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| 1 | The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism显示文摘在动物农业和药的抗菌素的 overuse 引起了一系列潜在的威胁到公共健康。Macleaya cordata 是从 Papaveraceae 家庭的药用的植物种,提供为抗菌剂的制造的一个安全资源为家畜喂添加剂。从 M. 的活跃成分 ? cordata 被知道包括 benzylisoquinoline 碱(偏爱) 象 sanguinarine (圣) 和 chelerythrine (CHE ) 那样的 ?,而是他们的新陈代谢的小径还得在这非模型植物被学习。在 M. 的圣和 CHE 的活跃生合成 ? cordata 被喂 13标记 C 的酷氨酸。为了增加,推进卓见,我们 de novo 定序 M 的整个染色体。cordata,第一从 Papaveraceae 家庭被定序。M.? 盖住 378 Mb 的 cordata 染色体与 43.5%being 编码 22,328 预言的编码蛋白质的基因 transposable 元素。作为基础 eudicot 的一个成员, M.? cordata 染色体缺乏 ? 发生在几乎所有 eudicots 的 paleohexaploidy 事件。从 genomics 数据, 16 的一个完全的集合 ? 新陈代谢 ? 为圣和 CHE 生合成的基因被检索,并且 14 项他们的生物化学的活动被验证。这些 genomics 和新陈代谢的数据在 M. 显示出保存 BIA 新陈代谢的小径 ? cordata 并且由庄稼改进或微生物引起的小径重建为圣和 CHE 的未来生产提供知识基础。 | Xiubin Liu Yisong Liu Peng Huang Yongshuo Ma Zhixing Qing Qi Tang Huifen Cao Pi Cheng Yajie Zheng Zejun Yuan Yuan Zhou Jinfeng Liu Zhaoshan Tang Yixiu Zhuo Yancong Zhang Linlan Yu Jialu Huang Peng Yang Qiong Peng dinbo Zhang Wenkai Jiang Zhonghua Zhang Kui Lin Dae-Kyun Ro Xiaoya Chen Xingyao Xiong Yi Shang Sanwen Huang Jianguo Zeng | 2017 | Molecular Plant2017，10，7： | 19 |
| 2 | A Chromosome-Scale Genome Assembly of Paper Mulberry(Bmussonetia papyrifera)Provides New Insights into Its Forage and Papermaking Usage显示文摘Paper mulberry(Broussonetia papyrifera)is a well-known woody tree historically used for Cai Lun papermaking,one of the four great inventions of ancient China.More recently,Paper mulberry has also been used as forage to address the shortage of feedstuff because of its digestible crude fiber and high protein contents.In this study,we obtained a chromosome-scale genome assembly for Paper mulberry using integrated approaches,including Illumina and PacBio sequencing platform as well as Hi-C,optical,and genetic maps.The assembled Paper mulberry genome consists of 386.83 Mb,which is close to the estimated size,and 99.25%(383.93 Mb)of the assembly was assigned to 13 pseudochromosomes.Comparative genomic analysis revealed the expansion and contraction in the flavonoid and lignin biosynthetic gene families,respectively,accounting for the enhanced flavonoid and decreased lignin biosynthesis in Paper mulberry.Moreover,the increased ratio of syringyl-lignin to guaiacyl-lignin in Paper mulberry underscores its suitability for use in medicine,forage,papermaking,and barkcloth making.We also identified the rootassociated microbiota of Paper mulberry and found that Pseudomonas and Rhizobia were enriched in its roots and may provide the source of nitrogen for its stems and leaves via symbiotic nitrogen fixation.Collectively,these results suggest that Paper mulberry might have undergone adaptive evolution and recruited nitrogen-fixing microbes to promote growth by enhancing flavonoid production and altering lignin monomer composition.Our study provides significant insights into genetic basis of the usefulness of Paper mulberry in papermaking and barkcloth making,and as forage.These insights will facilitate further domestication and selection as well as industrial utilization of Paper mulberry worldwide. | Xianjun Peng Hui Liu Peilin Chen Feng Tang Yanmin Hu Fenfen Wang Zhi Pi Meiling Zhao Naizhi Chen Hui Chen Xiaokang Zhang Xueqing Yan Min Liu Xiaojun Fu Guofeng Zhao Pu Yao Lili Wang He Dai Xuming Li Wei Xiong Wencai Xu Hongkun Zheng Haiyan Yu Shihua Shen | 2019 | Molecular Plant2019，12，5： | 18 |
