|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 2 | 声波激励的超小型纳机电系统磁电天线显示文摘当前的小型天线依赖于电磁波的谐振,因此天线的尺寸与电磁波波长相关。典型的天线尺寸大于波长的1/10,而进一步缩小天线尺寸在近十年来都是一个公开的挑战。介绍一种通过悬浮铁氧/压电薄膜异质结构的声波激励纳机械磁电天线。这种磁电天线通过其在声波谐振频率处的磁电效应接收和发射电磁波。磁电天线中的体声波激发铁磁薄膜的磁化振荡,产生电磁波的辐射;反之,天线感应电磁波的磁场,得到压电电压输出。这种磁电天线(尺寸仅为波长的千分之一)比现有小型天线的尺寸小1到2个数量级,但性能却没有降低,在便携式无线通信系统中具有很大的应用潜力。 | Tianxiang Nan Hwaider Lin Yuan Gao Alexei Matyushov Guoliang Yu Huaihao Chen Neville Sun Shengjun Wei Zhiguang Wang Menghui Li Xinjun Wang Amine Belkessam Rongdi Guo Brian Chen James Zhou Zhenyun Qian Yu Hui Matteo Rinaldi Michael E.McConney BrANDon M.Howe Zhongqiang Hu John G.Jones Gail J.Brown Nian Xiang Sun 张建强(翻译) 陈鼎鼎(审校) | 2017 | 通信对抗2017，36，4： | 8 |
| 3 | A Facile Modifier-free Approach to Fabricate Antistatic Superhydrophobic Composite Coatings with Remarkable Thermal Stability and Corrosion Resistance显示文摘Research on antistatic superhydrophobic surfaces has attracted widespread attention in some fields.However,in the application of superhydrophobic materials,fabricating stable and practical superhydrophobic surfaces through facile and low-cost approaches still faces considerable challenges.Herein,a polyphenylene sulfide(PPS)-based antistatic superhydrophobic composite coating with a high water contact angle(166°)and a low sliding angle(2°)was fabricated on a Q345 steel surface through a simple spray-coating method without any modifier.Furthermore,the as-prepared superhydrophobic coating also displayed excellent superhydrophobicity for water droplets at different pH values,as well as self-cleaning,anti-fouling and anti-icing properties.Importantly,the superhydrophobic coating still exhibited superhydrophobicity after calcination at 350°C for 1 h,indicating its outstanding thermal stability.Excellent antistatic and anticorrosion properties were obtained on the prepared coating surface,which allows the coating to be applied under harsh conditions.Benefiting from the above characteristics,compared with the commercial coating,the as-obtained antistatic superhydrophobic coating may be applied more widely in related fields. | Xiang Liu Dekun Zhang Zhiguang Guo | 2020 | Journal of Bionic Engineering2020，17，3： | 6 |
| 4 | Diagnostic criteria of latent autoimmune diabetes in adults(LADA):a review and reflection显示文摘Diabetes has become a major public health problem in China nowadays.There are almost 97 million diabetic patients nationwide.Latent autoimmune diabetes in adults(LADA)is a subtype of autoimmune diabetes.Although it has been reported for about 20 years,the diagnostic criteria of this disease remain controversial.The discussion mainly focused on serum autoantibodies,period of insulin need and age of diagnosis.Besides,β cell function,metabolic parameters,genetic factors and cell immunity may also contribute to the formulation of the criteria.Here,we aim to review and discuss the diagnostic criteria of latent autoimmune diabetes in adults. | Yu Liao Yufei Xiang Zhiguang Zhou | 2012 | Frontiers of Medicine2012，6，3： | 2 |
| 5 | Frequency, Immunogenetics, and Clinical Characteristics of Latent Autoimmune Diabetes in China (LADA China Study): A Nationwide, Multicenter, Clinic-Based Cross-Sectional Study显示文摘 | Zhou Zhiguang Xiang Yufei Ji Linong Jia Weiping Ning Guang Huang Gan Yang Lin Lin Jian Liu Zhenqi Hagopian William A Leslie R David | 2013 | Diabetes2013，，2： | 1 |
