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| 1 | Effect of wastewater COD/N ratio on aerobic nitrifying sludge granulation and microbial population shift显示文摘The effect of COD/N ratio on the granulation process and microbial population succession was investigated.Four identical sequencing batch reactors,R1,R2,R3 and R4,were operated with various initial COD/N ratios ranging from 0/200 to 800/200(m/m).Ethanol was fed as the source of COD.Aerobic granules were successfully cultivated in R2 and R3,operating with the COD/N ratio of 200/200 and 400/200,respectively.Scanning electron microscope observations indicated that short rod-shaped and spherical bacteria were dominant in R2,while granules produced in R3 were surrounded with a large amount of filamentous bacteria.The average specific nitritation rate in R2 and R3 were 0.019 and 0.008 mg N/(mg MLVSS.hr),respectively.Fluorescence in situ hybridization results demonstrated that nitrifying bacteria population was enriched remarkably in R2.It indicated that nitrification ability and nitrifying bacteria population were enriched remarkably at low COD/N ratio.However,no granules were formed in R1 and R4 which might attribute to either limited or excessive extracellular polymeric substances production.This study contributed to a better understanding of the role of COD/N ratio in nitrifying sludge granulation. | Lei Wu Chengyao Peng Yongzhen Peng Lingyun Li Shuying Wang Yong Ma | 2012 | Journal of Environmental Sciences2012，24，2： | 29 |
| 2 | Denitrifying phosphorus removal in a step-feed CAST with alternating anoxic-oxic operational strategy显示文摘A bench-scale cyclic activated sludge technology(CAST) was operated to study the biological phosphorus removal performance and a series of batch tests was carried out to demonstrate the accumulation of denitrifying polyphosphate-accumulating organisms(DNPAOs) in CAST system.Under all operating conditions,step-feed CAST with enough carbon sources in influent had the highest nitrogen and phosphorus removal effciency as well as good sludge settling performance.The average removal rate of COD,NH4+-N,PO43--P and total nitrogen(TN) was 88.2%,98.7%,97.5% and 92.1%,respectively.The average sludge volume index(SVI) was 133 mL/g.The optimum anaerobic/aerobic/anoxic(AOA) conditions for the cultivation of DNPAOs could be achieved by alternating anoxic/oxic operational strategy,thus a significant denitrifying phosphorus removal occurred in step-feed CAST.The denitrification of NOx--N completed quickly due to step-feed operation and enough carbon sources,which could enhance phosphorus release and further phosphorus uptake capability of the system.Batch tests also proved that polyphosphate-accumulating organisms(PAOs) in the step-feed process had strong denitrifying phosphorus removal capacity.Both nitrate and nitrite could be used as electron acceptors in denitrifying phosphorus removal.Low COD supply with step-feed operation strategy would favor DNPAOs accumulation. | MA Juan PENG Yongzhen WANG Shuying WANG Li LIU Yangt MA Ningpin | 2009 | Journal of Environmental Sciences2009，21，9： | 27 |
| 3 | Relationship between Cognition Function and Hippocampus Structure after Long-term Microwave Exposure显示文摘Objective To analyze the effects of long-term microwave exposure on hippocampal structure and function in the rat.Methods Experiments were performed on 184 male Wistar rats(three exposure groups and a sham group).Microwaves were applied daily for 6 min over 1 month at average power densities of 2.5,5,and 10 mW/cm2.Learning and memory abilities were assessed by Morris water maze.High performance liquid chromatography was used to detect neurotransmitter concentrations in the hippocampus.Hippocampal structures were observed by histopathological analysis.Results Following long-term microwave exposure there was a significant decrease in learning and memory activity in the 7 d,14 d,and 1 m in all three microwave exposure groups.Neurotransmitter concentrations of four amino acids(glutamate,aspartic acid,glycine,and gamma-aminobutyric acid) in hippocampus were increased in the 2.5 