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| 1 | Chemical composition of PM_(2.5) during winter in Tianjin,China显示文摘PM2.5 samples for 24 h were collected during winter in Tianjin,China. The ambient mass concentration and chemical composition of the PM2.5 were determined. Ionic species were analyzed by ion chromatog-raphy,while carbonaceous species were determined with the IMPROVE thermal optical reectance(TOR) method,and inorganic elements were measured by inductively coupled plasma-atomic emission spec-trometer. The daily PM2.5 mass concentrations ranged from 48.2 to 319.2 g/m3 with an arithmetic average of 144.6 g/m3. The elevated PM2.5 in winter was mostly attributed to combustion sources such as vehicle exhaust,heating,cooking and industrial emissions,low wind speeds and high relative humidity(RH) ,which were favorable for pollutant accumulation and formation of secondary pollutants. By chem-ical mass balance,it was estimated that about 89.1% of the PM2.5 mass concentrations were explained by carbonaceous species,secondary particles,crustal matters,sea salt and trace elements. Organic material was the largest contributor,accounting for about 32.7% of the total PM2.5 mass concentrations. SO42-,NO3-,Cl- and NH4+ were four major ions,accounting for 16.6%,11.5%,4.7% and 6.0%,respectively,of the total mass of PM2.5. | Jinxia Gu Zhipeng Bai Weifang Li Liping Wu Aixia Liu Haiyan Dong Yiyang Xie | 2011 | Particuology2011，9，3： | 60 |
| 2 | Mode-locked 2.8-μm fluoride fiber laser:from soliton to breathing pulse显示文摘The mode-locked fluoride fiber laser(MLFFL)is an exciting platform for directly generating ultrashort pulses in the mid-infrared(mid-IR).However,owing to difficulty in managing the dispersion in fluoride fiber lasers,MLFFLs are restricted to the soliton regime,hindering pulse-energy scaling.We overcame the problem of dispersion management by utilizing the huge normal dispersion generated near the absorption edge of an infrared-bandgap semiconductor and promoted MLFFL from soliton to breathing-pulse mode-locking.In the breathing-pulse regime,the accumulated nonlinear phase shift can be significantly reduced in the cavity,and the pulse-energy-limitation effect is mitigated.The breathing-pulse MLFFL directly produced a pulse energy of 9.3 nJ and pulse duration of 215 fs,with a record peak power of 43.3 kW at 2.8μm.Our work paves the way for the pulse-energy and peak-power scaling of mid-IR fluoride fiber lasers,enabling a wide range of applications. | Zhipeng Qin Guoqiang Xie Hongan Gu Ting Hai Peng Yuan Jingui Ma Liejia Qian | 2019 | Advanced Photonics2019，1，6： | 9 |
| 3 | Structural and Functional Tailoring of Melanin-Like Polydopamine Radical Scavengers显示文摘Melanin is a ubiquitous but poorly understood polymeric,dark brown to black pigment biomaterial found both in nature and by organic synthesis.Its structural heterogeneity and disordered covalent/noncovalent interactions make it a grand challenge to tune and improve the physical and biological properties of both melanin sources.Herein,we report a facile one-pot fabrication approach for synthetic melanins with controlled size and composition via copolymerization of dopamine and basic amino acid such as arginine in an aqueous solution.The resulting arginine-doped polydopamine melanin-like nanoparticles possess less ordered nonplanar microstructures within the particles,whereas the conventional polydopamine-based melanins contain a variety of compactπ-stacked microstructures.The assembly of these distinct polymeric microstructures could lead the preceding ones for greater accessibility to free radicals,with resultant stronger free-radical scavenging effect,and thus,exhibit superior antioxidant performance toward cellular oxidative stress.This work has inspired us to continue to fabricate new synthetic melanin pigments with tunable and improved functions by rational structural tailoring. | Peng Yang Zhipeng Gu Fang Zhu Yiwen Li | 2020 | CCS Chemistry2020，2，2： | 4 |
