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| 1 | Protein-Protein Interactions in the Regulation of WRKY Transcription Factors显示文摘自从一个 WRKY 抄写因素的第一份报告,现在是几乎 20 年, SPF1,从香甜的土豆。大进步从那以后在在植物生长,开发,和对关於生命、不能生活的应力的回答建立 WRKY 抄写因素的多样的生物角色被取得了。尽管有功能的差异,几乎所有分析 WRKY 蛋白质认出 TTGACC/T W 盒子序列并且,因此除核心 W 盒子倡导者元素的仅仅的识别以外的机制是必要的完成 WRKY 抄写因素的规章的特性。在过去的几年的研究表明了 WRKY 抄写因素身体上在发信号,抄写,并且染色质改变与角色与大量蛋白质交往。交往 WRKY 蛋白质的研究提供了重要卓见进抄写因素的重要家庭的成员的行动的规定和模式。稍微改变的 WRKY 领域和在每七个 WRKY 亚科以内保存的另外的蛋白质主题参予 proteinprotein 相互作用并且调停,这也出现了在 WRKY 蛋白质之间并且在在重要生物过程的调整的 WRKY 和另外的规章的蛋白质之间的复杂功能的相互作用。在这评论,我们为 WRKY 抄写因素总结 proteinprotein 相互作用的研究并且讨论交往的搭挡怎么作出贡献,到 WRKY 抄写因素的复杂规章、功能的网络的建立,在不同层次。 | Yingjun Chi Yan Yang Yuan Zhou Jie Zhou Baofang Fan Jing-Quan Yu Zhixiang Chen | 2013 | Molecular Plant2013，6，2： | 39 |
| 2 | Oceanic barrier layer variation induced by tropical cyclones in the Northwest Pacific显示文摘According to Argo profiles and one-dimensional Price-Weller-Pinkel models, the oceanic barrier layer variation induced by tropical cyclones is adequately analyzed in the Northwest Pacific. Results show that tropical cyclones mainly aff ect the oceanic barrier layer through intensifying and weakening pre-existed barrier layer. The former even may generate new one after tropical cyclones’ passage. The latter can make pre-existed one disappear. Local wind stress and precipitation, the dominant factors, primarily determine the variation of barrier layer. Negative eff ects of wind mainly focus on the north of 20°N. This phenomenon is more meaningful for slow tropical cyclones. Conversely, positive eff ects of wind and precipitation center on the south of 20°N in the Northwest Pacific. Some data indicate that the barrier layer variation is also closely related with initial mixed layer depth and barrier layer thickness. | ZHANG Zhixiang LIU Lingling WANG Fan | 2019 | Journal of Oceanology and Limnology2019，37，2： | 3 |
| 3 | Detecting visually salient scene areas and deriving their relative spatial relations from continuous street-view panoramas显示文摘A salient scene is an area within an image that contains visual elements that stand out from surrounding areas.They are important for distinguishing landmarks in first-person-view(FPV)applications and determining spatial relations in images.The relative spatial relation between salient scenes acts as a visual guide that is easily accepted and understood by users in FPV applications.However,current digitally navigable maps and location-based services fall short of providing information on visual spatial relations for users.This shortcoming has a critical influence on the popularity and innovation of FPV applications.This paper addresses the issue by proposing a method for detecting visually salient scene areas(SSAs)and deriving their relative spatial relationships from continuous panoramas.This method includes three critical steps.First,an SSA detection approach is introduced by fusing region-based saliency derived from super-pixel segmentation and the frequency-tuned saliency model.The method focuses on a segmented landmark area in a panorama.Secondly,a street-view-oriented SSA generation method is introduced by matching and merging the visual SSAs from continuous panoramas.Thirdly,a continuous geotagged panorama-based referencing approach is introduced to derive the relative spatial relationships of SSAs from continuous panoramas.This information includes the relative azimuth,elevation angle,and the relative distance.Experiment results show that the error for the SSA relative azimuth angle is approximately±6°(with an average error of 2.67°),and the SSA relative elevation angle is approximately±4°(with an average error of 1.32°)when using Baidu street-view panoramas.These results demonstrate the feasibility of the proposed approach.The method proposed in this study can facilitate the development of FPV applications such as augmented reality(AR)and pedestrian navigation using proper spatial relation. | Fangli Guan Zhixiang Fang Tao Yu Mingxiang Feng Fan Yang | 2020 | International Journal of Digital Earth2020，13，12： | 2 |
