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| 1 | A nowcasting model for the prediction of typhoon tracks based on a long short term memory neural network显示文摘It is of vital importance to reduce injuries and economic losses by accurate forecasts of typhoon tracks. A huge amount of typhoon observations have been accumulated by the meteorological department, however, they are yet to be adequately utilized. It is an effective method to employ machine learning to perform forecasts. A long short term memory(LSTM) neural network is trained based on the typhoon observations during 1949–2011 in China's Mainland, combined with big data and data mining technologies, and a forecast model based on machine learning for the prediction of typhoon tracks is developed. The results show that the employed algorithm produces desirable 6–24 h nowcasting of typhoon tracks with an improved precision. | GAO Song ZHAO Peng PAN Bin LI Yaru ZHOU Min XU Jiangling ZHONG Shan SHI Zhenwei | 2018 | Acta Oceanologica Sinica2018，37，5： | 17 |
| 2 | Strategies to approach high performance in Cr^(3+)-doped phosphors for high-power NIR-LED light sources显示文摘Broadband near-infrared(NIR)-emitting phosphors are key for next-generation smart NIR light sources based on blue LEDs.To achieve excellent NIR phosphors,we propose a strategy of enhancing the crystallinity,modifying the micromorphology,and maintaining the valence state of Cr^(3+) in Ca_(3)Sc_(2)Si_(3)O_(12) garnet(CSSG).By adding fluxes and sintering in a reducing atmosphere,the internal quantum efficiency(IQE)is greatly enhanced to 92.3%.The optimized CSSG:6% Cr^(3+) exhibits excellent thermal stability.At 150℃,97.4% of the NIR emission at room temperature can be maintained.The fabricated NIR-LED device emits a high optical power of 109.9mW at 520 mA.The performances of both the achieved phosphor and the NIR-LED are almost the best results until now.The mechanism for the optimization is investigated.An application of the NIR-LED light source is demonstrated. | Zhenwei Jia Chenxu Yuan Yongfu Liu Xiao-Jun Wang Peng Sun Lei Wang Haochuan Jiang Jun Jiang | 2020 | Light(Science & Applications)2020，9，1： | 16 |
| 3 | Organic amendments increase corn yield by enhancing soil resilience to climate change显示文摘A 22-year field experiment was conducted in Gongzhuling, Jilin province, China to investigate corn yield response to fertilization practice. Compared to an unfertilized control(CK), all fertilization treatments, including inorganic nitrogen fertilizer only(N), balanced inorganic fertilizers(NPK), NPK plus corn straw(SNPK), and NPK plus farmyard manure(MNPK), resulted in significant increases in corn yield. However, only organic matter amendments sustained increasing yield trends, with annual rates of 0.137 and 0.194 t ha-1for the SPNK and MNPK treatments, respectively(P < 0.05). During the 22 years, the daily mean, maximum and minimum temperatures increased by 0.50, 0.53, and 0.46 °C per decade, whereas precipitation displayed no significant change but showed large seasonal variation. According to a regression analysis, increased air temperature exerted positive effects on corn yields under the SNPK and the MNPK treatments. Under both treatments,soil organic carbon contents and soil nutrient availabilities increased significantly compared to their initial levels in 1990, whereas soil bulk density and total porosity changed slightly under the two treatments, which showed higher soil water storage than other treatments. In contrast, significant increases in soil bulk density and decreases in soil total porosity and soil nutrient availability were observed under the CK, N and NPK treatments. The contributions of soil fertility to corn yield were 28.4%, 37.9%, 38.4%, 39.0%,and 42.9% under CK, N, NPK, SNPK, and MNPK treatments, respectively, whereas climate changes accounted for 27.0%, 14.6%, 12.4%, 11.8%, and 10.8%. These results indicate that, in Northeast China, organic matter amendments can mitigate negative and exploit positive effects of climate change on crop production by enhancing soil quality. | Zhenwei Song Hongjun Gao Ping Zhu Chang Peng Aixing Deng Chengyan Zheng Md Abdul Mannaf Md Nurul Islam Weijian Zhang | 2015 | The Crop Journal2015，3，2： | 8 |