| 4 | Ultrasmall Nanoparticle ROS Scavengers Based on Polyhedral Oligomeric Silsesquioxanes显示文摘Although tremendous efforts have been devoted to the structural and functional tailoring of natural polyphenol-functionalized nan oparticles,preparing ultrasmall sized(<6 nm)particles with precisely-defined structures has remained a grand challenge.In this work,we reported the preparation of ultra-small and precisely structured polyhedral oligomeric silsesquioxanes(POSS)-based polyphenol nanopartides(T8^-,T10^-,and T12^-GAPOSS)by accurately functionalizing the POSS surface with plant polyphenol gallic acid units via thiol-Michael'click'reactions.Those polyphenol nanoparticles exhibited strong free radical scavenging capacity,good biocompatibility and ability to resist cell oxidative damage,which dem on strated great potentials in inhibiting oxidative stress in duced pathologies. | Zhan Li Haotian Li Jianhua Zhang Xianhu Liu Zhipeng Gu Yiwen Li | 2020 | Chinese Journal of Polymer Science2020，38，11： | 2 |
| 5 | Non-covalent glycosylated gold nanoparticles/peptides nanovaccine as potential cancer vaccines显示文摘Herein,we firstly developed a non-covalent glycosylated gold nanoparticles/peptides nanovaccine which is assembled byβ-cyclodextrin(β-CD)based host-guest recognitions.This nanovaccine can generate significant titers of antibodies and improve the therapeutic effect against melanoma,suggesting the immunogenicity of peptide antigens can be improved by loading with this carrier.The novel vaccine carrier provides a platform for the transport of various antigens especially T cell-independent antigens. | Liming Zeng Zonglang Liao Wenwei Li Qijuan Yuan Peng Wu Zhipeng Gu Zhongqiu Liu Guochao Liao | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
| 6 | Generation of selectable marker-free transgenic rice resistant to chewing insects using two co-transformation systems显示文摘生产可选没有标记(SMF ) 对咀嚼昆虫抵抗的转基因的米饭,杆菌 thuringiensis cryIA (c) 基因(Bt ) 被使用二个调停 Agrobacterium 的合作转变系统介绍进二个精英装饰用的梨树米饭变化。一个系统与在一 Agrobacterium 紧张的单个微型双胞胎 T-DNA 二进制向量,它由二个分开的 T-DNA 区域组成,当其它包含可选的标记基因时,带 Bt 的, hygromycin 抵抗基因(HPT ) 。另外的系统在二种分开的 Agrobacterium 文化使用二分开的二进制向量,包含单个原生质标志上的 Bt 或 HPT 基因。怀有 Bt 和可选的标记基因的很多独立转基因的米饭线被获得。结果证明 Bt 基因和 HPT 基因的合作转变频率由由二个分开的二进制向量系统(4.52%) 比那使用微型双胞胎 T-DNA 向量系统(29.87%) 是高得多的。然而,从 co 转基因的植物(21.74%) 的后代获得的 SMF 转基因的米饭植物的频率为后者比那为微型双胞胎 T-DNA 向量系统是更低的(50 – 60%) 。ELISA 的数据暗示表示 Bt 蛋白质作为 0.025 – 被测定; 0.103% 总数长叶在转基因的植物的可溶的蛋白质。因此,没有可选的标记基因,转基因的米饭衬里的几精英被选择。在 vitro 并且在 vivo 昆虫生物鉴定的从两个的结果显示 SMF 转基因的米饭被显示对有斑纹的茎 borer 和米饭叶文件夹高度抵抗。而且处于没有使用的任何杀虫药剂的一个自然的地条件,所有转基因的大米植物被发现到别被大米叶文件夹伤害,而野类型严重被损害。 | Hengxiu Yu Quanhong Yao Ling Wang Zhipeng Zhao Zhiyun Gong Shuzhu Tang Qiaoquan Liu Minghong Gu | 2009 | Progress in Natural Science:Materials International2009，19，11： | 2 |
| 7 | Modification of collagen with a natural derived cross-linker, alginate dialdehyde显示文摘 | Yang Hu Lan Liu Zhipeng Gu Weihua Dan Nianhua Dan Xixun Yu | 2014 | Carbohydrate Polymers2014，，： | 1 |
| 8 | Modification ofconagen with a natural de- rived cross-linker, alginat~ dialdchyde 显示文摘 | Yang Hu Lan Liu Zhipeng Gu | 2014 | Carbohydr Polym2014，，102： | 1 |
| 9 | Whole wheat flour coating with antioxidant property accelerates tissue remodeling for enhanced wound healing显示文摘As a daily food for billions of people for thousands of years,whole grain is rich in phenolic compounds and may have huge potentials to provide natural antioxidants.Herein,owing to the significant biomedical potential,the effect of whole wheat flour solution as antioxidant wound coating for enhanced wound healing has been studied.The results show that the low concentration of whole wheat flour solutions have good biocompatibility and can scavenge radical and intracellular ROS in vitro,accelerating tissue remodeling in vivo to promote wound healing.This kind of whole wheat flour solution has great potential application for cutaneous wound repair. | Caihong Xian Zhipeng Gu Guiting Liu Jun Wu | 2020 | Chinese Chemical Letters2020，31，6： | 1 |
