonic boundaries—the Ailaoshan-Red River,ChongshanLincang-Inthanon,and Gaoligong-Mogok shear zones—delineate the first-order tectonic framework in this region.The most striking structural features in the block interiors are a series of NW-and NE-trending fault systems,such as the Dayingjiang,Longlin-Ruili,Nantinghe,Red River,Weixi-Qiaohou,and Lancang-Genma faults,which have conjugate geometric relationships.In this study,we review these structures’geometric and kinematic characteristics and deformation histories.A synthesis of existing geological observations,geomorphological analyses,and chronological data reveals three major Cenozoic tectonothermal events,including crustal shortening,strike-slip shearing,and kinematic reversal.The boundary structures controlled the tectonic extrusion of plateau material during the early Oligocene-early Miocene.In the mid-late Miocene,NW-and NE-trending fault systems mostly experienced diachronous slip-sense inversions.The onset and spatial trend of regional kinematic reversal are constrained by existing chronologic data.Together with geophysical and geodetic observations,the activity and geodynamic drivers of the major fault systems and regional deformation styles are explored,revealing that the SE Tibetan Plateau underwent a transition from discrete(lateral block extrusion)to diffuse deformation in the mid-late Miocene.The intracontinental crustal deformation and its coupling with dynamic processes at depth during the plateau growth are discussed in the context of the IndiaEurasia convergence. | Yang WANG Yuejun WANG Peizhen ZHANG Jinjiang ZHANG Bo ZHANG Jing LIU-ZENG Renjie ZHOU Weitao WANG Huiping ZHANG Zhangjun LI | 2022 | Science China Earth Sciences2022，65，4： | 1 |
| 13 | Contemporary kinematic models and moment deficit of Chinese mainland显示文摘There are lots of achievements about kinematics of Chinese mainland and its vicinity determined from historic earthquake data,Quaternary fault rates and geodesy observations,which provide basic data for analysis of seismic hazard in study areas.Based on impreciseness in using energy of 47 earthquakes with magnitude greater than 7.0 in previous study,we firstly collected source parameters,surface ruptures and displacements of major earthquakes carefully,and divided them into small segmentations with these data gathered.Secondly,we determined contemporary deformation field from latest earthquake mechanisms,Quaternary fault slip rates and geodesy observations.Finally,we evaluated moment deficit of study areas from historic earthquake data and predicted deformation field,and removed 10 percent of aseismic deformation.Combining with previous results,we analyzed the seismic hazard of study areas.The results show that there are some areas with large moment deficit in Chinese mainland.There are also large moment deficit areas,including regions around the Ordos Block,southeastern coast of China and the Bakal rift zone.Previous studies show that there may be some potential earthquakes in the near future in parts of areas mentioned above. | Zhangjun Li Jinwei Ren Shanlan Qin | 2017 | Geodesy and Geodynamics2017，8，3： | 1 |
| 14 | The parametric source method for measuring characteristics of underwater acoustic materials in a pressure vessel显示文摘A truncated broadband parametric array with a primary frequency of 500 kHz and difference frequency range of 1 kHz to 30 kHz was designed as a sound source of the underwater acoustic material measurement system.By analyzing the theoretical calculation and actual measurement results in array directivity of the truncated broadband parametric source at typical frequencies,we observed that the curves of the two results were basically consistent,which proved that the calculation model was correct.Application of bell-shaped short-duration pulse to achieve broadband measurement for characteristics of underwater acoustic materials was beneficial to reduce the effects of diffraction from the panel edges.The measurement system was established for measuring