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| 1 | Ambient volatile organic compounds pollution in China显示文摘Owing to rapid economic and industrial development,China has been suffering from degraded air quality and visibility. Volatile organic compounds(VOCs)are important precursors to the formation of ground-level ozone and hence photochemical smog. Some VOCs adversely affect human health. Therefore,VOCs have recently elicited public concern and given new impetus to scientific interest. China is now implementing a series of polices to control VOCs pollution. The key to formulating policy is understanding the ambient VOCs pollution status. This paper mainly analyzes the species,levels,sources,and spatial distributions of VOCs in ambient air. The results show that the concentrations of ambient VOCs in China are much higher than those of developed countries such as the United States and Japan,especial benzene,which exceeds available standards. At the same time,the ozone formation potential(OFP)and secondary organic aerosol formation potential(SOAFP)of various VOCs are calculated. Aromatics and alkenes have much higher OFPs,while aromatics have higher SOAFP. The OFPs of ambient VOCs in the cities of Beijing,Guangzhou and Changchun are very high,and the SOAFP of ambient VOCs in the cities of Hangzhou,Guangzhou and Changchun are higher. | Xinmin Zhang Zhigang Xue Hong Li Li Yan Yuan Yang Yi Wang Jingchun Duan Lei Li Fahe Chai Miaomiao Cheng Weiqi Zhang | 2017 | Journal of Environmental Sciences2017，29，5： | 34 |
| 2 | Plankton community composition in the Three Gorges Reservoir Region revealed by PCR-DGGE and its relationships with environmental factors显示文摘To explore the relationships between community composition and the environment in a reservoir ecosystem, plankton communities from the Three Gorges Reservoir Region were studied by PCR-denaturing gradient gel electrophoresis fingerprinting. Bacterial and eukaryotic operational taxonomic units (OTUs), generated by DGGE analysis of the PCR-amplified 16S and 18S rRNA genes, were used as surrogates for the dominant 'biodiversity units'. OTU composition among the sites was heterogeneous; 46.7% of the total bacterial OTUs (45) and 64.1% of the eukaryotic OTUs (39) were identified in less than half of the sampling sites. Unweighted pair group method with arithmetic averages (UPGMA) clustering of the OTUs suggested that the plankton communities in the Xiangxi Rive sites were not always significantly different from those from the Yangtze River sites, despite clear differences in their environmental characterizations. Canonical correspondence analysis (CCA) was applied to further investigate the relationships between OTU composition and the environmental factors. The first two CCA ordination axes suggested that the bacterial community composition was primarily correlated with the variables of NO3--N, dissolved oxygen (DO), and SiO32--Si, whereas, the eukaryotic community was mainly correlated with the concentrations of DO, PO43--P, and SiO32--Si. | YAN Qingyun YU Yuhe FENG Weisong YU Zhigang CHEN Hongtao | 2008 | Journal of Environmental Sciences2008，20，6： | 27 |
| 3 | The Chrysanthemum nankingense Genome Provides Insights into the Evolution and Diversification of Chrysanthemum Flowers and Medicinal Traits显示文摘The Asteraceae (Compositae),a large plant family of approximately 24 000-35 000 species,accounts for^10% of all angiosperm species and contributes a lot to plant diversity.The most representative members of the Asteraceae are the economically important chrysanthemums (Chrysanthemum L.)that diversified through reticulate evolution.Biodiversity is typically created by multiple evolutionary mechanisms such as wholegenome duplication 0NGD)or polyploidization and locally repetitive genome expansion.However,the lack of genomic data from chrysanthemum species has prevented an in-depth analysis of the evolutionary mechanisms involved in their diversification.Here,we used Oxford Nanopore long-read technologyto sequence the diploid Chrysanthemum nankingense genome,which represents one of the progenitor genomes of domesticated chrysanthemums.Our analysis revealed that the evolution of the C.nankingense genome was driven by bursts