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| 1 | The Prospective Two-Dimensional Graphene Nanosheets: Preparation, Functionalization, and Applications显示文摘Graphene, as an intermediate phase between fullerene and carbon nanotube, has aroused much interests among the scientific community due to its outstanding electronic, mechanical, and thermal properties.With excellent electrical conductivity of 6000 S/cm, which is independent on chirality, graphene is a promising material for high-performance nanoelectronics, transparent conductor, as well as polymer composites. On account of its Young's Modulus of 1 TPa and ultimate strength of 130 GPa, isolated graphene sheet is considered to be among the strongest materials ever measured. Comparable with the single-walled carbon nanotube bundle,graphene has a thermal conductivity of 5000 W/(m·K), which suggests a potential application of graphene in polymer matrix for improving thermal properties of the graphene/polymer composite. Furthermore, graphene exhibits a very high surface area, up to a value of 2630 m^2/g. All of these outstanding properties suggest a wide application for this nanometer-thick, two-dimensional carbon material. This review article presents an overview of the significant advancement in graphene research: preparation, functionalization as well as the properties of graphene will be discussed. In addition, the feasibility and potential applications of graphene in areas, such as sensors, nanoelectronics and nanocomposites materials, will also be reviewed. | Zhi Yang Rungang Gao Nantao Hu Jing Chai Yingwu Cheng Liying Zhang Hao Wei Eric Siu-Wai Kong Yafei Zhang | 2012 | Nano-Micro Letters2012，4，1： | 16 |
| 2 | H2 strain attenuated live hepatitis A vaccines:protective efficacy in a hepatitis A outbreak显示文摘AIM To investigate the protective efficacy ofH2 strain attenuated live hepatitis A vaccines(H2-strain vaccines)in hepatitis A(HA)outbreaks.METHODS With the permission of theirparents,5551 pre-school and grade 1-3 primaryschool children were inoculated with 1 dose(106.5TCID50)of H2-strain vaccines in anonrandomized,controlled trial conducted inFucheng County,Hebei Province in May 1997.Another 6485 children in the same grades andcompatible in gender and age were enrolled ascontrols.Epidemiological and serological surveywas conducted to evaluate the protectiveefficacy of the vaccines.ELISA was used todetect serum IgM anti-HAV.RESULTS HA outbreak started in early May1998,peaked in the middle of the same month,and lasted about 80 days.Overall 302 HA caseswere found,192(53.58%)were 5-9 years old.One vaccinee and 25 control cases were found tohave hepatitis A,which account for 0.28%(1/356)and 5.92%(25/422)of all vaccinees andcontrols in the 14 villages,respectively.The protective efficacy of vaccines was 95.27%(95% Cl:85.83%-104.72%).In subjects testedfor anti-HAV IgM from 13 villages,1(0.40%)overt and 11(4.06%)asymptomatic HAV caseswere found in 271 vaccinees,but 21(6.69%)ofovert and asymptomatic ones were found in 314controls.CONCLUSION H2 strain vaccines were excellent in preventing overt hepatitis A, but not so effective in preventing asymptomatic hepatitis A virus infection. A booster dose might be needed to get permanent reliable immunity. | Yu Liang Zhao Zong Da Meng Zhi Yi Xu Jun Jie Guo Shao Ai Chai Cheng Gang Duo Xuan Yi Wang Jin Feng Yao Hong Bin Liu Shun Xiang Qi Hui Bin Zhu | 2000 | World Journal of Gastroenterology2000，6，6： | 7 |
| 3 | Design and synthesis of novel triazole antifungal derivatives based on the active site of fungal lanosterol 14a-demethylase(CYP51)显示文摘一系列 1-(1H-1,2,4-triazole-1-yl )-2-(2,4-difluorophenyl)-3-(N-isoproyl-N-substituted-amino)-2-propanols 根据 lanosterol 14a-demethylase (CYP51 ) 的活跃地点被设计了并且综合。他们的结构被 MS 和 1 H NMR。在 vitro,这些综合混合物的抗真菌的活动与八人的病原的真菌被作比较。结果证明所有标题混合物对测试到某程度的真菌展出了活动。混合物 3c, 3d, 7a, 7b 和 7c 展出了更多的有势力对将近除了曲霉属菌 fumigatus,真菌比 fluconazole 测试了的所有的抗真菌的活动。 | Zhi Gang Dan Jun Zhang Shi Chong Yu Hong Gang Hu Xiao Yun Chai Qing Yan Sun Qiu Ye Wu | 2009 | Chinese Chemical Letters2009，20，8： | 5 |
