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| 1 | National survey of doctor-reported secondary preventive treatment for patients with acute coronary syndrome in China显示文摘 | LI Jing LI Xi Yiping Chen Zhengming Chen ZHANG Li-hua FENG Fang ZHANG Hai-bo LIU Jia-min GAO Yan HUNDEI Wuhan-bilige LI Li JIANG Li-xin | 2013 | Chinese Medical Journal2013，，18： | 5 |
| 2 | Research progress on bulk nanobubbles显示文摘There are still fundamental problems lying in the basic research of bulk nanobubbles.Are the bulk nanobubbles reported in the literature nano scale bubbles or contaminants in fact?At present,there is not yet sufficient experimental evidence to show that the bulk nanoparticles are only gas bubbles but not other nano scale contaminants.If they are indeed nanobubbles,what causes the bulk nanobubbles observed in the literature to be much more stable than being predicted by the Epstein-Plesset theory?This paper firstly discusses the contradiction between the traditional theory prediction and the observed lifetime of the bulk nanobubbles,and then discusses whether the so-called nanobubbles are gas aggregates.We review the existing typical models,and the influence of different conditions on the stability of bulk nanobubbles,for paving the road to a clear understanding of the stability mechanism of bulk nanobubbles.In addition,the representative production methods and characterization methods of bulk nanobubbles are discussed in order to offer some guidance to their wide range of commercial applications. | Le Sun Fenghua Zhang Xiaoming Guo Zhengming Qiao Yi Zhu Nuo Jina Yan Cui Weimin Yang | 2022 | Particuology2022，20，1： | 2 |
| 3 | Synthesis and Biological Activity of Novel Furan/Thiophene and Piperazine-Containing (Bis)1,2,4-triazole Mannich Bases显示文摘Mannich 基于的新奇 furan/thiophene 和包含 piperazine 1,2,4-triazole Mannich 底和二度(1,2,4-triazole ) 的系列方便地作为中介与 triazole Schiff 底,各种各样的 piperazine 衍生物,和甲醛经由 Mannich 反应被综合了在好收益。他们的结构被融化点描绘, 1 H NMR, 13 C NMR,红外和元素的分析。初步的生物鉴定证明在 vitro 并且在对几测试的 vivo 杀菌剂活动重要的展出的大多数混合物种真菌。在 32 新混合物之中,包含 trifluoromethyl 混合物比包含甲基的显示出优异活动。几混合物例如 F8, F9, F10, G5, H7, H8, I3 和 I4,在现在的学习期间与对不同真菌的一些商业杀真菌剂是可比较的,进一步的在结构上能被优化。同时,几混合物在 100 µg/mL 和 KARI 对 Brassica campestris 显示出好 herbicidal 活动在 200 µg/mL 的禁止的活动。然而,混合物在初步的研究在 200 µg/mL 对东方粟蚕展出了差的杀虫的活动。研究结果将为新农业化肥的设计和发现向有用信息提供新奇杂环的结构。 | Baolei Wang Yanxia Shi Yizhou Zhan Liyuan Zhang Yan Zhang Lizhong Wang Xiao Zhang Yonghong Li Zhengming Li Baoju Li | 2015 | Chinese Journal of Chemistry2015，33，10： | 2 |
| 4 | Synthesis and insecticidal evaluation of novel sulfide-containing amide derivatives as potential ryanodine receptor modulators显示文摘With the aim of discovering new bioactive pesticides for crop protection,a series of novel sulfidecontaining amide derivatives A were efficiently synthesized via a strategy of modifying the“amide”structure of anthranilic diamide insecticides.The single-crystal structures of A2-3 and A4-5 were firstly reported.The bioassay results showed that most of the synthesized compounds display moderate to high insecticidal activities.Particularly,some sulfone-containing compounds,e.g.,A2-3,A3-3 and A6-3,not only possessed favorable lethality rate(50%–100%)against P.xylostella at a concentration of 0.1 mg/L,but also held good activities towards a variety of agricultural pests such as M.separata,C.pipiens pallen,H.armigera and O.nubilalis;the larvicidal activities of A4-1 and A6-1 towards P.xylostella were close to that of chlorantraniliprole at 0.01 mg/L.The calcium imaging experiments revealed that the representative compounds A2-3 and A6-3 are potential ryanodine receptor(RyR)modulators.The structure–activity relationships were discussed in detail.These results provide useful information for further design and development of novel insecticides. | Yan Zhang Yuxin Li Huan Li Junfeng Shang Zhengming Li Baolei Wang | 2022 | Chinese Chemical Letters2022，33，1： | 1 |