of repetitive element expansion and WGD events including a recentWGD that distinguishes chrysanthemum from sunflower,which diverged from chrysanthemum approximately 38.8 million years ago.Variations of ornamental and medicinal traits in chrysanthemums are linked to the expansion of candidate gene families by duplication events including paralogous gene duplication.Collectively,our study of the assembled reference genome offers new knowledge and resources to dissect the history and pattern of evolution and diversification of chrysanthemum plants,and also to accelerate their breeding and improvement. | Chi Song Yifei Liu Aiping Song Gangqiang Dong Hongbo Zhao Wei Sun Shyam Ramakrishnan Ying Wang Shuaibin Wang Tingzhao Li Yan Niu Jiafu Jiang Bin Dong Ye Xia Sumei Chen Zhigang Hu Fadi Chen Shilin Chen | 2018 | Molecular Plant2018，11，12： | 24 |
| 4 | TRPV1 activation improves exercise endurance and energy metabolism through PGC-1α upregulation in mice显示文摘 | Zhidan Luo Liqun Ma Zhigang Zhao Hongbo He Dachun Yang Xiaoli Feng Shuangtao Ma Xiaoping Chen Tianqi Zhu Tingbing Cao Daoyan Liu Bernd Nilius Yu Huang Zhencheng Yan Zhiming Zhu | 2012 | Cell Research2012，22，3： | 18 |
| 5 | Sources and characteristics of fine particles over the Yellow Sea and Bohai Sea using online single particle aerosol mass spectrometer显示文摘Marine aerosols over the East China Seas are heavily polluted by continental sources. During the Chinese Comprehensive Ocean Experiment in November 2012, size and mass spectra of individual atmospheric particles in the size range from 0.2 to 2.0 μm were measured on board by a single particle aerosol mass spectrometer(SPAMS). The average hourly particle number(PN)was around 4560 ± 3240 in the South Yellow Sea(SYS), 2900 ± 3970 in the North Yellow Sea(NYS), and 1700 ± 2220 in the Bohai Sea(BS). PN in NYS and BS varied greatly over 3 orders of magnitude, while that in SYS varied slightly. The size distributions were fitted with two log-normal modes. Accumulation mode dominated in NYS and BS, especially during episodic periods. Coarse mode particles played an important role in SYS. Particles were classified using an adaptive resonance theory based neural network algorithm(ART-2a). Six particle types were identified with secondary-containing, aged sea-salt, soot-like, biomass burning, fresh sea-salt,and lead-containing particles accounting for 32%, 21%, 18%, 16%, 4%, and 3% of total PN,respectively. Aerosols in BS were relatively enriched in particles from anthropogenic sources compared to SYS, probably due to emissions from more developed upwind regions and indicating stronger influence of continental outflow on marine environment. Variation of source types depended mainly on origins of transported air masses. This study examined rapid changes in PN, size distribution and source types of fine particles in marine atmospheres. It also demonstrated the effectiveness of high-time-resolution source apportionment by ART-2a. | Huaiyu Fu Mei Zheng Caiqing Yan Xiaoying Li Huiwang Gao Xiaohong Yao Zhigang Guo Yuanhang Zhang | 2015 | Journal of Environmental Sciences2015，27，3： | 12 |
| 6 | Low-frequency E-field Detection Array(LFEDA)-Construction and preliminary results显示文摘In recent years, locating total lightning at the VLF/LF band has become one of the most important directions in lightning detection. The Low-frequency E-field Detection Array(LFEDA) consisting of nine fast antennas was developed by the Chinese Academy of Meteorological Sciences in Guangzhou between 2014 and 2015. This paper documents the composition of the LFEDA and a lightning-locating algorithm that applies to the low-frequency electric field radiated by lightning pulse discharge events(LPDEs). Theoretical simulation and objective assessment of the accuracy and detection efficiency of LFEDA have been done using Monte Carlo simulation and artificial triggered lightning experiment, respectively. The former results show that having a station in the network with a comparatively long baseline improves both the horizontal location accuracy in the direction perpendicular to the baseline and the vertical location accuracy along the baseline. The latter results show that detection efficiencies for triggered lightning