and 5 mW/cm2 groups and decreased in the 10 mW/cm2 group.There was evidence of neuronal degeneration and enlarged perivascular spaces in the hippocampus in the microwave exposure groups.Further,mitochondria became swollen and cristae were disordered.The rough endoplasmic reticulum exhibited sacculated distension and there was a decrease in the quantity of synaptic vesicles.Conclusion These data suggest that the hippocampus can be injured by long-term microwave exposure,which might result in impairment of cognitive function due to neurotransmitter disruption. | ZHAO Li PENG Rui Yun WANG Shui Ming WANG Li Feng GAO Ya Bing DONG Ji LI Xiang SU Zhen Tao | 2012 | Biomedical and Environmental Sciences2012，25，2： | 27 |
| 4 | Diagnostic performance of contrast-enhanced ultrasound and enhanced magnetic resonance for breast nodules显示文摘In the current study, we sought to evaluate the diagnostic efficacies of conventional ultrasound(US), contrastenhanced US(CEUS), combined US and CEUS and magnetic resonance imaging(MRI) in detecting focal solid breast lesions. Totally 117 patients with 120 BI-RADS category 4A-5 breast lesions were evaluated by conventional US and CEUS, and MRI, respectively. SonoVue was used as contrast agent in CEUS and injected as an intravenous bolus; nodule scan was performed 4 minutes after bolus injection. A specific sonographic quantification software was used to obtain color-coded maps of perfusion parameters for the investigated lesion, namely the time-intensity curve.The pattern of contrast enhancement and related indexes regarding the time-intensity curve were used to describe the lesions, comparatively with pathological results. Histopathologic examination revealed 46 benign and 74 malignant lesions. Sensitivity, specificity, and accuracy of US in detecting malignant breast lesions were 90.14%, 95.92%, and 92.52%, respectively. Meanwhile, CE-MRI showed sensitivity, specificity, and accuracy of 88.73%, 95.92%, and91.67%, respectively. The area under the ROC curve for combined US and CEUS in discriminating benign from malignant breast lesions was 0.936, while that of MRI was 0.923, with no significant difference between them, as well as among groups. The time-intensity curve of malignant hypervascular fibroadenoma and papillary lesions mostly showed a fast-in/fast-out pattern, with no good correlation between them(kappa <0.20). In conclusion, the combined use of conventional US and CEUS displays good agreement with MRI in differentiating benign from malignant breast lesions. | Cuiying Li Haiyan Gong Lijun Ling Liwen Du Tong Su Shui Wang Jie Wang | 2018 | The Journal of Biomedical Research2018，32，3： | 27 |
| 5 | Unscented extended Kalman filter for target tracking显示文摘A new method of unscented extended Kalman filter (UEKF) for nonlinear system is presented. This new method is a combination of the unscented transformation and the extended Kalman filter (EKF). The extended Kalman filter is similar to that in a conventional EKF. However, in every running step of the EKF the unscented transformation is running, the deterministic sample is caught by unscented transformation, then posterior mean of nonlinearity is caught by propagating, but the posterior covariance of nonlinearity is caught by linearizing. The accuracy of new method is a little better than that of the unscented Kalman filter (UKF), however, the computational time of the UEKF is much less than that of the UKF. | Changyun Liu Penglang Shui Song Li | 2011 | Journal of Systems Engineering and Electronics2011，22，2： | 21 |
