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| 1 | Optical phase mining by adjustable spatial differentiator显示文摘Phase is a fundamental resource for optical imaging but cannot be directly observed with intensity measurements.The existing methods to quantify a phase distribution rely on complex devices and structures and lead to difficulties of optical alignment and adjustment.We experimentally demonstrate a phase mining method based on the so-called adjustable spatial differentiation,by analyzing the polarization of light reflection from a single planar dielectric interface.Introducing an adjustable bias,we create a virtual light source to render the measured images with a shadow-cast effect.From the virtual shadowed images,we can further recover the phase distribution of a transparent object with the accuracy of 0.05λRMS.Without any dependence on wavelength or material dispersion,this method directly stems from the intrinsic properties of light and can be generally extended to a broad frequency range. | Tengfeng Zhu Junyi Huang Zhichao Ruan | 2020 | Advanced Photonics2020，2，1： | 6 |
| 2 | The use of fire at Zhoukoudian:evidence from magnetic susceptibility and color measurements显示文摘In order to provide direct evidence for the use of fire by humans at Locality 1,Zhoukoudian,we examine the burnt and unburnt sediments of newly excavated area in Layer 4 by detailed measurements of magnetic susceptibility,color,and diffuse reflectance spectrum.Results show that the magnetic susceptibility and redness of the burnt sediments are remarkably higher than those of other areas on the same level:up to*22 times for magnetic susceptibility and*3 times for redness of those of the adjacent unburnt sediments.Fine-grained(superparamagnetic/stable single-domain)magnetite and hematite grains make dominant contributions to the distinctly high values of magnetic susceptibility and redness in the burnt sediments.Diffuse reflectance spectroscopy results show that the burnt sediments contain more hematite than those of other areas and localities 2 and 3.High-temperature magnetic susceptibility measurements demonstrate that the burnt sediments have been heated above 700°C.Those changes in low-frequency magnetic susceptibility and redness are impossibly resulted from natural fires,thus most likely signaling the human activities of controlled use of fire.However,further work is needed to confirm whether or not these heat-affected sediments were produced in situ. | Yan Zhang Zhengtang Guo Chenglong Deng Shuangquan Zhang Haibin Wu Chunxia Zhang Junyi Ge Deai Zhao Qin Li Yang Song Rixiang Zhu | 2014 | Chinese Science Bulletin2014，59，10： | 6 |
| 3 | NON-YELLOWING2 (NYE2), a Close Paralog of NYE1, Plays a Positive Role in Chlorophyll Degradation in Arabidopsis显示文摘 | Wu, Shouxin Li, Zhongpeng Yang, Lifeng Xie, Zuokun Chen, Junyi Zhang, Wei Liu, Tianqi Gao, Shan Gao, Jiong Zhu, Yihua Xin, Jiwen Ren, Guodong Kuai, Benke | 2016 | Molecular Plant2016，9，4： | 6 |
| 4 | Rapid Assessment on Potential Risks of Schistosomiasis Transmission—7 PLADs,China,2019 and 2021显示文摘Summary What is already known about this topic?Oncomelania hupensis(O.hupensis)and livestock are main infection sources of schistosomiasis.The schistosome infected O.hupensis and livestock’s feces are important risk factors in the transmission of schistosomiasis.What is added by this report?The potential risks of schistosomiasis transmission remain prevalent,giving an early warning to local government with information on existing transmission risks.It is expected that the effectiveness and efficiency of schistosomiasis surveillance could be improved by conducting rapid risk assessment at the beginning of transmission season. | Junyi He Hongqing Zhu Ziping Bao Lijuan Zhang Yinlong Li Ting Feng Suying Guo Wangping Deng Can Wang Hui Dang Tiewu Jia Chao Lyu Zhiqiang Qin Chunli Cao Jing Xu Shizhu Li Xiaonong Zhou | 2021 | China CDC weekly2021，3，51： | 5 |
