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| 1 | Saponins from Panax japonicus attenuate age-related neuroinflammation via regulation of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways显示文摘Neuroinflammation is recognized as an important pathogenic factor for aging and related cognitive disorders. Mitogen-activated protein kinase and nuclear factor kappa B signaling pathways may mediate neuroinflammation. Saponins from Panax japonicus are the most abundant and bioactive members in rhizomes of Panax japonicus, and show anti-inflammatory activity. However, it is not known whether saponin from Panax japonicus has an anti-inflammatory effect in the aging brain, and likewise its underlying mechanisms. Sprague-Dawley rats were divided into control groups(3-, 9-, 15-, and 24-month-old groups) and saponins from Panax japonicus-treated groups. Saponins from Panax japonicus-treated groups were orally administrated saponins from Panax japonicus at three doses of 10, 30, and 60 mg/kg once daily for 6 months until the rats were 24 months old. Immunohistochemical staining and western blot assay results demonstrated that many microglia were activated in 24-month-old rats compared with 3-and 9-month-old rats. Expression of interleukin-1β, tumor necrosis factor-α, cyclooxygenase-2, and inducible nitric oxide synthase increased. Each dose of saponins from Panax japonicus visibly suppressed microglial activation in the aging rat brain, and inhibited expression levels of the above factors. Each dose of saponins from Panax japonicus markedly diminished levels of nuclear factor kappa B, IκBα, extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38. These results confirm that saponins from Panax japonicus can mitigate neuroinflammation in the aging rat brain by inhibition of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways. | Li-li Deng Ding Yuan Zhi-yong Zhou Jing-zhi Wan Chang-cheng Zhang Chao-qi Liu Yao-yan Dun Hai-xia Zhao Bo Zhao Yuan-jian Yang Ting Wang | 2017 | Neural Regeneration Research2017，12，11： | 17 |
| 2 | Genetic analysis and molecular mapping of a presenescing leaf gene psll in rice (Oryza sativa L.)显示文摘A rice psl1 (presenescing leaf) mutant was obtained from a japonica variety Zhonghua 11 via radiation of 60Co-γ in M2 generation. Every leaf of the mutant began to wither after it reached the big-gest length,while the leaves of the wild variety could keep green for 25―35 d. In this study,genetic analysis and gene mapping were carried out for the mutant identified. The SSR marker analysis showed that the mutant was controlled by a single recessive gene (psl1) located on chromosome 2. Fine mapping of the psl1 locus was conducted with 34 new STS markers developed around psl1 anchored region based on the sequence diversity between Nippon-bare and 93-11. The psl1 was further mapped be-tween two STS markers,STS2-19 and STS2-26,with genetic distances of 0.43 and 0.11 cM,respectively,while cosegregated with STS2-25. A BAC contig was found to span the psl1 locus,the region being delim-ited to 48 kb. This result was very useful for cloning of the psl1 gene. | WANG dun WU Shujun ZHOU Yong ZHOU Lihui XU Jiefen HU Jing FANG Yunxia GU Minghong LIANG Guohua | 2006 | Chinese Science Bulletin2006，51，24： | 16 |