| 6 | Microwave Exposure Impairs Synaptic Plasticity in the Rat Hippocampus and PC12 Cells through Over-activation of the NMDA Receptor Signaling Pathway显示文摘Objective The aim of this study is to investigate whether microwave exposure would affect the N-methyl-D-aspartate receptor(NMDAR) signaling pathway to establish whether this plays a role in synaptic plasticity impairment. Methods 48 male Wistar rats were exposed to 30 m W/cm2 microwave for 10 min every other day for three times. Hippocampal structure was observed through H&E staining and transmission electron microscope. PC12 cells were exposed to 30 m W/cm2 microwave for 5 min and the synapse morphology was visualized with scanning electron microscope and atomic force microscope. The release of amino acid neurotransmitters and calcium influx were detected. The expressions of several key NMDAR signaling molecules were evaluated. Results Microwave exposure caused injury in rat hippocampal structure and PC12 cells, especially the structure and quantity of synapses. The ratio of glutamic acid and gamma-aminobutyric acid neurotransmitters was increased and the intracellular calcium level was elevated in PC12 cells. A significant change in NMDAR subunits(NR1, NR2 A, and NR2B) and related signaling molecules(Ca2+/calmodulin-dependent kinase II gamma and phosphorylated c AMP-response element binding protein) were examined. Conclusion 30 m W/cm2 microwave exposure resulted in alterations of synaptic structure, amino acid neurotransmitter release and calcium influx. NMDAR signaling molecules were closely associated with impaired synaptic plasticity. | XIONG Lu SUN Cheng Feng ZHANG Jing GAO Ya Bing WANG Li Feng ZUO Hong Yan WANG Shui Ming ZHOU Hong Mei XU Xin Ping DONG Ji YAO Bin Wei ZHAO Li PENG Rui Yun | 2015 | Biomedical and Environmental Sciences2015，28，1： | 16 |
| 7 | Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression显示文摘Mass spectrometry(MS)-based omics technologies are now widely used to profile small molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic phenotypes.The metabolomes of cells,tissues,and organisms comprise a variety of molecules including lipids,amino acids,sugars,organic acids,and so on.Metabolomics mainly focus on the hydrophilic classes,while lipidomics has emerged as an independent omics owing to the complexities of the organismal lipidomes.The potential roles of lipids and small metabolites in disease pathogenesis have been widely investigated in various human diseases,but system-level understanding is largely lacking,which could be partly attributed to the insufficiency in terms of metabolite coverage and quantitation accuracy in current analytical technologies.While scientists are continuously striving to develop high-coverage omics approaches,integration of metabolomics and lipidomics is becoming an emerging approach to mechanistic investigation.Integration of metabolome and lipidome offers a complete atlas of the metabolic landscape,enabling comprehensive network analysis to identify critical metabolic drivers in disease pathology,facilitating the study of interconnection between lipids and other metabolites in disease progression.In this review,we summarize omics-based findings on the roles of lipids and metabolites in the pathogenesis of selected major diseases threatening public health.We also discuss the advantages of integrating lipidomics and metabolomics for in-depth understanding of molecular mechanism in disease pathogenesis. | Raoxu Wang Bowen Li Sin Man Lam Guanghou Shui | 2020 | Journal of Genetics and Genomics2020，47，2： | 15 |
| 8 | The Interactions among DWARF10,Auxin and Cytokinin Underlie Lateral Bud Outgrowth in Rice显示文摘Previous studies have shown that DWARF10(D10) is a rice ortholog of MAX4/RMS1/DAD1,encoding a carotenoid cleavage dioxygenase and functioning in strigolactones/strigolactone-derivatives(SL) biosynthesis.Here we use D10-RNA interference(RNAi) transgenic plants similar to d10 mutant in phenotypes to investigate the interactions among D10,auxin and cytokinin in regulating rice shoot branching.Auxin levels in node 1 of both decapitated D10-RNAi and wild type plants decreased significantly,showing that decapitation does reduce endogenous auxin concentration,but decapitation has no clear effects on auxin levels in node 2 of the same plants.This implies that node 1 may be the location where a possible interaction between auxin and D10 gene would be detected.D10 expression in node 1 is inhibited by decapitation,and this inhibition can be restored by exogenous auxin application,indicating that D10 may play an important role in auxin regulation of SL.The decreased expression of most OsPINs