| 3 | Aberrant activation of latent transforming growth factor-β initiates the onset of temporomandibular joint osteoarthritis显示文摘There is currently no effective medical treatment for temporomandibular joint osteoarthritis(TMJ-OA) due to a limited understanding of its pathogenesis. This study was undertaken to investigate the key role of transforming growth factor-β(TGF-β)signalling in the cartilage and subchondral bone of the TMJ using a temporomandibular joint disorder(TMD) rat model, an ageing mouse model and a Camurati–Engelmann disease(CED) mouse model. In the three animal models, the subchondral bone phenotypes in the mandibular condyles were evaluated by μCT, and changes in TMJ condyles were examined by TRAP staining and immunohistochemical analysis of Osterix and p-Smad2/3. Condyle degradation was confirmed by Safranin O staining, the Mankin and OARSI scoring systems and type X collagen(Col X), p-Smad2/3 a and Osterix immunohistochemical analyses. We found apparent histological phenotypes of TMJ-OA in the TMD, ageing and CED animal models, with abnormal activation of TGF-βsignalling in the condylar cartilage and subchondral bone. Moreover, inhibition of TGF-β receptor I attenuated TMJ-OA progression in the TMD models. Therefore, aberrant activation of TGF-β signalling could be a key player in TMJ-OA development. | Liwei Zheng Caixia Pi Jun Zhang Yi Fan Chen Cui Yang Zhou Jianxun Sun Quan Yuan Xin Xu Ling Ye Xu Cao Xuedong Zhou | 2018 | Bone Research2018，6，4： | 13 |
| 4 | Aquathermolysis of conventional heavy oil with superheated steam显示文摘This paper presents a new aquathermolysis study of conventional heavy oil in superheated steam.A new high temperature autoclave was designed,where volume and pressure could be adjusted. Aquathermolysis was studied on two different conventional heavy oil samples under different reaction times and temperatures.Experimental results show that aquathermolysis does take place for conventional heavy oil.As reaction time increases,the oil viscosity reduces.However,the reaction will reach equilibrium after a certain period of time and won’t be sensitive to any further reaction time any more. Analysis shows that,while resin and asphaltenes decrease,saturated hydrocarbons and the H/C ratio increase after reaction.The main mechanism of aquathermolysis includes hydrogenization,desulfuration reaction of resin and asphaltenes,etc. | Song Guangshou Zhou Tiyao Cheng Linsong Wang Yunxian Tian Guoqing Pi Jian Zhang Zheng | 2009 | Petroleum Science2009，6，3： | 6 |
| 5 | Improved performance of aluminum pigments encapsulated in hybrid inorganic-organic films显示文摘An organic silane acrylate resin(PMBK) was synthesized by free-radical solution polymerization using methyl methacrylate,butyl acrylate and(3-methacryloxypropyl)trimethoxysilane as monomers.Aluminum(Al) particles were then encapsulated in inorganic-organic hybrid films that were prepared by hydrolysis and condensation of PMBK and tetraethyl orthosilicate(TEOS) on the surface of Al pigments.Characterization results showed that PMBK and TEOS could simultaneously hydrolyze and condense with hydroxyl groups on the surface of the Al particles to form composite Al particles coated with inorganic-organic hybrid films.Compared with raw Al particles,the corrosion resistance and adhesive properties of paint films containing the composite Al particles were improved greatly,while the glossiness of the paint films decreased slightly,from 48.6° to 