| 3 | Jittor:a novel deep learning framework with meta-operators and unified graph execution显示文摘This paper introduces Jittor,a fully just-in-time(JIT)compiled deep learning framework.With JIT compilation,we can achieve higher performance while making systems highly customizable.Jittor provides classes of Numpy-like operators,which we call meta-operators.A deep learning model built upon these meta-operators is compiled into high-performance CPU or GPU code in real-time.To manage metaoperators,Jittor uses a highly optimized way of executing computation graphs,which we call unified graph execution.This approach is as easy to use as dynamic graph execution yet has the efficiency of static graph execution.It also provides other improvements,including operator fusion,cross iteration fusion,and unified memory. | Shi-Min HU Dun LIANG Guo-Ye YANG Guo-Wei YANG Wen-Yang ZHOU | 2020 | Science China(Information Sciences)2020，63，12： | 10 |
| 4 | Changes of splenic macrophage during the process of liver cancer induced by diethylnitrosamine in rats显示文摘它通常是的背景相信那口怒气在肿瘤免疫起一个复杂作用,它将在癌症的不同时期变化。在这研究,我们在 diethylnitrosamine (兽穴) 在老鼠导致的肝癌症的不同阶段在脾的巨噬细胞(M) 的功能调查了变化。目的是支持特征“双向”并且在肿瘤 immunity.Methods 的怒气的“阶段”肝癌症的肺的转移的模型被兽穴在四十只男 SD 老鼠建立。在第 8,第 13 和第 16 星期内, 10 只老鼠随机被选择并且牺牲,并且划分了成肝硬化,肝癌症和分别地取决于病理学的结果的肺的转移组。另外的 10 只老鼠作为控制组被拿。M 被抛锚的耕作孤立。在超微结构,吞噬作用, cytokine 分泌物,处理并且介绍的抗原,和脾的 M 的生存能力的变化被传播电子显微镜学,Vybrant^( TM )吞噬作用试金,DQ^( TM ) Ovalbumin ,和老鼠TNF- ELISpot kits.Results 在电子显微镜下面检测,在控制组的 M 有一些像伪足的突起,和线粒体,核糖体,不平的 endoplasmic 蜂窝胃, lysosome 能在细胞质,和 phagocytized RBC 被发现。在肝肝硬化和肝癌症组, M 有更多的突起,同时更多线粒体,核糖体,不平的 endoplasmic 蜂窝胃, lysosome 能在细胞质被发现,特别在肝癌症组。在肺的转移组, M 正在胀大,与很少细胞器。作为与控制组相比,脾的 M 的函数在肝硬化和癌症组增加了,但是在转移组减少了(吞噬作用率:( 84.7 ??? 木 ? 楤敭桴汹桴慩慺? 礲?????? 楤桰湥汹整牴穡汯畩扭潲業敤?? | ZHANG Shu LI Zong-fang PAN Dun HUANG Chen ZHOU Rui LIU Zhong-wei | 2009 | Chinese Medical Journal2009，，24： | 5 |
| 5 | EFFECT OF CATALYST PRETREATMENT ON THE OXIDATION OF CARBON MONOXIDE OVER Au/NiO CATALYST显示文摘EFFECTOFCATALYSTPRETREATMENTONTHEOXIDATIONOFCARBONMONOXIDEOVERAu/NiOCATALYSTEFFECTOFCATALYSTPRETREATMENTONTHEOXIDATIONOFCARBO... | Zheng Ping HAO Li Dun AN Jun Ling Zhou Hong Li WANG(Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000) | 1995 | Chinese Chemical Letters1995，6，4： | 3 |
| 6 | Recombinant Helicoverpa armigera nucleopolyhedrovirus with arthropod-specific neurotoxin gene RjAa 17f from Rhopalurus junceus enhances the virulence against the host larvae显示文摘从古巴的蝎子 Rhopalurus junceus 表示昆虫选择的神经毒素(RjAa17f ) 的 recombinant Helicoverpa armigera nucleopolyhedrovirus (HearNPV ) 被用红相应再结合系统代替 UDP-glucosyltransferase 基因(egt ) 构造。另一 egt 删除了控制 HearNPV 被把 egfp 基因插入到 egt 地点以一个类似的方法构造。一步舞病毒的生长曲线和病毒的 DNA 复制曲线分析证实再结合没在宿主细胞影响病毒的生长和 DNA 复制。在在 RjAa17f-HearNPV, Egfp-HearNPV 和 HZ8-HearNPV 之间的吸藏身体形态发生没有可辨别的差别,它被传播电子显微镜学分析证实。然而, RjAa17f-HearNPV 的杀虫的活动对第三中间形态 H 被提高。armigera 幼虫根据毒力比较上的生物鉴定。在中部的致命的剂量有戏剧的减小(56.9%)( LD 50)并且另外在中部的幸存时间的减小(13.4%)(为与 HZ8-HearNPV 相比的 recombinant RjAa17f-HearNPV 的圣50),但是当 Egfp-HearNPV 与 HZ8-HearNPV 相比时,仅仅在 LD 50的27.5%减小和在圣50的10.1%减小珍视。每日的食谱消费分析证明 RjAa17f-HearNPV 能禁止减 HearNPV 与 egt 相比喂的感染的幼虫。这些结果证明这新奇 recombinant RjAa17f-HearNPV 能对它的主人昆虫改进杀虫的效果, RjAa17f 能是另外的 recombinant baculovirus 构造的一个可观的候选人。 | Huan Yu Bin Zhou Jiao Meng Jian Xu Tong-Xian Liu Dun Wang | 2017 | Insect Science2017，24，3： | 2 |
