|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Randomized Latent Factor Model for High-dimensional and Sparse Matrices from Industrial Applications显示文摘Latent factor(LF) models are highly effective in extracting useful knowledge from High-Dimensional and Sparse(HiDS) matrices which are commonly seen in various industrial applications. An LF model usually adopts iterative optimizers,which may consume many iterations to achieve a local optima,resulting in considerable time cost. Hence, determining how to accelerate the training process for LF models has become a significant issue. To address this, this work proposes a randomized latent factor(RLF) model. It incorporates the principle of randomized learning techniques from neural networks into the LF analysis of HiDS matrices, thereby greatly alleviating computational burden. It also extends a standard learning process for randomized neural networks in context of LF analysis to make the resulting model represent an HiDS matrix correctly.Experimental results on three HiDS matrices from industrial applications demonstrate that compared with state-of-the-art LF models, RLF is able to achieve significantly higher computational efficiency and comparable prediction accuracy for missing data.I provides an important alternative approach to LF analysis of HiDS matrices, which is especially desired for industrial applications demanding highly efficient models. | Mingsheng Shang Xin Luo Zhigang Liu Jia Chen Ye Yuan MengChu Zhou | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，1： | 11 |
| 2 | Design and optimization of a linker for fusion protein construction显示文摘Bivalent,bispecific single-chain antibody fusion protein construction appears to be a promising tool for tumor therapy.One of its drawbacks is that the function and activity of the fusion proteins have varied affinity and/or anti-tumor activity compared with the original molecules from which they are derived.A more optimized linker for fusion proteins would confer more favorable biological activities upon bispecific single-chain antibodies.Thus,it is critical to design and optimize an inter-peptide linker.With different functional domains and optimized linkers,fusion proteins provide a solid base for targeted immune therapy for malignancies.In this paper,we review the inter-peptide linker studies and the design of an optimized linker using genetic algorithms.The spatial structure of the fusion protein can be predicted by using genetic and bioinformatics research.Based on current research,the future focus will be on different correlation models to perform simulations of spatial structures and drug molecule design. | Jianhua Zhang Jun Yun Zhigang Shang Xiaohui Zhang Boronz Pan | 2009 | Progress in Natural Science:Materials International2009，19，10： | 5 |
| 3 | Modeling and analysis of Schistosoma Argonaute protein molecular spatial conformation显示文摘Objective:To analyze the amino acid sequence composition,secondary structure,the spatial conformation of its domain and other characteristics of Argonaute protein.Methods:Bioinformatics tools and the internet server were used.Firstly,the amino acid sequence composition features of the Argonaute protein were analyzed,and the phylogenetic tree was constructed.Secondly,Argonaute protein's distribution of secondary structure and its physicochemical properties were predicted.Lastly,the protein functional expression form of the domain group was established through the Phyre-based analysis on the spatial conformation of Argonaute protein domains.Results:593 amino acids were encoded by Argonaute protein,the phylogenetic tree was constructed,and Argonaute protein's distribution of secondary structure and its physicochemical properties were obtained through analysis.In addition,the functional expression form which comprised the N-terminal PAZ domain and C-terminal Piwi domain for the Argonaute protein was obtained with Phyre.Conclusions:The information relationship between the structure and function of the Argonaute protein can be initially established with bioinformatics tools and the internet server,and this provides the theoretical basis for further clarifying the function of Schistosoma Argonaute protein. | Jianhua Zhang Zhigang Shang Xiaohui Zhang Yuntao Zhang | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 4 |
