|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A Regional Ocean Reanalysis System for Coastal Waters of China and Adjacent Seas显示文摘A regional ocean reanalysis system for the coastal waters of China and adjacent seas has been developed by the National Marine Data and Information Service(NMDIS).It produces a dataset package called CORA (China ocean reanalysis).The regional ocean model used is based on the Princeton Ocean Model with a generalized coordinate system(POMgcs).The model is parallelized by NMDIS with the addition of the wave breaking and tidal mixing processes into model parameterizations.Data assimilation is a sequential three-dimensional variational(3D-Var) scheme implemented within a multigrid framework.Observations include satellite remote sensing sea surface temperature(SST),altimetry sea level anomaly(SLA),and temperature/salinity profiles.The reanalysis fields of sea surface height,temperature,salinity,and currents begin with January 1986 and are currently updated every year. Error statistics and error distributions of temperature,salinity and currents are presented as a primary evaluation of the reanalysis fields using sea level data from tidal gauges,temperature profiles,as well as the trajectories of Argo floats.Some case studies offer the opportunity to verify the evolution of certain local circulations.These evaluations show that the reanalysis data produced provide a good representation of the ocean processes and phenomena in the coastal waters of China and adjacent seas. | Guijun Han Wei Li Xuefeng Zhang Dong Li Zhongjie He Xidong Wang Xinrong Wu Ting Yu Jirui Ma | 2011 | Advances in Atmospheric Sciences2011，28，3： | 27 |
| 2 | Isoliquiritigenin inhibits TGF-β1-induced fibrogenesis through activating autophagy via PI3K/AKT/mTOR pathway in MRC-5 cells显示文摘Isoliquiritigenin(ISL),a natural flavonoid derived from the root of liquorice,has been reported to possess anti-inflammatory and antioxidant activities.Previous studies have found that ISL plays a crucial role in anti-fibrosis of adipose tissue and renal tissue;however,its effect on pulmonary fibrogenesis has not been demonstrated.In this study,we aimed to explore the roles and the underlying mechanisms of ISL in TGF-β1-induced fibrogenesis using human lung fibroblast-derived MRC-5 cells.Cell proliferation and migration were determined by MTT and wound healing assay,respectively.The expression levels of alpha-smooth muscle actin(α-SMA),collagen type I alpha 1(COLIA1)and fibronectin(FN),microtubule-associated protein light chain 3(LC3)and related signaling molecules were detected by quantitative real-time PCR,western blot and immunofluorescence assay,correspondingly.EGFP-LC3 transfection was used for autophagy analysis.The results showed that ISL inhibited the TGF-β1-induced proliferation and migration,and down-regulated the expressions ofα-SMA,COLIA1 and FN.ISL treatment led to up-regulation of LC3 in TGF-β1-treated MRC-5 cells,accompanied by significant decrease in the phosphorylation levels of phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),and mammalian target of rapamycin(mTOR).In addition,the inhibitory effects of ISL on TGF-β1-induced fibrogenic features in MRC-5 cells were enhanced by pretreatment with autophagy activator Rapmycin and PI3K/AKT inhibitor LY294002 and reversed by autophagy inhibitor 3-methyladenine and PI3K/AKT activator IGF-1.Taken together,our results demonstrated that ISL could attenuate the fibrogenesis of TGF-β1-treated MRC-5 cells by activating autophagy via suppressing the PI3K/AKT/mTOR pathway.Therefore,ISL holds a great potential to be developed as a novel therapeutic agent for the treatment of pulmonary fibrosis. | Jinjuan He Hao Peng Meifang Wang Ying Liu Xingrong Guo Bin Wang Longjun Dai Xueqin Cheng Zhongji Meng Leyong Yuan Fenglin Cai Yijun Tang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 16 |
