|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Advances on strategies for searching for next generation thermal barrier coating materials显示文摘Thermal barrier coating(TBC) materials play important roles in gas turbine engines to protect the Nibased super-alloys from the high temperature airflow damage. High melting point, ultra-low thermal conductivity, large thermal expansion coefficient, excellent damage tolerance and moderate mechanical properties are the main requirements of promising TBC materials. In order to improve the efficiency of jet and/or gas turbine engines, which is the key of improved thrust-to-weight ratios and the energysaving, significant efforts have been made on searching for enhanced TBC materials. Theoretically, density functional theory has been successfully used in scanning the structure and properties of materials, and at the same time predicting the mechanical and thermal properties of promising TBC materials for high and ultrahigh temperature applications, which are validated by subsequent experiments. Experimentally,doping and/or alloying are also widely applied to further decrease their thermal conductivities. Now, the strategy through combining theoretical calculations and experiments on searching for next generation thermal insulator materials is widely adopted. In this review, the common used techniques and the recent advantages on searching for promising TBC materials in both theory and experiments are summarized. | Bin Liu Yuchen Liu Changhua Zhu Huimin Xiang Hongfei Chen Luchao Sun Yanfeng Gao Yanchun Zhou | 2019 | Journal of Materials Science & Technology2019，35，5： | 24 |
| 2 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 3 | Toxicities and risk assessment of heavy metals in sediments of Taihu Lake, China, based on sediment quality guidelines显示文摘The occurrence, toxicities, and ecological risks of five heavy metals(Pb, Cu, Cd, Zn and Ni) in the sediment of Taihu Lake were investigated in this study. To evaluate the toxicities caused by the heavy metals, the toxicities induced by organic contaminants and ammonia in the sediments were screened out with activated carbon and zeolite. The toxicities of heavy metals in sediments were tested with benthic invertebrates(tubificid and chironomid).The correlations between toxicity of sediment and the sediment quality guidelines(SQGs)derived previously were evaluated. There were significant correlations(p < 0.0001) between the observed toxicities and the total risk quotients of the heavy metals based on SQGs,indicating that threshold effect level(TEL) and probable effect level(PEL) were reliable to predict the toxicities of heavy metals in the sediments of Taihu Lake. By contrast, the method based on acid volatile sulfides(AVS) and simultaneously extracted metals(SEM),such as ∑SEM/AVS and ∑SEM-AVS, did not show correlations with the toxicities. Moreover,the predictive ability of SQGs was confirmed by a total predicting accuracy of 77%. Ecological risk assessment based on TELs and PELs showed that the contaminations of Pb, Cu, Cd and Zn in the sediments of Taihu Lake were at relatively low or medium levels. The risks caused by heavy metals in the sediments of northern bay of the lake, which received more wastewater discharge from upper stream, were higher than other area of the lake. | Yanfeng Zhang Yuwei Han Jinxi Yang Lingyan Zhu Wenjue Zhong | 2017 | Journal of Environmental Sciences2017，29，12： | 16 |
| 4 | An East Asian land-sea atmospheric heat source difference index and its relation to general circulation and summer rainfall over China显示文摘Using a monthly precipitation dataset of 160 stations over China and a daily and monthly National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR) reanalysis dataset from 1961 to 2006, we here define an East Asian land-sea atmospheric heat source difference index ILSQD and investigate its relationship to summer rainfall in China and East Asian general circulation. The results show that ILSQD more closely reflects the anomalous variations in summer monsoon phenomena; in the high-index (HI) cases, the strong low-level southerlies over East China and the strong high-level westerlies over middle latitudes indicate an active summer monsoon, and vice versa in the low-index (LI) cases. This index also reflects summer rainfall anomalies over East China; in the HI (LI) cases rainfall increases (decreases) over North China and at the same time decreases (increases) over the mid-lower Yangtze River valley and the southern Yangtze River. Hence, ILSQD can be utilized as a summer monsoon index. There is also remarkable correlation between ILSQD in March and the following summer rainfall over the mid-lower Yangtze River valley. Finally, the Community Atmospheric Model Version 3.1 (CAM3.1) of NCAR is used to run numerical experiments, which verify that the anomalous summer precipitation in simulations is similar to that of diagnosis analysis based on the anomalous summer atmospheric heating forcing. Similarly, the atmospheric heating rate in March can force summer rainfall anomalies in the simulations just as observed in the data. | Zhang Bo Zhou XiuJi Chen LongXun Zhu YanFeng Zhao Bin | 2010 | Science China Earth Sciences2010，53，11： | 6 |