| 5 | Synthesis,insecticidal activities,and SAR studies of novel piperazine-containing heterocyclic mono-/di-/tri-amide derivatives显示文摘Diamide compounds such as chlorantraniliprole,a famous anthranilic diamide insecticide targeting the insect ryanodine receptor(Ry R),have received continuous attention in pesticide research during the past 15 years owing to their excellent insecticidal potentials.With the aim of discovering new heterocyclic pesticides used for crop protection,based on the structural information of compound M from the reported pharmacophore-based virtual screening for Ry R insecticides and diamide compound,a series of new heterocyclic mono-,di-,and tri-amide derivatives containing piperazine moiety have been synthesized in this paper.The new compounds were identified and confirmed by melting point,^(1)H NMR,^(13)C NMR and HRMS.Compound M was firstly validated for insecticidal activities,and the new synthesized compounds were all made comprehensive insecticidal evaluations against diamondback moth and oriental armyworm.The bioassay results showed that some of the compounds exhibit favorable insecticidal potentials,particularly some novel piperazine-containing heterocyclic mono-/di-/tri-amide derivatives such as 8 g,14 a,15 a,15 g,15 i,15 j,15 k,15 l,and 15 m could be used as new insecticidal leading structures for further study(e.g.,towards diamondback moth,15i-15 m LC_(50):0.0022-0.0081 mg/L).The structure-activity relationships of the compounds discussed in detail provide useful guidance for further design and development of new insecticides. | Huan Li Hang Liu Yan Zhang Na Yang Lixia Xiong Zhengming Li Baolei Wang | 2021 | Chinese Chemical Letters2021，32，9： | 1 |
| 6 | Synthesis of novel N-pyridylpyrazole derivatives containing 1,2,4-oxadiazole moiety via 1,3-dipolar cycloaddition and their structures and biological activities显示文摘A series of novel 1,2,4-oxadiazole-containing N-pyridylpyrazole derivatives 12 a-h were efficiently synthesized with pivaldehyde,pyridylpyrazole carboxylic acid and arylamine as raw materials via 1,3-dipolar cycloaddition.Their structures were identified by melting points,1 H NMR,13 C NMR and elemental analysis or HRMS.The exploration on the single-crystal structures of 12 c and 12 g revealed the stereochemical and substituent oriental characteristics,and the relevance of the structure and the reaction activity of this type of compounds.The preliminary bioassays indicated that several compounds had good insecticidal activities,among which 12 c showed a lethality rate of 80%towards Mythimna separata Walker at 200μg/mL;some of the compounds exhibited favorable fungicidal activities at 50μg/mL against Physalospora piricola,Rhizoctonia cereal,Sclerotinia sclerotiorum,etc.Among which,12 a,12 b,12 c and 12 h could be considered as new fungicidal leading compounds for further structural optimization.These discoveries along with the structure-activity relationship analysis in this paper will provide useful guidance for the innovative studies on new pyridylpyrazole derivatives and their applications in agrochemical area. | Yan Zhang Junfeng Shang Huan Li Hang Liu Haibin Song Baolei Wang Zhengming Li | 2020 | Chinese Chemical Letters2020，31，5： | 1 |
| 7 | Analysis of internal (n-1)mer deletion sequences in synthetic oligodeoxyribonucleotides by hybridization to an immobilized probe array显示文摘 | Danhua Chen Zhengming Yan Douglas L | 1999 | Nucleic Acids Res1999，27，2： | 1 |
| 8 | 显示文摘 | Yan Li Zhengming Huang Yandong Lǚ | 2006 | European polymer Journal2006，42，7： | 1 |
| 9 | Electrospinning of nylon-6,66,1010 terpolymer显示文摘 | Yan Li Zhengming Huang Yandong Lǚ | 2006 | European Polymer Journal2006，，7： | 1 |
| 10 | PF-00477736 mediates checkpoint kinase 1 signaling pathway and potentiates docetaxel-induced efficacy in xenografts显示文摘 | Zhang C Yan ZhengMing Painter C L | 2009 | Clin Cancer Res2009，15，14： | 1 |
| 11 | Design, Synthesis, Structure-Activity Relationship and Insecticidal Activities of Trifluoromethyl-Containing Sulfiliminyl and Sulfoximinyl Phthalic Acid Diamide Structure显示文摘Due to a novel mode action,low toxicity to mammals and low residue characteristics,phthalic acid diamides have aroused considerable interests in agricultural chemistry.With introduction of N-cyano,N-trifluoroacetyl,N-carbamoylsulfiliminyl and sulfoximinyl substituents into phthalamides,12 novel derivatives containing trifluoromethyl moiety were designed and synthesized.All title compounds were characterized by ^(1)H NMR and high-resolution mass spectrometry.The preliminary results of biological activity assessment indicated that some title compounds exhibited moderate to good insecticidal activities against oriental armyworm(Pseudaletia separata Walker).In particular,Va gave higher activity against oriental armyworm and diamondback moth.The present work reported that the new trifluoromethylated diamides incorporating N-trifluoroacetylsulfoximinyl moieties are potential lead compounds for further structure optimization,providing some insight into the relating structure-activity relationship. | Sha Zhou Tao Yan Sha Zhou Xuewen Hua Baolei Wang Yucheng Gu Lixia Xiong Yongqiang Li Zhengming Li | 2014 | Chinese Journal of Chemistry2014，32，7： | 1 |
