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| 1 | Effect of phosphorylation of MAPK and Stat3 and expression of c-fos and c-jun proteins on hepatocarcinogenesis and their clinical significance显示文摘AIM To study the effect of phosphorylation ofMAPK and Stat3 and the expression of c-fos andc-jun proteins on hepatocellular carcinogenesisand their clinical significance.METHODS SP immunohistochemistry was usedto detect the expression of p42/44MAPK, p-Stat3,c-fos and c-jun proteins in 55 hepatocellularcarcinomas (HCC) and their surrounding livertissues.RESULTS The positive rates and expressionlevels of p42/44MAPK, p-Stat3, c-fos and c-junproteins in HCCs were significantly higher thanthose in pericarcinomatous liver tissues (PCLT).A positive correlation was observed between theexpression of p42/44MAPK and c-fos proteins, andbetween p-Stat3 and c-jun, but there was nosignificant correlation between p42/44MAPK and p-Stat3 in HCCs and their surrounding livertissues.CONCLUSION The abnormalities of Ras/Rat/MAPK and JAKs/ Stat3 cascade reaction maycontribute to malignant transformation ofhepatocytes. Hepatocytes which are positive forp42/ 44MAPK, c-fos or c-jun proteins may bepotential malignant pre-cancerous cells.Activation of MAPK and Stat3 proteins may be anearly event in hepatocellular carcinogenesis. | De Yun Feng Hui Zheng Yi Tan Rui Xue Cheng Department of Pathology, Hunan Medical University, Changsha 410078, Hunan Province, China New England Biolab, MA, USA | 2001 | World Journal of Gastroenterology2001，7，1： | 75 |
| 2 | Clinical characteristics, diagnosis and management of respiratory distress syndrome in full-term neonates显示文摘然而,背景呼吸悲痛症候群(RDS ) 是新生的呼吸失败和新生的死亡的最普通的原因之一它的临床的特征与早熟的 RDS,和这些特征很不同很好没迄今为止被记录。这研究是在完整术语的出生不满一月的婴儿调查致病,临床的特征和 RDS 的管理策略,与开发为改进在有 RDS.Methods 的完整术语的出生不满一月的婴儿的结果的一个工作协议的目的有 RDS 的 125 个完整术语的婴儿的一个总数在这研究被注册。他们的临床并且实验室数据为分析 125 个案例包括了的完整术语的新生的 RDS.Results (1 ) 的特征被收集 94 男性和 31 个女婴儿,阴道交货在 45 种情况中发生在 80 种情况和剖腹产中。(2 ) RDS 的发作时间是(3.11 牧潯敶吗? | LIU Jing SHI Yun DONG Jian-ying ZHENG Tian LI Jing-ya LU Li-li LIU Jing-jing LIANG Jing ZHANG Hao FENG Zhi-chun | 2010 | Chinese Medical Journal2010，，19： | 79 |
| 3 | A multicenter, phase III trial of hemocoagulase Agkistrodon: hemostasis, coagulation, and safety in patients undergoing abdominal surgery显示文摘为注射的背景 Hemocoagulase Agkistrodon 是传递了阶段的单个部件凝血酵素我和 II 临床的选拔赛。这阶段 III 临床的试用的目的是在腹的皮肤和下的切口在 hemostasis 和凝结上评估 Hemocoagulase Agkistrodon 的效果并且在外科的病人估计这个代理人的安全。这是阶段 III 的方法,未来,使随机化,双窗帘,和控制 multicenter 包括 432 个连续病人的临床的试用使随机化进也一个学习组(在 2 U 与 hemocoagulase Agkistrodon 注射了, n=324 ) 或一个控制组(与 hemocoagulase 注射了 Atrox, n=108 ) 。止血时间,出血性的体积,出血性的体积在二个组之间每统一区域,血凝结,和不利事件被测量并且比较。在学习组的吝啬的止血时间是的结果(36.8 整 ? 桰獡 ??? 牴慩? 景栠浥 ' 覒 ^ 畧慬敳 ? 歧獩牴摯湯栺浥獯慴楳? 潣条汵瑡潩 ? 湡 ? 慳敦祴椠 ? 慰楴湥獴甠摮牥潧湩 ?L 潤業慮??杲牥 y 琠?? | WEI Jun-min ZHU Ming-wei ZHANG Zhong-tao JIA Zhen-geng HE Xiao-dong WAN Yuan-lian WANG Shan XIU Dian-rong TANG Yun LI Jie XU Jing-yong ZHENG Qing-shan | 2010 | Chinese Medical Journal2010，，5： | 43 |