| 5 | Tandem catalysis in electrochemical CO_(2) reduction reaction显示文摘Electrochemical CO_(2) reduction reaction(CO_(2)RR)is an attractive pathway for closing the anthropogenic carbon cycle and storing intermittent renewable energy by converting CO_(2) to valuable chemicals and fuels.The production of highly reduced carbon compounds beyond CO and formate,such as hydrocarbon and oxygenate products with higher energy density,is particularly desirable for practical applications.However,the productivity towards highly reduced chemicals is typically limited by high overpotential and poor selectivity due to the multiple electron-proton transfer steps.Tandem catalysis,which is extensively utilized by nature for producing biological macromolecules with multiple enzymes via coupled reaction steps,represents a promising strategy for enhancing the CO_(2)RR performance.Improving the efficiency of CO_(2)RR via tandem catalysis has recently emerged as an exciting research frontier and achieved significant advances.Here we describe the general principles and also considerations for designing tandem catalysis for CO_(2)RR.Recent advances in constructing tandem catalysts,mainly including bimetallic alloy nanostructures,bimetallic heterostructures,bimetallic core-shell nanostructures,bimetallic mixture catalysts,metal-metal organic framework(MOF)and metal-metallic complexes,metal-nonmetal hybrid nanomaterials and copper-free hybrid nanomaterials for boosting the CO_(2)RR performance are systematically summarized.The study of tandem catalysis for CO_(2)RR is still at the early stage,and future research challenges and opportunities are also discussed. | Yating Zhu Xiaoya Cui Huiling Liu Zhenguo Guo Yanfeng Dang Zhanxi Fan Zhicheng Zhang Wenping Hu | 2021 | Nano Research2021，14，12： | 5 |
| 6 | Numerical Investigation of the Unsteady Tip Leakage Flow and Rotating Stall Inception in a Transonic Compressor显示文摘It is well known that tip leakage flow has a strong effect on the compressor performance and stability. This paper reports on a numerical investigation of detailed flow structures in an isolated transonic compressor rotor-NASA Rotor 37 at near stall and stalled conditions aimed at improving understanding of changes in 3D tip leakage flow structures with rotating stall inception.Steady and unsteady 3D Navier-Stokes analyses were conducted to investigate flow structures in the same rotor.For steady analysis,the predicted results agree well with the experimental data for the estimation of compressor rotor global performance.For unsteady flow analysis, the unsteady flow nature caused by the breakdown of the tip leakage vortex in blade tip region in the transonic compressor rotor at near stall condition has been captured with a single blade passage.On the other hand, the time-accurate unsteady computations of multi-blade passage at near stall condition indicate that the unsteady breakdown of the tip leakage vortex triggered the short length-scale-spike type rotating stall inception at blade tip region.It was the forward spillage of the tip leakage flow at blade leading edge resulting in the spike stall inception. As the mass flow ratio is decreased,the rotating stall cell was further developed in the blade passage. | Yanfeng Zhang Xingen Lu Wuli Chu Junqiang Zhu | 2010 | Journal of Thermal Science2010，19，4： | 5 |
| 7 | Locating Parent Lightning Strokes of Sprites Observed over a Mesoscale Convective System in Shandong Province,China显示文摘In this paper, we report the location results for the parent lightning strokes of more than 30 red sprites observed over an asymmetric mesoscale convective system(MCS) on 30 July 2015 in Shandong Province, China, with a long-baseline lightning location network of very-low-frequency/low-frequency magnetic field sensors. The results show that almost all of these cloud-to-ground(CG) strokes are produced during the mature stage of the MCS, and are predominantly located in the trailing stratiform region, which is similar to analyses of sprite-productive MCSs in North America and Europe. Comparison between the location results for the sprite-producing CG strokes and those provided by the World Wide Lightning Location Network(WWLLN) indicates that the location accuracy of WWLLN for intense CG strokes in Shandong Province is typically within 10 km, which is consistent with the result based on analysis of 2838 sprite-producing CG strokes in the continental United States. Also, we analyze two cases where some minor lightning discharges in the parent flash of sprites can also be located, providing an approach to confine the thundercloud region tapped by the sprite-producing CG strokes. | Anjing HUANG Gaopeng LU Hongbo ZHANG Feifan LIU Yanfeng FAN Baoyou ZHU Jing YANG Zhichao WANG | 2018 | Advances in Atmospheric Sciences2018，35，11： | 5 |