47.0°.In alkaline media(pH 11),the volume of evolved H_2 of composite Al particles was only 3.5 mL,whereas that of raw Al was 83.5 mL.The glossiness of paint films containing composite Al particles decreased by 1.66%after immersion in alkaline media for24 h,whereas that of raw Al decreased by 14.82%.Peel-off tests of the paint films showed that the composite particles moved slightly away from the paint films.In contrast,the raw Al particles were seriously desquamated,suggesting encapsulation of hybrid films can greatly improve the adhesive properties of Al particles in paint films. | Pihui Pi Chao Liu Xiufang Wen Lianfu Zheng Shouping Xu Jiang Cheng | 2015 | Particuology2015，13，2： | 5 |
| 6 | Pharmacokinetics of aminophylline delivered to the small intestine and colon using remote controlled capsules显示文摘背景获专利的 remote controlled 囊(RCC ) 最近被开发了在允许对的评价的人的内脏提供 noninvasive 药交货给选择地点地区性胃肠(官方补给) 在正常生理的环境下面的药吸收。这研究的目的是用 RCC 和监视的一个磁性的标记( MMM )在官方补给的道在这药的地点特定的交货以后调查 aminophylline 吸收的率和程度 technique.Methods 这研究在 12 个健康男题目被进行,在里面一三处理,使随机化,有7天的冲刷的转线路举止。合格题目通过一个口头的政府收到了 150 mg aminophylline 剂量,或经由 remote controlled 囊,送到小肠或上升冒号。MMM 被采用监视 RCC 的官方补给的运输,并且无线电频率信号被用来在目标地点激活囊。血样品在常规间隔被获得直到 24 小时柱子剂量 / 激活。血浆 theophylline 集中被一个 TDx 系统分析器测量。有 aminophylline 的口头的 dosing 线路的 PK 侧面的比较在交货以后被执行到小肠和 colon.Results RCC 很好在志愿者被容忍。小肠和上升冒号的吝啬的囊激活时间是 2.07 个小时和 6.08 小时柱子剂量。 Aminophylline 与胃相比从小肠有类似的吸收侧面,与在曲线( AUC_t )下面的一个区域92%的比率对胃,而是从上升冒号的更低的吸收侧面,与47.2%的 AUC_t 比率对 stomach.Conclusions RCC 和 MMM 技术提议的业主在 noninvasive 下面在人在药的肠的吸收上获得数据的机会调节。Aminophylline 很快并且高效地从小肠被吸收。当尽管有效吸收从上升冒号被观察,结肠的吸收被差的水条件限制时。这为修改版本的明确的表达以及其他的剂量形式的合理开发提供一个机会。 | LIU Hong-ying PI Xi-tian ZHENG Xiao-lin HOU Wen-sheng CUI Jian-guo | 2010 | Chinese Medical Journal2010，，3： | 4 |
| 7 | A Preliminary Study of the Noninvasive Remote Control System for Rat Bio-Robot显示文摘A system is described here that can noninvasively control the navigation of freely behaving rat via ultrasonic,epidermaland LED photic stimulators on the back.The system receives commands from a remote host computer to deliver specifiedelectrical stimulations to the hearing,pain and visual senses of the rat respectively.The results demonstrate that the three stimuliwork in groups for the rat navigation.We can control the rat to proceed and make right and left turns with great efficiency.Thisexperiment verified that the rat was able to reach a setting destination in the way of cable with the help of a person through theappropriate coordination of the three stimulators.The telemetry video camera mounted on the head of the rat also achieveddistant image acquisition and helped to adjust its navigation path over a distance of 300 m.In a word,the non-invasive motioncontrol navigation system is a good,stable and reliable bio-robot. | Xitian Pi~(1,2),Shuangshuang Li~1,Lin Xu~1,Hongying Liu~1,Shenshan Zhou~1,Kang Wei~1,Zhenyu Wang~1,Ziru Jia,Xiaolin Zheng~(1,2),Zhiyu Wen~2 1.Bioengineering College,Chongqing University,Chongqing 400030,P.R.China 2.Key Laboratories for National Defense Science and Technology of Innovative Micro-Nano Devices and System Technology,Chongqing University,Chongqing 400030,P.R.China | 2010 | Journal of Bionic Engineering2010，7，4： | 4 |