| 4 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 5 | LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy显示文摘Diabetic cardiomyopathy(DCM)is a common complication in diabetic patients.The molecular mechanisms of DCM remain to be fully elucidated.The intronic long noncoding RNA of DACH1(lnc DACH1)has been demonstrated to be closely associated with heart failure and cardiac regeneration.In this study,we investigated the role of lnc DACH1 in DCM and the underlying molecular mechanisms.The expression of lnc DACH1 was increased in DCM hearts and in high glucose-treated cardiomyocytes.Knockout of lnc DACH1 reduced mitochondrial oxidative stress,cell apoptosis,cardiac fibrosis and hypertrophy,and improved cardiac function in DCM mice.Overexpression of lnc DACH1 exacerbated mitochondria-derived reactive oxygen species(ROS)level and apoptosis,decreased activity of manganese superoxide dismutase(Mn-SOD);while silencing of lnc DACH1 attenuated ROS production,mitochondrial dysfunction,cell apoptosis,and increased the activity of Mn-SOD in cardiomyocytes treated with high glucose.Lnc DACH1 directly bound to sirtuin3(SIRT3)and facilitated its degradation by ubiquitination,therefore promoting mitochondrial oxidative injury and cell apoptosis in mouse hearts.In addition,SIRT3 silencing abrogated the protective effects of lnc DACH1 deficiency in cardiomyocytes.In summary,lnc DACH1 aggravates DCM by promoting mitochondrial oxidative stress and cell apoptosis via increasing ubiquitination-mediated SIRT3 degradation in mouse hearts.Inhibition of lnc DACH1 represents a novel therapeutic strategy for the intervention of diabetic cardiomyopathy. | Qi Zhang Danyang Li Xue Dong Xiaowen Zhang Junwu Liu Lili Peng Bo Meng Qi Hua Xinyu Pei Lu Zhao Xiaoxi Hu Yang Zhang Zhenwei Pan Yanjie Lu Baofeng Yang | 2022 | Science China(Life Sciences)2022，65，6： | 4 |
| 6 | Controlling dispersion and morphology of MoS2 nanospheres by hydrothermal method using SiO2 as template显示文摘Monodispersed MoS_2 nanospheres were successfully synthesized by using SiO_2 as hard template. The size and morphology of the MoS_2 nanospheres could be finely controlled by the content of SiO_2 and sulfur precursors. Furthermore, higher surface area of monodispersed MoS_2 nanospheres exhibited high reaction rate for hydrodesulfurization(HDS) of dibenzenethiophene(DBT). | Zhenwei Zhang Peng Wang Fei Wang Yaqing Li Wei Lu Xingmao Jiang Xia Gui Zhi Yun | 2018 | Chinese Journal of Chemical Engineering2018，26，5： | 3 |
| 7 | Comparison of Rural Human Settlement System Between China’s Developed and Underdeveloped Regions显示文摘Recently, the Central Government of China has listed the construction of new socialist countryside as one of the major historic tasks amid the country’s modernization, declaring that the construction of | PENG Zhenwei,Professor,College of Architecture and Urban Planning,Tongji University,Shanghai,P. R. China. SUN Jie,Postgraduate,College of Architecture and Urban Planning,Tongji University,Shanghai,P. R. China. Editorial Department | 2007 | China City Planning Review2007，16，4： | 1 |
| 8 | Angular momentum holography via a minimalist metasurface for optical nested encryption显示文摘Metasurfaces can perform high-performance multi-functional integration by manipulating the abundant physical dimensions of light,demonstrating great potential in high-capacity information technologies.The orbital angular momentum(OAM)and spin angular momentum(SAM)dimensions have been respectively explored as the independent carrier for information multiplexing.However,fully managing these two intrinsic properties in information multiplexing remains elusive.Here,we propose the concept of angular momentum(AM)holography which can fully synergize these two fundamental dimensions to act as the information carrier,via a single-layer,non-interleaved metasurface.The underlying mechanism relies on independently controlling the two spin eigenstates and arbitrary overlaying them in each operation channel,thereby spatially modulating the resulting waveform at will.As a proof of concept,we demonstrate an AM meta-hologram allowing the reconstruction of two sets of holographic images,i.e.,the spin-orbital locked and the spin-superimposed ones.Remarkably,leveraging the designed dual-functional AM meta-hologram,we demonstrate a novel optical nested encryption scheme,which is able to achieve parallel information transmission with ultra-high capacity and security.Our work opens a new avenue for optionally manipulating the AM,holding promising applications in the fields of optical communication,information security and quantum science. | Hui Yang Peng He Kai Ou Yueqiang Hu Yuting Jiang Xiangnian Ou Honghui Jia Zhenwei Xie Xiaocong Yuan Huigao Duan | 2023 | Light(Science & Applications)2023，12，4： | 1 |
