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| 1 | Chebyshev Approximation for Fast Frequency- Sweep Analysis of Electromagnetic Scattering Problem显示文摘 | CHEN Mingsheng WU Xianliang HUANG Zhixiang SHA Wei | 2006 | Chinese Journal of Electronics2006，15，4： | 13 |
| 2 | Fluorination vs. chlorination: a case study on high performance organic photovoltaic materials显示文摘Halogenation is a very efficient chemical modification method to tune the molecular energy levels, absorption spectra and molecular packing of organic semiconductors. Recently, in the field of organic solar cells(OSCs), both fluorine-and chlorinesubstituted photovoltaic materials, including donors and acceptors, demonstrated their great potentials in achieving high power conversion efficiencies(PCEs), raising a question that how to make a decision between fluorination and chlorination when designing materials. Herein, we systemically studied the impact of fluorination and chlorination on the properties of resulting donors(PBDB-T-2 F and PBDB-T-2 Cl) and acceptors(IT-4 F and IT-4 Cl). The results suggest that all the OSCs based on different donor and acceptor combinations can deliver good PCEs around 13%–14%. Chlorination is more effective than fluorination in downshifting the molecular energy levels and broadening the absorption spectra. The influence of chlorination and fluorination on the crystallinity of the resulting materials is dependent on their introduction positions. As chlorination has the advantage of easy synthesis, it is more attractive in designing low-cost photovoltaic materials and therefore may have more potential in largescale applications. | Yun Zhang Huifeng Yao Shaoqing Zhang Yunpeng Qin Jianqi Zhang Liyan Yang Wanning Li Zhixiang Wei Feng Gao Jianhui Hou | 2018 | Science China Chemistry2018，61，10： | 11 |
| 3 | An A-D-A′-D-A type unfused nonfullerene acceptor for organic solar cells with approaching 14%efficiency显示文摘In recent years,power conversion efficiency(PCE)of organic solar cells(OSCs)has made significant improvement.A large number of studies were reported to achieve high PCEs through exploring new active layer materials,especially the high efficiency fused ring acceptors(FRAs).Compared with FRAs,another type of so-called unfused-ring acceptors(UFAs),possessing some advantages such as simple synthesis and low cost,have attracted a lot of attention.Herein,a new UFA BTzO-4F,incorporating with a benzotriazole moiety and S···O intramolecular noncovalent interactions,has been successfully synthesized.The photovoltaic device based on PBDB-T:BTzO-4F achieved a record PCE of 13.8%for UFAs,which indicates that introducing the benzotriazole moiety is an effective strategy for high quality acceptors.Thus,these findings of this work demonstrate the great potential of UFAs for high performance OSCs. | Xingzheng Liu Yanan Wei Xin Zhang Linqing Qin Zhixiang Wei Hui Huang | 2021 | Science China Chemistry2021，64，2： | 7 |
| 4 | Ternary Organic Solar Cells Based on Two Non-fullerene Acceptors with Complimentary Absorption and Balanced Crystallinity显示文摘Summary of main observation and conclusion The ternary blend structure has been demonstrated as an effective approach to increase the power conversion efficiency of organic solar cells.An effective approach to enhance the power conversion efficiency of ternary solar cells is based on two non-fullerene acceptors with complimentary absorption range and balanced crystallinity.In this work,we have introduced a high crystallinity small-molecule acceptor,named C8IDTT-4CI with appropriate alkyl side chains into a low crystalline blend of conjugated polymer donor PBDT-TPD and fused-ring electron acceptor ITIC-4F.A ternary device based on the blend PBDT-TPD:1TIC-4F:C81DTT-4CI exhibits a best power conversion efficiency of 9.51%with a simultaneous improvement of the short-circuit current density to 18.76 mA-cm^-2 and the fill factor up to 67.53%.The absorption onset for C8IDTT-4CI is located at 900 nm,so that the well complementary light absorption is beneficial to the photocurrent.In addition,the existence of high crystallinity C8IDTT-4CI in the ternary device is found helpful to modulate crystallinity,improve heterojunction morphologies and stacking structure,therefore to realize higher charge mobility and better performance. | Lan Xie Chen Yang Ruimin Zhou Zhen Wang Jianqi Zhang Kun Lu Zhixiang Wei | 2020 | Chinese Journal of Chemistry2020，38，9： | 7 |
