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| 1 | Water-Saving and High-Yielding Irrigation for Lowland Rice by Controlling Limiting Values of Soil Water Potential显示文摘现在的学习调查了一个灌溉系统是否能被建立节省水和增加谷物产量在灌溉低地大米(Oryza sativa L.) 在领域水平由合适的用水管理提高水生产率。用二地成年的米饭栽培变种,二个灌溉系统;常规灌溉和节省水的灌溉,被进行。在节省水的灌溉系统,限制与特定的生长阶段有关的土壤水潜力的价值作为灌溉索引被建议。与排水在在哪儿的常规灌溉相比在另外的时间,增加的谷物在 7.4% ~ 11.3% 产出的节省水的灌溉,在 24.5% ~ 29.2% 的减少的灌溉用水,和增加的水生产率中间季节、充满(谷物每灌溉用水的立方的米让步) 在 43.1% ~ 50.3% 。节省水的灌溉显著地增加了产量指数,改进 milling 和外观质量,在根流血提高了玉米素 + 玉米素核糖甙集中并且提高了在谷物的蔗糖 synthase,腺苷 diphosphateglucose pyrophosphorylase,淀粉 synthase 和淀粉分叉酶的活动。我们的结果由控制限制根和谷物,还原剂水输入,和增加谷物的生理的活动产出的与阶段能提高的特定的生长有关的土壤水潜力的价值显示那节省水的灌溉。 | Jianchang Yang Kai Liu Zhiqin Wang Yong Du Jianhua Zhang | 2007 | Journal of Integrative Plant Biology2007，49，10： | 46 |
| 2 | High- and Ultrahigh-pressure Metamorphism and Retrogressive Textures of Gneiss in the Donghai Area——Evidence from gneisses in drillhole ZK2304显示文摘In the gneisses from the drillhole ZK2304 of the Donghai area, there have been preserved high- and ultrahigh-pressure metamorphic mineral assemblages, a series of complicated retrogressive textures and relevant metamorphic reactions. In addition to garnet, jadeititic-clinopyroxene and rutile, other peak stage (M2) minerals in some gneisses include phengite, aragonite and coesite or quartz pseudomorphs after coesite. The typical peak-stage mineral assemblages in gneisses are characterized by garnet + jadeitic-clinopyroxene + rutile + coesite, garnet + jadeitic-clinopyroxene + phengite + rutile ± coesite and garnet + jadeitic-clinopyroxene + aragonite + rutile ± coesite. The grossular content (Gro) in garnet is high and may reach 50. 1 mol%. The SiO2 content of phengite ranges from 54.37% to 54.84% with 3.54-3.57 p.f.u. Quartz pseudomorphs after coesite occur as inclusions in garnet.The gneisses of the Donghai area have been subjected to multistage recrystallization and exhibit a closewise P-T | LIU Fulai, XU Zhiqin, XU Huifen and YANG Jingsui Institute of Geology, CAGS, 26 Baiwanzhuang Rd., Beijing 100037 Zhu Xiling | 1999 | Acta Geologica Sinica(English Edition)1999，73，3： | 12 |
| 3 | Mineral inclusions of zircon and UHP metamorphic evidence from paragneiss and orthogneiss of pre-pilot drill-hole CCSD-PP2 in north Jiangsu Province,China显示文摘Coesite inclusions, together with omphacite, jadeite, garnet and phengite inclusions, were identified in zircons separates from almost all gneissic core samples of pre-pilot drillhole CCSD-PP2 by the Laser Raman spectros-copy and the cathodoluminescence method. These data indicate that gneissic rocks consisting of paragneisses and or-thogneisses ubiquitously experienced UHP metamorphism. This research may be of great significance for an in-depth study of the subduction-exhumation mechanism of the Sulu UHP metamorphic belt and selecting the drilling site for the Chinese Continental Scientific Drilling Project. | LIU Fulai XU Zhiqin YANG Jingsui S Maruyama J.G.Liou I.Katayama H.Masago | 2001 | Chinese Science Bulletin2001，46，12： | 12 |
| 4 | Crustal Structure of the Indus-Tsangpo Suture Zone and its Ophiolites, Southern Tibet显示文摘The>2000-km-long Indus-Tsangpo suture zone(ITSZ)in southern Tibet marks the boundary between the India and Eurasia plates and contains the remnants of the Neotethyan oceanic lithosphere,ophiolitic mélanges,flysch units and continental rocks.Field-based structural analyses and drill core observations from the | XU Zhiqin DILEK Yildrim YANG Jingsui LIANG Fenghua LIU Fei BA Dengzhu CAI Zhihui LI Guangweia DONG Hanwen | 2015 | Acta Geologica Sinica(English Edition)2015，89，A02： | 10 |
