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| 1 | A Regional Ocean Reanalysis System for Coastal Waters of China and Adjacent Seas显示文摘A regional ocean reanalysis system for the coastal waters of China and adjacent seas has been developed by the National Marine Data and Information Service(NMDIS).It produces a dataset package called CORA (China ocean reanalysis).The regional ocean model used is based on the Princeton Ocean Model with a generalized coordinate system(POMgcs).The model is parallelized by NMDIS with the addition of the wave breaking and tidal mixing processes into model parameterizations.Data assimilation is a sequential three-dimensional variational(3D-Var) scheme implemented within a multigrid framework.Observations include satellite remote sensing sea surface temperature(SST),altimetry sea level anomaly(SLA),and temperature/salinity profiles.The reanalysis fields of sea surface height,temperature,salinity,and currents begin with January 1986 and are currently updated every year. Error statistics and error distributions of temperature,salinity and currents are presented as a primary evaluation of the reanalysis fields using sea level data from tidal gauges,temperature profiles,as well as the trajectories of Argo floats.Some case studies offer the opportunity to verify the evolution of certain local circulations.These evaluations show that the reanalysis data produced provide a good representation of the ocean processes and phenomena in the coastal waters of China and adjacent seas. | Guijun Han Wei Li Xuefeng Zhang Dong Li Zhongjie He Xidong Wang Xinrong Wu Ting Yu Jirui Ma | 2011 | Advances in Atmospheric Sciences2011，28，3： | 27 |
| 2 | Advances in longitudinal studies of amnestic mild cognitive impairment and Alzheimer's disease based on multi-modal MRI techniques显示文摘Amnestic mild cognitive impairment(aMCI) is a prodromal stage of Alzheimer's disease(AD), and 75%–80% of aMCI patients fi nally develop AD. So, early identifi cation of patients with aMCI or AD is of great signifi cance for prevention and intervention. According to cross-sectional studies, it is known that the hippocampus, posterior cingulate cortex, and corpus callosum are key areas in studies based on structural MRI(sMRI), functional MRI(fMRI), and diffusion tensor imaging(DTI) respectively. Recently, longitudinal studies using each MRI modality have demonstrated that the neuroimaging abnormalities generally involve the posterior brain regions at the very beginning and then gradually affect the anterior areas during the progression of aMCI to AD. However, it is not known whether follow-up studies based on multi-modal neuroimaging techniques(e.g., sMRI, fMRI, and DTI) can help build effective MRI models that can be directly applied to the screening and diagnosis of aMCI and AD. Thus, in the future, large-scale multi-center follow-up studies are urgently needed, not only to build an MRI diagnostic model that can be used on a single person, but also to evaluate the variability and stability of the model in the general population. In this review, we present longitudinal studies using each MRI modality separately, and then discuss the future directions in this fi eld. | Zhongjie Hu Liyong Wu Jianping Jia Ying Han | 2014 | Neuroscience Bulletin2014，30，2： | 7 |
| 3 | Seismic traveltime inversion of 3D velocity model with triangulated interfaces显示文摘Seismic traveltime tomographic inversion has played an important role in detecting the internal structure of the solid earth. We use a set of blocks to approximate geologically complex media that cannot be well described by layered models or cells. The geological body is described as an aggregate of arbitrarily shaped blocks,which are separated by triangulated interfaces. We can describe the media as homogenous or heterogeneous in each block. We define the velocities at the given rectangle grid points for each block,and the heterogeneous velocities in each block can be calculated by a linear interpolation algorithm. The parameters of the velocity grid positions are independent of the model parameterization,which is advantageous in the joint inversion of the velocities and the node depths of an interface. We implement a segmentally iterative ray tracer to calculate traveltimes in the 3D heterogeneous block models.The damped least squares method is employed in seismic traveltime inversion,which includes the partial derivatives of traveltime with respect to the depths of nodes in the triangulated interfaces and velocities defined in rectangular grids. The numerical tests indicate that the node depths of a triangulated interface and homogeneous velocity distributions can be well inverted in a stratified model. | Fei Li Tao Xu Minghui Zhang Zhenbo Wu Chenglong Wu Zhongjie Zhang Jiwen Teng | 2014 | Earthquake Science2014，27，2： | 5 |