| 9 | The Geological Significance of the Deformation and Geochronology of the Xiaotian–Mozitan Shear Zone in the Dabie Orogenic Belt(East-Central China)显示文摘The Xiaotian–Mozitan Shear Zone(XMSZ)is the boundary of the Dabie High-grade Metamorphic Complex(DHMC)and the North Huaiyang Tectonic Belt.It was deformed in ductile conditions with a top-to-NW/WNW movement.Geothermometers applied to mineral parageneses in mylonites of the shear zone give a temperature range of 623–691°C for the predeformation and 515–568°C for the syndeformation,respectively,which indicates a retrograde process of evolution.A few groups of zircon U-Pb ages were obtained from undeformed granitic veins and different types of deformed rocks in the zone.Zircons from the felsic ultramylonites are all magmatic,producing a weighted mean 206Pb/238U age of 754±8.1 Ma,which indicates the time of magmatic activities caused by rifting in the Neoproterozoic.Zircons from the granitic veins,cutting into the mylonites,are also of magmatic origin,producing a weighted mean 206 Pb/238 U age of 130±2.5 Ma,which represents the time of regional magmatic activity in the Cretaceous.Zircons from the mylonitic gneisses are of anatectic-metamorphic origins and are characterized by a core-mantle interior texture,which yielded several populations of ages including the Neoproterozoic ages with a weighted mean 206 Pb/238 U age of 762±18 Ma,similar to that of the felsic ultramylonites and the Early Cretaceous ages with a weighted mean 206Pb/238U age of 143±1.8 Ma,indicating the anatectic metamorphism in the Dabie Orogenic Belt(DOB).Based on integrated analysis of the structure,thermal conditions of ductile deformation and the contact relations of the dated rocks,the activation time of the Xiaotian–Mozitan Shear Zone is constrained between~143 Ma and 130 Ma,during which the DOB was undergoing a transition in tectonic regime from compression to extension.Therefore,the deformation and evolution of this shear zone plays an instrumental role in fully understanding this process.This research also inclines us to the interpretation of it as an extensional detachment,with regard to the tectonic properties of the shear zone.It may also be part of a continental scale extension in the background of the North China Block’s cratonic destruction,dominated by the subduction and roll-back of the Paleo-Pacific plate,but more detailed work is needed in order to unravel its complicated development. | HUANG Peng SONG Chuanzhong XIAO Wenjiao LI Jiahao ZHOU Kefa WANG Jinlin NIJIATI Abuduxun LI Zhenwei | 2021 | Acta Geologica Sinica(English Edition)2021，95，2： | 1 |
| 10 | Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1-BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy显示文摘Radiotherapy is widely used in the management of advanced colorectal cancer(CRC).However,the clinical efficacy is limited by the safe irradiated dose.Sensitizing tumor cells to radiotherapy via interrupting DNA repair is a promising approach to conquering the limitation.The BRCA1-BARD1 complex has been demonstrated to play a critical role in homologous recombination(HR)DSB repair,and its functions may be affected by HERC2 or BAP1.Accumulated evidence illustrates that the ubiquitination-deubiquitination balance is involved in these processes;however,the precise mechanism for the cross-talk among these proteins in HR repair following radiation hasn’t been defined.Through activity-based profiling,we identified PT33 as an active entity for HR repair suppression.Subsequently,we revealed that BAP1 serves as a novel molecular target of PT33 via a CRISPR-based deubiquitinase screen.Mechanistically,pharmacological covalent inhibition of BAP1 with PT33 recruits HERC2 to compete with BARD1 for BRCA1 interaction,interrupting HR repair.Consequently,PT33 treatment can substantially enhance the sensitivity of CRC cells to radiotherapy in vitro and in vivo.Overall,these findings provide a mechanistic basis for PT33-induced HR suppression and may guide an effective strategy to improve therapeutic gain. | Xin Yue Tingyu Liu Xuecen Wang Weijian Wu Gesi Wen Yang Yi Jiaxin Wu Ziyang Wang Weixiang Zhan Ruirui Wu Yuan Meng Zhirui Cao Liyuan Le Wenyan Qiu Xiaoyue Zhang Zhenyu Li Yong Chen Guohui Wan Xianzhang Bu Zhenwei Peng Ran-yi Liu | 2023 | Acta Pharmaceutica Sinica B2023，13，8： | 1 |
| 11 | Electron transport properties of magnetic granular films显示文摘In this paper,we present a review of electron transport properties of magnetic granular films.Magnetic granular films are nanocomposite materials which consist of magnetic nanoparticles embedded in a nonmagnetic matrix or assembling of magnetic nanoparticles.According to the style of the nonmagnetic matrix,microstructure and the electron transport mechanism of the films,the magnetic granular films were divided into three groups:(1) magnetic metal-metal granular films,(2) magnetic metal-insulator granular films and(3) magnetic nanocluster-assembled granular films.Moreover,we also systematically review the magnetic properties,transport properties and magnetoresistance effect of size-monodispersed Co and Fe nanocluster-assembled films. | PENG DongLiang WANG JunBao WANG LaiSen LIU XiaoLong WANG ZhenWei CHEN YuanZhi | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，1： | 1 |