| 8 | Effects of capture and captivity on plasma corticosterone and metabolite levels in breeding Eurasian Tree Sparrows显示文摘Background: Bringing free-living animals into captivity subjects them to the stress of both capture and captivity, leading to the alteration of normal physiological processes and behaviors through activation of the hypothalamic– pituitary–adrenal axis. In free-living birds, although elevated plasma corticosterone (CORT) is an important adaptation regulating physiological and behavioral responses during the process of capture and captivity stress, little information is currently available on the effects of such stress on plasma metabolite levels. Methods: We examined the effects of immediate capture and 24-h captivity on body mass, body condition, plasma CORT, and metabolite levels including glucose (Glu), triglyceride (TG), total cholesterol (TC), uric acid (UA), in breeding Eurasian Tree Sparrows (Passer montanus). Results: CORT and Glu levels were increased significantly by the stress of capture, whereas TC and UA levels decreased. Body mass, body condition declined notably after 24 h in captivity, but CORT, Glu, and UA levels increased. Furthermore, male sparrows had lower TG levels after both capture and captivity than those of females. The relationships between plasma CORT and metabolite levels varied between sexes. Conclusions: Our results revealed that the metabolic status of Eurasian Tree Sparrows could be dramatically altered by capture and captivity. Monitoring the dynamic effects of both capture and captivity on plasma CORT, metabolite levels in a free-living bird contributes to a better understanding of the stress-induced pathways involved in sexdependent energy mobilization. | Mo Li Weiwei Zhu Yang Wang Yanfeng Sun Juyong Li Xuelu Liu Yuefeng Wu Xuebin Gao Dongming Li | 2019 | Avian Research2019，10，2： | 5 |
| 9 | Thermal difference between the Tibetan Plateau and the plain east of Plateau and its influence on rainfall over China in the summer显示文摘There exist thermal differences between the Tibetan Plateau (TP) and the plain east of the TP, and between land and sea in East Asia. The influence of the land-sea thermal contrast on the precipitation in East China has been widely investigated; however, a few studies have paid attention to the role of the TP-plain thermal difference. Thus, using the National Center for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR) reanalysis data and the observation data of China from 1951 to 2007, the area-mean temperature difference between the TP (27.5°-40°N, 80°-100°E) and the plain (27.5° -40°N,110°-120°E) at 500 hPa is defined as an index (dexT-C) of the TP-plain thermal difference in East Asia. The relationship between the dexT-C and East Asian general circulation and the rainfall in China in the summer has been explored. Diagnostic analysis and numerical simulation show that the TP-plain thermal difference is closely related to the rainfall over West China (90°-110°E) in the summer. High values of the dexT-C correspond to the large thermal difference between the TP and the plain, strengthening the heat low over the TP, southward of the northwestern Pacific subtropical high, southern flood and northern drought in West China (90°-110°E), and vice versa. From 1951 to 2007, the variation in dexT-C exhibits a remarkable oscillation and ascending trend, and the abnormal rainfall pattern over West China (90°-110°E) also changes from 'northern flood and southern drought' to 'southern flood and northern drought'. The above research is favorable to knowing how the two-stage thermal differences influence summer rainfall in China. | ZHU YanFeng ZHANG Bo CHEN LongXun | 2010 | Chinese Science Bulletin2010，55，14： | 5 |
| 10 | Micelle or polymersome formation by PCL-PEG-PCL copolymers as drug delivery systems显示文摘Polye-caprolactone)-b-poly(ethylene glycol)-b-poly(e-caprolactone)(PCL-b-PEG-b-PCL,PCEC) triblock copolymers have been widely investigated in last several decades.Here,by altering the weight ratio of monomers in ring-opening polymerization,a series of PCEC triblock copolymers with varying hydrophobicity were synthesized,which were characterized by FTIR,1 H NMR,GPC and DSC.When PCEC copolymers with different weight ratios of PCL/PEG were dispersed in different aqueous solutions,they could self-assemble and form two distinctive nanoparticular structures:micelles or polymersomes.We then chose paclitaxel(PTX) as the model drug and encapsulate PTX into PCEC polymeric micelles and polymersomes.The physicochemical characterizations of the nanoparticles such as morphology,the size and distribution,zeta potential,drug loading content,and encapsulation efficiency were also performed.Our results showed that polymeric micelles or polymersomes from PCEC both displayed narrow size distributions and could achieve high drug loading efficiencies.In vitro cellular uptake results suggested that Nile Red loaded polymeric micelles or polymersomes displayed more internalization after 24 h incubation than those after 4 h incubation.These findings suggest that polymeric micelles and polymersomes based on PCL-b-PEG-b-PCL copolymers have great potential to effectively delivery hydrophobic drugs. | Chunyan Hu Zhuo Chen Shengjie Wu Yanfeng Han Hai Wang Hongfan Sun Deling Kong Xigang Leng Chun Wang Linhua Zhang Dunwan Zhu | 2017 | Chinese Chemical Letters2017，28，9： | 4 |