| 3 | Ultrafast all-optical terahertz modulation based on an inverse-designed metasurface显示文摘Metasurface plays a key role in various terahertz metadevices,while the designed terahertz metasurface still lacks flexibility and variety.On the other hand,inverse design has drawn plenty of attention due to its flexibility and robustness in the application of photonics.This provides an excellent opportunity for metasurface design as well as the development of multifunctional,high-performance terahertz devices.In this work,we demonstrate that,for the first time,a terahertz metasurface supported by the electromagnetically induced transparency(EIT)effect can be constructed by inverse design,which combines the particle swarm optimization algorithm with the finite-difference time-domain method.Incorporating germanium(Ge)film with inverse-designed metasurface,an ultrafast EIT modulation on the picosecond scale has been experimentally verified.The experimental results suggest a feasibility to build the terahertz EIT effect in the metasurface through an optimization algorithm of inverse design.Furthermore,this method can be further utilized to design multifunctional and high-performance terahertz devices,which is hard to accomplish in a traditional metamaterial structure.In a word,our method not only provides a novel way to design an ultrafast all-optical terahertz modulator based on artificial metamaterials but also shows the potential applications of inverse design on the terahertz devices. | WEIBAO HE MINGYU TONG ZHONGJIE XU YUZE HU XIANG’AI CHENG TIAN JIANG | 2021 | Photonics Research2021，9，6： | 4 |
| 4 | Platinum-Group Element Geochemical Characteristics of the Picrites and High-Ti Basalts in the Binchuan Area,Yunnan Province显示文摘云南的 Binchuan 区域在扬采·布洛克的西方的边缘位于 Emeishan 大火的省的西方的部分。在现在的学习,在大约 1440 m 的厚度的 Wuguiqing 侧面主要由 high-Ti 暗岩组成,与未成年者一起在在辉石有的上面的部分的更低的部分和安山岩, trachytes ,和流纹岩的辉石相对更高的铂组元素( PGE )内容( PGE=16.328.2 ppb ),与高 Cu/Zr 和 Pd/Zr 比率,和低 S 内容( 5.0316.9 ppm ),显示父母岩浆由 Emeishan 大火的省的部分融化的高度S不饱和、产生( ELIP 稍微高的 Cu/Pd 比率(11 00024 000 ) 相对原始披风的建议 0.007% 硫化物在披风来源被保留了。high-Ti 暗岩的 PGE 内容展出一个更宽的范围(PGE=0.51730.8 ppb ) 。在中间、上面的部分的样品在 PGE 被弄空并且有 Nd ( 260 妈)比率从 2.8~2.2 ,在上升触发的硫浸透和大约0.446%0.554%硫化物的分离期间建议父母岩浆的那外壳的污染,并且硫化物分离过程可以也为存款关上到学习暗岩的 magmatic Cu-Ni-PGE 硫化物提供形成矿石的材料。在这区域表演 Pt-Pd 的样品打原始使披风正常化的 PGE 模式,和 Pd/Ir 比率比原始披风( Pd/Ir=1 )的高,显示在红外组铂组元素( IPGE )和Pd组铂组元素( PPGE )之间的明显的区别被橄榄石或铬铁矿分别主要在岩浆进化期间控制。大多数样品的 Pd/Pt 比率比披风(Pd/Pt=0.55 ) 的平均比率高,证明区别发生在磅和 Pd 之间。在辉石的区别可能与在披风在分离倔强的磅合金阶段招待的磅相关;而在 high-Ti 暗岩的区别可能与 Fe 磅合金的分别被联系,与 Ir-Ru-Os 合金一同沉淀。一些 high-Ti 暗岩样品展出否定 Ru 异例,可能由早使结晶的铬铁矿由于 laurite 的移动收集了。 | BAI Mei ZHONG Hong ZHU Weiguang BAI Zhongjie HE Defeng | 2013 | Acta Geologica Sinica(English Edition)2013，87，1： | 3 |
| 5 | Improvement of short-term forecasting in the northwest Pacific through assimilating Argo data into initial fields显示文摘在温度和咸度的短期的预报精确性上吸收南船座数据进起始的域的影响是使用西方的诺思太平洋的一个预报系统估计的份量上,在有一个概括坐标系统(POMgcs ) 的普林斯顿海洋模型的库上。这个系统使用顺序的 multigrid 三维变化(3DVAR ) 吸收观察数据的分析计划。二个数字实验在吸收数据进起始的域的进程除常规温度和海表面温度(SST ) 以外有或没有南船座温度和咸度侧面数据被进行。预报错误被在预报时期期间使用独立温度和咸度侧面估计,包括水平地平均的根均方差( H-RMSEs )的垂直分布和垂直地平均的吝啬的错误( MEs )和空间地平均的根均方差( S-RMSEs )的时间的变化的水平分布。在二个实验之间的比较证明南船座数据的吸收显著地改进预报精确性,与为温度,和咸度最大的 H-RMSE 的 24% 减小预报更显然被改进,平均深入地比 300 m 浅的为 H-RMSEs 50% 落下。如此的改进被温度和咸度的相对一致的采样在时空从南船座流浪者引起。 | FU Hongli CHU Peter C HAN Guijun HE Zhongjie LI Wei ZHANG Xuefeng | 2013 | Acta Oceanologica Sinica2013，32，7： | 2 |