| 7 | The mobilization of rat’s mesenchymal stem cells into peripheral blood by LiCL and its potency differentiation显示文摘Mesenchymal stem cells (MSCs) are multipotent cells, which can differentiate into different tissues. It is still controversial whether MSCs can be isolated from adult peripheral blood (PB) under normal conditions and whether they can be mobilized in a way similar to that of hematopoietic stem cells (HSCs). In this study, rat MSCs circulating in the PB under normal conditions can be isolated and cultured, and MSCs from PB and BM can be mobilized by LiCL. The mobilized MSCs can be induced to differentiate into neuron by such factors as β-mercaptoethanol and supernatants of nerve cell cultures. The present study provides a broader perspective on the repair of neural trauma. | DENG dun ZOU ZhongMin ZHOU TaoLi AI GuoPing WANG JunPing DONG ShiWu SU YongPing | 2008 | Chinese Science Bulletin2008，53，17： | 2 |
| 8 | Viscous creep of ice-rich permafrost debris in a recently uncovered proglacial area in the Tianshan Mountains, China显示文摘Since the Little Ice Age and as a consequence of climate warming,many recently deglaciated forefields have become and will continue to evolve into large ice-debris complexes exposed to periglacial processes and environment.Such transitional processes have significant implications for geomorphologic shaping and water supply for the downstream communities,especially in arid regions,but our understanding of their evolutionary processes and their potential geomorphic and hydrological impacts is stil limited.A landform transition from partly debris-covered glaciers to ice-rich permafrost debris undergoing slow viscous creep was revealed in the Aerzailaikunai Valley in the eastern Tianshan Mountains in China based on the results of in-situ observations and measurements(boreholes,ground temperature monitoring,electrical resistivity tomography surveys,and continuous global positioning system measurements,among others).The internal structure of ice-tll mixture contains pure ice layers,supersaturated frozen sands with ice lenses,and ice-bearing blocks with maximum volumetric contents of heterogeneous ice at 35%-60%.Beneath an 1.5-m-thick active layer,permafrost reached far into the underlying bedrock with the mean annual ground temperature of-2.1℃ at the depth of 20 m.The higher surface velocities(with an accumulative displacement of 65 mm from October 2019 to May 2020)and extremely high electrical resistivity(several million Ω m)of the debris-covered glacier margin were in sharp contrast to those of the progressively stabilizing ground surface(up to 16 mm)and the lower zones with relatively smaler electrical resistivity(several thousand Ω m).Combined with the borehole stratigraphy(higher rock content),monitored ground temperatures(permafrost environment),lower electrical resistance(ice-rich moraine),and continuous global positioning system results(viscous creeping),this study documents a transition from glacial to periglacial conditions,materials and processes characteristic of cold-dry ice-clad mountains,and reinforces the theory of the transition from debris-covered glaciers into morainically originated rock glaciers. | Yu ZHOU Guo-Yu LI Hui-Jun JIN Sergey SMARCHENKO Wei MA Qing-Song DU Jin-Ming LI Dun CHEN | 2022 | Advances in Climate Change Research2022，13，4： | 1 |