| 4 | Generation and antitumor effects of an engineered and energized fusion protein VL-LDP-AE composed of single-domain antibody and lidamycin显示文摘Type IV collagenase plays a pivotal role in invasion, metastasis and angiogenesis of tumor. Single domain antibodies are attractive as tumor-targeting vehicle because of their much smaller size com-pared with antibody molecules produced by conventional methods. Lidamycin (LDM) is a potent enediyne-containing antitumor antibiotic. In this study an engineered and energized fusion protein VL-LDP-AE composed of lidamycin and VL domain of mAb 3G11 directed against type IV collagenase was prepared using a novel two-step method. First a VL-LDP fusion protein was constructed by DNA recombination. Secondly VL-LDP-AE was obtained by molecular reconstitution. In MTT assay, VL-LDP-AE showed potent cytotoxicity to HT-1080 cells and KB cells with IC50 values of 8.55×10-12 and 1.70×10-11 mol/L, respectively. VL-LDP-AE showed antiangiogenic activity in chick chrorioallantoic membrane (CAM) assay and tube formation assay. In in vivo experiments, VL-LDP-AE was proved to be more effective than free LDM against the growth of subcutaneously transplanted hepatoma 22 in mice. Drugs were given intravenously on day 3 and 10 after tumor transplantation. Compared in terms of maximal tolerated doses, VL-LDP-AE at 0.25 mg/kg suppressed the tumor growth by 89.5%, LDM at 0.05 mg/kg by 69.9%, and mitomycin at 1 mg/kg by 35%. Having a molecular weight of 25.2 kDa, VL-LDP-AE was much smaller than other reported antibody-based drugs. The results suggested that VL-LDP-AE would be a promising candidate for tumor targeting therapy. And the 2-step approach could serve as a new technology platform for making a series of highly potent engineered antibody-based drugs for a variety of cancers. | MIAO QingFang, SHANG BoYang, OUYANG ZhiGang, LIU XiaoYun & ZHEN YongSu Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China | 2007 | Science China(Life Sciences)2007，50，4： | 3 |
| 5 | Effects of taping on grinding quality of silicon wafers in backgrinding显示文摘Taping is often used to protect patterned wafers and reduce fragmentation during backgrinding of silicon wafers.Grinding experiments using coarse and fine resinbond diamond grinding wheels were performed on silicon wafers with tapes of different thicknesses to investigate the effects of taping on peak-to-valley(PV),surface roughness,and subsurface damage of silicon wafers after grinding.Results showed that taping in backgrinding could provide effective protection for ground wafers from breakage.However,the PV value,surface roughness,and subsurface damage of silicon wafers with taping deteriorated compared with those without taping although the deterioration extents were very limited.The PV value of silicon wafers with taping decreased with increasing mesh size of the grinding wheel and the final thickness.The surface roughness and subsurface damage of silicon wafers with taping decreased with increasing mesh size of grinding wheel but was not affected by removal thickness.We hope the experimental finding could help fully understand the role of taping in backgrinding. | Zhigang DONG Qian ZHANG Renke KANG Shang GAO Haijun LIU | 2021 | Frontiers of Mechanical Engineering2021，16，3： | 1 |
| 6 | A system approach to the synthesis and design of flexible site utility system显示文摘 | SHANG Zhigang KOKOSSIS Antonis | 2005 | Chemical Engineering Science2005，60，： | 1 |
| 7 | A systematic approach to the synthesis and design of flexible site utility systems显示文摘 | Shang Zhigang Kokossis Antonis | | 0，，16： | 1 |