| 6 | Enrichment of Platinum-group Elements(PGE) and Re-Os Isotopic Tracing for Porphyry Copper(Gold) Deposits显示文摘Platinum-group elements(PGE) in PGE-rich porphyry copper(gold) deposits are mainly Pt and Pd,whereas the concentrations of other PGE(Ru,Rh,Os,Ir) are significantly low.Moreover,Pt and Pd mainly exist in sulfides in the forms of crystal lattice or tiny platinum-group mineral(PGM) inclusions.The present data show that there is a positive relationship between Pt and Pd concentrations and Cu(Au) in porphyry copper(gold) deposits.The comparison of chondritenormalized PGE distribution patterns between the ore-bearing porphyry intrusions and ore-barren porphyry intrusions in arc setting,187Os/188 Os,87Sr/86 Sr and S isotopes for porphyry copper(gold) deposits shows that PGEs were mainly derived from the mantle,and fluids from subduction zones devoted trivial PGE to the magma.The porphyry copper(gold) deposits associated with subducted events are most probably enriched in PGE,whereas those related to crustal thickening,lithospheric delamination or underplating rarely concentrate PGE.The osmium isotopic compositions in porphyry copper(gold) deposits reveal that(187Os/188Os)i values are highly variable and not lower than those of primitive upper mantle(PUM) and mantle peridotite,however,osmium concentrations are commonly lower than mantle peridotite,suggesting that parental magmas of some porphyry intrusions had experienced crustal contamination during magma evolution.Experimental investigations have proved that PGE exist in the forms of Cl- and HS- complexes during transportation and migration of the oreforming fluids.This paper summarizes previous studies including crucial controlling factors and mechanisms for PGE enrichment,and points out that the mantle-derived magmas parental to porphyry intrusions are the prerequisite for PGE enrichment in porphyry copper(gold) deposits.Favorable physical and chemical conditions(including salinity,temperature,pressure,pH,and oxygen fugacity) in hydrothermal fluids crucially control the PGE enrichment,and sulfur concentrations of melts play important roles in this process as well. | HE Xiaohu ZHONG Hong ZHU Weiguang BAI Zhongjie HU Wenjun | 2014 | Acta Geologica Sinica(English Edition)2014，88，4： | 2 |
| 7 | Application of the Multigrid Data Assimilation Scheme to the China Seas’ Temperature Forecast显示文摘 | Li Wei Xie Yuanfu He Zhongjie Han Guijun Liu Kexiu Ma Jirui Li Dong | 2008 | Journal of Atmospheric and Oceanic Technology2008，，11： | 1 |
| 8 | Application of wind profiler data to rainfall analyses in Tazhong Oilfield region,Xinjiang,China显示文摘To improve the level of meteorological service for the Oilfield region in the Taklimakan Desert,the Urumqi Institute of Desert Meteorology of the China Meteorological Administration(CMA) conducted a detection experiment by means of wind profiling radar(WPR) in Tazhong Oilfield region of Xinjiang,China in July 2010.By using the wind profiler data obtained during the rainfall process on 27 July,this paper analyzed the wind field features and some related scientific issues of this weather event.The results indicated that:(1) wind profiler data had high temporal resolution and vertical spatial resolution,and could be used to analyze detailed vertical structures of rainfall processes and the characteristics of meso-scale systems.Before and after the rain event on 27 July,the wind field showed multi-layer vertical structures,having an obvious meso-scale wind shear line and three airflows from different directions,speeding up the motion of updraft convergence in the lower atmosphere.Besides,the wind directions before and after the rainfall changed inversely with increasing height.Before the rain,the winds blew clockwise,but after the onset of the rain,the wind directions became counterclockwise mainly;(2) the temperature advection derived from wind profiler data can reproduce the characteristics of low-level