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| 1 | Analysis of the global T_m–T_s correlation and establishment of the latitude-related linear model显示文摘In this study,the correlation between Tm,a key variable in GNSS water vapor inversion,and surface temperature(Ts)was calculated on a global scale based on the global geodetic observing system(GGOS)atmosphere Tmdata and European centre for medium-range weather forecasts(ECMWF)surface temperature data.The results show that their correlation is mainly affected by latitudes,and the correlation is stronger at high latitudes and weaker at low latitudes.Although the correlation is relatively weak in the tropic areas,the temperature changes so little in a year in these areas that we can still achieve good Tmresults by linear regression model.Based on these facts,‘‘GGOS atmosphere’’Tmdata and ECMWF Tsdata from 2005 to2011 were used to establish the global latitude-related linear regression model.The new model has root mean square error(RMSE)of 3.2,3.3,and 4.4 K,respectively,compared with respect to the‘‘GGOS atmosphere’’data,COSMIC data,and radiosonde data and is more accurate than the Bevis Tm–Tsrelationship. | Yibin Yao Bao Zhang Chaoqian Xu Jiajun Chen | 2014 | Chinese Science Bulletin2014，59，19： | 14 |
| 2 | Applicability of Bevis Formula at Different Height Levels and Global Weighted Mean Temperature Model Based on Near-earth Atmospheric Temperature显示文摘Weighted mean temperature(T m)is a critical parameter in Global Navigation Satellite System(GNSS)technology to retrieve precipitable water vapor(PWV).It is convenient to obtain high-precision T m estimates near surface utilizing Bevis formula and surface temperature.However,some researches pointed out that the Bevis formula has large uncertainties in high-altitude regions.We investigate the applicability of the Bevis formula at different height levels and find that the Bevis formula has relatively high precision when the altitude is low,while with altitude increasing,the precision decreases gradually.To solve the problem,we analyze the relationship between T m and atmospheric temperature within the near-earth space range(the height range between 0~10 km)and find that they have a high correlation on a global scale.Accordingly,we build a global weighted mean temperature model based on near-earth atmospheric temperature.Validation results of the model show that this model can provide high-precision T m estimation at any height level in the near-earth space range. | Yibin YAO Zhangyu SUN Chaoqian XU | 2020 | Journal of Geodesy and Geoinformation Science2020，3，1： | 14 |
| 3 | Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling显示文摘室的肥大是心血管的疾病的事件的一个强大、独立的预言者。低剂量的乙酰水杨酸酸(阿司匹林) 的脉管的性质通过血小板 cyclooxygenase 的不可逆的抑制提供心血管的好处 1;然而,可能的 anti-hypertrophic 性质和阿司匹林的潜在的机制没详细被调查。在这研究,健康野类型的雄的老鼠随机被划分成三个组并且使遭到了到横向的大动脉的收缩(TAC ) 或假冒的操作。操作 TAC 的老鼠与低剂量的阿司匹林的人的等价物被对待(10 mg 吗? | Samuel Chege Gitau Xuelian Li Dandan Zhao Zhenfeng Guo Haihai Liang Ming Qian Lifang Lv Tianshi Li Bozhi Xu Zhiguo Wang Yong Zhang Chaoqian Xu Yanjie Lu Zhiming Du Hongli Shan Baofeng Yang | 2015 | Frontiers of Medicine2015，9，4： | 6 |
| 4 | A global empirical model for mapping zenith wet delays onto precipitable water vapor using GGOS Atmosphere data显示文摘The importance of water vapor in research of global climate change and weather forecast cannot be over emphasized; therefore substantial efforts have been made in exploring the optimal methods to measure water vapor. It is well-established that with a conversion factor, zenith wet delays can be mapped onto precipitable water vapor(PWV). However, the determination of the exact conversion factor depends heavily on the accurate calculation of a key variable, weighted mean temperature of the troposphere(T_m). As a critical parameter in Global Positioning System(GPS) meteorology, T_m has recently been modeled into a global grid known as GWMT. The GWMT_model only requires the location and the day of year to calculate T_m. Despite the advantages that the GWMT_model offers, anomalies still exist in oceanic areas due to low sampling resolution. In this study, we refine the GWMT_model by incorporating the global T_m grid from Global Geodetic Observing System(GGOS) and obtain an improved model, GWMT-G. The results indicate that the GWMT-G model successfully addresses the anomaly in oceanic areas in the GWMT_model and significantly improves the accuracy of T_m in other regions. | YAO YiBin XU ChaoQian ZHANG Bao CAO Na | 2015 | Science China Earth Sciences2015，58，8： | 6 |