| 5 | An all-round AI-Chemist with a scientific mind显示文摘The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence(AI)laboratory.Several AI-based systems or robots with specific chemical skills have been demonstrated,but conducting all-round scientific research remains challenging.Here,we present an all-round AI-Chemist equipped with scientific data intelligence that is capable of performing basic tasks generally required in chemical research.Based on a service platform,the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans accordingly.It can control a mobile robot in-house or online to automatically execute the complete experimental process on 14 workstations,including synthesis,characterization and performance tests.The experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization,allowing a new hypothesis for the next iteration to be proposed.The competence of the AI-Chemist has been scrutinized by three different chemical tasks.In the future,the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory. | Qing Zhu Fei Zhang Yan Huang Hengyu Xiao LuYuan Zhao XuChun Zhang Tao Song XinSheng Tang Xiang Li Guo He BaoChen Chong JunYi Zhou YiHan Zhang Baicheng Zhang JiaQi Cao Man Luo Song Wang GuiLin Ye WanJun Zhang Xin Chen Shuang Cong Donglai Zhou Huirong Li Jialei Li Gang Zou WeiWei Shang Jun Jiang Yi Luo | 2022 | National Science Review2022，9，10： | 5 |
| 6 | Wavelet analysis of coastal-trapped waves along the China coast generated by winter storms in 2008显示文摘This study applies the wavelet analysis to the tidal gauge records, alongshore winds, atmospheric temperature and pressure along the China coast in winter 2008. The analysis results show three events of sea level oscillations(SLOs) on the shelf induced by winter storms. The first event occurred from January 9 to 21. The SLO periods were double-peaked at 1.6–5.3 and 7.0–16.0 d with the power densities of 0.04–0.05 and 0.10–0.15 m2·d, respectively.The second event occurred from February 5 to 18. The SLO period was single-peaked at 2.3–3.5 d with power density of 0.03–0.04 m2·d. The third event occurred from February 20 to March 8. The SLO periods were doublepeaked at 1.5–4.3 and 6.1–8.2 d with the power densities of 0.08–0.11 and 0.02–0.08 m2·d, respectively. The SLOs propagated along the coast from Zhejiang in north to Guangdong in south. The phase speeds ranged about 9–29m/s from Kanmen to Pingtan, 5–11 m/s from Xiamen to Huizhou and 11–22 m/s from Huizhou to Shuidong. The dispersion relation of the SLOs shows their nature of coastal-trapped wave. | LI Junyi ZHENG Quanan HU Jianyu FAN Zhenhua ZHU Jia CHEN Tao ZHU Benlu XU Ying | 2015 | Acta Oceanologica Sinica2015，34，11： | 5 |
| 7 | Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cancers.Accumulating evidence suggests inherited genetic susceptibility to lung cancer.The present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) patients.Methods: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 mutations.Results: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline BRCA.Conclusions: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC patients.Results suggested a lack of association between germline BRCA status and treatment outcome of EGFR-TKI.In addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 8 | Twist-driven separation of p-type and n-type dopants in single-crystalline nanowires显示文摘The distribution of dopants significantly influences the properties of semiconductors,yet effective modulation and separation of p-type and n-type dopants in homogeneous materials remain challenging,especially for nanostructures.Employing a bond orbital model with supportive atomistic simulations,we show that axial twisting can substantially modulate the radial distribution of dopants in Si nanowires(NWs)such that dopants of smaller sizes than the host atom prefer atomic sites near the NW core,while dopants of larger sizes are prone to staying adjacent to the NW surface.We attribute such distinct behaviors to the twist-induced inhomogeneous shear strain in NW.With this,our investigation on codoping pairs further reveals that with proper choices of codoping pairs,e.g.B and Sb,n-type and p-type dopants can be well separated along the NW radial dimension.Our findings suggest that twisting may lead to realizations of p–n junction configuration and modulation doping in single-crystalline NWs. | Dong-Bo Zhang Xing-Ju Zhao Gotthard Seifert Kinfai Tse Junyi Zhu | 2019 | National Science Review2019，6，3： | 2 |