flashes and return strokes are 100% and 95%, respectively. The average planar location error for return strokes of triggered lightning flashes is 102 m. By locating LPDEs in thunderstorms, we find that LPDEs are consistent with convective regions as indicated by strong reflectivity columns, and present a reasonable distribution in the vertical direction.In addition, the LFEDA can reveal an image of lightning development through mapping the channels of lightning. Based on three-dimensional locations, the vertical propagation speed of the preliminary breakdown and the changing trend of the leader's speed in an intra-cloud and a cloud-to-ground flash are investigated. The research results show that the LFEDA has the capability for three-dimensional location of lightning, which provides a new technique for researching lightning development characteristics and thunderstorm electricity. | SHI DongDong ZHENG Dong ZHANG Yang ZHANG YiJun HUANG ZhiGang LU WeiTao CHEN ShaoDong YAN Xu | 2017 | Science China Earth Sciences2017，60，10： | 10 |
| 7 | Ultrasound-Guided Transmuscular Quadratus Lumbar Block Reduces Opioid Consumption after Laparoscopic Partial Nephrectomy显示文摘Objectives Transmuscular quadratus lumborum block(TQLB)may provide postoperative analgesia in patients undergoing intraperitoneal surgeries.The purpose of this study was to examine the potential efficacy of TQLB among patients undergoing retroperitoneal procedures,such as the laparoscopic partial nephrectomy(LPN).Methods This prospective,randomized,controlled study was conducted from August 2017 to November 2018 at Peking Union Medical College Hospital(Beijing,China).Patients who were scheduled for a LPN,aged 18・70 years old with an ASA physical status score of I-II were randomly assigned to receive either TQLB with 0.6 ml/kg of 0.5%ropivacaine plus general anesthesia(TQLB group)or general anesthesia alone(control group).Patient-controlled intravenous analgesia with morphine was initiated immediately upon surgery completion.The primary outcome was the cumulative consumption of morphine within 8 h after surgery.The secondary outcome included postoperative consump廿ons of morphine at other time points,pain score at rest and during activity,postoperative nausa and vomitting(PONV),and recovery related parameters.Results Totally 30 patients per group were recruited in the study.The 8 h consumption of morphine was lower in theTQLB group than in the control group(median,0.023 mg/kg vs.0.068 mg/kg,U=207.5,P<0.001).No significant differences were observed in postoperative pain scores between the two groups.Patients in the TQLB group had fewer episodes of PONV(20%vs.47%,χ2=4.&P=0.028)in the first 24 h after surgery and higher scores for quality of recovery(mean,13&6 vs.131.9,t=-2.164,P=0.035)120 h after surgery than the controls.Conclusions TQLB resulted in an opioid-sparing effect during the early postoperative period following LPN,as well as a lower incidence of PONV and improved quality of recovery. | Xulei Cui Xu Li Minna Li Yuelun Zhang Yi Xie Weigang Yan Yushi Zhang Zhigang Ji Yuguang Huang | 2020 | Chinese Medical Sciences Journal2020，35，4： | 10 |
| 8 | Effects of tooth bending damage on the leakage performance and rotordynamic coefficients of labyrinth seals显示文摘Tooth bending damage resulting from an intense impact by the rotor sometimes occurs in the transient operation.To investigate the influence of after-damage clearance and tooth bending length on the leakage performance and rotordynamic coefficients of labyrinth seals,three tooth bending damages were taken into consideration,including the unbent tooth damage(abbreviated as Unbent),the partial tooth bending damage(abbreviated as Pbent)and the complete tooth bending damage(abbreviated as Cbent).The transient CFD solution was utilized to calculate the leakage flow rates and rotordynamic coefficients of labyrinth seals with clearances of 0.3,0.4,0.5,0.6 mm for three tooth bending damages.The obtained result shows that the Unbent tooth damage leaks least while the Pbent tooth bending damage leaks most,and an increase of 6.1%for Cbent tooth bending damage and an increase of 19.4%for Pbent tooth bending damage are discovered at the tooth clearance of 0.6 mm in comparison with the Unbent tooth damage.Compared to the Unbent tooth damage,the effective damping for Pbent tooth bending damage and Cbent tooth bending damage is lower and drops by 9.7%–33.6%and 8.5%–22.6%respectively at the tooth clearance of 0.6 mm,suggesting that Pbent tooth bending damage or Cbent tooth bending damage tends to weaken the seal stability when compared to the Unbent tooth damage. | Yaoxing CHEN Zhigang LI Jun LI Xin YAN | 2020 | Chinese Journal of Aeronautics2020，33，4： | 9 |