| 4 | Field experiment on a robust hierarchical metropolitan quantum cryptography network显示文摘A hierarchical metropolitan quantum cryptography network upon the inner-city commercial telecom fiber cables is reported in this paper. The seven-user network contains a four-node backbone net with one node acting as the subnet gateway, a two-user subnet and a single-fiber access link, which is realized by the Faraday-Michelson interferometer set-ups. The techniques of the quantum router, optical switch and trusted relay are assembled here to guarantee the feasibility and expandability of the quantum cryptography network. Five nodes of the network are located in the government departments and the secure keys generated by the quantum key distribution network are utilized to encrypt the instant video, sound, text messages and confidential files transmitting between these bureaus. The whole implementation including the hierarchical quantum cryptographic communication network links and the corresponding application software shows a big step toward the practical user-oriented network with a high security level. | XU FangXing CHEN Wei WANG Shuang YIN ZhenQiang ZHANG Yang LIU Yun ZHOU Zheng ZHAO YiBo LI HongWei LIU Dong HAN ZhengFu GUO GuangCan | 2009 | Chinese Science Bulletin2009，54，17： | 40 |
| 5 | A review of lithium-ion battery safety concerns:The issues,strategies,and testing standards显示文摘Efficient and reliable energy storage systems are crucial for our modern society.Lithium-ion batteries(LIBs)with excellent performance are widely used in portable electronics and electric vehicles(EVs),but frequent fires and explosions limit their further and more widespread applications.This review summarizes aspects of LIB safety and discusses the related issues,strategies,and testing standards.Specifically,it begins with a brief introduction to LIB working principles and cell structures,and then provides an overview of the notorious thermal runaway,with an emphasis on the effects of mechanical,electrical,and thermal abuse.The following sections examine strategies for improving cell safety,including approaches through cell chemistry,cooling,and balancing,afterwards describing current safety standards and corresponding tests.The review concludes with insights into potential future developments and the prospects for safer LIBs. | Yuqing Chen Yuqiong Kang Yun Zhao Li Wang Jilei Liu Yanxi Li Zheng Liang Xiangming He Xing Li Naser Tavajohi Baohua Li | 2021 | Journal of Energy Chemistry2021，30，8： | 29 |
| 6 | Production of high-quality agarwood in Aquilaria sinensis trees via whole-tree agarwood-induction technology显示文摘我们使用了整个树的 agarwood 感应的技术在 20 个月以内从 Aquilaria sinensis 树生产 agarwood,并且评估了这 agarwood 的质量。结果证明它的特征以质地,化学成分,香精油内容,和乙醇可溶的摘录内容类似于高级野 agarwood 的那些,与远超过繁体中文药 agarwood 的要求的最後的质量,作为在中国药典 2010 显示了。就我们的知识而言,这是第一研究证明高质量的 agarwood 能在整个 A 被生产。经由一种化学上导致的技术的 sinensis 树。 | Xing Li Zhang Yang Yang Liu Jian He Wei Yun Yang Zheng Zhang Jun Qing Huang Huai Qiong Chen Yu Jun Liu | 2012 | Chinese Chemical Letters2012，23，6： | 28 |