| 12 | Optical topologicallattices of Bloch-type skyrmion and meron topologies显示文摘Optical skyrmions, quasiparticles that are characterized by the topologically nontrivial vectorial textures of optical parameters such as the electromagnetic field, Stokes parameters, and spin angular momentum, have aroused great attention recently. New dimensions for optical information processing, transfer, and storage have become possible, and developing multiple schemes for manipulating the topological states of skyrmions, thus, is urgent.Here we propose an approach toward achieving dynamic modulation of skyrmions via changing the field symmetry and adding chirality. We demonstrate that field symmetry governs the skyrmionic transformation between skyrmions and merons, whereas material chirality modulates the twist degree of fields and spins and takes control of the Néel-type–Bloch-type skyrmionic transition. Remarkably, the enantioselective twist of skyrmions and merons results from the longitudinal spin arising from the chirality-induced splitting of the hyperboloid in the momentum space. Our investigation, therefore, acts to enrich the portfolio of optical quasiparticles. The chiral route to topological state transitions will deepen our understanding of light–matter interaction and pave the way for chiral sensing, optical tweezers, and topological phase transitions in quantum matter. | Qiang Zhang Zhenwei Xie Peng Shi Hui Yang Hairong He Luping Du Xiaocong Yuan | 2022 | Photonics Research2022，10，4： | 1 |
| 13 | Correction: Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal lcancergrowth显示文摘In the process of collating the raw data,the authors noticed an inadvertent mistake occurred in Fig.3b that needs to be corrected after online publication of the article.In Fig.3b,as a result of an error in the graphics panel arrangement process,the band of NEMO was repeatedly inserted asβ-actin by mistake.The correct band is shown as below and in the updated Fig.3b.The correction did not affect any of our results or discussion as present in the original publication.We regret any inconvenience this has caused. | Zhenlong Yu Jian Gao Xiaolei Zhang Yulin Peng Wenlong Wei Jianrong Xu Zhenwei Li Chao Wang Meirong Zhou Xiangge Tian Lei Feng Xiaokui Huo Min Liu Mingliang Ye De-an Guo Xiaochi Ma | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 14 | Tumor-on-a-chip:from bioinspired design to biomedical application显示文摘Cancer is one of the leading causes of human death,despite enormous efforts to explore cancer biology and develop anticancer therapies.The main challenges in cancer research are establishing an efficient tumor microenvironment in vitro and exploring efficient means for screening anticancer drugs to reveal the nature of cancer and develop treatments.The tumor microenvironment possesses human-specific biophysical and biochemical factors that are difficult to recapitulate in conventional in vitro planar cell models and in vivo animal models.Therefore,model limitations have hindered the translation of basic research findings to clinical applications.In this review,we introduce the recent progress in tumor-on-a-chip devices for cancer biology research,medicine assessment,and biomedical applications in detail.The emerging tumor-on-a-chip platforms integrating 3D cell culture,microfluidic tech no logy,and tissue engineeri ng have successfully mimicked the pivotal structural and functional characteristics of the in vivo tumor microenvironment.The recent advances in tumor-on-a-chip platforms for cancer biology studies and biomedical applications are detailed and an a lyzed in this review.This review should be valuable for further understanding the mechanisms of the tumor evolution process,screening anticancer drugs,and developing cancer therapies,and it addresses the challenges and potential opportunities in predicting drug screening and cancer treatment. | Xingxing Liu Jiaru Fang Shuang Huang Xiaoxue Wu Xi Xie Ji Wang Fanmao Liu Meng Zhang Zhenwei Peng Ning Hu | 2021 | Microsystems & Nanoengineering2021，7，3： | 0 |