| 5 | LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis显示文摘Cardiac fibrosis is one of the crucial pathological factors in the heart,and various cardiac conditions associated with excessive fibrosis can eventually lead to heart failure.However,the exact molecular mechanism of cardiac fibrosis remains unclear.In the present study,we show that a novel lnc RNA that we named cardiac fibrosis-associated regulator(CFAR)is a profibrotic factor in the heart.CFAR was upregulated in cardiac fibrosis and its knockdown attenuated the expression of fibrotic marker genes and the proliferation of cardiac fibroblasts,thereby ameliorating cardiac fibrosis.Moreover,CFAR acted as a ce RNA sponge for mi R-449a-5p and derepressed the expression of LOXL3,which we experimentally established as a target gene of mi R-449a-5p.In contrast to CFAR,mi R-449a-5p was found to be significantly downregulated in cardiac fibrosis,and artificial knockdown of mi R-449a-5p exacerbated fibrogenesis,whereas overexpression of mi R-449a-5p impeded fibrogenesis.Furthermore,we found that LOXL3 mimicked the fibrotic factor TGF-β1 to promote cardiac fibrosis by activating m TOR.Collectively,our study established CFAR as a new profibrotic factor acting through a novel mi R-449a-5p/LOXL3/m TOR axis in the heart and therefore might be considered as a potential molecular target for the treatment of cardiac fibrosis and associated heart diseases. | Mingyu Zhang Bowen Zhang Xiaohan Wang Jiahang Song Ming Tong Zheng Dong Jiaonan Xu Meng Liu Yuan Jiang Ning Wang Ying Wang Zhimin Du Yanyan Liu Rong Zhang Chaoqian Xu | 2023 | Science China(Life Sciences)2023，66，4： | 1 |
| 6 | The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes显示文摘 | Chaoqian Xu Yanjie Lu Zhenwei Pan Wenfeng Chu Xiaobin Luo Huixian Lin Jiening Xiao Hongli Shan Zhiguo Wang and Baofeng Yang | | Journal of Cell Science0，120，17： | 1 |
| 7 | Lanthanum doped octacalcium phosphate/polylactic acid scaffold fabricated by 3D printing for bone tissue engineering显示文摘Lanthanum(La)has tremendous potential in the treatment and prevention of bone diseases especially osteoporosis and metabolic disorders.However,controlling its distribution and keeping the release of La^(3+)ions sustained and steady in the body is still a big challenge.In this study,we prepared La-OCP powders via co-precipitation method,and further prepared La-OCP/PLA porous scaffolds by 3 D printing.La^(3+)was successfully introduced into the OCP crystal structure and substituted Ca^(2+)at the Ca-5 and Ca-8 sites.In particular,some La^(3+)ions were deposited on the crystal surface in the form of nanoparticles.Both octacalcium phosphate(OCP,Ca_(8)H_(2)(PO_(4))_6·5 H_(2)O)crystals and nanoparticles played as the carriers for La^(3+)ions.The La-OCP/PLA scaffolds displayed obvious mineralization effects and sustained release of La^(3+).The scaffolds contained a uniform structure with rough micro surface topography which acted as a suitable pathway for BMSCs cells to adhere,grow and proliferation.At a certain La^(3+)concentration,the extracts from La-OCP/PLA scaffolds increased the expression of osteogenesis-related genes,thus promoting the osteogenic differentiation of BMSCs.Moreover,the extracts regulated the immune responses.The experiment in vivo proved that La-OCP/PLA porous scaffolds were safe and could enhance bone defect regeneration in vivo.These findings suggest that 3 D printed La-OCP/PLA porous scaffolds have promising potentials in bone tissue engineering. | Zeya Xu Bin Lin Chaoqian Zhao Yanjin Lu Tingting Huang Yan Chen Jungang Li Rongcan Wu Wenge Liu Jinxin Lin | 2022 | Journal of Materials Science & Technology2022，，23： | 1 |
| 8 | Carrier phase-based ionospheric observables using PPP models显示文摘The ionosphere is one of the major error sources in Global Navigation Satellite System(GNSS) positioning,navigation and timing.Estimating the ionospheric delays precisely is of great interest in the GNSS community.To date,GNSS observables for ionospheric estimation are most commonly based on carrier phase smoothed code measurements.However,leveling errors,which affect the performance of ionospheric modeling and differential code bias(DCB) estimation,exist in the carrier phase smoothed code observations.Such leveling errors are caused by the multipath and the short-term variation of DCB.To reduce these leveling errors,this paper investigates and estimates the ionospheric delays based on carrier phase measurements without the leveling errors.The line-of-sight ionospheric observables with high precision are calculated using precise point positioning(PPP) techniques,in which carrier phase measurements are the principal observables.Ionosphere-free and UofC PPP models are applied and compared for their effectiveness to minimize the leveling errors.To assess the leveling errors,single difference of ionospheric observables for a short baseline is examined.Results show that carrier phasederived ionospheric observables from PPP techniques can effectively reduce the leveling errors.Furthermore,we compared the PPP ionosphere estimation model with the conventional carrier phase smoothed code method to assess the bias consistency and investigate the biases in the ionospheric observables. | Yan Xiang Yang Gao Junbo Shi Chaoqian Xu | 2017 | Geodesy and Geodynamics2017，8，1： | 0 |
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