| 7 | Regulating effects of arsenic trioxide on cell death pathways and inflammatory reactions of pancreatic acinar cells in rats显示文摘背景煽动性的 cytokines 在尖锐胰腺炎的发展起一个关键作用,这被接受,那么堵住煽动性的反应的开始可以减轻尖锐胰腺炎的病理学的变化。我们在 vitro 在胰腺的 acinar 房间的 apoptosis 和 oncosis 上学习了砷三氧化物(As2O3 ) 的规章的效果,在尖锐 pancreatitis.Methods 上的 vivo 和它的治疗学的效果,胰腺的 acinar 房间被 collagenase 消化方法孤立。孤立的胰腺的 acinar 房间的 Apoptosis 和 oncosis 与 Hoechst 33258+PI 或 Annexin V+PI 被检测两倍荧光灯的染色。淀粉酶并且喂奶脱氢酶版本被测量。尖锐胰腺炎被 caerulein 的 intraperitoneal 注射在 Wistar 老鼠导致,并且 apoptosis 与把方法标记的终端 dUTP 刻痕结束被检测。肿瘤 necorsis 因素(TNF-) mRNA, myeloperoxidase,原子 factor-B 并且胰腺的损坏的组织学的分级是在那里的 measured.Results 是增加的 apoptosis 但是在有 As2O3 的处理以后的胰腺的 acinar 房间的减少的 oncosis。层次喂奶脱氢酶和淀粉酶版本显著地在在对待的 As2O3 的对待的 group.Myeloperoxidase 内容,TNF- mRNA 水平,原子 factor-B 激活和病理学的分数组织的 As2O3 被减少比在未经治疗的 group.Conclusions As2O3 能导致 apoptosis 和胰腺的 acinar 的还原剂 oncosis 的显著地低房间,因此导致 acinar 房间的 endocellular 酶的减少的版本,减少了煽动性的房间渗入并且减少 inflamma | XUE Dong-bo ZHANG Wei-hui YUN Xiao-guang SONG Chun ZHENG Biao SHI Xing-ye WANG Hai-yang | 2007 | Chinese Medical Journal2007，，8： | 26 |
| 8 | Effect of HCV NS_3 protein on P53 protein expression in hepatocarcinogenesis显示文摘NTRODUCTIONHepatocelularcarcinoma(HCC)isoneofthemostcommonhumancancersintheworld.Recently,theHCVinfectionwasfoundtobeanetiolo... | FENG De Yun, CHEN Rui Xue, PENG Yong, ZHENG Hui and YAN Ya Hui | 1999 | World Journal of Gastroenterology1999，5，1： | 25 |
| 9 | Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis显示文摘 | Yao Chen Yuxuan Zheng Yun Gao Zhen Lin Suming Yang Tongtong Wang Qiu Wang Nannan Xie Rong Hua Mingxi Liu Jiahao Sha Michael D. Griswold Jinsong Li Fuchou Tang Ming-Han Tong | 2018 | Cell Research2018，28，9： | 26 |
| 10 | Coupled Fluid-structure Flutter Analysis of a Transonic Fan显示文摘A coupled 液体结构方法被开发为拍翅在 turbomachinery 的片颤动的分析。途径基于空气动力学、结构的方程及时同时在被行进的液体结构相互作用的时间领域答案。三维(3D ) 不稳定的雷纳兹一般水准海军司烧(RANS ) 方程与 multiblock 被解决动态使空气动力学的力量变形上的有限体积计划评估的格子。有 multigrid 的双走时间的技术和一个有效含蓄的计划被采用及时行进答案。片颤动与片运动被每个模式的回答的线性联合在不稳定的负担下面在计算的一个气动弹性变形模型一起被建模。代码在不稳定的流动的预言被验证拍翅震荡的串联的行为并且被使用拍翅以设计速度的一把接近音速的扇子的分析。 | ZHENG Yun YANG Hui | 2011 | Chinese Journal of Aeronautics2011，24，3： | 22 |
| 11 | The ReaxFF reactive force-field: development, applications and future directions显示文摘The reactive force-field(ReaxFF)interatomic potential is a powerful computational tool for exploring,developing and optimizing material properties.Methods based on the principles of quantum mechanics(QM),while offering valuable theoretical guidance at the electronic level,are often too computationally intense for simulations that consider the full dynamic evolution of a system.Alternatively,empirical interatomic potentials that are based on classical principles require significantly fewer computational resources,which enables simulations to better describe dynamic processes over longer timeframes and on larger scales.Such methods,however,typically require a predefined connectivity between atoms,precluding simulations that involve reactive events.The ReaxFF method was