| 4 | An experimental model of an electrical injury to the peripheral nerve 显示文摘 | Fan Kunwu Zhu Zhixiang Den Zhiyun | 2005 | Burns2005，31，6： | 1 |
| 5 | Realizing transmitted metasurface cloak by a tandem neural network显示文摘Being invisible at will has been a long-standing dream for centuries, epitomized by numerous legends;humans have never stopped their exploration steps to realize this dream. Recent years have witnessed a breakthrough in this search due to the advent of transformation optics, metamaterials, and metasurfaces. However, the previous metasurface cloaks typically work in a reflection manner that relies on a high-reflection background, thus limiting the applications. Here, we propose an easy yet viable approach to realize the transmitted metasurface cloak, just composed of two planar metasurfaces to hide an object inside, such as a cat. To tackle the hard-to-converge issue caused by the nonuniqueness phenomenon, we deploy a tandem neural network(T-NN) to efficiently streamline the inverse design. Once pretrained, the T-NN can work for a customer-desired electromagnetic response in one single forward computation, saving a great amount of time. Our work opens a new avenue to realize a transparent invisibility cloak, and the tandem-NN can also inspire the inverse design of other metamaterials and photonics. | ZHENG ZHEN CHAO QIAN YUETIAN JIA ZHIXIANG FAN RAN HAO TONG CAI BIN ZHENG HONGSHENG CHEN ERPING LI | 2021 | Photonics Research2021，9，5： | 1 |
| 6 | Effect of Combined Application of Humic Acid and Urea on the Wheat Growth and Yield显示文摘This paper aims to research the effects of combined application of humic acid and urea on the wheat yield and yield component,and establish rational fertilizer application scheme of wheat. Split plot experiment was adopted. Two types of phosphorus fertilizer( adding humic acid or not) was assigned to the main plot,and four types of top dressing modes( different amount of urea and humic acid urea) were used in subplots. Effects of combined application of humic acid and urea on the wheat yield and yield component were researched. 375 kg / ha ordinary DAP + 150 kg / ha urea was used as base fertilizer; topdressing of 300 kg / ha urea humate could effectively promote the plant height,leaf area coefficient and aboveground dry matter amount. Adding humic acid in urea in topdressing significantly enhanced the wheat yield and economic coefficient of wheat. Adding humic acid in urea in topdressing has better effects of yield increasing than base fertilizer,and can be used for large scale extension. | Xin XUE Zhiwei XUE Zhijun SONG Fan ZHANG Zhixiang WANG Yong HAN | 2016 | Asian Agricultural Research2016，8，9： | 1 |
| 7 | Smoothing effect in the broadband laser through a dispersive wedge显示文摘 | Runwu Peng Yunxia Ye Zhixiang Tang Chujun Zhao Shuangchun Wen Dianyuan Fan | 2006 | Optics Communications2006，，1： | 1 |
| 8 | A pathogen and salicylic acid induced WRKY DNA binding activity recognizes the elicitor response ele- ment of the tobacco class I chitinase gene promoter显示文摘 | YANG Peizhen CHEN Chunhong WANG Zeping FAN Bao- fang CHEN Zhixiang | 1999 | The Plant Journal1999，18，2： | 1 |
| 9 | Arabidopsis Sigma Factor Binding Proteins Are Activators of the WRKY33 Transcription Factor in Plant Defense(W)显示文摘 | Lai Zhibing Li Ying Wang Fei Cheng Yuan Fan Baofang Yu Jing-Quan Chen Zhixiang | 2011 | EN2011，，10： | 1 |
| 10 | Structural and Functional Analysis of VQ Motif-Containing Proteins in Arabidopsis as Interacting Proteins ofWRKY Transcription Factors1[W][OA]显示文摘 | Cheng Yuan Zhou Yuan Yang Yan Chi Ying-Jun Zhou Jie Chen Jian-Ye Wang Fei Fan Baofang Shi Kai Zhou Yan-Hong Yu Jing-Quan Chen Zhixiang | 2012 | Plant Physiology2012，，2： | 1 |
| 11 | A Semiempirical Method to Calculate Continuum Gamma-ray Spectra and Multiplicities From Neutron-induced Reactions显示文摘 | Fan Sheng Zhao Zhixiang | 1996 | Nucl Sci Eng1996，124，： | 1 |
| 12 | Low-pass spatial filtering using a two-dimensional self-collimating photonic crystal显示文摘 | Tang Zhixiang Fan Dianyuan Wen Shuangchun | 2007 | Chin Opt Lett2007，5，1： | 1 |