| 12 | Synthesis and structure-insecticidal activity relationship of novel phenylpyrazole carboxylic acid derivatives containing fluorine moiety显示文摘A series of novel phenylpyrazole carboxylic acid derivatives containing fluorine moiety,i.e.,diamides 11,simple aryl-bearing amides 12 and acylthioureas 14 were successfully synthesized based on the key fluo ro-containing phe nylpyrazole acid intermediate.The new compounds were identified and confirmed by melting point,1H NMR,13C NMR and elemental analysis or HRMS.The bioassay results indicated that some of the compounds possessed excellent insecticidal activities towards oriental armyworm,diamondback moth and corn borer at low concentrations.For examples,compounds 11a,11e-g and 14b exhibited remarkable larvicidal activities with LC50 values of 0.13-0.39 mg/L and 0.0002-0.0014 mg/L against oriental armyworm and diamondback moth,respectively,were comparable with those of the control chlorantraniliprole.Particularly,lie were found superior to chlorantraniliprole in oriental armyworm tests(LC50:0.23 mg/L vs.0.26 mg/L);11a,lie,11f and 14c in diamondback moth tests with LC50 values of 0.0002 mg/L,0.0002 mg/L,0.0008 mg/L and 0.0005 mg/L,respectively,we re more effective than that of chlorantraniliprole.In addition,12 a also showed a promising insecticidal potential and development/optimization advantage.Compounds 11a,lle-g,12a,14b and 14c could be considered as possible new leading structures for further study.The SAR investigation indicated that the compounds with fluorine motif(e.g.,-F,-CF2H,-CF3)held apparently favorable insecticidal potentials,which provided useful guidance for further design/development of new phenylpyrazole-containing agrochemicals. | Baolei Wang Hongxue Wang Hang Liu Lixia Xiong Na Yang Yan Zhang Zhengming Li | 2020 | Chinese Chemical Letters2020，31，3： | 1 |
| 13 | Aqueous-soluble components of sporoderm-removed Ganoderma lucidum spore powder promote ferroptosis in oral squamous cell carcinoma显示文摘Objective: Ferroptosis is a novel cell death process which displays a promising role in cancer treatment.However, clinically available drugs targeting ferroptosis are rarely used, and yet there are no studies reporting on inducing ferroptosis via Chinese herbal extracts. Here we explored the tumor inhibition effects of Ganoderma lucidum(G. lucidum) on oral squamous cell carcinoma(OSCC). Specifically, we aimed to clarify the biological mechanism of components in the dietary, aqueous-soluble sporoderm-removed G. lucidum spore powder(A-GSP).Methods: Preliminary transcriptome analysis revealed the significant enrichment of the ferroptosis pathway.Cellular Fe2+, glutathione(GSH), malondialdehyde(MDA), reactive oxygen species(ROS) and lipid peroxide levels were measured to identify ferroptosis occurrence. Western blotting was used to measure ferroptosis-related proteins. Changes in mitochondria morphology and function were observed with transmission electron microscopy(TEM) and ATP detection assays. Ferroptosis inhibitor ferrostatin-1 was then used to verify the anti-tumor effects of A-GSP. Finally, nude mice xenograft models of oral cancer confirmed that A-GSP inhibited tumor growth.Results: A-GSP promoted ferroptosis in oral cancer cells by inducing Fe2+influx, GSH depletion, as well as lipid peroxide and ROS accumulation. Ferroptosis-related proteins exhibited corresponding changes, particularly Acylco A synthetase long chain family member 4(ACSL4) increase and glutathione peroxidase 4(GPX4) decrease. A-GSP considerably lowered mitochondrial volume and ridge number, while significantly decreasing ATP production. Ferrostatin-1 reversed all of these A-GSP-induced changes. In vivo, A-GSP exerted a ferroptosismediated tumor-suppressing effect without observable adverse reactions.Conclusions: Our findings demonstrate the therapeutic potential of A-GSP for treating patients with OSCC by targeting ferroptosis. | Xiangping Wu Qingnan Wu Yan Wang Yehai Liu Zhenhao Li Qingchuan Liu Zhengming Huang Mingyan Li Bin Zhang Qimin Zhan | 2023 | Chinese Journal of Cancer Research2023，35，2： | 0 |