developed to help bridge this gap.Approaching the gap from the classical side,ReaxFF casts the empirical interatomic potential within a bond-order formalism,thus implicitly describing chemical bonding without expensive QM calculations.This article provides an overview of the development,application,and future directions of the ReaxFF method. | Thomas P Senftle Sungwook Hong Md Mahbubul Islam Sudhir B Kylasa Yuanxia Zheng Yun Kyung Shin Chad Junkermeier Roman Engel-Herbert Michael J Janik Hasan Metin Aktulga Toon Verstraelen Ananth Grama Adri CT van Duin | 2016 | npj Computational Materials2016，，1： | 22 |
| 12 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 13 | High-resolution records of Holocene from the Shuangchi Maar Lake in Hainan Island显示文摘The results of sedimentary characteristics, grain-size, clay mineral, C/N and pollen analysis reveal the evolution history of the Shuangchi Maar Lake of Hainan Island as well as the short-term climate variations in tropical areas. It is testified that the Maar sediment system was sensitive in recording the rapid climate changes in the Holocene. These multidisciplinary results demonstrate that the thermal maximum in the Holocene climate lasted from 7200 to 2700 aBP, with several abrupt ephemeral vibrations occurring between 7250-6120 aBP and at around 4460, 3850 and 2700 aBP. In the late Holocene, particularly at ~2700 aBP, a distinct environmental change indicating an important climate transition in the tropical eastern Asia was recorded, probably responding to the enhancement of ENSO phenomena in the Pacific Ocean. In addition, the high-resolution algae record clearly indicates periodical climate fluctuations at 500 a cyclicity during the last 2500 years. | ZHENG Zhuo, WANG Jianghua, WANG Bing, LIU Chunlian, ZOU Heping, ZHANG Hua, DENG Yun & BAI Yan Department of Earth Sciences, Zhongshan University, Guangzhou 510275, China (e-mail: ee29@zsu.edu.cn) | 2003 | Chinese Science Bulletin2003，48，5： | 20 |
| 14 | Congenital vascular rings:a rare cause of respiratory distress in infants and children显示文摘背景先天的脉管的戒指可以经常在婴儿和小孩子引起 unexplained 呼吸症状。他们的诊断和治疗经常被推迟。脉管的戒指的很少研究在学习是与先天的脉管的 rings.Methods 描述临床的演讲,诊断和婴儿和孩子的外科的管理的这的 China.The 目的被报导了临床的历史,物理考试,调查,图象研究和外科的干预回顾地在 7 个孩子被评估(年龄范围:2 个月 -- 4 年,平均数 7 月) 与先天的脉管的 rings.Chest, X 光线照相术在所有病人被执行。有 3-dimensional (3D ) 的 Echocardiography 和计算断层摄影术(CT ) 重建在 6 个病人被执行。Esophagography,心脏的 catheterization 和 angiography,和 bronchoscopy 在 1, 1 和 4 个孩子,被执行 7 个病人中的六个有的 respectively.Results 呼吸症状包括周期性的咳嗽, stridor 和喘息。在症状的发作的年龄从 1 个月到 11 个月。胸 X 光检查没显示出在脉管的戒指上重要的任何东西,除支气管炎和肺病以外。提高对比的 CT 在 6 个病人诊断了脉管的戒指。有的四个病人加倍大动脉的拱门,二平衡拱门,二是正确的拱门主导。一个病人与左系带有一个恰好大动脉的拱门, 1 个病人有一个肺的动脉弹弓。Echocardiography 没能在 2 个病人诊断脉管的戒指。1 个病人的 esophagogram 显示出食道的压缩。4 个病人的 Bronchoscopy 显示出远侧的气管的压缩。7 个病人中的五个经历了脉管的戒指的外科的分割。外科的观察在每个 patient.Conclusions 病人,特别婴儿或幼仔证实了 CT 调查结果与象长期的咳嗽, stridor 和喘息那样的周期性的呼吸症状,孩子们应该被检查因为先天的脉管的提高 rings.Contrast 的 CT 的可能的存在能清楚地显示出脉管的戒指的解剖。作为一种 noninvasive 技术, echocardiography 对诊断有用。在征兆的病人的早外科的管理是有效的。 | MA Gui-qin LI Zhong-zhi LI Xiao-feng PENG Yun DU Zhong-dong JIN Lan-zhong WANG Fang-yun WEI Hai-yan ZHENG Lin ZHANG Xin | 2007 | Chinese Medical Journal2007，，16： | 19 |