| 4 | Pathological features of COVID-19-associated lung injury:a preliminary proteomics report based on clinical samples显示文摘The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality.However,the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown.To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach,fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia.After virus inactivation,a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues.We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism,blood coagulation,immune response,angiogenesis,and cell microenvironment regulation.Several inflammatory factors were upregulated,which was possibly caused by the activation of NF-κB signaling.Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered.Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection,and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic. | Ling Leng Ruiyuan Cao Jie Ma Danlei Mou Yunping Zhu Wei Li Luye Lv Dunqin Gao Shikun Zhang Feng Gong Lei Zhao Bintao Qiu Haiping Xiang Zhongjie Hu Yingmei Feng Yan Dai Jiang Zhao Zhihong Wu Hongjun Li Wu Zhong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 5 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 6 | Effects of Ta Addition on NiTi Shape Memory Alloys显示文摘The effect of Ta addition on the martensitic transformation characteristics and the X-ray visibility on NiTi shape memory alloy have been studied in (Ni51Ti49)1-x Tax system. It was found that the transformation temperatures of the Ni51Ti49 binary alloy increased drastically by an addition of 0-4 at. pct Ta, but only slightly when the concentration exceeded 4 at. pct, the addition of Ta greatly decreases the sensitivity of the martensitic transformations to the variation in the Ni-Ti ratio. The addition of Ta to the NiTi binary alloy can improve its X-ray visibility. | Jianlu MA, Jiangnan LIU+, Zhengpin WANG and Fei XUE (Dept. of Materials Science & Engineering, Xi’an Institute of Technology, Xi’an 710032, China) Kuang-Hsi WU and Zhongjie PU (Department of Mechanical Engineering, Florida International University, USA) | 2000 | Journal of Materials Science & Technology2000，16，5： | 3 |
| 7 | A radiation-hardened-by-design technique for suppressing SET in charge pump of PLL frequency synthesizer显示文摘This paper presents a single event transient(SET) suppressor circuit,which can suppress the effect of SET in charge pump(CP) on the whole PLL frequency synthesizers,and at the same time it brings little negative effect to the system during normal operation.Because the proposed SET suppressor circuit only includes a resistor,a PMOS and an NMOS device,little area penalty is introduced.By preventing SET propagating from CP to low pass filter(LPF) and VCO when a single event strikes on CP output node,the system shows excellent hardness to SET in CP.Mixed simulations are performed on TCAD workbench.The results show that a single event with an LET at 80 MeV cm 2 /mg can only induce approximately 2.3 mV disturbance on the control voltage of VCO. | HAN BenGuang GUO ZhongJie WANG XiHu WU LongSheng LIU YouBao | 2013 | Science China(Technological Sciences)2013，56，2： | 2 |
| 8 | National Alveolar Echinococcosis Distribution--China, 2012−2016显示文摘What is already known about this topic?Both alveolar echinococcosis(AE)and cystic echinococcosis are endemic in China,among which alveolar echinococcosis has a very high mortality rate.What is added by this report?The survey results showed the prevalence and scope of AE in China and identified high-risk groups including children,monks,herdsmen and illiterate people.At the same time,all the cases found in the survey(more than 90%of the patients did not go to the hospital for diagnosis and treatment before survey)were promptly diagnosed and treated.What are the implications for public health practice?This study provides information for the development of a plan for AE prevention and control and for the implementation of interventions targeted to high-risk populations. | Canjun Zheng Chuizhao Xue Shuai Han Zhongjie Li Hu Wang Liying Wang Ying Wang Qian Wang Yu Feng Yanyan Hou Xiao Ma Junying Ma Xiumin Han Gongsang Quzhen Xiaofeng Jiang Weidong Guo Xianglin Wu Yaming Yang Lei Cao Fanka Li Weiqi Chen Xinliu Yan Shicheng Yu Meihua Fu Qing Yu Ning Xiao Jiangping Cao Jun Yan Weiping Wu Xiao-nong Zhou | 2020 | China CDC weekly2020，2，1： | 2 |