| 4 | Synthesis and fungicidal activity of novel strobilurin analogues containing substituted N-phenylpyrimidin-2-amines显示文摘包含代替的 N-phenylpyrimidin-2-amines 的很多新奇 strobilurin 类似物被综合。这些新混合物的结构被 1 H NMR,红外和元素的分析。在温室的生物评估证明几混合物在 25 mg/L 举办好杀菌剂活动。 | Hui Chao Li Bao Shan Chai Zhi Nian Li Ji Chun Yang Chang Ling Liu | 2009 | Chinese Chemical Letters2009，20，11： | 4 |
| 5 | Deformation mode-determined misorientation and microstructural characteristics in rolled pure Zr sheet显示文摘In this work, commercially pure Zr sheets were subjected to β air cooling and then rolled to different reductions(10% and 50%)at room temperature. Microstructures of both the β-air-cooled and the rolled specimens were well characterized by electron channelling contrast imaging and electron backscatter diffraction techniques, with special attentions paid to their misorientation characteristics. Results show that the β-air-cooled specimen owns a Widmanst?tten structure featured by lamellar grains with typical phase transformation misorientations. The 10% rolling allows prismatic slip and tensile twinning({11-21}<11-2-6> and{10-12}<10-11>) to be activated profusely, which produce new low-angle(~3°–5°) and high-angle(~35° and ~85°) misorientation peaks, respectively. After increasing the rolling reduction to 50%, twinning is suppressed and dislocation slip becomes the dominant deformation mode, with the lamellar grains highly elongated and aligned towards the rolling direction.Meanwhile, only one strong low-angle misorientation peak related to the prismatic slip is presented in the 50%-rolled specimen,with all other peaks disappeared. Analyses on local misorientations reveal that hardly any residual strains exist in the β-air-cooled specimen, which should be related to their sufficient relaxation during slow cooling. Residual strains introduced by 10% rolling are heterogeneously distributed near grain/twin boundaries while heavier deformation(50% rolling) produces much larger residual strains pervasively existing throughout the specimen microstructure. | CHAI LinJiang XIA JiYing ZHI Yan GOU YinNing CHEN LiangYu YANG ZhiNan GUO Ning | 2018 | Science China(Technological Sciences)2018，61，9： | 3 |
| 6 | A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2显示文摘The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying asymptomatic and presymptomatic carriers of the virus,and thus highlights a strong motivation for diagnostics with high sensitivity that can be rapidly deployed.On the other hand,several concerning SARS-CoV-2 variants,including Omicron,are required to be identified as soon as the samples are identified as‘positive’.Unfortunately,a traditional PCR test does not allow their specific identification.Herein,for the first time,we have developed MOPCS(Methodologies of Photonic CRISPR Sensing),which combines an optical sensing technology-surface plasmon resonance(SPR)with the‘gene scissors’clustered regularly interspaced short palindromic repeat(CRISPR)technique to achieve both high sensitivity and specificity when it comes to measurement of viral variants.MOPCS is a low-cost,CRISPR/Cas12a-systemempowered SPR gene-detecting platform that can analyze viral RNA,without the need for amplification,within 38 min from sample input to results output,and achieve a limit of detection of 15 fM.MOPCS achieves a highly sensitive analysis of SARS-CoV-2,and mutations appear in variants B.1.617.2(Delta),B.1.1.529(Omicron)and BA.1(a subtype of Omicron).This platform was also used to analyze some recently collected patient samples from a local outbreak in China,identified by the Centers for Disease Control and Prevention.This innovative CRISPR-empowered SPR platform will further contribute to the fast,sensitive and accurate detection of target nucleic acid sequences with single-base mutations. | Zhi Chen Jingfeng Li Tianzhong Li Taojian Fan Changle Meng Chaozhou Li Jianlong Kang Luxiao Chai Yabin Hao Yuxuan Tang Omar AAl-Hartomy Swelm Wageh Abdullah GAl-Sehemi Zhiguang Luo Jiangtian Yu Yonghong Shao Defa Li Shuai Feng William J.Liu Yaqing He Xiaopeng Ma Zhongjian Xie Han Zhang | 2022 | National Science Review2022，9，8： | 3 |