the sound pressure reflection coefficients,sound pressure transmission coefficients and absorption coefficients of the large panel sample in the pressure vessel.The size of this tank isφ4 m×12 m,the maximum hydrostatic pressure is 4.5 MPa,and the corresponding measuring frequency range is from 1 kHz to 30 kHz.The measured curves had a good agreement with theoretical curves,which verified that the parametric source measurement method was feasible.Then,the sound absorption properties of the rubber plate sample were measured under different hydrostatic pressures.The studying results could show that the parametric source measurement method had the potential application in the limited space water,such as the pressure vessel. | LI Shui YI Yan ZHANGJun | 2020 | Chinese Journal of Acoustics2020，39，1： | 1 |
| 15 | Antioxidant Flavone Glycosides From the Root of Pteroxygonum giraldii显示文摘 | Li Baolin Yang Zhangjun Jiang Lining | 2009 | Bull Korea Chem Soc2009，30，07： | 1 |
| 16 | An R2R3-type myeloblastosis transcription factor MYB103 is involved in phosphorus remobilization显示文摘The members of myeloblastosis transcription factor(MYB TF)family are involved in the regulation of biotic and abiotic stresses in plants.However,the role of MYB TF in phosphorus remobilization remains largely unexplored.In the present study,we show that an R2R3 type MYB transcription factor,MYB103,is involved in phosphorus(P)remobilization.MYB103 was remarkably induced by P deficiency in cabbage(Brassica oleracea var.capitata L.).As cabbage lacks the proper mutant for elucidating the mechanism of MYB103 in P deficiency,another member of the crucifer family,Arabidopsis thaliana was chosen for further study.The transcript of its homologue AtMYB103 was also elevated in response to P deficiency in A.thaliana,while disruption of AtMYB103(myb103)exhibited increased sensitivity to P deficiency,accompanied with decreased tissue biomass and soluble P concentration.Furthermore,AtMYB103 was involved in the P reutilization from cell wall,as less P was released from the cell wall in myb103 than in wildtype,coinciding with the reduction of ethylene production.Taken together,our results uncover an important role of MYB103 in the P remobilization,presumably through ethylene signaling. | Fangwei Yu Shenyun Wang Wei Zhang Hong Wang Li Yu Zhangjun Fei Jianbin Li | 2020 | Food Production, Processing and Nutrition2020，2，1： | 0 |
| 17 | An RNA-RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity显示文摘Hepatocellular carcinoma(HCC)is the global leading cause of cancer-related deaths due to the deficiency of targets for precision therapy.A new modality of epigenetic regulation has emerged involving RNA-RNA crosstalk networks where two or more competing endogenous RNAs(ceRNAs)bind to the same microRNAs.However,the contribution of such mechanisms in HCC has not been well studied.Herein,potential HMGB1-driven RNA-RNA crosstalk networks were evaluated at different HCC stages,identifying the mT0RC2 component RICTOR as a potential HMGB1 ceRNA in HBV^(+)early stage HCC.Indeed,elevated HMGB1 mRNA was found to promote the expressio n of RICTOR mRNA through competitively bin ding with the miR-200 family,especially miR-429.Functio nal assays emplo ying overexpressi on or in terference strategies dem on strated that the HMGB1 and RICTOR 3zuntra nslated regions(UTR)epigenetically promoted the malignant proliferation,self-renewal,and tumorigenesis in HCC cells.Intriguingly,in terference agai nst HMGB1 and RICTOR in HCC cells promoted a stron ger an ti-PD-L1 immuno therapy resp on se,which appeared to associate with the production of PD-L1^(+)exosomes.Mechanistically,the HMGB1-driven RNA-RNA crosstalk network facilitated HCC cell glutamine metabolism via dual mechanisms,activating a positive feedback loop involving mT0RC2-AKT-C-MYC to upregulate glutamine synthetase(GS)expression,and inducing mTORCI signaling to derepress SIRT4 on glutamate dehydrogenase(GDH).Meanwhile,this crosstalk network could impede the efficacy of immunotherapy