in shoot nodes of D10-RNAi plants may cause a reduced auxin transport capacity.Furthermore,effects of auxin treatment of decapitated plants on the expression of cytokinin biosynthetic genes suggest that D10 promotes cytokinin biosynthesis by reducing auxin levels.Besides,in D10-RNAi plants,decreased storage cytokinin levels in the shoot node may partly account for the increased active cytokinin contents,resulting in more tillering phenotypes. | Shuying Zhang Gang Li Jun Fang Weiqi Chen Haipai Jiang Junhuang Zou Xue Liu Xianfeng Zhao Xiaobing Li Chengcai Chu Qi Xie Xiangning Jiang Lihuang Zhu | 2010 | Journal of Integrative Plant Biology2010，52，7： | 14 |
| 9 | Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission显示文摘 | Xiaohong Shi Xuefei Wang Xixi Xu Yongliang Feng Shuzhen Li Shuying Feng Bo Wang Suping Wang | 2017 | Frontiers of Medicine2017，11，4： | 11 |
| 10 | A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis显示文摘 | Shuying Shen Xiaocan Guo Huan Yan Yi Lu Xinyan Ji Li Li Tingbo Liang Dawang Zhou Xin-Hua Feng Jonathan C Zhao Jindan Yu Xing-Guo Gong Lei Zhang Bin Zhao | 2015 | Cell Research2015，25，9： | 10 |
| 11 | Traveling wave tube measurements for low-frequency properties of underwater acoustic materials显示文摘A traveling wave tube measurement technique for measuring acoustic properties of underwater acoustic materials was developed.Water temperature and pressure environments of the ocean can be simulated in a water-filled tube,and the acoustic parameters of samples of underwater acoustic materials are measured in the range of low-frequency.A tested sample is located at central position of the tube.A pair of projectors is separately located at both ends of the tube.Using an active anechoic technique,the sound wave transmitting the tested sample is hardly reflected by the surface of secondary transducer.So the traveling sound field is built up in the tube.By separately calculating the transfer functions of every pair of double hydrophones in the sound fields from the both sides of the sample,its reflection coefficients and transmission coefficients are obtained.In the measurement system,the inside diameter of the tube isΦ208 mm,the working frequency range is from 100 to 4000 Hz,the maximum pressure is 5 MPa.The reflection coefficients and transmission coefficients of a water layer and a stainless steel layer samples are measured actually and calculated theoretically.The results show that the measured values are in good agreement with the values calculated,and the measurement uncertainty is not greater than 1.5 dB. | LI Shui LUO Maqi FAN Jinliang SHEN Jianxing | 2007 | Chinese Journal of Acoustics2007，26，4： | 9 |
| 12 | Microvascular protective role of pericytes in melatonin-treated spinal cord injury in the C57BL/6 mice显示文摘 | Jing Yingli Wu Qingbin Yuan Xiaochen Li Bingwei Liu Mingming Zhang Xiaoyan Liu Shuying Li Hongwei Xiu Ruijuan | 2014 | Chinese Medical Journal2014，，15： | 9 |
| 13 | AduoLa Fuzhenglin Down-regulates Microwave-induced Expression of β_1-adrenergic Receptor and Muscarinic Type 2 Acetylcholine Receptor in Myocardial Cells of Rats显示文摘This paper is aimed to study the effect of ADL on expression ofβ1-AR and M2-AchR in myocardial cells of rats exposed to microwave radiation.Immunohistochemistry,Western blot and image analysis were used to detect the expression ofβ1-AR and M2-AchR in myocardial cells at 7 and 14 | ZHANG Jing PENG Rui Yun GAO Ya Bing WANG Shui Ming YANG Lei Lei ZHAO Li DONG Ji YAO Bin Wei CHANG Gong Min XIONG Lu | 2014 | Biomedical and Environmental Sciences2014，27，3： | 9 |
| 14 | Acoustic radiation field of the truncated parametric source generated by a piston radiator:model and experiment显示文摘A theoretical model is presented to describe the parametric acoustic field generated by a piston radiator. In the model, the high-frequency primary wave interaction region that is truncated by a low-pass acoustic filter can be viewed as a cylindrical source within the Rayleigh distance of the piston. When the radius of the piston is much smaller than the length of the parametric region, this model is reduced to the Berketey’s End-Fire Line Army model. Comparison between numerical calculations and experimental measurement show that the generated parametric sound field (especially near the axis) agrees well with the experiment results. | ZHAO Xiaoliang,ZHU Zhemin,DU Gonghuan (Institute of Acoustics and State Key Laboratory of Modern Acoustics, Nanjing University Nanjing 210093) TANG Haiqing,LI Shui,MIAO Rongxing (Hangzhou Applied Acoustics Institute Fuyang, Hangzhou 311400) | 2001 | Chinese Journal of Acoustics2001，20，1： | 8 |