| 13 | A knowledge-inherited learning for intelligent metasurface design and assembly显示文摘Recent breakthroughs in deep learning have ushered in an essential tool for optics and photonics,recurring in various applications of material design,system optimization,and automation control.Deep learning-enabled on-demand metasurface design has been the subject of extensive expansion,as it can alleviate the time-consuming,low-efficiency,and experience-orientated shortcomings in conventional numerical simulations and physics-based methods.However,collecting samples and training neural networks are fundamentally confined to predefined individual metamaterials and tend to fail for large problem sizes.Inspired by object-oriented C++programming,we propose a knowledge-inherited paradigm for multi-object and shape-unbound metasurface inverse design.Each inherited neural network carries knowledge from the'parent'metasurface and then is freely assembled to construct the'offspring'metasurface;such a process is as simple as building a container-type house.We benchmark the paradigm by the free design of aperiodic and periodic metasurfaces,with accuracies that reach 86.7%.Furthermore,we present an intelligent origami metasurface to facilitate compatible and lightweight satellite communication facilities.Our work opens up a new avenue for automatic metasurface design and leverages the assemblability to broaden the adaptability of intelligent metadevices. | Yuetian Jia Chao Qian Zhixiang Fan Tong Cai Er-Ping Li Hongsheng Chen | 2023 | Light(Science & Applications)2023，12，4： | 0 |
| 14 | Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, cohort study显示文摘Sorafenib therapy improves overall survival(OS)in patients with FLT3 internal tandem duplication(ITD)acute myeloid leukemia(AML)undergoing allogeneic hematopoietic stem cell transplantation.We explored the efficacy of sorafenib therapy in this population with different concomitant genetic patterns.In this multi-center,cohort study,we enrolled patients with FLT3-ITD AML undergoing allogenic hematopoietic cell transplantation.Patients with sorafenib maintenance post-transplantation for at least four weeks were allocated to the sorafenib group,and otherwise to the control group. | Ruoyang Shao Yu Zhang Jinping He Fen Huang Zhiping Fan Kaibo Yang Yajing Xu Na Xu Yi Luo Lan Deng Xi Zhang Jia Chen Mingzhe Han Xudong Li Sijian Yu Hui Liu Xinquan Liang Xiaodan Luo Pengcheng Shi Zhixiang Wang Ling Jiang Xuan Zhou Ren Lin Yan Chen Sanfang Tu Jing Sun Yu Wang Qifa Liu Li Xuan | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 15 | Specialized endoplasmic reticulum-derived vesicles in plants:Functional diversity,evolution,and biotechnological exploitation显示文摘A central role of the endoplasmic reticulum(ER)is the synthesis,folding and quality control of secretory proteins.Secretory proteins usually exit the ER to enter the Golgi apparatus in coat protein complex II(COPII)-coated vesicles before transport to different subcellular destinations.However,in plants there are specialized ER-derived vesicles(ERDVs)that carry specific proteins but,unlike COPII vesicles,can exist as independent organelles or travel to the vacuole in a Golgi-independent manner.These specialized ERDVs include protein bodies and precursor-accumulating vesicles that accumulate storage proteins in the endosperm during seed development.Specialized ERDVs also include precursor protease vesicles that accumulate amino acid sequence KDEL-tailed cysteine proteases and ER bodies in Brassicales plants that accumulate myrosinases that hydrolyzes glucosinolates.These functionally specialized ERDVs act not only as storage organelles but also as platforms for signal-triggered processing,activation and deployment of specific proteins with important roles in plant growth,development and adaptive responses.Some specialized ERDVs have also been exploited to increase production of recombinant proteins and metabolites.Here we discuss our current understanding of the functional diversity,evolutionary mechanisms and biotechnological application of specialized ERDVs,which are associated with some of the highly remarkable characteristics important to plants. | Xie Li Xifeng Li Baofang Fan Cheng Zhu Zhixiang Chen | 2022 | Journal of Integrative Plant Biology2022，64，4： | 0 |