| 9 | A Brief Introduction to BNU-HESM1.0 and Its Earth Surface Temperature Simulations显示文摘Integrated assessment models and coupled earth system models both have their limitations in understanding the interactions between human activity and the physical earth system. In this paper,a new human–earth system model,BNUHESM1.0,constructed by combining the economic and climate damage components of the Dynamic Integrated Model of Climate Change and Economy to the BNU-ESM model,is introduced. The ability of BNU-HESM1.0 in simulating the global CO2 concentration and surface temperature is also evaluated. We find that,compared to observation,BNU-HESM1.0underestimates the global CO2 concentration and its rising trend during 1965–2005,due to the uncertainty in the economic components. However,the surface temperature simulated by BNU-HESM1.0 is much closer to observation,resulting from the overestimates of surface temperature by the original BNU-ESM model. The uncertainty of BNU-ESM falls within the range of present earth system uncertainty,so it is the economic and climate damage component of BNU-HESM1.0 that needs to be improved through further study. However,the main purpose of this paper is to introduce a new approach to investigate the complex relationship between human activity and the earth system. It is hoped that it will inspire further ideas that prove valuable in guiding human activities appropriate for a sustainable future climate. | YANG Shili DONG Wenjie CHOU Jieming FENG Jinming YAN Xiaodong WEI Zhigang YUAN Wenping GUO Yan TANG Yanli HU Jiacong | 2015 | Advances in Atmospheric Sciences2015，32，12： | 8 |
| 10 | Global warming projections using the human–earth system model BNU-HESM1.0显示文摘Future climate change is usually projected by coupled earth system models under specific emission scenarios designed by integrated assessment models(IAMs),and this offline approach means there is no interaction between the coupled earth system models and the IAMs.This paper introduces a new method to design possible future emission scenarios and corresponding climate change, in which a simple economic and climate damage component is added to the coupled earth system model of Beijing Normal University(BNU-ESM). With the growth of population and technological expertise and the declining emission-to-output ratio described in the Dynamic Integrated Climate-Economy model, the projected carbon emission is 13.7 Gt C, resulting in a 2.4 °C warming by the end of the twenty-first century(2080–2099) compared with1980–1999. This paper also suggests the importance of the land and ocean carbon cycle in determining the CO2 concentration in the atmosphere. It is hoped that in the near future the next generation of coupled earth system models that include both the natural system and the social dimension will be developed. | Shili Yang Wenjie Dong Jieming Chou Jinming Feng Zhigang Wei Yan Guo Xiaohang Wen Ting Wei Di Tian Xian Zhu Zhiyong Yang | 2016 | Science Bulletin2016，61，23： | 7 |
| 11 | Additive manufacturing of CNTs/PLA composites and the correlation between microstructure and functional properties显示文摘Owing to the facile,low cost,rapid,personalization characters,3D printing method has been one of the most attractive additive manufacturing processes in medicine,airplane,packaging and printing areas.In this work,a series of carbon nanotubes/polylactic acid(CNTs/PLA) composites were prepared through the combination of molten co-extrusion and 3D printing processes.The orientation and dispersion of CNTs in PLA matrix were investigated to explore the impact of 3D printing process on the morphology of CNTs/PLA composites via transmission electron microscopy,field emission scanning electron microscopy and Raman spectroscopy.X-ray