| 5 | Geochronology, Geochemistry and Tectonic Significance of the Early Carboniferous Gabbro and Diorite Plutons in West Ujimqin, Inner Mongolia显示文摘Early Carboniferous gabbros and diorites are distributed in West Ujimqin, Inner Mongolia. The LA-ICP-MS zircon U-Pb ages of the gabbro and diorite samples are 321± 2 Ma(MSWD=0.65) and 319.4± 1.5 Ma(MSWD=0.42), respectively. In addition, new geochemistry data from three gabbro and three diorite samples are presented. All six samples show high Al_2O_3 contents but low-TiO_2 contents, belonging to tholeiitic and calc-alkali basalt series. All of the samples have similar chondrite normalized REE patterns characterized by moderate depletion in LREE similar to normal middle oceanic ridge basalt(MORB). The MORB and PM-normalized trace element patterns show the enrichment in large ion lithophile elements(LILE, e.g., Rb, Ba and Sr), depletion in high field strength elements(HFSE) and distinctly negative Nb and Ta anomalies similar to volcanic arc basalt. Furthermore, as shown in the correlation plots of La/Ba vs. La/Nb, Ba/La vs. Ce/Pb, Th/La vs. Ce/Pb, Nb/La vs. Ba/Rb, and Nb/Y vs. La/Yb, the magma source has underwent contamination and metasomatism from the subduction fluid. According to the Zr/Nb, La/Nb, and La/Ta ratios and the Nb/Y vs. Zr/Y and Sm/Yb vs. La/Sm diagrams, the magma was derived from shallow depleted lithospheric mantle and formed by moderate(5%~20%) partial melting of spinel lherzolites. Tectonic setting discrimination diagrams reveal that the gabbros and diorites display both characteristics of MORB and volcanic arc basalt, which is consistent with their geochemical characteristics. On the basis of the geochemical features of these samples, combined with regional geological data and many previous researches in the study area, the Early Carboniferous gabbros and diorites of West Ujimqin are suggested to be formed in an intensely extensional rift setting, and a limited immature ocean basin probably formed after subsequent development. | Shiwei Ma Changfeng Liu Zhiqin Xu Zhiguang Zhou Jinyuan Dong Hongying Li | 2017 | Journal of Earth Science2017，28，2： | 10 |
| 6 | Brassinosteroids function in spikelet differentiation and degeneration in rice显示文摘Brassinosteroids(BRs) play crucial roles in many aspects of plant development. However, their function in spikelet differentiation and degeneration in rice(Oryza sativa L.) remains unclear. Here, we investigated the roles of these phytohormones in spikelet development in fieldgrown rice subjected to five different nitrogen(N)fertilization treatments during panicle differentiation. BR levels and expression of genes involved in BR biosynthesis and signal transduction were measured in spikelets. Pollen fertility and the number of differentiated spikelets were closely associated with 24-epicastasterone(24-epiCS) and 28-homobrassinolide(28-homoBL) levels in spikelets.Enhanced BR biosynthesis and signal transduction, in response to N treatment, enhanced spikelet differentiation, reduced spikelet degeneration, and increased grain yield. Increases in proton-pumping ATPase activity, ATPconcentration, energy charge, and antioxidant system(AOS) levels were consistent with 24-epiCS and28-homoBL concentrations. Exogenous application of 24-epiCS or 28-homoBL on young panicles induced a marked increase in endogenous 24-epiCS or 28-homoBL levels, energy charge, AOS levels, spikelet differentiation, and panicle weight. The opposite effects were observed following treatment with a BR biosynthesis inhibitor. Our findings indicate that, in rice, BRs mediate the effects of N fertilization on spikelet development and play a role in promoting spikelet development through increasing AOS levels and energy charge during panicle development. | Weiyang Zhang Kuanyu Zhu Zhiqin Wang Hao Zhang Junfei Gu Lijun Liu Jianchang Yang Jianhua Zhang | 2019 | Journal of Integrative Plant Biology2019，61，8： | 10 |