| 7 | Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases显示文摘Ras homolog(Rho)-associated kinases(ROCKs)belong to the serine-threonine kinase family,which plays a pivotal role in regulating the damage,survival,axon guidance,and regeneration of neurons.ROCKs are also involved in the biological effects of immune cells and glial cells,as well as the development of neurodegenerative disorders such as Alzheimer’s disease,Parkinson’s disease,and multiple sclerosis.Previous studies by us and others confirmed that ROCKs inhibitors attenuated the symptoms and progression of experimental models of the abovementioned neurodegenerative diseases by inhibiting neuroinflammation,regulating immune imbalance,repairing the blood-brain barrier,and promoting nerve repair and myelin regeneration.Fasudil,the first ROCKs inhibitor to be used clinically,has a good therapeutic effect on neurodegenerative diseases.Fasudil increases the activity of neural stem cells and mesenchymal stem cells,thus optimizing cell therapy.This review will systematically describe,for the first time,the effects of abnormal activation of ROCKs on T cells,B cells,microglia,astrocytes,oligodendrocytes,and pericytes in neurodegenerative diseases of the central nervous system,summarize the therapeutic potential of fasudil in several experimental models of neurodegenerative diseases,and clarify the possible cellular and molecular mechanisms of ROCKs inhibition.This review also proposes that fasudil is a novel potential treatment,especially in combination with cell-based therapy.Findings from this review add support for further investigation of ROCKs and its inhibitor fasudil for the treatment of neurodegenerative diseases. | Qing Wang Li-Juan Song Zhi-Bin Ding Zhi Chai Jie-Zhong Yu Bao-Guo Xiao Cun-Gen Ma | 2022 | Neural Regeneration Research2022，17，12： | 3 |
| 8 | A Facile Route for the Large Scale Fabrication of Graphene Oxide Papers and Their Mechanical Enhancement by Cross-linking with Glutaraldehyde显示文摘A facile route for the large scale production of graphene oxide(GO) papers and their mechanical enhancement has been presented in this work. The novel paper-like GO made from individual GO sheets in aqueous suspension can be achieved in large scale by a simple drop casting method on hydrophobic substrates.Significant enhancement in mechanical stiffness(341%) and fracture strength(234%) of GO paper have been achieved upon modification with a small amount(less than 10 wt%) of glutaraldehyde(GA). The cross-linking reaction takes place between hydroxyl groups on the surface of GO and aldehyde groups of GA, through forming hemiacetal structure, which can result in distinct mechanical enhancement of the GO papers. | Nantao Hu Lei Meng Rungang Gao Yanyan Wang Jing Chai Zhi Yang Eric Siu-Wai Kong Yafei Zhang | 2011 | Nano-Micro Letters2011，3，4： | 2 |