| 5 | Methyl jasmonate mediates melatonin-induced cold tolerance of grafted watermelon plants显示文摘Root–shoot communication has a critical role in plant adaptation to environmental stress.Grafting is widely applied to enhance the abiotic stress tolerance of many horticultural crop species;however,the signal transduction mechanism involved in this tolerance remains unknown.Here,we show that pumpkin-or figleaf gourd rootstock-enhanced cold tolerance of watermelon shoots is accompanied by increases in the accumulation of melatonin,methyl jasmonate(MeJA),and hydrogen peroxide(H_(2)O_(2)).Increased melatonin levels in leaves were associated with both increased melatonin in rootstocks and MeJA-induced melatonin biosynthesis in leaves of plants under cold stress.Exogenous melatonin increased the accumulation of MeJA and H_(2)O_(2) and enhanced cold tolerance,while inhibition of melatonin accumulation attenuated rootstock-induced MeJA and H_(2)O_(2) accumulation and cold tolerance.MeJA application induced H_(2)O_(2) accumulation and cold tolerance,but inhibition of JA biosynthesis abolished rootstock-or melatonin-induced H_(2)O_(2) accumulation and cold tolerance.Additionally,inhibition of H_(2)O_(2) production attenuated MeJA-induced tolerance to cold stress.Taken together,our results suggest that melatonin is involved in grafting-induced cold tolerance by inducing the accumulation of MeJA and H_(2)O_(2).MeJA subsequently increases melatonin accumulation,forming a self-amplifying feedback loop that leads to increased H_(2)O_(2) accumulation and cold tolerance.This study reveals a novel regulatory mechanism of rootstock-induced cold tolerance. | Hao Li Yanliang Guo Zhixiang Lan Kai Xu Jingjing Chang Golam Jalal Ahammed Jianxiang Ma Chunhua Wei Xian Zhang | 2021 | Horticulture Research2021，8，1： | 5 |
| 6 | Investigation of natural ventilation performance of large space circular coal storage dome显示文摘Large space circular coal storage dome(LSCCSD)offers an environmental and dependable alternative to open stockpiles,and it has been consequently widely applied in China.However,due to the lack of scientific guidelines,its natural ventilation performance is lower than expected.Natural ventilation potential strongly depends on the roof geometry and opening mode,which have not yet been investigated for LSCCSD.This paper presents a detailed evaluation of the impact of dome geometry(rise span ratio),opening height,and opening modes on the ventilation performance of LSCCSD.The evaluation is based on computational fluid dynamics(CFD)methods and is validated by available wind tunnel testing.We employed three evaluation indicators,which are wind pressure coefficient,effective ventilation rate,and wind speed ratio.The results demonstrate that the rise span ratio has a significant effect on the wind pressure difference and the effective ventilation rate increases by approximately 9%–42%with a single-annular opening.When double-annular openings are set in a strong positive pressure zone,the effective ventilation rate increases by 100%and the average wind speed ratio increases by 50%.When it is compared with single one with similar opening height,the effective ventilation rate increases by 25%.The optimum natural ventilation performance for LSCCSD is achieved at a rise span ratio of 0.37.In addition,the lateral middle opening is kept higher than the ridge top of the coal pile.The proposed evaluation approach and design parameters provided instructive information in the building design and ventilation control for LSCCSDs. | Yaohua Hou Chao Chen Yu Zhou Zhixiang Yang Shen Wei | 2021 | Building Simulation2021，14，4： | 4 |