| 7 | Tolerance to low phosphorus in rice varieties is conferred by regulation of root growth显示文摘Phosphorus use efficiency(PUE)can be improved through cultivation techniques and breeding.However,little is known about rice(Oryza sativa L.)agronomic and physiological traits associated with high PUE.We characterized the agronomic and physiological traits of rice varieties with different tolerances to low phosphorus in nutrient solution.Two varieties with strong tolerance to low phosphorus(STVs)and two with weak tolerance(WTVs)were grown at normal(NP,control)and low phosphorus(LP,1/20 of NP)concentrations.Plants grown at LP produced significantly lower grain yield than those grown at NP.WTVs yields were lower than STVs yields.Compared to NP,LP significantly increased phosphorus translocation efficiency(PTE),internal phosphorus efficiency(IPE)and phosphorus harvest index(PHI).Under the LP condition,PTE and IPE were higher for STVs than for WTVs.LP also reduced tiller number,shoot biomass,leaf area index(LAI),leaf photosynthetic rate,and mean root diameter of both kinds of varieties at the main growth stages,but to a lower extent in STVs.LP significantly increased the number of productive tillers,root biomass,root-shoot ratio,root bleeding rate,and root acid phosphatase(RAP)activity.Total root length,root oxidation activity(ROA),and root total and active absorbing surface areas for STVs were significantly increased under LP,whereas the opposite responses were observed for WTVs.Total root length,ROA,root bleeding rate,root active absorbing surface area,and RAP activity were positively and significantly correlated with grain yield,PTE,and IPE.These results suggest that the tolerance of rice varieties to a low-phosphorus growth condition is closely associated with root growth with higher biomass and activity. | Yaping Deng Chuanbao Men Shengfeng Qiao Wenjie Wang Junfei Gu Lijun Liu Zujian Zhang Hao Zhang Zhiqin Wang Jianchang Yang | 2020 | The Crop Journal2020，8，4： | 8 |
| 8 | The effect of integrative crop management on root growth and methane emission of paddy rice显示文摘In previous studies, integrative crop management (ICM) improved shoot growth and grain yield of rice (Oryza sativa L.). However, little is known about the effect of ICM on root growth and methane (CH4) emission of paddy rice. In this study, two rice varieties, Wuyunjing 24 and Yongyou 2640, were grown. A field experiment was conducted with three crop management treatments including zero nitrogen fertilization (0N), local farmer practice (LFP), and ICM. Root morphophysiological traits and CH4 emission from the paddy field were investigated. ICM significantly increased mean grain yield by 29.9%, with the effect attributed mainly to an increase in mean total number of spikelets by 26.4% compared to LFP. ICM increased root and shoot biomass, root length, number of roots, root oxidation activity (ROA), root bleeding rate, and root total and active absorbing surface area by respectively 24.4%, 25.7%, 17.1%, 9.3%, 18.7%, 29.5%, 12.1%, and 24.7%. The concentrations of malic, succinic, and acetic acids in root exudates were respectively 5.8%, 6.0%, and 10.5% higher in ICM than in LFP. Compared to LFP, ICM significantly decreased the rate of CH4 emission during emission peak stages and reduced total CH4 emission by 17.1%. The root morphophysiological traits were positively and significantly correlated with grain yield, whereas root length, specific root length, ROA, and root total and active absorbing surface area were negatively and significantly correlated with total CH4 emission. These results suggest that ICM could achieve the dual goals of increasing grain yield and reducing the greenhouse gas effect by improving the root morphology and physiological traits of paddy rice. | Hao Zhang Hailang Liu Danping Hou Yilei Zhou Mengzhu Liu Zhiqin Wang Lijun Liu Junfei Gu Jianchang Yang | 2019 | The Crop Journal2019，7，4： | 8 |