| 10 | Preparation of chitosan/silk fibroin blending membrane fixed with alginate dialdehyde for wound dressing 显示文摘 | GU Zhipeng XIE Huixu HAUNG Chengcheng | 2013 | International Journal of Biological Macromolecules2013，58，： | 1 |
| 11 | Superabsorbent poly(acrylic acid) and antioxidant poly(ester amide) hybrid hydrogel for enhanced wound healing显示文摘Wound healing dressing is increasingly needed in clinical owing to the large quantity of skin damage annually.Excessive reactive oxygen species(ROS)produced through internal or external environmental influences can lead to lipid peroxidation,protein denaturation,and even DNA damage,and ultimately have harmful effects on cells.Aiming to sufficiently contact with the wound microenvironment and scavenge ROS,superabsorbent poly(acrylic acid)and antioxidant poly(ester amide)(PAA/PEA)hybrid hydrogel has been developed to enhance wound healing.The physical and chemical properties of hybrid hydrogels were studied by Fourier-transform infrared(FTIR)absorption spectrum,compression,swelling,degradation,etc.Besides,the antioxidant properties of hybrid hydrogels can be investigated through the free radical scavenging experiment,and corresponding antioxidant indicators have been tested at the cellular level.Hybrid hydrogel scaffolds supported the proliferation of human umbilical vein endothelial cells and fibroblasts,as well as accelerated angiogenesis and skin regeneration in wounds.The healing properties of wounds in vivo were further assessed on mouse skin wounds.Results showed that PAA/PEA hybrid hydrogel scaffolds significantly accelerated the wound healing process through enhancing granulation formation and re-epithelialization.In summary,these superabsorbent and antioxidative hybrid hydrogels could be served as an excellent wound dressing for full-thickness wound healing. | Jianhua Zhang Junfei Hu Baoshu Chen Tianbao Zhao Zhipeng Gu | 2021 | Regenerative Biomaterials2021，8，2： | 1 |
| 12 | Manipulating the antioxidative capacity of melanin-like nanoparticles by involving condensation polymerization显示文摘Melanin is ubiquitous in nature and plays important roles in physiological activities especially in keeping the oxidative balance.Both natural and synthetic melanin were synthesized via the free radical polymerization of 5,6-dihydroxyindole(DHI)monomer,which may lead to the inherent compactπ-conjugation stacking microstructures and finally results in limited antioxidative capacities.To address this issue,we have strived to involve condensation polymerization during the melanin synthetic process,aiming to disrupt the compact stacking microstructures and improve the total antioxidative performance.The resulting melaninlike nanoparticles(NPs)indeed possessed less compact stackingπ-conjugation structures and decreased density,which further demonstrated enhanced antioxidative abilities compared with conventional melanin-like polymers such as poly-5,6-dihydroxyindole(Poly-DHI)and polydopamine(PDA).Their excellent free radical scavenging capability was further confirmed by the intracellular cell protection effects against reactive oxygen species(ROS)as well as in vivo therapy for acute diseases including acute kidney injury and acute liver injury.This work would promote future work toward new types of melanin-inspired nanomaterials with tunable and improved functions beyond nature. | Peng Yang Tianyou Wang Jianhua Zhang Hengjie Zhang Wanjie Bai Gaigai Duan Wei Zhang Jinrong Wu Zhipeng Gu Yiwen Li | 2023 | Science China Chemistry2023，66，5： | 1 |