| 6 | Associations of insulin resistance and beta-cell function with abnormal lipid profile in newly diagnosed diabetes显示文摘Background:Abnormal lipids are strong predictors of cardiovascular disease in type 1 diabetes mellitus(T1DM)and type 2 diabetes mellitus(T2DM).However,the potential associations of insulin resistance(IR)and beta-cell function(BCF)with abnormal lipids in newly diagnosed T1DM or T2DM patients are not fully understood.Methods:A cross-sectional survey of 15,928 participants was conducted.Homeostasis model assessment and postprandial C-peptide levels were used to estimate IR and BCF.A restricted cubic spline(RCS)nested in binary logistic regression was used to examine the associations of IR and BCF with abnormal lipids.Results:High triglyceride(TG),low high-density lipoprotein cholesterol,and high low-density lipoprotein cholesterol(LDL-C)accounted for 49.7%,47.8%,and 59.2%of the participants,respectively.In multivariable analysis,high IR was associated with an increased risk of high TGs(P for trend<0.001)in T1DM and is associated with an elevated risk of high TG and low HDL-C(all P for trend<0.01)in T2DM.Low BCF was not associated with risks of dyslipidemia in patients with T1DM or T2DM after adjustment for potential confounders.Conclusion:High IR had different associations with the risk of dyslipidemia in newly diagnosed T1DM and T2DM patients,suggesting that early treatment that improves IR may benefit abnormal lipid metabolism. | Xiaohan Tang Xiang Yan Houde Zhou Gan Huang Xiaohong Niu Hongwei Jiang Heng Su Xilin Yang Xia Li Zhiguang Zhou | 2022 | Chinese Medical Journal2022，135，21： | 1 |
| 7 | Tribological performance of ionic liquid-lubricated carbon brush/collector ring current-carrying friction system显示文摘The lubricity and anti-wear ability of ionic liquids(ILs)were studied by a current-carrying friction test on IL-lubricated carbon brushes.The results indicated that the conductivity and wear resistance of different ILs are different,and may vary for different carbon brushes.The E468e carbon brush was found to be more sensitive to IL lubrication than D172 carbon brush.Importantly,an analysis of the wear surfaces of the D172 and E468e carbon brushes revealed that,due to the different materials of the two carbon brushes and the composition of the IL,the lubrication effect on the carbon brushes was different.The viscosity of the IL will affect its wettability on the carbon brush surface.The better the wettability,the easier the movement of ions on the surface,which makes it easier to form a conductive physical adsorption film.Therefore,in practice,a better IL must be selected by considering the wettability of IL and carbon brushes. | Yang Fu Hongling Qin Xiang Xu Xiaolong Zhang Zhiguang Guo | 2020 | Biosurface and Biotribology2020，6，4： | 1 |
| 8 | Analysis on the Characteristics of the Kalpin Ms5.3 Earthquake Sequence of December 1,2013 and Anomalies before the Earthquake显示文摘This paper introduces the basic parameters,focal mechanism solutions and earthquake sequence characteristics of the Kalpin M_S5.3 earthquake sequence of December 1,2013,and analyzed seismic activity before the earthquake,the adjacent tectonic features and the precursory anomaly at fixed points within a range of 200 km. Research indicates:(1) The earthquake occurred on Kalpin fault,the source rupture type is thrust faulting with sinistral strike-slip component.( 2) The earthquake sequence is mainshock-aftershock type,with the aftershock distribution attenuating quickly and trending NE.(3) Abnormal seismic activity before the earthquake was characterized by seismically nesting quiescence of MS2. 0-4. 0 earthquakes,seismic quiescence of MS4. 0 earthquakes and seismic belts of MS3. 0 earthquakes in the Kalpin block, abnormal enhancement zone of moderate earthquakes on Puchang fault and seismological parameters.(4) Anomalies of precursory observation data at fixed stations are mainly characterized by mutation. Apart from the borehole tiltmeter in Halajun, the spatial distribution of other abnormal precursors showed a phenomenon of migration from the near field to far field and from the epicenter to the peripheries. | Liu Jiaruning Wang Qiong Nie Xiaohong Gao Ge Zhang Linlin Zhang Zhiguang Xiang Yang | 2017 | Earthquake Research in China2017，31，3： | 0 |