| 9 | Initial movement of the Karakorum Fault in western Tibet:constraints from SHRIMP U-Pb dating of zircons显示文摘The Karakorum Fault zone(KFZ)plays an important role in understanding the formation,evolvement and deformation of the Tibetan Plateau.The high-T dextral shearing metamorphic rocks,e.g.,mylonites or mylonitized gneisses-granites,locally crop out along the southeastern part of the KFZ in the Ayila Ri’gyüRange area.The SHRIMP U-Pb dating of the syn-kinematic crystallized zircons indicates that the initial age of the KFZ is^27 Ma,~10 Ma older than previous results.The extensive high-T dextral shearing along the KFZ started at least at 27-20 Ma,accompanied by the syn-kinematic emplacement of leuco-granites.Deformation and concomitant fluid circulation during shearing most likely occurred as early as at 25-13 Ma.The KFZ probably grew from southeast to northwest along the fault as a result of continuous convergence between the India plate and Eurasia plate. | LI HaiBing Franck VALLI LIU DunYi XU ZhiQin YANG JingSui Nicolas ARNAUD Paul TAPPONNIER Robin LACASSIN CHEN SongYong QI xuexiang | 2007 | Chinese Science Bulletin2007，52，8： | 6 |
| 10 | Effect of irrigation regime on grain yield,water productivity,and methane emissions in dry direct-seeded rice grown in raised beds with wheat straw incorporation显示文摘Dry direct-seeded rice grown in raised beds is becoming an important practice in the wheat–rice rotation system in China.However,little information has been available on the effect of various irrigation regimes on grain yield,water productivity(WP),nitrogen use efficiency(NUE),and greenhouse gas emission in this practice.This study investigated the question using two rice cultivars in 2015 and 2016 grown in soil with wheat straw incorporated into it.Rice seeds were directly seeded into raised beds,which were maintained under aerobic conditions during the early seedling period.Three irrigation regimes:continuous flooding(CF),alternate wetting and drying(AWD),and furrow irrigation(FI),were applied from 4.5-leaf-stage to maturity.Compared with CF,both AWD and FI significantly increased grain yield,WP,and internal NUE,with greater increases under the FI regime.The two cultivars showed the same tendency in both years.Both AWD and FI markedly increased soil redox potential,root and shoot biomass,root oxidation activity,leaf photosynthetic NUE,and harvest index and markedly decreased global warming potential,owing to substantial reduction in seasonalThe results demonstrate that adoption of either AWD or FI could increase grain yield and resource-use efficiency and reduce environmental risks in dry direct-seeded rice grown on raised beds with wheat straw incorporation in the wheat–rice rotation system. | Zhiqin Wang Daojian Gu Sarah S.Beebout Hao Zhang Lijun Liu Jianchang Yang Jianhua Zhang | 2018 | The Crop Journal2018，6，5： | 6 |
| 11 | Ultrahigh-pressure and Retrograde Metamorphic Ages for Paleozoic Protolith of Paragneiss in the Main Drill Hole of the Chinese Continental Scientific Drilling Project(CCSD-MH),SW Sulu UHP Terrane显示文摘激光拉曼光谱学和阴极射线发光(CL ) 想象大多数锆石晶体在在 Maobei 钻工程(CCSD-MH ) 的中国 ContinentalScientific 的主要钻孔与帕拉片麻岩分开了的表演,西南的 Sulu 岩层,包含 low-pressuremineral-bearing 由岩屑形成的核心,忍受 coesite 披风并且忍受石英或矿物质 inclusion-freerims。在锆石产出的这些 zoned 上标明日期三个分离、有意义的年龄组的虾 U-Pb。Thedetrital 核心从 659 ~ 313 妈产出大年龄跨度,显示为分析帕拉片麻岩的 protolith 年龄是古生代的而非原生地。忍受 coesite 披风产出 228 ±的加权平均值年龄为 UHP 事件的 5 妈。忍受石英的最外面的边界产出 213 ±的加权平均值年龄为与在 Sulu UHP 岩层的地区性的闪石外形变态有关的倒退的事件的 6 妈。与在 CCSD-MH 标明日期结果 fromorthogneiss 的以前的虾 U-Pb 结合了, Neoproterozoic 花岗石的 protolith 和 Paleozoicsedimentary 岩石是到披风深度在的潜水艇 ducted,这被建议晚三叠纪。大约 1500 万年以后, Sulu UHP 变质岩被掘出到中间外壳的层次并且由 anamphibole 外形退化变质酌套印了。从 SHRIMP 数据和变形的磅条件推出的发掘率是大约 6.7 km/Ma。如此的快发掘建议 Sulu UHPparagneiss 和正片麻岩作为一个快活的裂片的主导的部分向表面回来了,开作为平板裂缝的后果引起了。 | LIU Fulai XU Zhiqin XUE Huaimin ZHOU Kaifu | 2006 | Acta Geologica Sinica(English Edition)2006，80，3： | 5 |