| 9 | Inhibition of hepatitis B virus gene expression and replication by endoribonuclease-prepared siRNA显示文摘 | Zhongji Meng Yang Xu Jun Wu Yongjun Tian Thekla Kemper Barbara Bleekmann Micheal Roggendorf Dongliang Yang Mengji Lu | 2008 | Journal of Virological Methods2008，，1： | 1 |
| 10 | Heavy rainfall triggered loess-mudstone landslide and subsequent debris flow in Tianshui, China显示文摘 | Peng Jianbing Fan Zhongjie Wu Di | 2015 | Engineering Geology2015，186，： | 1 |
| 11 | Structural variation and parallel evolution of apomixis in citrus during domestication and diversification显示文摘Apomixis,or asexual seed formation,is prevalent in Citrinae via a mechanism termed nucellar or adventitious embryony.Here,multiple embryos of a maternal genotype form directly from nucellar cells in the ovule and can outcompete the developing zygotic embryo as they utilize the sexually derived endosperm for growth.Whilst nucellar embryony enables the propagation of clonal plants of maternal genetic constitution,it is also a barrier to effective breeding through hybridization.To address the genetics and evolution of apomixis in Citrinae,a chromosome-level genome of the Hongkong kumquat(Fortunella hindsii)was assembled following a genome-wide variation map including structural variants(SVs)based on 234 Citrinae accessions.This map revealed that hybrid citrus cultivars shelter genome-wide deleterious mutations and SVs into heterozygous states free from recessive selection,which may explain the capability of nucellar embryony in most cultivars during Citrinae diversification.Analyses revealed that parallel evolution may explain the repeated origin of apomixis in different genera of Citrinae.Within Fortunella,we found that apomixis of some varieties originated via introgression.In apomictic Fortunella,the locus associated with apomixis contains the FhRWP gene,encoding an RWP-RK domain-containing protein previously shown to be required for nucellar embryogenesis in Citrus.We found the heterozygous SV in the FhRWP and CitRWP promoters from apomictic Citrus and Fortunella,due to either two or three miniature inverted transposon element(MITE)insertions.A transcription factor,FhARID,encoding an AT-rich interaction domain-containing protein binds to the MITEs in the promoter of apomictic varieties,which facilitates induction of nucellar embryogenesis.This study provides evolutionary genomic and molecular insights into apomixis in Citrinae and has potential ramifications for citrus breeding. | Nan Wang Xietian Song Junli Ye Siqi Zhang Zhen Cao Chenqiao Zhu Jianbing Hu Yin Zhou Yue Huang Shuo Cao Zhongjie Liu Xiaomeng Wu Lijun Chai Wenwu Guo Qiang Xu Brandon S.Gaut Anna M.G.Koltunow Yongfeng Zhou Xiuxin Deng | 2022 | National Science Review2022，9，10： | 1 |
| 12 | An Improved Global Shutter Pixel with Extended Output Range and Linearity of Compensation for CMOS Image Sensor显示文摘An improved global shutter pixel structure with extended output range and linearity of compensation is proposed for CMOS image sensor. The potential switching of the sample and hold capacitor bottom plate outside the array is used to solve the problem of the serious swing limitation, which will attenuate the dynamic range of the image sensor. The non-linear problem caused by the substrate bias effect in the output process of the pixel source follower is solved by using the mirror FD point negative feedback self-establishment technology outside the array. The approach proposed in this paper has been verified in a global shutter CMOS image sensor with a scale of 1024×1024 pixels. The test results show that the output range is expanded from 0.95 V to 2 V, and the error introduced by the nonlinearity is sharply reduced from280 mV to 0.3 mV. Most importantly, the output range expansion circuit does not increase the additional pixel area and the power consumption. The power consumption of linearity correction circuit is only 23.1μW, accounting for less than 0.01% of the whole chip power consumption. | GUO Zhongjie YU Ningmei WU Longsheng | 2021 | Chinese Journal of Electronics2021，30，1： | 1 |