| 16 | Study on Control Effect of Invasive Banana Fusarium Disease(Fusarium oxysporum f.sp.cubense tropical race 4)by Different Varieties and Fertilization Treatments显示文摘[Objective]The paper was to understand the field resistance performance of different banana varieties and the prevention and control ef-fect of different fertilizers,so as to provide technical reference for the prevention and control of Fusarium wilt.[Method]Field trials were set up with three treatments:shrimp peptide organic fertilizer+shrimp peptide special protection+shrimp peptide fruit Yekang(simplified as shrimp peptide organic fertilizer treatment),conventional organic fertilizer+microbial preparations(simplified as microbial treatment),and conventional or-ganic fertilizer(simplified as control).Four different banana varieties of Brazilian banana,Guijiao No.1,Nantianhuang,and Yunjiao No.1 were se-lected for the field trial.The disease incidence of Fusarium wilt and the control effects of three fertilizers were investigated during four time periods.[Result]The disease incidence of four varieties in three treatments varied.The disease incidence of Nantianhuang and Yunjiao No.1 were signifi-cantly lower than that of other two varieties.There was also significant difference in disease incidence of three treatments.The disease incidence from high to low was control>shrimp peptide organic fertilizer treatment>microbial treatment.The average monthly TR4 pathogen content in heavily infected banana plantation was more than 2000 copies,while the highest one reached 15148.9 copies.[Conclusion]Microbial agents reduced the disease incidence of Fusarium wilt to some content.Nantianhuang and Yunjiao No.1 showed the highest disease resistance compared with other varieties.However,their resistance needs to be further improved before practical application. | Long Yuan Yang Baoming Huang Yuling Bai Tingting Xu Shengtao Yin Kesuo Fan Huacai Zeng Li Li Xundong Guo Zhixiang Li Yongping Yang Derong Li Jinping Zheng Sijun | 2020 | Plant Diseases and Pests2020，11，1： | 0 |
| 17 | Multiomics analysis reveals metabolic subtypes and identifies diacylglycerol kinase α (DGKA) as a potential therapeutic target for intrahepatic cholangiocarcinoma显示文摘Background:Intrahepatic cholangiocarcinoma(iCCA)is a highly heteroge-neous and lethal hepatobiliary tumor with few therapeutic strategies.The metabolic reprogramming of tumor cells plays an essential role in the develop-ment of tumors,while the metabolic molecular classification of iCCA is largely unknown.Here,we performed an integrated multiomics analysis and metabolic classification to depict differences in metabolic characteristics of iCCA patients,hoping to provide a novel perspective to understand and treat iCCA.Methods:We performed integrated multiomics analysis in 116 iCCA samples,including whole-exome sequencing,bulk RNA-sequencing and proteome anal-ysis.Based on the non-negative matrix factorization method and the protein abundance of metabolic genes in human genome-scale metabolic models,the metabolic subtype of iCCA was determined.Survival and prognostic gene analy-ses were used to compare overall survival(OS)differences between metabolic subtypes.Cell proliferation analysis,5-ethynyl-2’-deoxyuridine(EdU)assay,colony formation assay,RNA-sequencing and Western blotting were performed to investigate the molecular mechanisms of diacylglycerol kinaseα(DGKA)in iCCA cells.Results:Three metabolic subtypes(S1-S3)with subtype-specific biomarkers of iCCA were identified.These metabolic subtypes presented with distinct prog-noses,metabolic features,immune microenvironments,and genetic alterations.The S2 subtype with the worst survival showed the activation of some special metabolic processes,immune-suppressed microenvironment and Kirsten ratsar-coma viral oncogene homolog(KRAS)/AT-rich interactive domain 1A(ARID1A)mutations.Among the S2 subtype-specific upregulated proteins,DGKA was further identified as a potential drug target for