through mTORCI-P70S6K dependent PD-L1 production and PD-L1^(+)exosomes activity.In conclusion,our study highlights the non-coding regulatory role of HMGB1 with implicatio ns for RNA-based therapeutic targeting together with a predictio n of an ti-PD-L1 immuno therapy in HCC. | Yanping Wei Xuewu Tang Yibin Ren Yun Yang Fengliang Song Jingbo Fu Shuowu Liu Miao Yu Jing Chen Suyang Wang Kecheng Zhang Yexiong Tan Zhipeng Han Lixjn Wei Baohua Zhang Zhangjun Cheng Liang Li Hongyang Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 18 | Geodetic constraints on contemporary three-dimensional crustal deformation in the Laji Shan—Jishi Shan tectonic belt显示文摘The Laji Shan—Jishi Shan tectonic belt(LJTB),located in the southern part of the northeastern Tibetan Plateau(NETP),is a tectonic window to reveal regional tectonic deformation in the NETP.However,its kinematics in the Holocene remains controversial.We obtain the latest and dense horizontal velocity field based on data collected from our newly constructed and existing GNSS stations.Combined with fault kinematics from geologic observations,we analyze the crustal deformation characteristics along the LJTB.The results show that:(1)The Laji Shan fault(LJF)is inactive,and the northwest-oriented Jishi Shan fault(JSF)exhibits a significant dextral and thrust slip.(2)The transpression along the arc-shaped LJTB accommodates deformation transformation between the dextral Riyue Shan fault and the sinistral west Qinling fault.(3)With the continuous pushing of the Indian plate,internal strains in the Tibetan Plateau are continuously transferred in the northeast via the LJTB as they are gradually dissipated near the LJTB and translated into significant crustal uplift in these regions. | Wenquan Zhuang Duxin Cui Ming Hao Shangwu Song Zhangjun Li | 2023 | Geodesy and Geodynamics2023，14，6： | 0 |
| 19 | Microseismic Concentration Zones before and after the February 12,2014 M_S 7.3 Yutian Earthquake and the Possible Indication of an Earthquake Risk Zone显示文摘Since 2001, there have occurred in succession the 2001 Kunlun Mountains M S8. 1earthquake,the 2008 Wenchuan M S8. 0 earthquake,the 2010 Yushu M S7. 1 earthquake and the 2012 Lushan M S7. 0 earthquake in the periphery of the Bayan Har block. By comparison of the characteristics of seismic strain release variations before and after the Kunlun Mountains M S8. 1 earthquake in the same time length in the geodynamical related regions,we found that the seismic strain release was obviously enhanced after the earthquake in the Longmenshan area,Batang area,and the NS-trending valleys at the west of the Hot Spring Basin. The Wenchuan earthquake occurred in the first area,and the Yushu earthquake is related to the second area. After the earthquake rupture occurred on the East Kunlun fault zone on the northern boundary of the Bayan Har Block,crustal materials on the south side of the fault zone migrated to the southeast,leading to a concentration of tectonic deformation in the Longmenshan thrust belt, e ventually rupturing on the Longmenshan thrust belt. This earthquake case illustrates that seismicity enhancement zones are possibly prone to long-term destructive earthquakes. After the M S7. 3 earthquake in Yutian,Xinjiang on February 12,2014,earthquake frequency and seismic strain release markedly increased in the junction area between the eastern Qilian Mountain tectonic belt and the Altun Tagh fault zone,where more attention should be paid to the long-term seismic risk. | Hu Chaozhong Chen Dan Yang Panxin Xiong Renwei Li Zhangjun | 2015 | Earthquake Research in China2015，29，2： | 0 |
| 20 | 靶向eIF4AI的N-末端抑制其催化循环显示文摘文章简介蛋白翻译是中心法则的最后一环,是控制细胞内蛋白质稳态的关键生命过程。蛋白翻译起始是整个翻译过程中最关键的限速步骤,翻译过程的失调与神经发育类疾病以及恶性肿瘤等多种疾病密切相关。真核蛋白翻译起始因子eIF4A是最早被发现的DEAD盒(DEAD-box)RNA解旋酶超家族成员。 | 蒋晨晓 汤叶根 丁露露 Renke Tan Xiaojing Li Junyan Lu Jing Jiang Zhaomeng Cui Zhewei Tang Wei Li Zhangjun Cao Tilman Schneider-Poetsch Wei Jiang Cheng Luo 丁滪 刘建伟 党永军 | 2020 | 科学新闻2020，，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员