thermodynamic evolution in the process of rainfall,which is capable to reflect the variation trend of hydrostatic stability in the atmosphere.In the early stage of the precipitation on 27 July,the lower atmosphere was mainly affected by warm advection which had accumulated unstable energy for the rainfall event and was beneficial for the occurrence of updraft motion and precipitation;(3) the 'large-value zone' of the radar reflectivity factor Z was virtually consistent with the onset and end of the rainfall,the height for the formation of rain cloud particles,and precipitation intensity.The reflectivity factor Z during this event varied approximately in the range of 18-38 dBZ and the rain droplets formed mainly at the layer of 3,800-4,500 m. | MinZhong WANG WenShou WEI Qing HE XinChun LIU ZhongJie ZHAO | 2012 | Journal of Arid Land2012，4，4： | 1 |
| 9 | Application of the Sequential Three-Dimensional Variational Method to Assimilating SST in a Global Ocean Model显示文摘 | He Zhongjie Xie Yuanfu Li Wei Li Dong Han Guijun Liu Kexiu Ma Jirui | 2008 | Journal of Atmospheric and Oceanic Technology2008，，6： | 1 |
| 10 | Validation of a method of estimating age,modeling growth,and describing the age composition of Coilia mystus from the Yangtze Estuary,China显示文摘 | HE Wenping LI Zhongjie LIU Jiashou | 2008 | ICES Journal of Marine Science2008，，65： | 1 |
| 11 | Applica- tion of the sequential three-dimensional variational method to assimilating SST in a global ocean model 显示文摘 | HE Zhongjie XIE Yuanfu LI Dong | 2008 | Journal of Atmospheric and Oceanic Technology2008，25，6： | 1 |
| 12 | Application of the Multigrid Data Assimilation Scheme to the China Seas’ Temperature Forecast显示文摘 | Li Wei Xie Yuanfu He Zhongjie Han Guijun Liu Kexiu Ma Jirui Li Dong | | Journal of Atmospheric and Oceanic Technology0，，： | 1 |
| 13 | Application of the Sequential Three-Dimensional Variational Method to Assimilating SST in a Global Ocean Model显示文摘 | He Zhongjie Xie Yuanfu Li Wei Li Dong Han Guijun Liu Kexiu Ma Jirui | | Journal of Atmospheric and Oceanic Technology0，，： | 1 |
| 14 | A novel intelligent gear fault diagnosis model based on EMD and multi-class TSVM显示文摘 | Zhongjie Shen Xuefeng Chen Xiaoli Zhang Zhengjia He | 2011 | Measurement2011，，1： | 1 |
| 15 | Au23(CR)14 nanocluster restores fibril Aβ’s unfolded state with abolished cytotoxicity and dissolves endogenous Aβplaques显示文摘The misfolding of amyloid-β(Aβ)peptides from the natural unfolded state toβ-sheet structure is a critical step,leading to abnormal fibrillation and formation of endogenous Aβplaques in Alzheimer’s disease(AD).Previous studies have reported inhibition of Aβfibrillation or disassembly of exogenous Aβfibrils in vitro.However,soluble Aβoligomers have been reported with increased cytotoxicity;this might partly explain why current clinical trials targeting disassembly of Aβfibrils by anti-Aβantibodies have failed so far.Here we show that Au23(CR)14(a new Au nanocluster modified by Cys-Arg(CR)dipeptide)is able to completely dissolve exogenous mature Aβfibrils into monomers and restore the natural unfolded state of Aβpeptides from misfoldedβ-sheets.Furthermore,the cytotoxicity of Aβ40 fibrils when dissolved by Au23(CR)14 is fully abolished.More importantly,Au23(CR)14 is able to completely dissolve endogenous Aβplaques in brain slices from transgenic AD model mice.In addition,Au23(CR)14 has good biocompatibility and infiltration ability across the blood–brain barrier.Taken together,this work presents a promising therapeutics candidate for AD treatment,and manifests the potential of nanotechnological approaches in the development of nanomedicines. | Wenkang Zhang Guanbin Gao Zhongjie Ma Zhuoying Luo Meng He Taolei Sun | 2020 | National Science Review2020，7，4： | 0 |