| 7 | Fluorination-substitution effect on all-small-molecule organic solar cells显示文摘Due to the strong crystallinity and anisotropy of small molecules, matched molecular photoelectric properties and morphologies between small molecules and non-fullerene acceptors are especially important in all-small-molecule organic solar cells(OSCs).Introducing fluorine atoms has been proved as an effective strategy to achieve a high device performance through tuning molecular energy levels, absorption and assembly properties. Herein, we designed a novel benzodithiophene-based small molecule donor BDTF-CA with deep highest occupied molecular orbital(HOMO) energy level. All-small-molecule OSCs were fabricated by combing non-fullerene acceptor IDIC with different fluorine-atom numbers. Two or four fluorine atoms were introduced to the end-capped acceptor of IDIC, which are named as IDIC-2 F and IDIC-4 F, respectively. With the increase of fluorination from IDIC to IDIC-4 F, the open circuit voltage(Voc) of the devices decreased, while hole and electron mobilities of the active layers increased by one order of magnitude. Contributed to the most balanced Voc, short-circuit current(Jsc) and fill factor(FF), the device based on BDTF-CA/IDIC-2 F achieved the highest power conversion efficiency of 9.11%. | Qiong Wu Dan Deng Jianqi Zhang Wenjun Zou Yang Yang Zhen Wang Huan Li Ruimin Zhou Kun Lu Zhixiang Wei | 2019 | Science China Chemistry2019，62，7： | 3 |
| 8 | Combining chlorination and sulfuration strategies for high-performance all-small-molecule organic solar cells显示文摘Three small-molecule donors based on dithieno [2,3-d:2’,3 ’-d’]-benzo[1,2-b:4,5-b’] dithiophene(DTBDT)unit were designed and synthesized by side chain regulation with chlorinated or/and sulfurated substitutions(namely ZR1,ZR1-Cl,and ZR1-S-Cl respectively),along with a crystalline non-fullerene acceptor IDIC-4 Cl with a chlorinated 1,1-dicyanomethylene-3-indanone(IC) end group.Energy levels,molar extinction coefficients and crystallinities of three donor molecules can be effectively altered by combining chlorination and sulfuration strategies.Especially,the ZR1-S-Cl exhibited the best absorption ability,lowest higher occupied molecular orbital(HOMO) energy level and highest crystallinity among three donors,resulting in the corresponding all-small-molecule organic solar cells to produce a high power conversion efficiency(PCE) of 12.05% with IDIC-4 Cl as an acceptor. | Ruimin Zhou Chen Yang Wenjun Zou Muhammad Abdullah Adil Huan Li Min Lv Ziyun Huang Menglan Lv Jianqi Zhang Kun Lu Zhixiang Wei | 2021 | Journal of Energy Chemistry2021，30，1： | 3 |
| 9 | MicroRNA Signaling Pathway Network in Pancreatic Ductal Adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma(PDAC) is considered to be the most lethal and aggressive malignancy with high mortality and poor prognosis. Their responses to current multimodal therapeutic regimens are limited. It is urgently needed to identify the molecular mechanism underlying pancreatic oncogenesis. Twelve core signaling cascades have been established critical in PDAC tumorigenesis by governing a wide variety of cellular processes. Micro RNAs(mi RNAs) are aberrantly expressed in different types of tumors and play pivotal roles as post-transcriptional regulators of gene expression. Here, we will describe how mi RNAs regulate different signaling pathways that contribute to pancreatic oncogenesis and progression. | Longhao Sun Corrine Ying Xuan Chua Weijun Tian Zhixiang Zhang Paul J.Chiao Wei Zhang | 2015 | Journal of Genetics and Genomics2015，42，10： | 3 |