| 15 | Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients显示文摘 | Lu Wen Jingyi Li Huahu Guo Xiaomeng Liu Shengmin Zheng Dafang Zhang Weihua Zhu Jianhui Qu Limin Guo Dexiao Du Xiao Jin Yuhao Zhang Yun Gao Jie Shen Hao Ge Fuchou Tang Yanyi Huang Jirun Peng | 2015 | Cell Research2015，25，11： | 19 |
| 16 | Infection with novel coronavirus(SARS-CoV-2)causes pneumonia in Rhesus macaques显示文摘The 2019 novel coronavirus(SARS-CoV-2)outbreak is a major challenge for public health.SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases,with a mortality rate of^6.4%worldwide(based on World Health Organization daily situation report).However,the dynamics of viral infection,replication and shedding are poorly understood.Here,we show that Rhesus macaques are susceptible to the infection by SARS-CoV-2.After intratracheal inoculation,the first peak of viral RNA was observed in oropharyngeal swabs one day post infection(1 d.p.i.),mainly from the input of the inoculation,while the second peak occurred at 5 d.p.i.,which reflected on-site replication in the respiratory tract.Histopathological observation shows that SARS-CoV-2 infection can cause interstitial pneumonia in animals,characterized by hyperemia and edema,and infiltration of monocytes and lymphocytes in alveoli.We also identified SARS-CoV-2 RNA in respiratory tract tissues,including trachea,bronchus and lung;and viruses were also re-isolated from oropharyngeal swabs,bronchus and lung,respectively.Furthermore,we demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2.The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics. | Chao Shan Yan-Feng Yao Xing-Lou Yang Yi-Wu Zhou Ge Gao Yun Peng Lian Yang Xue Hu Jin Xiong Ren-Di Jiang Hua-Jun Zhang Xiao-Xiao Gao Cheng Peng Juan Min Ying Chen Hao-Rui Si Jia Wu Peng Zhou Yan-Yi Wang Hong-Ping Wei Wei Pang Zheng-Fei Hu Long-Bao Lv Yong-Tang Zheng Zheng-Li Shi Zhi-Ming Yuan | 2020 | Cell Research2020，30，8： | 19 |
| 17 | The Frattini Subalgebra of Restricted Lie Superalgebras显示文摘在现在的论文,我们学习限制谎言 superalgebra 的 Frattini subalgebra (L,[p ]) 。我们首先看那是否 L = A 1 鈯? A 2 鈯?鈯? A n 一,然后? p (L)=? p (一 1 )+? p (一 2 )+?+? p ( n ),在每 A i 是 L 的 p 鈥搃d eal 的地方。我们然后获得二结果:F (L)=?(L)= J (L)= L (1 ) 如果并且仅当 L 是 nilpotent;如果 L 是可解决的, F p (L) 和 F (L) 是 L 的 nilpotent 理想。另外,必要、足够的条件被作出对有利的裁决 ? p 鈥揻r ee 限制了谎言 superalgebras。最后,我们讨论 E 鈥損鈥搑e stricted 谎言 superalgebras 和 E 鈥搑e stricted 谎言 superalgebras 的关系。关键词限制了谎言 superalgebras - E 鈥損鈥搑e stricted 谎言 superalgebras - Frattini p 鈥搒u balgebra -蠁 p 鈥揻r ee - p 鈥揺l ementary 先生(2000 ) 题目分类 17B40 - 17B50 由中国(资助号码 10271076 ) | Liang Yun CHEN Dao Ji MENG Yong Zheng ZHANG | 2006 | Acta Mathematica Sinica,English Series2006，22，5： | 18 |