| 8 | Recovering unknown topology in a two-layer multiplex network:One layer infers the other layer显示文摘There have been increasing interests in studying multiplex dynamical networks recently.This paper focuses on topology identiflcation of two-layer multiplex networks with peer-to-peer interlayer couplings.For a two-layer network model in which different layers have different coupling patterns,we propose novel methods to recover unknown topological structure of one layer,using the information of the other layer known as a prior.The proposed methods make full use of the measured evolutional states of the multiplex network itself,and treat the layer with a known structure as an auxiliary layer which is designed to identify the unknown topological layer.Compared with the traditional synchronization-based identiflcation method,the proposed methods are in no need of constructing an additional auxiliary network to identify the unknown topological layer,and thus greatly reduce the cost of topology identiflcation.Finally,numerical simulations validate the effectiveness of the proposed methods. | LIU Hui SHANG ZhiCheng REN ZiYi LI Yan ZENG ZhiGang LU JunAn | 2022 | Science China(Technological Sciences)2022，65，7： | 1 |
| 9 | A system approach to the synthesis and design of flexible site utility system 显示文摘 | SHANG Zhigang KOKOSSIS A | 2005 | Chemical Engineering Science2005，60，16： | 1 |
| 10 | A system approach to the synthesis and design of flexible site utility system 显示文摘 | SHANG Zhigang KOKOSSIS A | 2005 | Chemical Engineering Science2005，60，16： | 1 |
| 11 | Edge chipping of silicon wafers in diamond grinding显示文摘 | Shang Gao Renke Kang Zhigang Dong B. Zhang | 2013 | International Journal of Machine Tools and Manufacture2013，，： | 1 |
| 12 | Genomic footprints of sorghum domestication and breeding selection for multiple end uses显示文摘Domestication and diversification have had profound effects on crop genomes.Originating in Africa and subsequently spreading to different continents,sorghum(Sorghum bicolor)has experienced multiple onsets of domestication and intensive breeding selection for various end uses.However,how these processes have shaped sorghum genomes is not fully understood.In the present study,population genomics analyses were performed on a worldwide collection of 445 sorghum accessions,covering wild sorghum and four end-use subpopulations with diverse agronomic traits.Frequent genetic exchanges were found among various subpopulations,and strong selective sweeps affected 14.68%(∼107.5 Mb)of the sorghum genome,including 3649,4287,and 3888 genes during sorghum domestication,improvement of grain sorghum,and improvement of sweet sorghum,respectively.Eight different models of haplotype changes in domestication genes from wild sorghum to landraces and improved sorghum were observed,and Sh1-and SbTB1-type genes were representative of two prominent models,one of soft selection or multiple origins and one of hard selection or an early single domestication event.We also demonstrated that the Dry gene,which regulates stem juiciness,was unconsciously selected during the improvement of grain sorghum.Taken together,these findings provide new genomic insights into sorghum domestication and breeding selection,and will facilitate further dissection of the domestication and molecular breeding of sorghum. | Xiaoyuan Wu Yuanming Liu Hong Luo Li Shang Chuanyuan Leng Zhiquan Liu Zhigang Li Xiaochun Lu Hongwei Cai Huaiqing Hao Hai-Chun Jing | 2022 | Molecular Plant2022，15，3： | 1 |
| 13 | In situ resource utilization of lunar soil for highly efficient extraterrestrial fuel and oxygen supply显示文摘Building up a lunar settlement is the ultimate aim of lunar exploitation.Yet,limited fuel and oxygen supplies restrict human survival on the Moon.Herein,we demonstrate the in situ resource utilization of lunar soil for extraterrestrial fuel and oxygen production,which may power up our solely natural satellite and supply respiratory gas.Specifically,the lunar soil is loaded with Cu species and employed for electro catalytic CO_(2)conversion,demonstrating significant production of methane.In addition,the selected component in lunar soil(i.e.MgSiO_(3))loaded with Cu can reach a CH_(4)F aradaic efficiency of 72.05% with a CH_(4)production rate of 0.8 mL/min at 600 mA/cm^(2).Simultaneously,an O_(2)production rate of 2.3 mL/min can be achieved.Furthermore,we demonstrate that our developed process starting from catalyst preparation to electrocatalytic CO_(2)conversion is so accessible that it can be operated in an unmmaned manner via a robotic system.Such a highly efficient extraterrestrial fuel and oxygen production system is expected to push forward the development of mankind’s civilization toward an extraterrestrial settlement. | Yuan Zhong Jingxiang Low Qing Zhu Yawen Jiang Xiwen Yu Xinyu Wang Fei Zhang Weiwei Shang Ran Long Yingfang Yao Wei Yao Jun Jiang Yi Luo Weihua Wang Jinlong Yang Zhigang Zou Yujie Xiong | 2023 | National Science Review2023，10，2： | 1 |