| 9 | 2020 Roadmap on two-dimensional nanomaterials for environmental catalysis显示文摘Environmental catalysis has drawn a great deal ofattention due to its clean ways to produce useful chemicals or carry out some chemical processes.Photocatalysis and electrocatalysis play important roles in these fields.They can decompose and remove organic pollutants from the aqueous environment,and prepare some fine chemicals.Moreover,they also can carry out some important reactions,such as 02 reduction reaction(ORR),O2 evolution reaction(OER),H2 evolution reaction(HER),CO2 reduction reaction(C02 RR),and N2 fixation(NRR).For catalytic reactions,it is the key to develop high-performance catalysts to meet the demand fortargeted reactions.In recentyears,two-dimensional(2 D) materials have attracted great interest in environmental catalysis due to their unique layered structures,which offer us to make use of their electronic and structural characteristics.Great progress has been made so far,including graphene,black phosphorus,oxides,layered double hydroxides(LDHs),chalcogenides,bismuth-based layered compounds,MXenes,metal organic frameworks(MOFs),covalent organic frameworks(COFs),and others.This content drives us to invite many famous groups in these fields to write the roadmap on two-dimensional nanomaterials for environmental catalysis.We hope that this roadmap can give the useful guidance to researchers in future researches,and provide the research directions. | Yulu Yang Mingguang Wu Xingwang Zhu Hui Xu Si Ma Yongfeng Zhi Hong Xia Xiaoming Liu Jun Pan Jie-Yinn Tang Siang-Piao Chai Leonardo Palmisano Francesco Parrino Junli Liu Jianzhong Ma Ze-Lin Wang Ling Tan Yu-Fei Zhao Yu-Fei Song Pardeep Singh Pankaj Raizada Deli Jiang Di Li R.A.Geioushy Jizhen Ma Jintao Zhang Song Hu Rongjuan Feng Gang Liu Minghua Liu Zhenhua Li Mingfei Shao Neng Li Jiahe Peng Wee-Jun Ong Nikolay Kornienko Zhenyu Xing Xiujun Fan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 10 | CRISPR-Cas12a-Empowered Electrochemical Biosensor for Rapid and Ultrasensitive Detection of SARS-CoV-2 Delta Variant显示文摘Coronavirus disease 2019(COVID-19)is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The gold standard method for the diagnosis of SARS-CoV-2 depends on quantitative reverse transcription-polymerase chain reaction till now,which is time-consuming and requires expensive instrumentation,and the confirmation of variants relies on further sequencing techniques.Herein,we first proposed a robust technique-methodology of electrochemical CRISPR sensing with the advantages of rapid,highly sensitivity and specificity for the detection of SARS-CoV-2 variant.To enhance the sensing capability,gold electrodes are uniformly decorated with electro-deposited gold nanoparticles.Using DNA template identical to SARS-CoV-2 Delta spike gene sequence as model,our biosensor exhibits excellent analytical detection limit(50 fM)and high linearity(R2=0.987)over six orders of magnitude dynamic range from 100 fM to 10 nM without any nucleic-acid-amplification assays.The detection can be completed within 1 h with high stability and specificity which benefits from the CRISPR-Cas system.Furthermore,based on the wireless micro-electrochemical platform,the proposed biosensor reveals promising application ability in point-of-care testing. | Chenshuo Wu Zhi Chen Chaozhou Li Yabin Hao Yuxuan Tang Yuxuan Yuan Luxiao Chai Taojian Fan Jiangtian Yu Xiaopeng Ma Omar AAl-Hartomy SWageh Abdullah GAl-Sehemi Zhiguang Luo Yaqing He Jingfeng Li Zhongjian Xie Han Zhang | 2022 | Nano-Micro Letters2022，14，10： | 2 |
| 11 | Cortical stimulation for treatment of neurological disorders of hyperexcitability: a role of homeostatic plasticity显示文摘Hyperexcitability of neural network is a key neurophysiological mechanism in several neurological disorders including epilepsy, neuropathic pain, and tinnitus. Although standard paradigm of pharmacological management of them is to suppress this hyperexcitability, such as having been exemplified by the use of certain antiepileptic drugs, their frequent refractoriness to drug treatment suggests likely different pathophysiological mechanism. Because the pathogenesis in these disorders exhibits a transition from an initial activity loss after injury or sensory deprivation to subsequent hyperexcitability and paroxysmal discharges, this process can be regarded as a process