| 15 | Sponge-like nickel phosphide-carbon nanotube hybrid electrodes for efficient hydrogen evolution over a wide pH range显示文摘经由水的电解的划算的氢生产为氢进化反应要求有效、持久的地球丰富的催化剂(她的) 在一个宽 pH 范围上。此处,我们报导像海绵的镍磷化物碳 nanotube (Ni x P/CNT ) 被非结晶的 Ni x P 催化剂到 threedimensional (3D ) 上多孔的 CNT 支持。这些混合物在酸、中立、基本的媒介为持续的氢进化展出优异催化活动。特别地, Ni x P/CNT 电极产生 10 和 100 mAapy 的 cathodic 水流,但是总是 regressed onanticoagulation。传单限制和最大的厚度的功课在二个组之间是显著地不同的( P ? P ?=? 0.005 )并且传单限制分数由一中部 1 [ quartiles 0 ; 2 ]( P ?=? 0.013 ),而在 anticoagulation 组,在 2.57 的最大的厚度 regressed ?甘油的 n 作为副产品。最后的紧张生产了 9.8 ? l 33 ?%( 从 205 ~ 272 ? mg/L ) 。直角的策略 inte?? | Shuying Wang Li Zhang Xiao Li Changli Li Rujing Zhang Yingjiu Zhang Hongwei Zhu | 2017 | Nano Research2017，10，2： | 8 |
| 16 | Boosting electrocatalytic water splitting via metal-metalloid combined modulation in quaternary Ni-Fe-P-B amorphous compound显示文摘Design and synthesis of highly efficient and cost-effective bifunctional catalysts for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)remain a big challenge.Herein,a quaternary amorphous nanocompound Ni-Fe-P-B has been synthesized by a facile,scalable co-reduction method.The Ni-Fe-P-B exhibits high electrocatalytic activity and outstanding durability for both HER and OER,delivering a current density of 10 mA·cm^-2 at overpotentials of 220 and 269 mV,respectively.When loaded on carbon fiber paper(CFP)as a bifunctional catalyst,the Ni-Fe-P-B@CFP electrode requires a low cell voltage of 1.58 V to obtain 10 mA·cm^-2 for overall water splitting with negligible recession over 60 h.The excellent catalytic performances of Ni-Fe-P-B mainly benefit from the metal-metalloid combined composition modulation and the unique amorphous structure.This work provides new insights into the design of robust bifunctional catalysts for water splitting,and may promote the development of multicomponent amorphous catalysts. | Wukui Tang Xiaofang Liu Ya Li Yanhui Pu Yao Lu Zhiming Song Qiang Wang Ronghai Yu Jianglan Shui | 2020 | Nano Research2020，13，2： | 8 |
| 17 | Modified unscented Kalman filter using modified filter gain and variance scale factor for highly maneuvering target tracking显示文摘To improve the low tracking precision caused by lagged filter gain or imprecise state noise when the target highly maneuvers, a modified unscented Kalman filter algorithm based on the improved filter gain and adaptive scale factor of state noise is presented. In every filter process, the estimated scale factor is used to update the state noise covariance Qk, and the improved filter gain is obtained in the filter process of unscented Kalman filter(UKF)via predicted variance Pk|k-1, which is similar to the standard Kalman filter. Simulation results show that the proposed algorithm provides better accuracy and ability to adapt to the highly maneuvering target compared with the standard UKF. | Changyun Liu Penglang Shui Gang Wei Song Li | 2014 | Journal of Systems Engineering and Electronics2014，25，3： | 8 |
| 18 | Transdermal permeation of Zanthoxylum bungeanum essential oil on TCM components with different lipophilicity显示文摘Objective:To investigate the percutaneous penetration enhancement effect of essential oil from Zanthoxylum bungeanum Maxim.