| 9 | Characteristics of gut microbiota in representative mice strains:Implications for biological research显示文摘Background:Experimental animals are used to study physiological phenomena,pathological mechanisms,and disease prevention.The gut microbiome is known as a potential confounding factor for inconsistent data from preclinical studies.Although many gut microbiome studies have been conducted in recent decades,few have focused on gut microbiota fluctuation among representative mouse strains.Methods:A range of frequently used mouse strains were selected from 34 isolation packages representing disease-related animal(DRA),immunity defect animal(IDA),or gene-editing animal(GEA)from the BALB/c and C57BL/6J backgrounds together with normal mice,and their microbial genomic DNA were isolated from mouse feces to sequence for the exploration of gut microbiota.Results:Mouse background strain,classification,introduced source,introduced year,and reproduction type significantly affected the gut microbiota structure(p<0.001 for all parameters),with background strain contributing the greatest influence(R^(2)=0.237).In normal groups,distinct gut microbiota types existed in different mouse strains.Sixty-four core operational taxonomic units were obtained from normal mice,and 12 belonged to Lactobacillus.Interestingly,the gut microbiota in C57BL/6J was more stable than that in BALB/c mice.Furthermore,the gut microbiota in the IDA,GEA,and DRA groups significantly differed from that in normal groups(p<0.001 for all).Compared with the normal group,there was a significantly higher Chao 1 and Shannon index(p<0.001 for all)in the IDA,GEA,and DRA groups.Markedly changed classes occurred with Firmicutes and Bacteroidetes.The abundances of Helicobacter,Blautia,Enterobacter,Bacillus,Clostridioides,Paenibacillus,and Clostridiales all significantly decreased in the IDA,GEA,and DRA groups,whereas those of Saccharimonas,Rikenella,and Odoribacter all significantly increased. | Jianguo Guo Chenchen Song Yunbo Liu Xuying Wu Wei Dong Hua Zhu Zhiguang Xiang Chuan Qin | 2022 | Animal Models and Experimental Medicine2022，5，4： | 0 |
| 10 | Prospective research on the efficacy and safety of oxcarbazepine as monotherapy and add-on therapy for partial epilepsy显示文摘The purpose of our research was to evaluate the efficacy,tolerance,and safety of oxcarbazepine(OXC)as monotherapy and add-on therapy for partial epilepsy.We carried out a prospective clinical follow-up trial at the Epilepsy Center of Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology.Sixty-seven patients with partial epilepsy received OXC therapy.The patients were randomly divided into a monotherapy group and an add-on therapy group.We observed the efficacy and safety in thefirst three months and the following three months respectively,and compared them with each other.There was a significant difference in the decrease of seizure frequency between the two groups(P=0.002).There was a significant difference in the percentage of seizure-free between the monotherapy and the add-on therapy groups in thefirst three months(P=0.02),and there were also statistical differences in the 50%response rate(P=0.017)and the percentage of seizure-free in the following three months(P=0.019).No difference was found in the 50%response rate,the 75%response rate,and the percentage of seizure-free between thefirst three months and the following three months in the whole group and the two subgroups(P>0.05).The incidence rate of side effects due to the therapy was 19.40%(13 of 67).The side effects were mainly found in thefirst three months.It is concluded that OXC is thefirst-line anti-epileptic drug(AED)for partial seizures,and could be used as the monotherapy and add-on therapy for newly diagnosed patients and patients that failed to tolerate or benefit from other AEDs. | Huicong KANG Xiaoyan LIU Hu QI Feng XU Xiang LI Yuan WANG Zhiguang LIU Suiqiang ZHU | 2009 | Frontiers of Medicine2009，3，2： | 0 |