| 10 | Molecular design revitalizes the low-cost PTV-polymer for highly efficient organic solar cells显示文摘Developing photovoltaic materials with simple chemical structures and easy synthesis still remains a major challenge in the industrialization process of organic solar cells(OSCs).Herein,an ester substituted poly(thiophene vinylene)derivative,PTVT-T,was designed and synthesized in very few steps by adopting commercially available raw materials.The ester groups on the thiophene units enable PTVT-T to have a planar and stable conformation.Moreover,PTVT-T presents a wide absorption band and strong aggregation effect in solution,which are the key characteristics needed to realize high performance in non-fullerene-acceptor(NFA)-based OSCs.We then prepared OSCs by blending PTVT-T with three representative fullerene-and NF-based acceptors,PC71 BM,IT-4 F and BTP-e C9.It was found that PTVT-T can work well with all the acceptors,showing great potential to match new emerging NFAs.Particularly,a remarkable power conversion efficiency of 16.20%is achieved in a PTVT-T:BTP-e C9-based device,which is the highest value among the counterparts based on PTV derivatives.This work demonstrates that PTVT-T shows great potential for the future commercialization of OSCs. | Junzhen Ren Pengqing Bi Jianqi Zhang Jiao Liu Jingwen Wang Ye Xu Zhixiang Wei Shaoqing Zhang Jianhui Hou | 2021 | National Science Review2021，8，8： | 3 |
| 11 | Self-assembly of conjugated polymers for anisotropic nanostructures显示文摘As their potential applications in various electronic devices increase, the preparation of anisotropic conjugated polymer nanostructures are highly desirable. This paper presents a review of the literature and our recent results on the self-assembly of one-, two- and three-dimensional anisotropic nanostructures using conjugated polymers as building blocks, including the formation of one-dimensional (1D) nanofibers and nanotubes, two-dimensional (2D) nanoribbons and nanosheets, and three-dimensional (3D) superstructures. The mechanisms guiding the formation of various nanostructures are analyzed by a cooperative effect of - stacking interaction and other noncovalent interactions. | YU Zai LU Kun WEI ZhiXiang | 2012 | Science China Chemistry2012，55，11： | 3 |
| 12 | A-π-D-π-A small-molecule donors with different end alkyl chains obtain different morphologies in organic solar cells显示文摘For bulk-heterojunction organic solar cells, the morphology of the blend films highly influence the exciton dissociation and charge transport process. In this work, two novel A-π-D-π-A(A represents the acceptor unit and D represents the donor unit) backbone structure small molecular electron donors based on two dimensional conjugated naphtho[1,2-b:5,6-b']dithiophene(NDT) with different end alkyl chains, named as NDT-3T-EH and NDT-3T-O, have been designed and synthesized. The photovoltaic property of NDT-3T-O-based device is better than that of the NDT-3T-EH and the best efficiency reaches 7.06%, and the photovoltaic property of NDT-3T-EH reaches 6.11%. The difference in the performance should be attributed to the different morphology and phase separation resulted from the different crystallinity and aggregation ability of two donors. The results demonstrate that the optimized end alkyl chains can be used to design A-π-D-π-A backbone structure small molecular electron donors for smallmolecule organic solar cells. | Yanan Shi Chen Yang Huan Li Lixuan Liu Ruimin Zhou Wenjun Zou Zhen Wang Qiong Wu Dan Deng Jianqi Zhang Kun Lu Zhixiang Wei | 2019 | Chinese Chemical Letters2019，30，4： | 3 |
| 13 | Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells显示文摘Background: The mitogen-activated extracellular signal-regulated kinase 1/2(MEK1/2) inhibitor trametinib has shown promising therapeutic effects on melanoma, but its efficacy on colorectal cancer(CRC) is limited. Synthetic lethality arises with a combination of two or more separate gene mutations that causes cell death, whereas individual mutations keep cells alive. This study aimed to identify the genes responsible for resistance to trametinib in CRC cells,using a synthetic lethal short hairpin RNA(shRNA) screening approach.Methods: We infected HT29 cells with a pooled lentiviral shRNA library and applied next-generation sequencing to identify shRNAs with reduced abundance after 8-day treatment of 20 nmol/L trametinib. HCT116 and HT29 cells were used in