(Z.bungeanum oil)on active components in externally-applied traditional Chinese medicines.Methods:Five model drugs,geniposide,puerarin,ferulic acid,tetramethylpyrazine,and osthole,were chosen based on their lipophilicity and tested using in vitro transdermal permeation studies consisting of Franz diffusion cells and full thickness rat abdominal skin.Scanning electron microscopy was employed to observe the morphological changes of rat skin tissue after treatment with Z.bungeanum oil.The molecular interactions between the oil and the polar head groups in stratum corneum(SC)lipids were monitored using molecular dynamic simulation,and the SC/vehicle partition coefficients and saturation solubilities of the selected model drugs treated with and without the oil were also determined to ascertain its mechanisms of action.Results:As oil concentration increased,the log ERflow trended toward a negative linear relationship with the lipophilicity of drugs.After treatment with Z.bungeanum oil,a mild lifting up and wrinkle on the SC surface were observed,and appeared to become more pronounced as oil concentration increased.There was no significant difference between the control and the Z.bungeanum oil at different concentrations in terms of saturation solubility of GP,while saturation solubilities of the 4 other drugs gradually increased as oil concentration increased.The oxygen-containing constituents in Z.bungeanum oil,such as terpinen-4-ol and 1,8-cineole,which accounted for 57.95%of total oil,could form stable hydrogen bonds with the polar head group of ceramide 3.Conclusion:Z.bungeanum oil facilitated transdermal permeation of drugs with different lipophilicity,including the extremely hydrophilic and lipophilic drugs,whereas it exhibited greater enhancement activity for strongly hydrophilic drugs.The mechanisms of transdermal permeation enhancement by the oil could be explained with SC/vehicle partition coefficient,saturation solubility,and the interactions with SC lipids. | Yi Lan Jingyan Wang Shuwang He Shuying Li Peng Tan Hongmei Lin Qing Wu | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，3： | 6 |
| 19 | Fabrication of mesoporous lignin-based biosorbent from rice straw and its application for heavy-metal-ion removal显示文摘Lignocellulosic biomass offers the most abundant renewable resource in replacing traditional fossil resources. However, it is still a major challenge to directly convert the lignin component into value-added materials. The availability of plentiful hydroxyl groups in lignin macromolecules and its unique three-dimensional structure make it an ideal precursor for mesoporous biosorbents. In this work, we reported an environmentally friendly and economically feasible method for the fabrication of mesoporous lignin-based biosorbent(MLBB) from lignocellulosic biomass through a SO_3micro-thermal-explosion process, as a byproduct of microcrystalline cellulose. BET analysis reveal the average pore-size distribution of 5.50 nm, the average pore value of 0.35 cm^3/g, and the specific surface area of 186 m^2/g. The physicochemical properties of MLBB were studied by fourier transform infrared spectroscopy(FTIR), attenuated-total-reflection fourier transform infrared spectroscopy(ATR-FTIR), X-ray photoelectron spectroscopy(XPS), and element analysis. These results showed that there are large amounts of sulfonic functional groups existing on the surface of this biosorbent. Pb(II) was used as a model heavy-metal-ion to demonstrate the technical feasibility for heavy-metal-ion removal. Considering that lignocellulosic biomass is a naturally abundant and renewable resource and SO_3micro-thermal-explosion is a proven technique, this biosorbent can be easily produced at large scale and become a sustainable and reliable resource for wastewater treatment. | Fang Xu Ting-Ting Zhu qing-quan Rao Sheng-Wen Shui Wen-Wei Li Hong-Bo He Ri-Sheng Yao | 2017 | Journal of Environmental Sciences2017，29，3： | 6 |
| 20 | Extraction of hydrogen chloride by a coupled reaction-solvent extraction process显示文摘A coupled 反应溶剂抽取过程被用来把 HCl 从模仿的蒸馏器浪费移开。各种各样的提炼之物和 diluents 的抽取表演被比较,在各种各样的 diluents 的 N235 (第三级的胺的混合物) 的明显的盐基度是坚定的。最好的结果作为提炼之物用 N235 和 isoamyl 酒精被获得并且稀释分别地。从联合抽取的 HCl 的收益与这个抽取系统是 75% 。为在两个的 HCl 的移动的机制直接、联合的抽取被调查。为联合抽取, R 3 NHCl 离子对建筑群涉及 HCl 移动。为直接抽取,机制在 HCl 的高集中包含了氢契约的形成。 | Yunzhao Li Xingfu Song Guilan Chen Shuying Sun Yanxia Xu Jianguo Yu | 2015 | Frontiers of Chemical Science and Engineering2015，9，4： | 6 |
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