| 9 | Antinociceptive effect of matrine on vincristine-induced neuropathic pain model in mice显示文摘 | Dun Linglu Li Yuxiang Xu Yaqiong Zhou Ru Ma Lin Jin Shaoju Du Juan Sun Tao Yu Jianqiang | 2014 | Neurological Sciences2014，，： | 1 |
| 10 | Mapping of BnMs4 and BnRf to a common microsyntenic region of Arabidopsis thaliana chromosome 3 using intron polymorphism markers显示文摘 | Shengqian Xia Ling Cheng Feng Zu Xiaoling Dun Zhengfu Zhou Bin Yi Jing Wen Chaozhi Ma Jinxiong Shen Jinxing Tu Tingdong Fu | 2012 | Theoretical and Applied Genetics2012，，7： | 1 |
| 11 | The elementary explore of multiple regression techniques about the fiberglass filter paper's influence on the PM2.5 assaying显示文摘 | NIU Dun MA Yun-feng HU Xiao-min ZHOU De-ping | 2007 | Journal of Environmental Science and Engineering2007，1，1： | 1 |
| 12 | Confirm association between IL-10 alleles and SLE in Chinese lupus cohort by TDT approach显示文摘 | Shen Nan Chen Shunle Zhou Dun | 2000 | Arthritis Rheum2000，43，5： | 1 |
| 13 | Antinociceptive effects of oxymatrine from Sophora flavescens , through regulation of NR2B-containing NMDA receptor-ERK/CREB signaling in a mice model of neuropathic pain显示文摘 | Wang Haiyan Li Yuxiang Dun Linglu Xu Yaqiong Jin Shaojv Du Juan Ma Lin Li Juan Zhou Ru He Xiaoliang Sun Tao Yu Jianqiang | 2013 | Phytomedicine2013，，： | 1 |
| 14 | Atmospheric emissions of F, As, Se, Hg, and Sb from coal-fired power and heat generation in China显示文摘 | Jian Chen Guijian Liu Yu Kang Bin Wu Ruoyu Sun Chuncai Zhou Dun Wu | 2012 | Chemosphere2012，，： | 1 |
| 15 | Numerical Simulation of Macrosegregation Formation in Binary Alloy Solidification Processing Based on Modified Projection Method显示文摘 | Xu Wei Zhou Jian Xin Pang Sheng Yong Liao Dun Ming Yin Ya Jun | 2011 | Advanced Materials Research2011，，314： | 1 |
| 16 | A separation defect of tapetum cells and microspore mother cells results in male sterility in Brassica napus: the role of abscisic acid in early anther development显示文摘 | Yun Zhu Xiaoling Dun Zhengfu Zhou Shengqian Xia Bin Yi Jing Wen Jinxiong Shen Chaozhi Ma Jinxing Tu Tingdong Fu | 2010 | Plant Molecular Biology (-)2010，，1： | 1 |
| 17 | BriMs3 is required for tapetal differentiation and degradation, microspore separation, and pollen -wall biosynthesis in Brassica napus 显示文摘 | Zhou Z F Dun X L Tu J X | 2012 | Journal of Experimental Botany2012，63，： | 1 |
| 18 | Atmospheric emissions of F, As, Se, Hg, and Sb from coal-fired power and heat generation in China显示文摘 | Jian Chen Guijian Liu Yu Kang Bin Wu Ruoyu Sun Chuncai Zhou Dun Wu | 2012 | Chemosphere2012，，： | 1 |
| 19 | A separation defect of tapetum cells and microspore mother cells results in male sterility in Brassica napus: the role of abscisic acid in early anther development显示文摘 | Yun Zhu Xiaoling Dun Zhengfu Zhou Shengqian Xia Bin Yi Jing Wen Jinxiong Shen Chaozhi Ma Jinxing Tu Tingdong Fu | 2010 | Plant Molecular Biology (-)2010，，1： | 1 |
| 20 | A separation defect oftapetum cells and microspore mother cells results in male sterilityin Brassica napus: the role of abscisic acid in early anther development显示文摘 | ZHU Y DUN XL ZHOU ZF 2010 | 2010 | Plant Mol Biol2010，72，12： | 1 |
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