validation studies. Stable ring finger protein 183(RNF183)-overexpressing cell lines were generated by pcDNA4-myc/his-RNF183 transfection. Stable RNF 183-knockdown cell lines were generated by infection of lentiviruses that express RNF183 shRNA, and small interference RNA(siRNA) was used to knock down RNF183 transiently.Quantitative real-time PCR was used to determine the mRNA expression. Western blotting, immunohistochemical analysis, and enzyme-linked immunosorbent assay(ELISA) were used to evaluate the protein abundance. MTT assay,colony formation assay, and subcutaneous xenograft tumor growth model were used to evaluate cell proliferation.Results: In the primary screening, we found that the abundance of RNF183 shRNA was markedly reduced after treatment with trametinib. Trametinib induced the expression of RNF183, which conferred resistance to drug-induced cell growth repression and apoptotic and non-apoptotic cell deaths. Moreover, interleukin-8(IL-8) was a downstream gene of RNF183 and was required for the function of RNF183 in facilitating cell growth. Additionally, elevated RNF183 expression partly reduced the inhibitory effect of trametinib on IL-8 expression. Finally, xenograft tumor model showed the synergism of RNF183 knockdown and trametinib in repressing the growth of CRC cells in vivo.Conclusion: The RNF183-IL-8 axis is responsible for the resistance of CRC cells to the MEK1/2 inhibitor trametinib and may serve as a candidate target for combined therapy for CRC. | Rong Geng Xin Tan Zhixiang Zuo Jiangxue Wu Zhizhong Pan Wei Shi Ranyi Liu Chen Yao Gaoyuan Wang Jiaxin Lin Lin Qiu Wenlin Huang Shuai Chen | 2017 | Chinese Journal of Cancer2017，36，12： | 2 |
| 14 | Practical Experiences of Delivering Multidrug-Resistant Tuberculosis Comprehensive Supportive Care Services in China显示文摘Summary What is already known about this topic?The World Health Organization consolidated guidelines on recommend care for tuberculosis(TB)and support for multidrug-resistant TB(MDR-TB)patients.But guidelines have not provided detailed guidance or tools for health services providers to implement comprehensive patient care. | Yunzhou Ruan Ling Li Lin Xu Yanlin Zhao Li Zhong Zhixiang Xu Kai Wang Wei Su Renzhong Li | 2021 | China CDC weekly2021，3，26： | 2 |
| 15 | Safety and efficacy of obinutuzumab in Chinese patients with B-cell lymphomas: a secondary analysis of the GERSHWIN trial显示文摘Background:Patients with relapsed/refractory B-cell lymphomas have limited treatment options.GERSHWIN is an open-label,single-arm,phase Ib study of obinutuzumab monotherapy in Chinese patients with histologically docu-mented CD20+relapsed/refractory chronic lymphocytic leukemia(CLL),diffuse large B-cell lymphoma(DLBCL),or follicular lymphoma(FL).The primary outcome measure of pharmacokinetics has been previously reported.We now present data on the secondary endpoint measures(e.g.,safety,and efficacy and pharmacodynamics).Methods:Patients received 1000 mg obinutuzumab intravenously on days 1,8,and 15 of cycle 1(CLL patients;first dose split over 2 days),and on day 1 of cycles 2-8.Each cycle lasted for 21 days;the treatment period was 24 weeks.All subjects receiving at least one dose of obinutuzumab were included in the analysis of safety,efficacy,as well as pharmacodynamics.Results:A total of 48 patients(>18 years of age)were enrolled(CLL:12;DLBCL:23;FL:13).The subjects received a median of two lines of anticancer treatment prior to the enrollment.Thirty-five patients(72.9%)had at least one adverse event(AE).The most frequent AE was infusion-related reactions(15 patients;31.3%),followed by pyrexia(11 patients;22.9%).Treatment-related AEs were reported in 28 patients(58.3%),and included one death(interstitial lung disease).End-of-treatment(EoT)response rate was 33.3%.Best overall response rate was 47.9%.Most CLL patients achieved a partial response at EoT(58.3%).CD19+depletion occurred in 75.0%of the patients with CLL,and all patients with FL and DLBCL.Conclusions:The safety and efficacy of obinutuzumab monotherapy in Chinese patients with B-cell lymphomas were similar to that observed in previous studies in non-Chinese patients;no new safety signals were observed. | Yan Qin Yuqin Song Zhixiang Shen Xin Du Wei Ji Wanling Hsu Jun Zhu Yuankai Shi | 2018 | Cancer Communications2018，38，1： | 2 |