iCCA,which promoted cell proliferation by enhancing phosphatidic acid(PA)metabolism and activating mitogen-activated protein kinase(MAPK)signaling.Conclusion:Viamultiomics analyses,we identified three metabolic subtypes of iCCA,revealing that the S2 subtype exhibited the poorest survival outcomes.We further identified DGKA as a potential target for the S2 subtype. | Weiren Liu Huqiang Wang Qianfu Zhao Chenyang Tao Weifeng Qu Yushan Hou Run Huang Zimei Sun Guiqi Zhu Xifei Jiang Yuan Fang Jun Gao Xiaoling Wu Zhixiang Yang Rongyu Ping Jiafeng Chen Rui Yang Tianhao Chu Jian Zhou Jia Fan Zheng Tang Dong Yang Yinghong Shi | 2024 | Cancer Communications2024，44，2： | 0 |
| 18 | Immune checkpoint inhibitors-associated cardiotoxicity in immunotherapy trials on gastrointestinal cancer patients显示文摘To the editor:Gastrointestinal(GI)cancer is the most common malignancy in China.[1]For many decades,the treatment options for GI cancers have been limited to surgery,radiotherapy,and chemotherapy.Over recent years,immune checkpoint inhibitors(ICIs)that target programmed cell death 1(PD-1),or its programmed death-ligand 1(PD-L1),have demonstrated promising efficacies and changed the treatment landscape in GI cancer.[2]However,immune-related adverse events(irAEs)can occur during ICI treatment.Furthermore,ICI-associared cardiotoxicity is a rare but potentially fatal toxic effect. | Li Yiqun Wang Yanfeng Li Ning Liang Xinjun Zhang Shu Fan Qingxia Yin Xianli Zhuang Zhixiang Liu Yunpeng Zhang Jingdong Kou Xiaoge Zhong Haijun Xu Binghe Huang Jing | 2022 | Chinese Medical Journal2022，，8： | 0 |
| 19 | LAND UTILIZATION COUNTERMEASURES AND CURRENT SITUATION OF HETAO IRRIGATION REGION IN INNER MONGOLIA显示文摘Hetao irrigation region is situated in the western part of Inner Mongolia. It stands bythe Yin·Shan mountain in the north, leans against the Yellow River in the south, nears theeastern side of Ulanbuhe Desert in the west and borders on Baotou in the east. It is 280kilometers in length from east to west. and 45-90 kilometers in width from north to south. | Cui Zhixiang Fan Runwei Dong Jinya Inner Mongolia Institute of Soil and Fertilizer Centre of Science and Technology, BayanNar Agriculture Deparment | 1993 | 干旱区资源与环境1993，7，Z1： | 0 |
| 20 | Vitamin D-binding protein in plasma microglia-derived extracellular vesicles as a potential biomarker for major depressive disorder显示文摘No well-established biomarkers are available for the clinical diagnosis of major depressive disorder(MDD).Vitamin D-binding protein(VDBP)is altered in plasma and postmortem dorsolateral prefrontal cortex(DLPFC)tissues of MDD patients.Thereby,the role of VDBP as a potential biomarker of MDD diagnosis was further assessed.Total extracellular vesicles(EVs)and brain cell-derived EVs(BCDEVs)were isolated from the plasma of first-episode drug-naïve or drug-free MDD patients and well-matched healthy controls(HCs)in discovery(20 MDD patients and 20 HCs)and validation cohorts(88 MDD patients and 38 HCs).VDBP level in the cerebrospinal fluid(CSF)from chronic glucocorticoid-induced depressed rhesus macaques or prelimbic cortex from lipopolysaccharide(LPS)-induced depressed mice and wild control groups was measured to evaluate its relationship with VDBP in plasma microglia-derived extracellular vesicles(MDEVs).VDBP was significantly decreased in MDD plasma MDEVs compared to HCs,and negatively correlated with HAMD-24 score with the highest diagnostic accuracy among BCDEVs.VDBP in plasma MDEVs was decreased both in depressed rhesus macaques and mice.A positive correlation of VDBP in MDEVs with that in CSF was detected in depressed rhesus macaques.VDBP levels in prelimbic cortex microglia were negatively correlated with those in plasma MDEVs in depressed mice.The main results suggested that VDBP in plasma MDEVs might serve as a prospective candidate biomarker for MDD diagnosis. | Gaojia Zhang Ling Li Yan Kong Dandan Xu Yu Bao Zhiting Zhang Zhixiang Liao Jiao Jiao Dandan Fan Xiaojing Long Ji Dai Chunming Xie Zhiqiang Meng Zhijun Zhang | 2024 | Genes & Diseases2024，11，2： | 0 |
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