| 14 | A system approach to the synthesis and design of flexible site utility system 显示文摘 | SHANG Zhigang KOKSSIS A | 2005 | Chemical Engineering Science2005，60，： | 1 |
| 15 | Radiation characteristics of intermittence exhaust noise显示文摘Aerodynamic characteristics, the noise characteristics in the course of intermittence exhaust are investigated and the expressions for sound pressure level of the noise generated by single-pole source and quadrupole source in the intermittence exhaust noise are established. The effects of all parameters in pneumatic system on the noise are also comprehensively studied. | ZHAO Shengdun SHANG Chunyang ZHAO Zhigang SHI Weixiang (School of Mechanical Engineering, Xi’an Jiaotong University Xi’an 710049) | 2000 | Chinese Journal of Acoustics2000，19，4： | 1 |
| 16 | Characterization of SOX3 Gene in an Ovoviviparous Teleost, Black Rockfish(Sebastes schlegeli)显示文摘Evolutionary evidence suggests that Sox3, a member of the high-mobility-group(HMG) family of transcription factors, is an ancestral precursor of Sry and is involved in sex determination similar to Sry. However, there is limited information regarding the SOX3 gene of the black rockfish(Sebastes schlegeli). In this study, we first isolated SOX3 gene from the gonads of S. schlegeli by homology cloning. The full-length of S. schlegeli SOX3(SsSOX3) c DNA was 1386 bp, comprising a 906-bp open reading frame, which encodes a peptide showing 93.6% and 93.9% homology with the Sox3 proteins of Epinephelus coioides and Oryzias latipe, respectively. Comparison of the cDNA sequence of the Ss SOX3 gene with the corresponding genomic DNA fragment revealed that the SsSOX3 gene consists of a single exon. Phylogenetic analysis demonstrated the evolutionary relationship of Ss SOX3 with other known SOXB1 genes in fish and tetrapods. The promoter region contains binding sites of several transcriptional factors that might participate in the regulation of Ss SOX3 expression. Quantitative real-time PCR analysis indicated that SsSOX3 was expressed in all the investigated larval developmental stages from 1 to 35 days after birth and the level of expression gradually decreased as the development proceeded. SsSOX3 exhibited sexually dimorphic expression in adult gonads, with high expression in the ovary but low expression in the testis. In situ hybridization revealed that SsSOX3 was strongly expressed in oocytes and follicular cells of ovaries but slightly expressed in germ cells of testicular tissues. Therefore, this study suggests that Ss SOX3 plays an important role in oogenesis and ovary differentiation in S. schlegeli. | MA Liman WANG Wenji SHANG Renjie ZHANG Quanqi QI Jie WANG Zhigang | 2019 | Journal of Ocean University of China2019，18，2： | 1 |
| 17 | CFD Analysis of Fluid-Dynamic and Heat Transfer Effects Generated by a Fixed Electricity Transmission Line Interacting with an External Wind显示文摘The flow past a fixed single transmission conductor and the related heat transfer characteristics are investigated using computational fluid dynamics and a relevant turbulence model.After validating the method through comparison with relevant results in the literature,this thermofluid-dynamic problem is addressed considering different working conditions.It is shown that the resistance coefficient depends on the Reynolds number.As expected,the Nusselt number is also affected by Reynolds number.In particular,the Nusselt number under constant heat flux is always greater than that under a constant wall temperature. | Yajuan Jia Lisha Shang Jiangping Nan Guangping Hu Zhigang Fang | 2022 | Fluid Dynamics & Materials Processing2022，18，2： | 0 |