| 14 | Insights into the dual-roles of alloying elements in the growth of Sn whiskers显示文摘The growth of Sn whiskers from Ti_(2)SnC/Sn-X(X=Sn,Bi,Pb,Ga)samples was studied in this work to understand the effect of alloying elements on whiskering behaviors.The mobility of source Sn atoms relating with the formation and migration of defects was found to be the critical factor dominating the growth rate,with the gathering of which to grow whiskers on the surface acts as an effective means to lower the enthalpy.As a result,the source Sn atoms would migrate to whisker root spontaneously,making the growth of whiskers the nature of materials,and external factors like compressive stress or oxidation are no more necessary but facilitate the whiskering process by promoting the mobility of source Sn atoms. | Yan Zhang Chengjie Lu Yun Dong Min Zhou Jiandang Liu Hongjun Zhang Bangjiao Ye ZhengMing Sun | 2022 | Journal of Materials Science & Technology2022，，22： | 0 |
| 15 | Tin whisker growth from titanium-tin intermetallic and the mechanism显示文摘Spontaneous growth of metal whiskers, represented by tin whiskers, has haunted tin-based platings and solder joints for decades and caused huge losses to the electronics industry. Despite numerous efforts, the underlying growth mechanism has been resisting interpretation, and the whiskering phenomenon even continues to expand its territory. Here, we report the growth of tin whiskers from a Ti6Sn5intermetallic.These tin whiskers share similar characteristics with those found on the platings or solder joints, but grow more and faster, with finer diameters. After tin whisker growth, Ti6Sn5retains its crystal structure,implying a dealloying process. Combining experimental and first-principles calculation results, we analyzed the growth mechanism of tin whiskers in detail, and proposed a diffusion-based growth model.The strain energy stored in Ti6Sn5during deformation provides a driving force for whisker growth, and the short-circuit diffusion paths generated by such deformation accelerate whisker growth. These findings identify the critical role of intermetallic substrate in the whiskering phenomenon, shedding new light for comprehensively understanding the whisker growth mechanisms. Furthermore, the plenty and rapid growth of tin whiskers also means a new method for the preparation of one-dimensional metallic materials. | Zhihua Tian Peigen Zhang Yan Zhang Jingwen Tang Yushuang Liu Jian Liu ZhengMing Sun | 2022 | Journal of Materials Science & Technology2022，，34： | 0 |
| 16 | Collimated gamma rays from laser wakefield accelerated electrons显示文摘Betatron radiation from laser wakefield accelerated electrons and X-rays scattered off a counter-propagating relativistic electron bunch arecollimated and hold the potential to extend the energy range to hard X-ray or gamma ray band. The peak brightness of these incoherent radiations could reach the level of the brightest synchrotron light sources in the world due to their femtosecond pulse duration and source sizedown to a few micrometers. In this article, the principle and properties of these radiation sources are briefly reviewed and compared. Then wepresent our recent progress in betatron radiation enhancement in the perspective of both photon energy and photon number. The enhancement istriggered by using a clustering gas target, arousing a second injection of a fiercely oscillating electron bunch with large charge or stimulating aresonantly enhanced oscillation of the ionization injected electrons. By adopting these methods, bright photon source with energy over 100 keVis generated which would greatly impact applications such as nuclear physics, diagnostic radiology, laboratory astrophysics and high-energydensity science. | Minghua Li Liming Chen Dazhang Li Kai Huang Yifei Li Yong Ma Wenchao Yan Mengze Tao Junhao Tan Zhengming Sheng Jie Zhang | 2018 | Matter and Radiation at Extremes2018，3，4： | 0 |