diffractometer,differential scanning calorimetry,and thermal gravity analysis were employed to study the crystal structure and thermal properties of the composites.In addition,the electrical conductivity of the prepared specimen revealed that the orientation of CNTs in PLA might enhance the conductivity of the composite.It was found that 3D printing process was beneficial to increasing the purity of CNTs,electrical conductivity and mechanical properties of CNTs/PLA composites. | Xing Zhou Jingrui Deng Changqing Fang Wanqing Lei Yonghua Song Zisen Zhang Zhigang Huang Yan Li | 2021 | Journal of Materials Science & Technology2021，，1： | 6 |
| 12 | Towards high-performance packet processing on commodity multi-cores: current issues and future directions显示文摘The demands of programmability have become more and more exigent as novel network services appear, such as E-commerce, social softwares, and online videos. Commodity multi-core CPUs have been widely applied in network packet processing to get high programmability and reduce the time-to-market. However,there is a great gap between the packet processing performance of commodity multi-core and that of the traditional packet processing hardware, e.g., NP(Network Process). Recently, optimization of the packet processing performance of commodity multi-cores has become a hot topic in industry and academia. In this paper, based on a detailed analysis of the packet processing procedure, firstly we identify two dominating overheads, namely the virtual-to-physical address translation and the packet buffer management. Secondly, we make a comprehensive survey on the current optimization methods. Thirdly, based on the survey, the heterogeneous architecture of the commodity multi-core + FPGA is proposed as a promising way to improve the packet processing performance.Fourthly, a novel Self-Described Buffer(SDB) management technology is introduced to eliminate the overheads of the allocation and deallocation of the packet buffers offloaded to FPGA. Then, an evaluation testbed, named PIOT(Packet I/O Testbed), is designed and implemented to evaluate the packet forwarding performance. I/O capacity of different commodity multi-core CPUs and the performance of optimization methods are assessed and compared based on PIOT. At last, the future work of packet processing optimization on multi-core CPUs is discussed. | TANG Lu YAN JinLi SUN ZhiGang LI Tao ZHANG MinXuan | 2015 | Science China Chemistry2015，58，12： | 5 |
| 13 | Combustion synthesis and magnetic investigation of nanosized CoFe_2O_4显示文摘Nanosized Co spinel ferrite was prepared by a combustion method. The grain size of resultant ferrite can becontrolled by the reaction conditions. Magnetic investigation revealed that the products with an average grain size of 4 nm behave as superparamagnetic materials and have zero coercive force; whereas the samples with an average grain size of 85 nm (near the size of critical single domain) have the maximal coercive force. There were the negative magnetic intergrain interactions which became stronger when the grain size neared that of the single domain. | XU Zhigang, CHENG Fuxiang, ZHOU Biao, LIAO Chunsheng & YAN ChunhuaState Key Laboratory of Rare Earth Materials Chemistry and Applications, PKU-HKU Joint Laboratory on Rare Earth Materials and Bioin-organic Chemistry, Peking University, Beijing 100871, China | 2001 | Chinese Science Bulletin2001，46，5： | 4 |
| 14 | PEA3 activates CXCR4 transcription in MDA-MB-231 and MCF7 breast cancer cells显示文摘(CXCR4 ) CXC chemokine 受体 4 是被显示了调停的房间表面受体包括肺,胸,肾,和前列腺的许多稳固的肿瘤的转移肿瘤。在这研究,我们发现 et 变体基因 4 的 overexpression (PEA3 ) 能在人的 MDA-MB-231 和 MCF-7 乳癌房间提高 CXCR4 mRNA 水平和 CXCR4 倡导者活动。PEA3 支持了 CXCR4 表示和乳癌转移。染色质 immunoprecipitation 试金证明 PEA3 能与 PEA3 表示向量在房间 transfected 绑在 CXCR4 倡导者。PEA3 siRNA 在 MDA-MB-231 和 MCF-7 房间稀释了 CXCR4 倡导者活动和 PEA3 的绑定到 CXCR4 倡导者。这些结果显示 PEA3 能激活 CXCR4 倡导者抄写并且支持乳癌转移。 | Shengmei Gu Li Chen Qi Hong Tingting Yan Zhigang Zhuang Qiaoqiao Wang Wei Jin Hua Zhu Jiong Wu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，10： | 4 |
| 15 | Knockdown of SLC39A7 inhibits cell growth and induces apoptosis in human colorectal cancer cells显示文摘 | Nengquan Sheng Li Yan Weiqiang You Gewen Tan Jianfeng Gong Hongqi Chen Yi Yang Landian Hu Zhigang Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，10： | 4 |