| 9 | Cytoplasmic and nuclear genome variations of rice hybrids and their parents inform the trajectory and strategy of hybrid rice breeding显示文摘The male sterility(MS)line is a prerequisite for efficient production of hybrid seeds in rice,a self-pollinating species.MS line breeding is pivotal for hybrid rice improvement.Understanding the historical breeding tra-jectory will help to improve hybrid rice breeding strategies.Maternally inherited cytoplasm is an appro-priate tool for phylogenetic reconstruction and pedigree tracing in rice hybrids.In this study,we analyzed the cytoplasmic genomes of 1495 elite hybrid rice varieties and identified five major types of cytoplasm,which correspond to different hybrid production systems.As the cytoplasm donors for hybrids,461 MS lines were also divided into five major types based on cytoplasmic and nuclear genomic architecture.Spe-cific core accessions cooperating with different fertility-associated genes drove the sequence divergence of MS lines.Dozens to hundreds of convergent and divergent selective sweeps spanning several agro-nomic trait-associated genes were identified among different types of MS lines.We further analyzed the cross patterns between different types of MS lines and their corresponding restorers.This study system-atically analyzed the cytoplasmic genomes of rice hybrids revealed their relationships with nuclear ge-nomes of MS lines,and illustrated the trajectory of hybrid rice breeding and the strategies for breeding different types of MS lines providing new insights for future improvement of hybrid rice. | Zhoulin Gu Zhou Zhu Zhen Li Qilin Zhan Qi Feng Congcong Zhou Qiang Zhao Yan Zhao Xiaojian Peng Bingxin Dai Rongrong Sun Yan Li Hengyun Lu Lei Zhang Tao Huang Junyi Gong Danfeng Lv Xuehui Huang Bin Han | 2021 | Molecular Plant2021，14，12： | 2 |
| 10 | Development of MATLAB-based computing software of minor shock hypocentral parameters显示文摘 | Zhu Xinyun Yu Junyi | 2008 | Northwestern Seismological Journal2008，30，4： | 1 |
| 11 | Riemann-Hilbert approach to TD equation with nonzero boundary condition显示文摘 | Junyi ZHU Linlin Wang Xianguo Geng | 2018 | Frontiers of Mathematics in China2018，13，5： | 1 |
| 12 | The draftgenome of a diploid cotton gossypium raimondii 显示文摘 | Kunbo Wang Zhiwen Wang Fuguang Li Wuwei Ye Junyi Wang Guoli Song Zhen Yue Lin Cong Haihong Shang Shilin Zhu Changsong Zou Qin Li Youlu Yuan Cairui Lu Hengling Wei Caiyun Gou Zequn Zheng Ye Yin Xueyan Zhang Kun Liu Bo Wang Chi Song Nan Shi Russell J Kohel Richard G Percy John Z Yu Yu-xian Zhu Jun Wang Shuxun Yu | 2012 | Nat Genet2012，，44： | 1 |
| 13 | Erratum to Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘In the published article1,the affiliation for the first author,Xingshcng Hu,is'Department of Medical Oncology,Cancer Hospital,Chinese Academy of Medical Sciences',we would like to update it to'Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China'.We apologize for the errors and for any confusion it may have caused. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2020 | Cancer Biology & Medicine2020，17，2： | 1 |
| 14 | A study of long-term sea level variability in the East China Sea显示文摘From the analyses of the satellite altimeter Maps of Sea Level Anomaly(MSLA) data, tidal gauge sea level data and historical sea level data, this paper investigates the long-term sea level variability in the East China Sea(ECS).Based on the correlation analysis, we calculate the correlation coefficient between tidal gauge and the closest MSLA grid point, then generate the map of correlation coefficient of the entire ECS. The results show that the satellite altimeter MSLA data is effective to observe coastal sea level variability. An important finding is that from map of correlation coefficient we can identify the Kuroshio. The existence of Kuroshio decreases the correlation between coastal and the Pacific sea level. Kurishio likes a barrier or a wall, which blocks the effect of the Pacific and the global change. Moreover, coastal sea level in the ECS is mainly associated with local systems rather than global change. In order to calculate the long-term sea level variability trend, the empirical mode decomposition(EMD) method is applied to derive the trend on each MSLA grid point in the entire ECS. According to the 2-D distribution of the trend and rising rate, the sea level on the right side of the axis of Kuroshio rise faster than in its left side. This result supports the barrier effect of Kuroshio in the ECS. For the entire ECS, the average sea level rose 45.0 mm between 1993 and 2010, with a rising rate of(2.5±0.4) mm/a which is slower than global average.The relatively slower sea level rising rate further proves that sea level rise in the ECS has less response to global change due to its own local system effect. | XU Ying LIN Mingsen ZHENG Quanan YE Xiaomin LI Junyi ZHU Benlu | 2015 | Acta Oceanologica Sinica2015，34，11： | 1 |