| 12 | Single-epoch RTK performance assessment of tightly combined BDS-2 and newly complete BDS-3显示文摘The BeiDou global navigation satellite system(BDS-3)constellation deployment has been completed on June 23,2020,with a full constellation comprising 30 satellites.In this study,we present the performance assessment of single-epoch Real-Time Kinematic(RTK)positioning with tightly combined BeiDou regional navigation satellite system(BDS-2)and BDS-3.We first investigate whether code and phase Differential Inter-System Biases(DISBs)exist between the legacy B1I/B3I signals of BDS-3/BDS-2.It is discovered that the DISBs are in fact about zero for the baselines with the same or different receiver types at their endpoints.These results imply that BDS-3 and BDS-2 are fully interoperable and can be regarded as one constellation without additional DISBs when the legacy B1I/B3I signals are used for precise relative positioning.Then we preliminarily evaluate the single-epoch short baseline RTK performance of tightly combined BDS-2 and the newly completed BDS-3.The performance is evaluated through ambiguity resolution success rate,ambiguity dilution of precision,as well as positioning accuracy in kinematic and static modes using the datasets collected in Wuhan.Experimental results demonstrate that the current BDS-3 only solutions can deliver comparable ambiguity resolution performance and much better positioning accuracy with respect to BDS-2 only solutions.Moreover,the RTK performance is much improved with tightly combined BDS-3/BDS-2,particularly in challenging or harsh conditions.The single-frequency single-epoch tightly combined BDS-3/BDS-2 solution could deliver an ambiguity resolution success rate of 96.9%even with an elevation cut-off angle of 40°,indicating that the tightly combined BDS-3/BDS-2 could achieve superior RTK positioning performance in the Asia-Pacific region.Meanwhile,the three-dimensional(East/North/Up)positioning accuracy of BDS-3 only solution(0.52 cm/0.39 cm/2.14 cm)in the kinematic test is significantly better than that of the BDS-2 only solution(0.85 cm/1.02 cm/3.01 cm)due to the better geometry of the current BDS-3 constellation.The tightly combined BDS-3/BDS-2 solution can provide the positioning accuracy of 0.52 cm,0.22 cm,and 1.80 cm,respectively. | Wanke Liu Mingkui Wu Xiaohong Zhang Wang Wang Wei Ke Zhiqin Zhu | 2021 | Satellite Navigation2021，2，1： | 4 |
| 13 | Application of time reversal mirror technique in microwave-induced thermo-acoustic tomography system显示文摘Microwave-induced thermo-acoustic tomography (MITAT) is a promising technique with great potential in biomedical imaging. It has both the high contrast of the microwave imaging and the high resolution of the ultrasound imaging. In this paper, the proportional relationship between the absorbed microwave energy distribution and the induced ultrasound source distribution is derived. Further, the time reversal mirror (TRM) technique based on the pseudo-spectral time domain (PSTD) method is applied to MITAT system. The simulation results show that high contrast and resolution can be achieved by the TRM technique based on PSTD method even for the received signals with very low signal-to-noise ratio (SNR) and the model parameter with random fluctuation. | CHEN GuoPing ZHAO ZhiQin ZHENG WenJun NIE ZaiPing LIU QingHuo | 2009 | Science China(Technological Sciences)2009，52，7： | 4 |
| 14 | Mineral inclusions in zircon domains and geological significance of SHRIMP U-Pb dating for coesite-bearing zircons of paragneiss in Sulu terrane, eastern China显示文摘Laser Raman spectroscopy and cathodoluminescence (CL) image reveal that zircons separated from paragneisses in the southwestern Sulu terrane (eastern China) preserve multi-stage mineral assemblages in different zircon domains. In the same paragneiss zircon sample, some zircon grains retain inherited (detrital) cores with abundant low-pressure mineral inclusions of Qtz + Phe + Ap + impurities and Qtz + Phe + impurities. The ultrahigh-pressure (UHP) metamorphic overgrowths mantles of these zircons preserve Coe, Coe + Phe and