| 16 | Spatiotemporal analysis of critical transportation links based on time geographic concepts: a case study of critical bridges in Wuhan, China显示文摘 | Zhixiang Fang Shih-Lung Shaw Wei Tu Qingquan Li Yuguang Li | 2012 | Journal of Transport Geography2012，，： | 2 |
| 17 | Dysregulated adaptive immune response contributes to severe COVID-19显示文摘Dear Editor,The outbreak of the new coronavirus 5ARS-CoV-2 has resulted in a global pandemic.Due to the lack of a specific drug against this virus,the current clinical management of this disease mainly depends on supportive care to reduce inflammatory responses and to keep the lung functioning1. | Kuai Yu Jingjing He Yongjian Wu Baosong Xie Xuefei Liu Bo Wei Haibo Zhou Bingliang Lin Zhixiang Zuo Wen Wen Wenxiong Xu Bin Zou Lai Wei Xi Huang Penghui Zhou | 2020 | Cell Research2020，30，9： | 1 |
| 18 | Nanostructures of polyaniline doped with inorganic acids显示文摘 | Zhang Zhiming Wei Zhixiang Wan Meixiang | 2002 | Macromolecules2002，35，： | 1 |
| 19 | Evaluation of groundwater sustainability based on groundwater age simulation in the Zhangye Basin of Heihe River watershed, northwestern China显示文摘Water resources, as the primary limiting factor, constrain the economic and social development in arid inland areas. The Zhangye Basin is a representative area of inland river basins, which is located in the middle parts of the Heihe River watershed, northwestern China. Facing with the huge water shortage, people exploited ground- water at a large scale in recent years. The reducing recharge from surface water and over-exploitation of ground- water led to the decline of groundwater levels and threatened the sustainability of water resources. This study con- structed a conceptual and numerical groundwater flow model and calibrated the model based on the observed wells. A solute transport model was built using MT3DMS to calculate the groundwater age distribution in the Zhangye Basin. The simulated result shows that the youngest groundwater is distributed near the most upstream areas in the model domain, which is less than 1,000 a, older groundwater is distributed in deeper parts of the aquifer and near the discharge outlets, ranging from 6,000 a to over 20,000 a. Spatial variation of groundwater ages in the middle area indicates the recharge diversity between unconfined and confined aquifer. Groundwater age can serve as an indicator to evaluate groundwater's renewal capacity and sustainability. The formation of groundwater resources in the lower stream area would spend 10,000 a or even more than 20,000 a, so exploitation of groundwater in these areas should be restrained. | Heng WEI HongLang XIAO ZhenLiang YIN ZhiXiang LU | 2014 | Journal of Arid Land2014，6，3： | 1 |
| 20 | Obinutuzumab治疗中国B细胞淋巴瘤患者的安全性和有效性:GERSHWIN试验的二次分析显示文摘背景与目的可供复发/难治性B细胞淋巴瘤患者选择的治疗方案很有限。GERSHWIN是一项研究obinutuzumab单药治疗经组织学确认的CD20+复发/难治性慢性淋巴细胞白血病(chronic lymphocytic leukemia,CLL)、弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)或滤泡性淋巴瘤(follicular lymphoma,FL)中国患者的疗效的开放标签、单臂、Ib期研究。先前已经报道了药代动力学的主要结局指标,在本研究中我们将报道次要终点指标(例如安全性、有效性和药效学)。方法在第1疗程的第1、8和15 d以及第2–8疗程的第1 d分别对患者静脉注射1000 mg obinutuzumab(CLL患者的首次给药分2 d进行)。每疗程为21 d,治疗24周。注射至少1次obinutuzumab的所有受试者均被纳入安全性、有效性以及药效学分析。结果共纳入48例(> 18岁)(CLL:12例;DLBCL:23例;FL:13例)患者,入组前接受了中位数为二线的治疗。35例(72.9%)患者出现至少1次不良事件(adverse event,AE)。最常见的AE是输液相关反应(15例;31.3%),其次是发热(11例;22.9%)。有28例(58.3%)患者出现与治疗相关的AE,其中1例死亡(间质性肺病)。治疗结束时(End-of-treatment,EoT)缓解率为33.3%,最佳总缓解率为47.9%。大多数CLL患者在EoT部分缓解(58.3%)。75.0%CLL患者及全部FL和DLBCL患者均出现CD19+减少。结论 Obinutuzumab单药治疗中国B细胞淋巴瘤患者的安全性和有效性与以往非中国患者的研究结果相似,没有观察到新的安全性指标。 | Yan Qin Yuqin Song Zhixiang Shen Xin Du Wei Ji Wanling Hsu Jun Zhu Yuankai Shi | 2019 | 癌症2019，38，2： | 1 |
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