| 8 | An intelligent electronic capsule system for automated detection of gastrointestinal bleeding显示文摘In clinical practice,examination of the hemorrhagic spot (HS) remains difficult.In this paper,we describe a remote controlled capsule (RCC) micro-system with an automated,color-based sensor to identify and localize the HS of the gastrointestinal (GI) tract.In vitro testing of the detecting sensor demonstrated that it was capable of discriminating mimetic intestinal fluid (MIF) with and without the hemoglobin (Hb) when the concentration of Hb in MIF was above 0.05 g/ml.Therefore,this RCC system is able to detect the relatively accurate location of the HS in the GI tract. | Hong-ying LIU Gang WANG Kang WEI Xi-tian PI Lan ZHU Xiao-lin ZHENG Zhi-yu WEN | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，12： | 2 |
| 9 | Adsorption behavior of Hg 2+ in aqueous solutions on a novel chelating cross-linked chitosan microsphere显示文摘 | Chunhua Xiong Leilei Pi Xinyi Chen Liqun Yang Chunan Ma Xuming Zheng | 2013 | Carbohydrate Polymers2013，，： | 2 |
| 10 | Aspirin plus clopidogrel therapy increases early venous graft patency after coronary artery bypass surgery a single-center, randomized, controlled trial 显示文摘 | Gao G Zheng Z Pi Y | 2010 | J Am Coll Cardiol2010，56，： | 1 |
| 11 | Aspirin plus clopidogrel thera- py increases early venous graft patency after coronary artery bypass surgery a single-center, randomized, controlled trial 显示文摘 | Gao G Zheng Z Pi Y | 2010 | J Am Col1 Cardiol2010，56，20： | 1 |
| 12 | Aspirin plus clopidogrel therapy in- creases early venous graft patency after coronary artery bypass surgery a single-center, randomized,controlled trial显示文摘 | Gao G Zheng Z Pi Y | 2010 | J Am Coil Cardiol2010，56，20： | 1 |
| 13 | Treatment ofpartially hydrolyzed polyacrylamide wastewater by combined Fentonoxidation and anaerobic biological processes 显示文摘 | PI Yongrui ZHENG Zhonghuan BAO Mutai | 2015 | ChemicalEngineering Journal2015，273，： | 1 |
| 14 | Cryptotanshinone protects primary rat cortical neurons from glutamate-in- duced neurotoxicity via the activation of the phosphatidyli- nositol 3-kinase/Akt signaling pathway显示文摘 | ZHANG F ZHENG W PI R | 2009 | Exp Brain Res2009，，193： | 1 |
| 15 | Activation of peroxisome proliferator- activated receptor- alpha prevents glycogen synthase 3 beta phosphorylation and inhibits cardiac hypertrophy显示文摘 | Li R Zheng W Pi R | 2007 | FEBS Lett2007，581，17： | 1 |
| 16 | Aspirin plus clopidogrel therapy increases early venous graft patency after coronary artery bypass surgery:A single-center,randomized,controlled trial显示文摘 | Gao G Zheng Z Pi Y | 2010 | J Am Coll Cardiol2010，56，20： | 1 |
| 17 | Muscle protein catabolism after severe burn: effects of IGF-1/IGFBP-3 treatment 显示文摘 | Herndon DN Ramzy PI DebRoy MA Zheng M Ferrando AA Chinkes DL Barret JP Wolfe RR Wolf SE | 1999 | Ann Surg1999，229，5： | 1 |
| 18 | Performance Sensitivity Analysis for Linear Systems with Stable Feedback Perturbations | GAO Zhi\|wei,\ ZHENG Pi′e,\ WANG Xian\|laiTianjin University, Tianjin 300072, China | 1999 | Systems Science and Systems Engineering1999，9，4： | 1 |
| 19 | Activation of peroxisome pro-liferator-activated receptor-a prevents glycogen synthase3p phosphorylation and inhibits cardiac hypertrophy 显示文摘 | Li R Zheng W Pi R | 2007 | FEBS Lett2007，581，17： | 1 |
| 20 | Organic–inorganic hybrid superhydrophobic surfaces using methyltriethoxysilane and tetraethoxysilane sol–gel derived materials in emulsion显示文摘 | Xiu-Fang Wen Kun Wang Pi-Hui Pi Jin-Xin Yang Zhi-Qi Cai Li-juan Zhang Yu Qian Zhuo-Ru Yang Da-feng Zheng Jiang Cheng | 2011 | Applied Surface Science2011，，3： | 1 |
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