| 16 | Tonian Tectonic-Strata Regions and their Geological Significance in China显示文摘The continent of China developed through the coalescence of three major cratons(North China, Tarim and Yangtze) and continental micro-blocks through the processes of oceanic crust disappearance and acceretionary-collision of continental crusts. The strata of the Chinese continental landmass are subdivided into 12 tectonic-strata regions. Based on the composition of geological features among the three main cratons, continental micro-blocks and other major global cratons, their affinities can be preliminarily deduced during the Tonian period, using evidence from sedimentary successions, paleobiogeography, tectonic and magmatic events. The Yangtze and Tarim cratons show that they have close affinities during the assembly-dispersal milestone of the Rodinia Supercontinent. The sedimentary record and magmatic age populations in the blocks suggest that there was a widespread, intensive magmatic event that resulted from a subduction process during ~1000–820 Ma, related to continental rifting around the Yangtze and Tarim cratons. However, they differ greatly from the North China Craton. The continental micro-blocks in the Panthalassic Ocean could have some missing connection with the North China Craton that persisted until the Middle-Late Devonian. In contrast, the Alxa Block showed a strong affinity with the Tarim Craton. The revised Tonian paleogeography of the Rodinia Supercontinent is a good demonstration of how to show the relationship between the main cratons and the continental micro-blocks. | XU Yadong ZHANG Kexin HE Weihong YU Yang KOU Xiaohu SONG Bowen LUO Mansheng WANG Lijun MA Zhongjie YANG Fengli | 2020 | Acta Geologica Sinica(English Edition)2020，94，4： | 0 |
| 17 | Characteristics ofβ-type Ti-41Nb alloy produced by laser powder bed fusion:Microstructure,mechanical properties and in vitro biocompatibility显示文摘Aβ-type Ti-41 Nb alloy with high relative density has been successfully fabricated by laser powder bed fusion(L-PBF)using pre-alloyed powders for potential implant application.The homogeneous microstructure can be achieved in L-PBF fabricated(L-PBFed)Ti-41 Nb alloy but slight composition segregation was detected along molten pool boundaries.The L-PBFed alloy was dominated by typical epitaxial columnar grains with strong(001)grain orientation along building direction(BD),and cellular structure was distinguished within the columnar grains.The main reasons for this microstructure can be attributed to effective thermal gradient and epitaxial growth.L-PBFed alloy exhibited higher mechanical strength compared with cold rolling plus annealing(CRA)alloy due to the finer grains,dislocations accumulation and different TRIP behaviors,accompanied by good ductility.It also exhibited much lower thermal conductivity and better hydrophilic feature than those of CP-Ti.Besides,the L-PBFed alloy exhibited slightly better cell spread and cell proliferation rates compared with CP-Ti.Moreover,L-PBFed alloy presented better alkaline phosphatase(ALP)activities and extracellular matrix(ECM)mineralization,which suggests that the L-PBFed alloy can stimulate the osteogenic differentiation of rat bone mesenchymal stem cells.The Ti-41 Nb alloy,fabricated by L-PBF,reveals a good combination of mechanical properties,physicochemical properties and biocompatibility,exhibiting the great potential as the dental implant. | Zhongjie Li Jiajun Qiu Hao Xu Anping Dong Lin He Guoliang Zhu Dafan Du Hui Xing Xuanyong Liu Baode Sun | 2022 | Journal of Materials Science & Technology2022，，29： | 0 |