| 13 | A Bioinspired Strategy Toward UV Absorption Enhancement of Melaninlike Polymers for Sun Protection显示文摘Due to the complexity of the structure within melanin and synthetic polymers(i.e.,polydopamine,PDA),it is a challenge to regulate the ultraviolet(UV)absorption.In nature,melanocytes can biosynthesize more pheomelanins than eumelanins via protein and gene overexpression for photoprotection when the UV irradiation is enhanced.During this biosynthetic pathway,L-cystine,transported by xCT gene,can be involved to form a new monomer structure incorporating a benzothiazole group,finally resulting in the formation of UV absorption-enhanced pheomelanin.Inspired by this,we have proposed a facile strategy to regulate the UV absorption of PDA by introducing the benzimidazole(BI)unit through the thiol-Michael addition reaction during the polymerization process.It was further found that the introduction of BI units not only significantly increased the content of chromophores and auxochromes,but also effectively restricted the red-shift of the absorption spectrum via interrupting the conjugated microstructure within PDA,both of which contribute to UV absorption enhancement.These UV absorption-enhanced PDA nanoparticles could be used to fabricate bio-inspired sunscreens for efficient sun protection.This work will provide a facile strategy to regulate UV absorption of melanin-like materials and open new horizons for the design and construction of bioinspired sunscreens. | Zhen Yang Jianhua Zhang Huijie Liu Junfei Hu Xianheng Wang Wanjie Bai Wei Zhang Ye Yang Zhipeng Gu Yiwen Li | 2023 | CCS Chemistry2023，5，10： | 1 |
| 14 | Tofu as excellent scaffolds for potential bone regeneration显示文摘Biomimetic scaffolds present the promising potential for bone regeneration.As a natural gel-like traditional food,tofu with porous architecture and proved biological safety indicated a good potential to be a natural scaffold and easy to be improved by surface modification.Hereon,we fabricated the tofubased scaffolds and systematically explored the potential for bone tissue engineering.In addition,the collagen has been introduced by simple coating to further enha nce the surface compatibility of the tofubased scaffold in bone regeneration.The results showed that the tofu-based scaffolds possessed good porous structure and cytocompatibility.Notably,the tofu-based scaffolds could improve the expression of osteogenesis-related genes and proteins,leading to better bone regeneration after 2 months of implantation.All the results indicated that to fu would become an outstanding sustainable natural porous scaffold for bone regeneration with excellent bioactivities. | Keqing Huang Guiting Liu Zhipeng Gu Jun Wu | 2020 | Chinese Chemical Letters2020，31，12： | 1 |
| 15 | Thermosensitive phase behavior and drug release of in situ N-isopropylacrylamide copolymer显示文摘 | Saibo Chen Hui Zhong Bin Gu Yinzhu Wang Xiaomo Li Zhipeng Cheng Lili Zhang Cheng Yao | 2012 | Materials Science & Engineering C2012，，8： | 1 |
| 16 | Modification of collagen with a naturalderived cross - linker, alginate dialdehyde 显示文摘 | Hu Yang Liu Lan Gu Zhipeng | 2014 | Carbohydrate Polymers2014，102，0： | 1 |
| 17 | Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis显示文摘Dear Editor,Angiogenesis is vital for the development and maintenance of functional organs,and also participates in diverse pathological processes,such as wound healing,oxygen tension,and tumorigenesis(Potente et al.,2011).Thus,understanding the molecular mechanisms responsible for angiogenesis has important clinical implications and may guide strategies for drug development. | Mingyue Ma Zhenxing Zhong Yuwen Zhu Yuan Gu Ruxin Jin Zhipeng Meng Yu Wang Fa-Xing Yu | 2023 | Protein & Cell2023，14，2： | 0 |