| 13 | Optimal-Setting Control for Complicated Industrial Processes and its Application Study 显示文摘 | Zhongjie Wang Qidi Wu Tianyou Chai | 2004 | Control Engineering Practice (S0967-0661)2004，12，1： | 1 |
| 14 | Inhibition of woodchuck hepatitis virus gene expression in primary hepatocytes by siRNA enhances the cellular gene expression显示文摘 | Zhongji Meng Song Qiu Xiaoyong Zhang Jun Wu Thomas Schreiter Yang Xu Dongliang Yang Michael Roggendorf J?rg Schlaak Mengji Lu | 2008 | Virology2008，，1： | 1 |
| 15 | Research on Column FPN and Black Level Calibration in Large Array CMOS Image Sensor显示文摘A technical investigation,research and implementation is presented to correct column fixed pattern noise and black level in large array Complementary metal oxide semiconductor(CMOS)image sensor.Through making a comparison among reported solution,and give large array CMOS image sensor design and considerations,according to our previous analysis on non-ideal factor and error source of piecewise Digital to analog converter(DAC)in multi-channels,an improving accurate piecewise DAC with adaptive switch technique is developed.The research theory has verified by a high dynamic range and low column Fixed pattern noise(FPN)CMOS image sensor prototype chip,which consisting of 8320×8320 pixel array was designed and fabricated in 55 nm CMOS 1P4M standard process.The chip active area is 48 mm×48 mm with a pixel size of 5.7μm×5.7μm.The measured results achieved a high intrinsic dynamic range of 75 d B,a low FPN and black level of 0.06%,a low photo response non-uniformity of 1.5%respectively,and an excellent raw sample image taken by the prototype sensor. | GUO Zhongjie YU Ningmei WU Longsheng | 2021 | Chinese Journal of Electronics2021，30，2： | 1 |
| 16 | A Self‑Powered,Highly Embedded and Sensitive Tribo‑Label‑Sensor for the Fast and Stable Label Printer显示文摘Label-sensor is an essential component of the label printer which is becoming a most significant tool for the development of Internet of Things(IoT).However,some drawbacks of the traditional infrared label-sensor make the printer fail to realize the high-speed recognition of labels as well as stable printing.Herein,we propose a selfpowered and highly sensitive tribo-label-sensor(TLS)for accurate label identification,positioning and counting by embedding triboelectric nanogenerator into the indispensable roller structure of a label printer.The sensing mechanism,device parameters and deep comparison with infrared sensor are systematically studied both in theory and experiment.As the results,TLS delivers 6 times higher signal magnitude than traditional one.Moreover,TLS is immune to label jitter and temperature variation during fast printing and can also be used for transparent label directly and shows long-term robustness.This work may provide an alternative toolkit with outstanding advantages to improve current label printer and further promote the development of IoT. | Xindan Hui Zhongjie Li Lirong Tang Jianfeng Sun Xingzhe Hou Jie Chen Yan Peng Zhiyi Wu Hengyu Guo | 2023 | Nano-Micro Letters2023，15，2： | 1 |
| 17 | , Coral reef degradation and metabolic performance of the scleractinan coral Porites lutea under anthropogenic impact along the NE coast of Hainan Island, South China Sea显示文摘 | Cornelia Roder Zhongjie Wu Claudio Richter | 2013 | Continental Shelf Research2013，57，： | 1 |
| 18 | Hepatitis B virus suppresses toll‐like receptor–mediated innate immune responses in murine parenchymal and nonparenchymal liver cells显示文摘 | Jun Wu Zhongji Meng Min Jiang Rongjuan Pei Martin Trippler Ruth Broering Agnes Bucchi Jan‐Peter Sowa Ulf Dittmer Dongliang Yang Michael Roggendorf Guido Gerken Mengji Lu Joerg F. Schlaak | 2009 | Hepatology2009，，： | 1 |
| 19 | Inhibition of hepatitis B virus gene expression and replication by endoribonucleaseprepared siRNA显示文摘 | Meng Zhongji Xu Yang Wu Jun | 2008 | J Virol Methods2008，150，2008： | 1 |
| 20 | Inhibition of hepatitis B virus gene expression and replication by endoribonuclease-prepared siRNA显示文摘 | Zhongji Meng Yang Xu Jun Wu Yongjun Tian Thekla Kemper Barbara Bleekmann Micheal Roggendorf Dongliang Yang Mengji Lu | 2008 | Journal of Virological Methods2008，，1： | 1 |
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