| 18 | Comparison of glycemic variability and glycated hemoglobin as risk factors of coronary artery disease in patients with undiagnosed diabetes显示文摘背景一个冠的动脉疾病( CAD )风险因素是著名的长期的多糖症的角色,并且 glycemic 可变性仍然是这研究的 debate.The 目的一件事是调查承认 glycemic 的协会有在有 undiagnosed 糖尿病 mellitus ( DM )的病人的 CAD 的存在和严厉的旅行和血红素 A1c ( HbA1c )我们学习了的 .Methods 286 最新诊断了 DM 没有优先的 revascularization 的病人为怀疑的 ischaemic ch 经历冠的 | MI Shu-hua SU Gong LI Zhao YANG Hong-xia ZHENG Hong TAO Hong ZHOU Yun TIAN Lei | 2012 | Chinese Medical Journal2012，，1： | 18 |
| 19 | N6-Methyladenine DNA Methylation in Japonica and Indica Rice Genomes and Its Association with Gene Expression,Plant Development, and Stress Responses显示文摘N6-Methyladenine (6mA)DNA methylation has recently been implicated as a potential new epigenetic marker in eukaryotes,including the dioot modelArabidopsis thaliana.However,the conservation and divergence of 6mA distribution patterns and functions in plants remain elusive.Here we report high-quality 6mA methylomes at single-nucleotide resolution in rice based on substantially improved genome sequences of two rice cultivars,Nipponbare (Nip;Japonica)and 93-11 (Indica).Analysis of 6mA genomic distribution and its association with transcription suggest that 6mA distribution and function is rather conserved between rice and Arabidopsis.We found that 6mA levels are positively correlated with the expression of key stressrelated genes,which may be responsible for the difference in stress tolerance between Nip and 93-11. Moreover,we showed that mutations in DDM1 cause defects in plant growth and decreased 6mA level. Our results reveal that 6mA is a conserved DNA modification that is positively associated with gene expression and contributes to key agronomic traits in plants. | Qian Zhang Zhe Liang Xuean Cui Changmian Ji Yun Li Pingxian Zhang Jingrong Liu Adeel Riaz Pu Yao Min Liu Yunpeng Wang Tiegang Lu Hao Yu Donglei Yang Hongkun Zheng Xiaofeng Gu | 2018 | Molecular Plant2018，11，12： | 18 |
| 20 | Prevalent false positives of azoospermia factor a (AZFa) microdeletions caused by single-nucleotide polymorphism rs72609647 in the sY84 screening of male infertility显示文摘复合聚合酶链反应(PCR ) 广泛地被用来检测 Y 染色体 microdeletions,它是男不孕的主要原因之一。两个都, Andrology (EAA ) 和欧洲分子的遗传优秀网络(EMQN ) 的欧洲学院为精子缺乏因素的察觉推荐了 sY84 和 sY86 标记的使用一(AZFa ) microdeletion 在为男不孕测试的 DNA 期间。在这研究,总共 630 中国男性的 AZF microdeletion 的大规模分析包括健康精液施主(n=200 ) ,有正常精子计数(n=226 ) 和有 nonobstructive 精子缺乏或严重 oligozoospermia (n=204 ) 的病人的不肥沃的男性,被执行。从 Y 染色体的 AZF 区域的一系列九个标注顺序的地点(圣) 标记被用来检测 microdeletions。所有教材基于生物工学信息的国家中心的建议被设计。不平常地高的发生(73/630, 11.6 %)sY84 不在但是 sY86 礼品遗传型在屏蔽的 AZFa microdeletion 被观察。定序胁腹 sY84 区域揭示了 73 个病人的一个总数与 sY84 不在但是 sY86 礼品遗传型从 5 ′ 在第五个底有 T-to-G transversion;反向的 sY84 教材的结束。这些流行假 positives,它是不仅在不肥沃的人观察了,而且在施主观察了,源于说出的单个核苷酸的多型性(SNP ) 在反向的 sY84 教材的指向的顺序的 rs72609647。我们的学习建议那一多型性能阻止的 rs72609647 的存在预先屏蔽在不肥沃的中国男性的 AZFa microdeletions 察觉的经常的假积极结果。给 SNP rs72609647 最近在一个中国个人,的深定序被发现当前的 EAA 和 EMQN 标准可以需要在不同人口之中被细看在教材绑定序列避免潜在的基因变化。 | Qing Wu Guo-Wu Chen Tao-Fei Yan Hui Wang Yu-Ling Liu Zheng Li Shi-Wei Duan Fei Sun Yun Feng Hui-Juan Shi | 2011 | Asian Journal of Andrology2011，13，6： | 13 |
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