| 16 | New Evidence of Detrital Zircon Ages for the Final Closure Time of the Paleo-Asian Ocean in the Eastern Central Asian Orogenic Belt(NE China)显示文摘Objective The NE China is located in the eastern segment of the Central Asian Orogenic Belt(CAOB),which is a large accretionary orogen between the Siberian Craton and the North China Craton(NCC).Many researches have discussed about the evolution of the Paleo-Asian Ocean(PAO)in the eastern CAOB.However,the timing of | DU Qingxiang HAN Zuozhen SHEN Xiaoli HAN Chao SONG Zhigang GAO Lihua HAN Mei ZHONG Wenjian YAN Junlei | 2017 | Acta Geologica Sinica(English Edition)2017，91，5： | 4 |
| 17 | Dietary Leucine Requirement for Juvenile Large Yellow Croaker Pseudosciaena crocea (Richardson,1846)显示文摘Dietary leucine requirement for juvenile large yellow croaker, Pseudosciaena crocea Richardson 1846 (initial body weight 6.0 g±0.1 g) was determined using dose-response method.Six isonitogenous (crude protein 43%) and isoenergetic (19 kJ g-1) practical diets containing six levels of leucine (Diets 1-6) ranging from 1.23% to 4.80% (dry matter) were made at about 0.7% increment of leucine.Equal amino acid nitrogen was maintained by replacing leucine with glutamic acid.Triplicate groups of 60 individuals were fed to apparent satiation by hand twice daily (05:00 and 17:30).The water temperature was 26-32℃, salinity 26-30 and dissolved oxygen approximately 7 mg L-1 during the experimental period.Final weight (FW) of large yellow croaker initially increased with increasing level of dietary leucine but then decreased at further higher level of leucine.The highest FW was obtained in fish fed diet with 3.30% Leucine (Diet 4).FW of fish fed the diet with 4.80% Leucine (Diet 6) was significantly lower than those fed Diet 4.However, no significant differences were observed between the other dietary treatments.Feed efficiency (FE) and whole body composition were independent of dietary leucine contents (P>0.05).The results indicated that leucine was essential for growth of juvenile large yellow croaker.On the basis of FW, the optimum dietary leucine requirement for juvenile large yellow croaker was estimated to be 2.92% of dry matter (6.79% of dietary protein). | LI Yan AI Qinghui MAI Kangsen XU Wei CHENG Zhenyan HE Zhigang | 2010 | Journal of Ocean University of China2010，9，4： | 4 |
| 18 | Effects of swirl brake axial arrangement on the leakage performance and rotor stability of labyrinth seals显示文摘Swirl brakes are usually introduced at the seal entrance in industry to improve the seal stability,especially for labyrinth seals suffering low seal clearance and high inlet preswirl ratio.However,how to arrange swirl brakes at the seal entrance to obtain better seal stability retains unknown,such as the axial distance between the brake trailing edge and the first tooth.To this end,the effects of the distance between brakes and the first tooth on the leakage flow rate and seal rotordynamic coefficients were numerically investigated at typical inlet preswirl ratios of 0.45 and0.8,and the predicted results were in comparison with the results for no-brake configuration.The obtained results disclose that the brake configuration arranged against the first tooth produces lower circumferential velocity in the downstream of the brakes as a result of the larger counterclockwise vortex moving from the brake trailing edge to the brake leading edge when compared to the brake configuration away from the first tooth.Besides,the dropped circumferential velocity in the downstream of brakes will cause larger pressure fluctuation in the circumferential direction and thus generates larger tangential force to restrain the rotor forward whirl.On the other hand,the effective damping is further increased when the distance between brakes and the first tooth decreases to zero,that is,the crossover frequency is even disappeared at the inlet preswirl ratio of 0.45 and successfully drops from 69.9 Hz to 32.7 Hz at the preswirl ratio of 0.8. | Yaoxing CHEN Zhigang LI Jun LI Xin YAN | 2021 | Chinese Journal of Aeronautics2021，34，1： | 4 |