other UHP mineral inclusions, indicating that these inherited (detrital) zircons from protoliths experienced metamorphic recrystallization during the Sulu UHP metamorphic event. However, other zircon grains preserve UHP mineral inclusions of Coe, Coe + Ap and Coe + Phe in the cores and mantles, whereas the outmost rims contain quartz (Qtz) and other low-pressure mineral inclusions. These phenomena prove that the second group zircons were crystallized at UHP metamorphic stage and overprinted by the late retrogressive metamorphism related to the Sulu terrane exhumation. SHRIMP U-Pb dating reveals that zircons separated from the paragneisses recorded complicated geochronological traces. Some zircons retain inherited cores with the 206Pb/238U ages of 284-754 Ma, indicating the complexity of the detrital zircons in protoliths. Coesite-bearing zircon domains recorded 238-266 Ma (with the average age of 245(14 Ma) for the UHP metamorphic event. The retrogressive rims of zircons recorded 213-223 Ma (with the average age of 217(15 Ma) for the late-stage amphibolite facies metamorphic event, indicating that the rapid exhumation time for the Sulu UHP terrane is about 220 Ma. | LIU Fulai YANG Jingsui XU Zhiqin | 2005 | Science China Earth Sciences2005，48，2： | 3 |
| 15 | Development of microwave-induced thermo-acoustic tomography prototype system显示文摘Due to its advantages in both contrast and resolution compared with conventional microwave or ultrasound imaging system, microwave-induced thermo-acoustic tomography (MITAT) has received more and more concerns in biologic tissue image field. In this paper, an integrated prototype of MITAT system is presented. Using this system, some basic experiments for biologic tissue objects with high water-content imbedded in fatty material have been done. In the MITAT experiments, the signals generated by two porcine muscle tissue strips with millimeter order scale in cross-section were collected. Images with both good contrast and resolution were obtained. In order to demonstrate the advantages of MITAT, some ultrasonic experiments were studied using a commercial ultrasonic linear array system. The comparisons of the results of both systems show the good performance of the MITAT prototype system for the detection of high water content targets, which is generally the same as the tumor in biologic tissue. | CHEN GuoPing ZHAO ZhiQin GONG Wei NIE ZaiPing LIU QingHuo | 2009 | Chinese Science Bulletin2009，54，23： | 3 |
| 16 | Effect of Planting Density,Fertilizer Level,and Number of Seedlings per Hole on Yield of Coix Lachryrma-jobi L.显示文摘In order to study high yield cultivation technology for Coix Lachryrma-jobi L.,and discuss the effect of planting density,fertilizer level,and number of seedlings per hole on yield of Coix Lachryrma-jobi L.,this paper took domesticated variety Xingren Small White Shell of Coix Lachryrma-jobi L. as an example. Using L9( 34) orthogonal design,it selected optimum combination of planting density,fertilizer level,and number of seedlings per hole to guide planting of Coix Lachryrma-jobi L.. Experiment indicated that the optimum planting density( spacing in the rows and spacing between rows) of Coix Lachryrma-jobi L. is 40 cm x 80 cm; the optimum fertilizer level is pure nitrogen 15 kg,pure phosphorus 15 kg and pure potassium 15 kg per mu; the optimum number of seedlings per hole is 5 seedlings per hole. Through variance analysis,it indicated that planting density exerts significance effect on the yield of Coix Lachryrma-jobi L. | Zhiqin SONG Maohong AO Gang SHEN Pengfei LIU | 2015 | Asian Agricultural Research2015，7，8： | 3 |