| 11 | Combination therapy with saxagliptin and vitamin D for the preservation ofβ-cell function in adult-onset type 1 diabetes:a multi-center,randomized,controlled trial显示文摘Disease modifying therapies aiming to preserveβ-cell function in patients with adult-onset autoimmune type 1 diabetes are lacking.Here,we conducted a multi-centre,randomized,controlled trial to assess theβ-cell preservation effects of saxagliptin alone and saxagliptin combined with vitamin D as adjunctive therapies in adult-onset autoimmune type 1 diabetes.In this 3-arm trial,301 participants were randomly assigned to a 24-month course of the conventional therapy(metformin with or without insulin)or adjunctive saxagliptin or adjunctive saxagliptin plus vitamin D to the conventional therapy.The primary endpoint was the change from baseline to 24 months in the fasting C-peptide.The secondary endpoints included the area under the concentration-time curve(AUC)for C-peptide level in a 2-h mixed-meal tolerance test,glycemic control,total daily insulin use and safety,respectively.The primary endpoint was not achieved in saxagliptin plus vitamin D group(P=0.18)and saxagliptin group(P=0.26).However,compared with the conventional therapy,2-h C-peptide AUC from 24 months to baseline decreased less with saxagliptin plus vitamin D(-276 pmol/L vs.-419 pmol/L;P=0.01),and not to the same degree with saxagliptin alone(-314 pmol/L;P=0.14).Notably,for participants with higher glutamic acid decarboxylase antibody(GADA)levels,the decline ofβ-cell function was much lower in saxagliptin plus vitamin D group than in the conventional therapy group(P=0.001).Insulin dose was significantly reduced in both active treatment groups than in the conventional therapy group despite all groups having similar glycemic control.In conclusion,the combination of saxagliptin and vitamin D preserves pancreaticβ-cell function in adult-onset autoimmune type 1 diabetes,an effect especially efficacious in individuals with higher GADA levels.Our results provide evidence for a novel adjunct to insulin and metformin as potential initial treatment for adult-onset type 1 diabetes.(ClinicalTrials.gov identifier:NCT02407899). | Xiang Yan Xia Li Bingwen Liu Jiaqi Huang Yufei Xiang Yuhang Hu Xiaohan Tang Ziwei Zhang Gan Huang Zhiguo Xie Houde Zhou Zhenqi Liu Xiangbing Wang Richard David Leslie Zhiguang Zhou | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 0 |
| 12 | Mutation spectrum in GNAQ and GNA11 in Chinese uveal melanoma显示文摘Uveal melanoma is the most common intraocular cancer in the adult eye.R183 and Q209 were found to be mutational hotspots in exon 4 and exon 5 of GNAQ and GNA11 in Caucasians.However,only a few studies have reported somaticmutations in GNAQ or GNA11 in uveal melanoma in Chinese.We extracted somatic DNA from paraffin-embedded biopsies of 63 Chinese uveal melanoma samples and sequenced the entire coding regions of exons 4 and 5 in GNAQ and GNA11.The results showed that 33%of Chinese uveal melanoma samples carried Q209 mutations while none had R183 mutation in GNAQ or GNA11.In addition,seven novel missense somatic mutations in GNAQ(Y192C,F194L,P170S,D236N,L232F,V230A,and M227I)and four novel missense somatic mutations in GNA11(R166C,I200T,S225F,and V206M)were found in our study.The high mutation frequency of Q209 and the novel missense mutations detected in this study suggest that GNAQ and GNA11 are common targets for somatic mutations in Chinese uveal melanoma. | Edward D.Zhang Meixia Zhang Gen Li Charlotte L.Zhang Zhihuan Li Guangxi Zang Zhiguang Su Ming Zhang Daoman Xiang Ling Zhao Jie Zhu | 2019 | Precision Clinical Medicine2019，2，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员