of functional compensation similar to homeostatic plasticity regulation, in which a set level of activity in neural network is maintained after injury-induced activity loss through enhanced network excitability. Enhancing brain activity, such as cortical stimulation that is found to be effective in relieving symptoms of these disorders, may reduce such hyperexcitability through homeostatic plasticity mechanism. Here we review current evidence of homeostatic plasticity in the mechanism of acquired epilepsy, neuropathic pain, and tinnitus and the effects and mechanism of cortical stimulation. Establishing a role of homeostatic plasticity in these disorders may provide a theoretical basis on their pathogenesis as well as guide the development and application of therapeutic approaches through electrically or pharmacologically stimulating brain activity for treating these disorders. | Zhi Chai Cungen Ma Xiaoming Jin | 2019 | Neural Regeneration Research2019，14，1： | 2 |
| 12 | EBSD Study of Microstructural and Textural Changes of Hot-Rolled Ti–6Al–4V Sheet After Annealing at 800 ℃显示文摘In this paper, electron backscatter diffraction and various other characterization and analysis techniques including X-ray diffraction, electron channeling contrast imaging and energy-dispersive spectrometry were jointly employed to investigate microstructural and textural changes of a hot-rolled Ti–6 Al–4 V(TC4) sheet after annealing at 800 ℃ for 5 h. In addition,the hardness variation induced by the annealing treatment is rationalized based on revealed microstructural and textural characteristics. Results show that the TC4 sheet presents a typical dual-phase(α +β) microstructure, with a-Ti as the major phase and short-rod-shaped b-Ti(minority) uniformly distributed throughout the a matrix. Most of a grains correspond to the un-recrystallized structures with a typical rolling texture(c//TD and \11–20[//ND) and dense low angle boundaries(LABs). After the annealing, the stored energy in the as-received specimen is significantly reduced, along with greatly decreased LABs density. Also, the annealing allows recrystallization and grain growth to occur, leading to weakening of the initial texture. Furthermore, the water quenching immediately after the annealing triggers martensitic transformation, which makes the high-temperature b phases be transformed into submicron a plates. The hardness of the annealed specimen is 320.5 HV, lower than that(367.0 HV) of the as-received specimen, which could be attributed to reduced LABs, grain growth and weakened texture. Nevertheless, the hardening effect from the fine martensitic plates could help to suppress a drastic hardness drop. | Ji-Ying Xia Lin-Jiang Chai Hao Wu Yan Zhi Yin-Ning Gou Wei-Jiu Huang Ning Guo | 2018 | Acta Metallurgica Sinica(English Letters)2018，31，11： | 2 |
| 13 | Angiotensin Ⅱ type Ⅰ receptor agonistic autoantibody-induced apoptosis in neonatal rat cardiomyocytes is dependent on the generation of tumor necrosis factor-α显示文摘血管收缩素 II 类型我受体论战的自身抗体(AT1-AA ) 与子间前和高血压有关并且有在胎盘刺激肿瘤坏死 factor-alpha (TNF-) 的生产的直接效果。TNF- 是 apoptosis 的一个已知的调停人。然而,很少研究在 cardiomyocytes 的 AT1-AA-induced apoptosis 以内报导了 TNF- 和它的关系的角色。在这研究,新生的老鼠 cardiomyocytes 与 AT1-AA 的各种各样的集中被对待。新生的老鼠 cardiomyocytes 的 apoptosis 是坚定的使用 TUNEL 试金和流动 cytometry。分泌 TNF- 的水平被连接酶的 immunosorbent 试金测量,并且 caspase-3 活动被一个 fluorogenic 朊酶试金工具包测量。AT1 受体封锁和 TNF 禁止者被增加决定他们是否能禁止 AT1-AA 的 apoptotic 效果。结果证明 AT1-AA 在一个剂量依赖者和时间依赖者举止导致了新生的老鼠 cardiomyocytes 的 apoptosis。AT1-AA 增加了 TNF 分泌物和 caspase-3 活动。AT1 受体封锁完全废除了 AT1-AA-induced TNF- 分泌物, caspase-3 激活,和 cardiomyocyte apoptosis。TNF- 受体禁止者显著地稀释的 AT1-AA-induced 新生的老鼠 cardiomyocyte apoptosis。在 pre 惊厥的病人的血浆的 AT1-AA 通过表明小径的 TNF-caspase 支持了新生的老鼠 cardiomyocyte apoptosis。 | Weiran Chai Wenhui Zhang Zhu Jin Yiping Feng Yanping Kuang Jianming Zhi | 2012 | Acta Biochimica et Biophysica Sinica2012，44，12： | 1 |