| 17 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 18 | Micro-area Chemical Composition and Preserved P-T Evolution Trace of Phengite in Albite Gneiss from the Donghai Ultrahigh-Pressure Metamorphic Area,East China显示文摘Study of micro-area chemical compositions indicates that phengite in albite gneiss from hole ZK2304 of the Donghai region has evident compositional zoning. SiO2 and tetrahedrally coordinated Si contents decrease, and Al2O3, AlIV and AlVI contents increase gradually from core to rim. However, K2O, MgO and FeO contents basically remain unchanged from core to rim. According to P-T estimates obtained from geothermometers and barometers, combined with previous experimental data, the core belt (micro-area I) of phengite was formed at T=637-672℃ and P=1.55-1.73 GPa, and the transitional belt (micro-area II) of the phengite were formed at r=594-654℃ and P=1.35-1.45 GPa. Towards the rim belt (micro-area III), the temperature decreased slightly, but the pressure decreased rapidly with r=542-630℃ and P=1.12-1.19 GPa. The P-T evolution path recorded by the compositional zoning of phengite is characterized by significant near-isothermal decompression, revealing that the gneiss has. undergone | LIU Fulai ZHANG Zeming XU Zhiqin YANG Jingsui XU Huifen | 2000 | Acta Geologica Sinica(English Edition)2000，74，2： | 2 |
| 19 | Development of a Liquid Chip Technique to Simultaneously Detect Taura Syndrome Virus( TSV) and Yellow Head Disease Virus( YHDV)显示文摘The aim is to develop a liquid chip technique to detect Taura syndrome virus( TSV) and yellow head disease virus( YHDV) on Penaeus orientalis simultaneously. The CP2 gene of TSV and N gene of YHDV in Gen Bank was analysed by using the software DNAStar 7. 0 to design the TSV-and YHDV-specific primers. The primers were labeled with biotin and subjected to amination modification. They were then coupled with fluorescence-coded microspheres and then used for hybridization with RT- PCR products of TSV and YHDV. The liquid chip detection technique for detection of TSV and YHDV was established by using BD FACSArray to detect fluorescence signal in the reaction system. This assay system had a high sensitivity to TSV and YHDV,with the detection of limit of 100 pg. Moreover,the assay was specific for the detection of TSV,YHDV and was not susceptible to cross with other viruses,including white spot syndrome virus( WSSV),spring viremia of carp virus( SVCV),infectious haematopoietic necrosis virus( IHNV). In conclusion,the liquid chip assay technique established in this study is highly sensitive and specific to TSV and YHDV detection. Moreover,it provides a novel,convenient and rapid approach for the detection of TSV and YHDV. | Yin Weili Zhang Sihua Yue Zhiqin Zheng Xiaolong Liu Hong | 2014 | Animal Husbandry and Feed Science2014，6，5： | 2 |
| 20 | Intercalation engineering of layered vanadyl phosphates for high performance zinc-ion batteries显示文摘Aqueous zinc-ion batteries(ZIBs) have attracted great attention as the candidates for large-scale energy storage system,recently,because of their low cost,environment-friendly,high safety,and high theoretical energy densities.Among the numerous cathode materials,layered structure vanadium based polyanionic compounds,such as VOPO_(4),exhibit high specific capacity for Zn ion storage.However,the low Zn ion diffusion coefficient and limited interlayer spacing make the cathodes low reversible capacity and inferior cycling stability.Herein,K ions were pre-intercalated into the VOPO_(4) layers via ions exchange adopting VOPO_(4)·2 H_(2) O as the precursor.When evaluated as the cathode for ZIBs,an excellent cycle stability of 400 cycles under a current density of 500 mA g^(-1) was achieved by the obtained KVOPO_(4) electrode,verifying the positive effect of intercalation engineering.Furtherly,a solid-solution reaction Zn ion storage mechanism was confirmed.This study provides a new insight to explore high performance cathode materials for ZIBs. | Kunjie Zhu Zhiqin Sun Pei Liu Haixia Li Yijing Wang Kangzhe Cao Lifang Jiao | 2021 | Journal of Energy Chemistry2021，30，12： | 2 |
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