| 15 | MiR-430 Can Affect the Mesoderm Formation and Metamorphosis of Paralichthys olivaceus by Targeting lefty Gene显示文摘MiR-430 is a non-coding small RNA that participates in early embryonic development by acting on the Nodal signaling pathway.Its functions in Paralichthys olivaceus(P.olivaceus),however,remain unclear.In this study,through biological information technology,we hypothesized lefty was the target gene of miR-430.Lefty is a divergent member of the transforming growth factor-β(TGF-β)superfamily,and is involved in regulating left-right patterning as an antagonist of the Nodal signaling pathway.To study the relationship between miR-430 and lefty gene,miR-430 and fluorescent expression vector were transfected into embryo cells.Our results showed that miR-430 has important effects on early embryonic development.It can inhibit the expressions of lefty and other genes related to Nodal signaling pathway.Additionally,the expression of miR-430 was involved in the metamorphosis of P.olivaceus.This study clarifies the function of miR-430 in P.olivaceus,which will be helpful for further research on the interactions between miR-430 and the Nodal signaling pathway. | LI Rui WANG Zhenwei SUN Minmin PENG Meiting QI Jie WANG Zhigang | 2020 | Journal of Ocean University of China2020，19，2： | 0 |
| 16 | Characterization of a small-molecule inhibitor targeting NEMO/IKKβto suppress colorectal cancer growth显示文摘NEMO/IKKβcomplex is a central regulator of NF-κB signaling pathway,its dissociation has been considered to be an attractive therapeutic target.Herein,using a combined strategy of molecular pharmacological phenotyping,proteomics and bioinformatics analysis,Shikonin(SHK)is identified as a potential inhibitor of the IKKβ/NEMO complex.It destabilizes IKKβ/NEMO complex with IC_(50) of 174 nM,thereby significantly impairing the proliferation of colorectal cancer cells by suppressing the NF-κB pathway in vitro and in vivo.In addition,we also elucidated the potential target sites of SHK in the NEMO/IKKβcomplex.Our study provides some new insights for the development of potent small-molecule PPI inhibitors. | Zhenlong Yu Jian Gao Xiaolei Zhang Yulin Peng Wenlong Wei Jianrong Xu Zhenwei Li Chao Wang Meirong Zhou Xiangge Tian Lei Feng Xiaokui Huo Min Liu Mingliang Ye De-an Guo Xiaochi Ma | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 0 |
| 17 | Design and comparative analysis of self-propelling drill bit applied to deep-sea stratum drilling robot显示文摘Robotic subsea stratum drilling robot is a method for new subsea stratigraphic geological investigation and resource exploration.Resistance at the front end is the main source of resistance to the robot’s motion in the strata.Since there is no continuous and strong downward drilling force as in conventional drilling rigs,robot movement relies heavily on the drill bit to reduce the drilling resistance.In this study we propose a self-propelling drill bit that can discharge soil debris to provide propulsive force and reduce the resistance.The key parameter of the drill bit design,the spiral blade lead angle,was determined by theoretical analysis of the drill bit’s soil discharging effect.To verify the structural advantages of the self-propelling drill bit in reducing resistance,a comparative analysis with a conventional conical drill bit was conducted.The drilling process of both bits was simulated using finite element simulation at various rotation speeds,the penetration force and torque data of both drill bits were obtained,and tests prepared accordingly in subsea soil were conducted.The simulations and tests verified that the penetration force of the self-propelling drill bit was lower than that of the conventional conical drill bit.The self-propelling drill bit can reduce the resistance effectively,and may play an important role in the stratum movement of drilling robots. | Peihao ZHANG Xingshuang LIN Hao WANG Jiawang CHEN Zhenwei TIAN Zixin WENG Ziqiang REN Peng ZHOU | 2023 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2023，24，10： | 0 |
| 18 | Expatiation on Small Towns : A Solid Foundation for the Research and Policy-Making of Small Towns in China显示文摘Expatiation on Small TownsAuthors:Zhao Hui et al.Year:2017Publisher:China Architecture and Building Press ISBN:9787112211036(285 pages,in Chinese)Expatiation on Small Towns concentrates on the four parts of smalltowns:people,life,economy,and space,the most crucial elementsthat can directly reflect the development of small towns in China.Itcan be said that this is an innovative research outcome on small townsin China over the years. | Peng Zhenwei Li Min | 2018 | China City Planning Review2018，27，1： | 0 |
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