| 18 | Unraveling the Effects of Austenitizing Temperature and Austenite Grain Size on the Crystallographic Characteristics and Mechanical Properties of Martensitic Transformation Products in a Low‑Alloy Steel显示文摘The influence of austenitizing temperature and austenite grain size on the crystallographic characteristics and mechanical properties of transformation products was investigated in a low-alloy steel.Annealing at a lower temperature after austenitization at 1050℃ can reduce the vacancy concentration and enhance the stability of austenite,thereby determining the martensite-start(Ms)temperature and density of twin-related V1/V2 variant pairs.V1/V2 variant pairs are predominately generated by autocatalytic nucleation,which can promote transformation by self-accommodation.Annealing at 800℃ after austenitization at 1050℃ generated the highest content of V1/V2 variant pairs,which contributed to high values of strength,Charpy impact energy,and elongation.In addition to refining the austenite grain size,niobium(Nb)microalloying increases the packet boundaries of the transformation products,mainly because the refined austenite grains provide more nucleation sites for the martensitic transformation.However,the density of block boundaries decreases after austenite refinement by Nb microalloying,owing to insufficient autocatalytic nucleation. | Binbin Wu Fangzhong Hu Zhiquan Wang Shaopeng Yang Rui Zhong Chengjia Shang Zhigang Yang Chi Zhang | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，4： | 0 |
| 19 | Identification of Polymorphic Markers by High-Resolution Melting(HRM)Assay for High-Throughput SNP Genotyping in Maize显示文摘The development of next generation sequencing(NGS)and high throughput genotyping are important techniques for the QTL mapping and genetic analysis of different crops.High-resolution melting(HRM)is an emerging technology used for detecting single-nucleotide polymorphisms(SNPs)in various species.However,its use is still limited in maize.The HRM analysis was integrated with SNPs to identify three types of populations(NIL population,RIL population and natural population),and the useful tags were screened.The patterns of temperatureshifted melting curves were investigated from the HRM analysis,and compared these with the kit.Among all 48 pairs of primers,10 pairs of them were selected:six pairs of primers for the NIL population,three pairs of primers for the RIL population,and one pair of primer for the natural population.The marker for the natural population was developed with a matching rate of 80%for the plant height trait,based on the data of the phenotypic characteristics measured in the field.This study provides an effective method for maize genotyping in the classification of maize germplasm resources,which can be applied to other plants for high-throughput SNP genotyping or further mapping. | Zhigang Shang Yongzhe Zhu Xinmei Guo Meiai Zhao | 2021 | Phyton-International Journal of Experimental Botany2021，90，6： | 0 |
| 20 | Evidence of Glacial Erratic Rollover Revealed by ^(10)Be and ^(26)Al Concentration Variations显示文摘Cosmogenic nuclide exposure dating is one of the most intensively applied dating methods with which to study glacial geomorphology.Glacial erratics have been the major dating objective in many studies.Some research has proposed that glacial erratics may undergo rollover and re-transportation during the late exposure stage,which can affect the dating results.However,there is no direct evidence to confirm this possibility.In this study,we collected seven samples from a vertical section inside a glacial erratic in the paleo-Daocheng ice cap in the southeastern Tibetan Plateau,measuring their contents of the cosmogenic nuclides ^(10)Be and ^(26)Al.The results show that from the top to the bottom,the concentrations of 10Be were(1.21±0.05)×10^(6),(1.00±0.02)×10^(6),(0.88±0.03)×10^(6),(0.77±0.02)×10^(6),(0.75±0.03)×10^(6),(0.95±0.03)×10^(6) and(1.46±0.04)×10^(6) atoms/g.The ^(10)Be concentrations decreased from(1.21±0.05)×10^(6) atoms/g to(0.75±0.03)×10^(6) atoms/g and then increased to(1.46±0.04)×10^(6) atoms/g,which is not consistent with the theoretical prediction of a gradual decrease.This phenomenon indicates that the glacial erratic may have rolled over at least once.The lower surface of the erratic could have been on top at some time in the past.Therefore,its exposure age was greater than the exposure age that was expected,based on its current orientation.This study provides numerical evidence for an erratic rollover event. | ZHANG Zhigang WANG Jian XU Xiaobin CHANG Zhiyang CUI Haitao LIANG Zhong CHEN Xia SHANG Zhiyuan | 2022 | Acta Geologica Sinica(English Edition)2022，96，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员