| 14 | A haplotype map of genomic variations and genome-wide association studies of agronomic traits in foxtail millet(Setaria italica)显示文摘 | Guanqing Jia Xuehui Huang Hui Zhi Yan Zhao QiangZhao Wenjun Li Yang Chai Lifang Yang Kunyan Liu Hengyun Lu Chuanrang Zhu Yiqi Lu Congcong Zhou Danlin Fan Qijun Weng Yunli Guo Tao Huang LeiZhang Tingting Lu Qi Feng Hangfei Hao HongkuanLiu Ping Lu Ning Zhang Yuhui Li Erhu Guo ShujunWang Suying Wang Jinrong Liu Wenfei Zhang GuoqiuChen Baojin Zhang Wei Li Yongfang Wang HaiquanLi Baohua Zhao Jiayang Li Xianmin Diao Bin HanJia | 2013 | Nature Genetics2013，45，8： | 1 |
| 15 | Synthesis, characterisation and liquid crystal properties of 2,5 - bis bromobenzenes 显示文摘 | Chun - peng Chai Qian Yang Xing - he Fan Xiao - fang Chen Zhi -hao Shen Qi -feng Zhou | 2008 | Liquid Crystals2008，35，2： | 1 |
| 16 | Cloning and Squence Analysis of the Micronuclear and Macronuclear Gene Encoding rab Protein of Euplotes Octocarinatus显示文摘 | WANG W ZHI H CHAI B F LIANG A H | 2005 | Biosci Biotechnol Biochem2005，69，3： | 1 |
| 17 | Polyacrylamide hydrogels with phenylboronic acid moieties for the imprinting of proteins显示文摘在这封信, N-acryloyl-3-aminophenylboronic 酸(AAPBA ) 为蛋白质印作为新功能的单体被综合然后检验。与 acrylamide 被异分子聚合生产印血红素或印溶解酵素的 hydrogels 被允许。在重捆测试的模板,印的胶化随 prepolymerization 配方的 AAPBA 数量的增加在特定的绑定显示出重要增加。这些结果显示 AAPBA 可以是为它和蛋白质分子的中等相互作用的有用功能的单体。 | Yan Wang Zhi Hua Chai Hong Yan He Yi Zhe Jiang Guo Qi Fu | 2010 | Chinese Chemical Letters2010，21，12： | 1 |
| 18 | Salinity effects on the 2014 warm “Blob” in the Northeast Pacific显示文摘A significant strong, warm “Blob”(a large circular water body with a positive ocean temperature anomaly) appeared in the Northeast Pacific (NEP) in the boreal winter of 2013 2014, which induced many extreme climate events in the US and Canada. In this study, analyses of the temperature and salinity anomaly variations from the Array for Real-time Geostrophic Oceanography (Argo) data provided insights into the formation of the warm “Blob” over the NEP. The early negative salinity anomaly dominantly contributed to the shallower mixed layer depth (MLD) in the NEP during the period of 2012 2013. Then, the shallower mixed layer trapped more heat in the upper water column and resulted in a warmer sea surface temperature (SST), which enhanced the warm “Blob”. The salinity variability contributed to approximately 60% of the shallowing MLD related to the warm “Blob”. The salinity anomaly in the warm “Blob” region resulted from a combination of both local and nonlocal effects. The freshened water at the surface played a local role in the MLD anomaly. Interestingly, the MLD anomaly was more dependent on the local subsurface salinity anomaly in the 100-150 m depth range in the NEP. The salinity anomaly in the 50-100 m depth range may be linked to the anomaly in the 100-150 m depth range by vertical advection or mixing. The salinity anomaly in the 100-150 m depth range resulted from the eastward transportation of a subducted water mass that was freshened west of the dateline, which played a nonlocal role. The results suggest that the early salinity anomaly in the NEP related to the warm “Blob” may be a precursor signal of interannual and interdecadal variabilities. | Hai Zhi Pengfei Lin Rong-Hua Zhang Fei Chai Hailong Liu | 2019 | Acta Oceanologica Sinica2019，38，9： | 1 |
| 19 | Effects of the free and pre-encapsulated calcium ions on the physical properties of whey protein edible film显示文摘 | CHAI Zhi SHANG Jiejing JIANG Yanfeng | 2010 | International Journal of Food Science and Technology2010，45，7： | 1 |
| 20 | Cloning and Sequence Analysis of the Micronuclear and Macronuclear Gene Encoding Rab Protein of Euplotes octocarinatus显示文摘 | WANG W ZHI H CHAI B F LIANG A H | 2005 | Biosci Biotechnol Biochem2005，69，3： | 1 |
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