| 18 | Newcastle disease virus suppresses antigen presentation via inhibiting IL-12 expression in dendritic cells显示文摘As a potential vectored vaccine,Newcastle disease virus(NDV)has been subject to various studies for vaccine development,while relatively little research has outlined the immunomodulatory effect of the virus in antigen presentation.To elucidate the key inhibitory factor in regulating the interaction of infected dendritic cells(DCs)and T cells,DCs were pretreated with the NDV vaccine strain LaSota as an inhibitor and stimulated with lipopolysaccharide(LPS)for further detection by enzyme-linked immunosorbent assay(ELISA),flow cytometry,immunoblotting,and quantitative real-time polymerase chain reaction(qRT-PCR).The results revealed that NDV infection resulted in the inhibition of interleukin(IL)-12p40 in DCs through a p38 mitogen-activated protein kinase(MAPK)-dependent manner,thus inhibiting the synthesis of IL-12p70,leading to the reduction in T cell proliferation and the secretion of interferon-(IFN-),tumor necrosis factor-α(TNF-α),and IL-6 induced by DCs.Consequently,downregulated cytokines accelerated the infection and viral transmission from DCs to T cells.Furthermore,several other strains of NDV also exhibited inhibitory activity.The current study reveals that NDV can modulate the intensity of the innate-adaptive immune cell crosstalk critically toward viral invasion improvement,highlighting a novel mechanism of virus-induced immunosuppression and providing new perspectives on the improvement of NDV-vectored vaccine. | Fulong NAN Wenlong NAN Xin YAN Hui WANG Shasha JIANG Shuyun ZHANG Zhongjie YU Xianjuan ZHANG Fengjun LIU Jun LI Xiaoqiong ZHOU Delei NIU Yiquan LI Wei WANG Ning SHI Ningyi JIN Changzhan XIE Xiaoni CUI He ZHANG Bin WANG Huijun LU | 2024 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2024，25，3： | 0 |
| 19 | Constructing bimodal nanoprobe based on Gd:AgInS_(2)/ZnS quantum dots for fluorometric/magnetic resonance imaging in mesenchymal stem cells显示文摘Mesenchymal stem cells(MSCs)hold great promise in regenerative medicine and received overwhelm-ing concerns to promote their therapeutic effects.Owing to the shortage of MSCs-specific biomarkers,bimodal imaging nanoprobes with integrated complementary information are of great importance in ameliorating the efficacy of MSCs terminal tracking.In this study,a noninvasive dual-mode imaging nanoprobe with enhanced detection sensitivity and spatial resolution based on alloyed Gd:AgInS_(2)/ZnS quantum dots(QDs)was first fabricated through a microwave-assisted heating method.The QDs with red emissive fluorescence exhibit excellent biocompatibility in MSCs under a confocal microscope.As for magnetic resonance imaging(MRI),the longitudinal relaxation rate of 11.1420 mM^(-1) S^(-1) of Gd:AgInS_(2)/ZnS QDs was achieved,which was 1.7 times higher than that of commercial MRI contrast agent(6.4667 mM^(-1) S^(-1)).Furthermore,the cellular internalization of Gd:AgInS_(2)/ZnS QDs exerts no significant effect on the adipogenesis of MSCs and is conducive to the observation of further adipogenic differentiation.Our work helps to verify the promising prospect to develop a bimodal nanoprobe of fluorescence/MRI based on Gd:AgInS_(2)/ZnS QDs,which could monitor the differentiation and migration of MSCs for further therapeu-tic approach. | Dan Yang Xian Wei Zhiyan Piao Zhongjie Cui Haiyang He Zhuoqi Wen Wanlu Zhang Le Wang Shiliang Mei Ruiqian Guo | 2023 | Journal of Materials Science & Technology2023，，17： | 0 |
| 20 | Dynamic Logic in Control显示文摘Dynamic Logic in ControlHeWeidong,YuXinyao,ChenZhongji&ZhangMinglian(Dept.ofAutomaticControlofBeijingUni.ofAero.&Astro.,Beiji... | He, Weidong Yu, Xinyao Chen, Zhongji Zhang, Minglian | 1994 | Journal of Systems Engineering and Electronics1994，5，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员