| 18 | Carrier-Free Deferoxamine Nanoparticles against Iron Overload in Brain显示文摘Although considerable progress has been achieved in treating iron-overload diseases with deferoxamine(DFO)-based biomaterials,high DFO loading and multifunctional integration in one system are still grand challenges.Herein,a series of carrier-free,high DFO-loading(∼80%),uniform spherical nanoparticles(NPs)assisted by polyphenols have been facilely developed with both efficient iron and reactive oxygen species-scavenging properties.Interestingly,those DFO-based NPs have demonstrated excellent scavenging performance in iron-overloaded cell model and energetically exhibited brain cell protection in vivo in intracerebral hemorrhage animal models.This study could provide a promising strategy to significantly improve the curative effect of DFO delivery systems for iron-overload diseases. | Fang Zhu Jian Zhong Junfei Hu Peng Yang Jianhua Zhang Minghua Zhang Yiwen Li Zhipeng Gu | 2023 | CCS Chemistry2023，5，1： | 0 |
| 19 | The long non-coding RNA DANA2 positively regulates drought tolerance by recruitingERF84 to promote JMJ29-mediated histone demethylation显示文摘Tens of thousands of long non-coding RNAs have been uncovered in plants,but few of them have been comprehensively studied for their biological function and molecular mechanism of their mode of action.Here,we show that the Arabidopsis long non-coding RNA DANA2 interacts with an AP2/ERF transcription factor ERF84 in the cell nucleus and then affects the transcription of JMJ29 that encodes a Jumonji C domain-containing histone H3K9 demethylase.Both RNA sequencing(RNA-seq)and genetic analyses demonstrate that DANA2 positively regulates drought stress responses through JMJ29.JMJ29 positively regulates the expression of ERF15 and GOLS2 by modulation of H3K9me2 demethylation.Accordingly,mutation of JMJ29 causes decreased ERF15 and GOLS2 expression,resulting in impaired drought tolerance,in agreement with drought-sensitive phenotypes of dana2 and erf84 mutants.Taken together,these results demonstrate that DANA2 is a positive regulator of drought response and works jointly with the transcriptional activator ERF84 to modulate JMJ29 expression in plant response to drought. | Pengxiang Zhang Reqing He Jun Yang Jingjing Cai Zhipeng Qu Rongxin Yang Jinbao Gu Zhen-Yu Wang David LAdelson Youlin Zhu Xiaofeng Cao Dong Wang | 2023 | Molecular Plant2023，16，8： | 0 |
| 20 | Propolis inspired sunscreens for efficient UV-protection and skin barrier maintenance显示文摘The direct use of naturally occurring,small molecular ingredients in bioinspired sunscreens has raised several concerns due to the instability,photocytotoxicity,and potential blood toxicity of those ingredients.In this work,we have employed natural ultraviolet(UV)-blocking molecule caffeic acid phenethyl ester(CAPE)from propolis to prepare poly(CAPE)nanoparticles(NPs)as the main bioactive ingredient to fabricate propolis-inspired hydrogel sunscreens.Compared with small molecular CAPE,poly(CAPE)NPs exhibited better dispersion and stability in water,as well as lower physiological toxicity and skin permeability.And the resulting composite hydrogels demonstrated promising properties including water-resistant whereas can be easily erased by warm water as well as safety when interacting with skin.More importantly,the hydrogel sunscreens showed excellent UV protection properties both in vitro and in vivo,and the positive effects in maintaining skin barrier functions.This work provides new strategies towards the facile construction of nature-inspired robust sunscreens in the future. | Yu Fu Ruoyu Wan Lei Yang Lidan Xiong Junfei Hu Jie Tang Hailun He Zhipeng Gu Li Li Yiwen Li | 2022 | Nano Research2022，15，9： | 0 |
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