| 15 | Algebro-geometric constructions of the(2 + 1)-dimensional differential-difference equation显示文摘 | Zhu Junyi Geng Xianguo | 2007 | Physical Letter A2007，368，6： | 1 |
| 16 | A brief review of formation energies calculation of surfaces and edges in semiconductors显示文摘To have a high quality experimental growth of crystals, understanding the equilibrium crystal shape(ECS) in different thermodynamic growth conditions is important. The factor governing the ECS is usually the absolute surface formation energies for surfaces(or edges in 2D) in different orientations. Therefore, it is necessary to obtain an accurate value of these energies in order to give a good explanation for the observation in growth experiment. Historically, there have been different approaches proposed to solve this problem. This paper is going to review these representative literatures and discuss the pitfalls and advantages of different methods. | Chuen-Keung Sin Jingzhao Zhang Kinfai Tse Junyi Zhu | 2020 | Journal of Semiconductors2020，41，6： | 1 |
| 17 | stAPAminer:Mining Spatial Patterns of Alternative Polyadenylation for Spatially Resolved Transcriptomic Studies显示文摘Alternative polyadenylation(APA)contributes to transcriptome complexity and gene expression regulation and has been implicated in various cellular processes and diseases.Singlecell RNA sequencing(scRNA-seq)has enabled the profiling of APA at the single-cell level;however,the spatial information of cells is not preserved in scRNA-seq.Alternatively,spatial transcriptomics(ST)technologies provide opportunities to decipher the spatial context of the transcriptomic landscape.Pioneering studies have revealed potential spatially variable genes and/or splice isoforms;however,the pattern of APA usage in spatial contexts remains unappreciated.In this study,we developed a toolkit called stAPAminer for mining spatial patterns of APA from spatially barcoded ST data.APA sites were identified and quantified from the ST data.In particular,an imputation model based on the k-nearest neighbors algorithm was designed to recover APA signals,and then APA genes with spatial patterns of APA usage variation were identified.By analyzing wellestablished ST data of the mouse olfactory bulb(MOB),we presented a detailed view of spatial APA usage across morphological layers of the MOB.We compiled a comprehensive list of genes with spatial APA dynamics and obtained several major spatial expression patterns that represent spatial APA dynamics in different morphological layers.By extending this analysis to two additional replicates of the MOB ST data,we observed that the spatial APA patterns of several genes were reproducible among replicates.stAPAminer employs the power of ST to explore the transcriptional atlas of spatial APA patterns with spatial resolution.This toolkit is available at http://gffzz188fe103f8f1460asqvcpbqxvkk9w6onn.ffgz.tsg.suse.edu.cn/BMILAB/stAPAminer and http://gffzz77e3413bc06540edsqvcpbqxvkk9w6onn.ffgz.tsg.suse.edu.cn/biocode/tools/BT007320. | Guoli Ji Qi Tang Sheng Zhu Junyi Zhu Pengchao Ye Shuting Xia Xiaohui Wu | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 1 |
| 18 | An Approach on Automatic Test Data Generation with Predicate Constraint Solving Technique显示文摘 | Chen Jifeng Zhu Li Shen Junyi | 2006 | International Journal of Information Technology2006，12，3： | 1 |
| 19 | Decomposition of the discrete Ablowitz-Ladik hierarchy显示文摘 | Geng Xianguo Dai Huihui Zhu Junyi | 2007 | Studies in Applied Mathematics2007，118，3： | 1 |
| 20 | The generalized version of dressing method with applications to AKNS equations显示文摘 | Zhu Junyi Geng Xianguo | | 0，，01： | 1 |
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