| 19 | Four-year dynamic observation and study on standardized management of elderly patients with type 2 diabetes in Beijing Yongding Road Community显示文摘Purpose:This study aimed to understand the joint standard of blood glucose,blood li-pids,and blood pressure in elderly patients>60 years of age with type 2 diabetes in the Beijing Yongding Road Community.Methods:One hundred ninety-two elderly patients>60 years of age who were diagnosed with type 2 diabetes in Yongding Road Community served as the investigation subjects,under-went standard management,and the dynamic changes in blood glucose,blood lipids,and blood pressure were monitored for 48 months.Results:At the end of the observation period,the standard rates of fasting blood glucose and postprandial blood glucose were 72.55%and 80.00%,respectively,which were increased compared with 55.73%and 56.08%at baseline(P<0.01).The standard rate of HbA1c was 59.81%,which was increased compared with 53.44%at baseline(P>0.05).The standard rates of TG and LDL-C were 76.71%and 60.38%,respectively,which were increased compared with 54.69%and 34.74%at base-line,and the standard rate of HDL-C was 13.64%,which was decreased compared with 40.10%at baseline(P<0.01).The standard rate of BP was 58.33%,which was increased compared with 38.54%at baseline(P<0.01).The optimal control rate of blood glucose for 48 months(the standard times of the total measurement times in 48 months≥75%)was higher;the fasting blood glucose was 52.17%,the 2-h postprandial blood glucose was 60.22%,and the HbA1c was 46.45%.The optimal control rate of blood lipids was lower;LDL-C was 17.49%and HDL-C was 13.59%.The optimal control rate of BP was 9.13%.At the end of the observation period,the levels of fasting blood glucose and postprandial blood glucose were decreased by 0.7 mmol/L and 1.48 mmol/L,respectively,compared with the base-line(P<0.01).The level of HbA1c was decreased by 0.18%compared with the baseline(P<0.05).The levels of LDL-C and HDL-C were decreased by 0.4 mmol/L and 0.23 mmol/L,respectively,compared with the baseline(P<0.01).The levels of SBP and DBP were decreased by 4 mmHg compared with the baseline(P<0.01).At the end of the observation period,the joint standard rate of the three indices of HbA1c,LDL-C,and BP was 24.72%,which was increased compared with 6.25%at baseline(P<0.01).Conclusion:Standardized management of elderly patients with diabetes in the Community can improve the joint standard rate of blood glucose,blood lipids,and blood pressure.The op-timal control rate and joint standard rate are the important indices for evaluating the quality of diabetes management. | Yue Li Dongyun Shen Wei Zhang Yimin Wang Hongmei Li Jie Geng Liying Yang Zhijun Xiao Yan Liu Zhigang Feng Linying Cao Yan Jin Lixia Shi | 2014 | Family Medicine and Community Health2014，2，2： | 4 |
| 20 | Peniazaphilones A—I,Produced by Co-culturing of Mangrove Endophytic Fungi,Penicillium sclerotiorum THSH-4 and Penicillium sclerotiorum ZJHJJ-18显示文摘Co-culturing the mangrove endophytic fungus Penicillium sclerotiorum THSH-4 with Penicillium sclerotiorum ZJHJJ-18 in PDB medium resulted in the production of nine new azaphilones derivatives,peniazaphilones A—I(1-9),and six known azaphilones derivatives(10-15).Their structures were elucidated by analysis of detailed spectroscopic data,single-crystal X-ray diffraction,ECD spectra,^(13)C NMR calculation and DP4+analysis.It is noteworthy that compound 1 with an isoquinoline quinone moiety,was isolated from natural source for the first time.Besides,compound 2 is the third reported phenylhydrazone derivative from fungi.In the bioactivity assays,compounds 1,12,14 and 15(IC_(50)=4.71-17.64μmol/L)exhibited potent inhibition of LPS-induced NO release from RAW264.7 without obvious cytotoxicity within 50μmol/L compared to the positive control indomethacin(IC_(50)=35.27μmol/L).Moreover,compounds 1 and 13 displayed moderate to strong cytotoxicity to A549 and MDA-MB-435,with IC_(50) values in the range of 6.84-14.63μmol/L.Together compound 1 showed moderate broad-spectrum antibacterial activity. | Wencong Yang Jie Yuan Qi Tan Yan Chen Yujia Zhu Hongming Jiang Ge Zou Zhenming Zang Bo Wang Zhigang She | 2021 | Chinese Journal of Chemistry2021，39，12： | 3 |
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