| 17 | Preface to Special Topic: Extreme High-Field Physics Driven by Lasers显示文摘With the continuous development of high power laser technologies,lasers with peak power at 10 petawatt(PW)or above are becoming available soon in a few laboratories worldwide.Such lasers may be focused to an intensity above 1023 W/cm2,at which heavy elements such as uranium can be stripped of electrons,entirely leaving behind pure atomic nuclei,and electrons can be accelerated to more than 10 GeV.We are entering an unprecedented regime of laser-matter interactions,where collective effects,relativistic effects,and quantum electrodynamic(QED)effects all play significant roles.Extremely rich nonlinear physics in this regime could be tested experimentally,such as radiation reaction,gamma-ray and pair production via different processes,laser driven nuclear physics,laser-vacuum polarization,etc.It is expected that the new understanding of physics for these extreme high field conditions will lead to a wide range of applications. | Zhengming Sheng Bjorn Manuel Hegelich Stefan Weber Yan Yin | 2019 | Matter and Radiation at Extremes2019，4，6： | 0 |
| 18 | Vegard’s law deviating Ti_(2)(Sn_(x)Al_(1−x))C solid solution with enhanced properties显示文摘The achievement of chemical diversity and performance regulation of MAX phases primarily relies on solid solution approaches.However,the reported A-site solid solution is undervalued due to their expected chemical disorder and compliance with Vegard’s law,as well as discontinuous composition and poor purity.Herein,we synthesized high-purity Ti_(2)(Sn_(x)Al_(1−x))C(x=0–1)solid solution by the feasible pressureless sintering,enabling us to investigate their property evolution upon the A-site composition.The formation mechanism of Ti_(2)(Sn_(x)Al_(1−x))C was revealed by thermal analysis,and crystal parameters were determined by Rietveld refinement of X-ray diffraction(XRD).The lattice constant(a)adheres to Vegard’s law,while the lattice constant(c)and internal free parameter(zM)have noticeable deviations from the law,which is caused by the significant nonlinear distortion of Ti_(6)C octahedron as Al atoms are substituted by Sn atoms.Also,the deviation also results in nonlinear changes in their physicochemical properties,which means that the solid solution often exhibits better performance than end members,such as hardness,electrical conductivity,and corrosion resistance.This work offers insights into the deviation from Vegard’s law observed in the A-site solid solution and indicates that the solid solution with enhanced performance may be obtained by tuning the A-site composition. | Zhihua Tian Peigen Zhang Wenwen Sun Bingzhen Yan Zhengming Sun | 2023 | Journal of Advanced Ceramics2023，12，8： | 0 |
| 19 | Synthesis, Structure and Biological Activities of Novel 2-(Trifluoromethyl)- 6-arylimidazo[2,1-b][1,3,4]-thiadiazole (bis-)Mannich Base Derivatives Containing Substitutedpiperazine Moiety显示文摘 | Yan Zhang Zhengming Li Haibin Song Baolei Wang | 2018 | Chinese Journal of Chemistry2018，36，7： | 0 |
| 20 | Selective growth of tin whiskers from its alloys on Ti_(2)SnC显示文摘The spontaneous growth of metal whiskers has been investigated for more than 70 years.However,there is still no agreement on its growth mechanism,and moreover,new characteristics of this whiskering phenomenon continue to emerge.In this study,Ti_(2)SnC is found to be capable of extracting Sn out of its alloys(Sn Bi,Sn Ag)by selectively growing Sn whiskers,and the Sn whiskers share the features of the traditional whiskers on platings and solders.Replacing the Ti_(2)SnC substrate with Ti C or Si C,under the same conditions,however,the selective growth of Sn whisker does not happen,which means Ti_(2)SnC plays a critical role in it.Based on the unique crystal structure of Ti_(2)SnC,active Sn atoms diffusing through the basal planes of Ti_(2)SnC is proposed to explain the selectivity.The driving force is suggested to be the high interfacial energy between Ti_(2)SnC and tin.This study is of importance to further understand the growth mechanism of metallic whiskers,and it may be also possible to be harnessed to develop paradigm-shifting technologies of metal purification and metallic whisker/nanowire preparation. | Jingwen Tang Peigen Zhang Yushuang Liu Chengjie Lu Yan Zhang Wei He Wubian Tian Wei Zhang Zhengming Sun | 2020 | Journal of Materials Science & Technology2020，54，19： | 0 |
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