| 11 | Scalable salt-templated directed synthesis of high-quality MoS_(2) nanosheets powders towards energetic and environmental applications显示文摘Two-dimensional(2D)transition metal dichalcogenides(TMDCs)have emerged as perfect platforms for developing applications in nano-electronics,catalysis,energy storage and environmental-related fields due to their superior properties.However,the low-cost,batch production of high-quality 2D TMDCs remains a huge challenge with the existing synthetic strategies.Herein,we present a scalable chemical vapor deposition(CVD)approach for the batch production of high-quality MoS_(2) nanosheet powders,by using naturally abundant,water-soluble and recyclable NaCl crystal powders as templates.The high-quality MoS_(2) nanosheets powders are achieved by a facile water dissolution-filtration process,by virtue of the excellent dispersibility of the as-grown products in water.The internal mechanism for the scalable synthesis strategy is explored.The applications of the MoS_(2) nanosheets powders are also demonstrated as catalysts or adsorbents in hydrogen evolution reaction(HER)and organic dyes adsorption,respectively.This work should hereby pave ways for the mass production and application of powdery TMDCs in energetic and environmental related fields. | Lijie Zhu Pengfei Yang Yahuan Huan Shuangyuan Pan Zhaoqian Zhang Fangfang Cui Yuping Shi Shaolong Jiang Chunyu Xie Min Hong Jiatian Fu Jingyi Hu Yanfeng Zhang | 2020 | Nano Research2020，13，11： | 4 |
| 12 | Preparation of InSb nanocrystals embedded in SiO_2 thin films显示文摘InSb nanocrystals embedded in SiO 2 thin films were prepared by rf magnetron cosputtering technique. THe observation by transmission electron microscope showed that InSb nanocrystals dispersed uniformly in SiO-2 matrices. InSb nanocrystals with different sizes can be obtained by changing the annealing condition. The average size of InSb nanocrystals depended on annealing temperature and time, but not on the t 1/3 rules. X-ray photoelectron spectroscopy and X-ray diffraction were also applied to the analyses of the composite thin films. | ZHU Kaigui 1, SHI Jianzhong 1, WEI Yanfeng 2 and ZHANG Lide 1 1. Institute of Solid State Physics, Chinese Academy of Science, Hefei 230031, China 2. State Key Laboratory of Surface Physics, Fudan University, Shanghai 200433, China | 1998 | Chinese Science Bulletin1998，43，19： | 4 |
| 13 | Progressive paradoxical sleep deprivation impairs partial memory following learning tasks in rats显示文摘BACKGROUND: Complex learning tasks result in a greater number of paradoxical sleep phases, which can improve memory. The effect of paradoxical sleep deprivation, induced by 'flower pot' technique, on spatial reference memory and working memory require further research. OBJECTIVE: To observe the effect of progressive paradoxical sleep deprivation in rats, subsequent to learning, on memory using the Morris Water Maze. DESIGN, TIME AND SETTING: Controlled observation experiment. The experiment was performed at the Laboratory of Neurobiology, Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Lanzhou University from December 2006 to October 2007. MATERIALS: Twenty-eight, male, Wistar rats, 3-4 months old, were provided by the Experimental Animal Center of Lanzhou University. The Morris Water Maze and behavioral analyses system was purchased from Genheart Company, Beijing, China. METHODS: All animals, according to a random digits table, were randomly divided into paradoxical sleep deprivation, tank control, and home cage control groups. Paradoxical sleep deprivation was induced by the 'flower pot' technique for 72 hours, housing the rats on small platforms over water. Rats in the 'tank control' and 'home cage control' groups were housed either in a tank with large platforms over the water or in normal cages without paradoxical sleep deprivation. MAIN OUTCOME MEASURES: Morris Water Maze was employed for task learning and spatial memory testing. Rats in all groups were placed at six random starting points each day for four consecutive days. Each placement was repeated for two trials; the first trial represented reference memory and the second working memory. Rats in the first trial were allowed to locate the submerged platform within 120 seconds. Data, including swimming distance, escape latency, swimming velocity, percentage of time in correct quarter, and memory scores were recorded and analyzed automatically by behavioral analyses systems for Morris Water Maze. RESULTS: Twenty-eight rats were included in the final analysis, without any loss. In the first trial, between day 2 and 4, escape latency and swimming distance increased significantly in the paradoxical sleep deprivation group compared to the home cage control and tank control groups (P < 0.01); percentage of time in correct quarter and memory scores, however, decreased in the paradoxical sleep deprivation group compared to the home cage control and tank control groups (P < 0.01). The escape latency, swimming distance, percentage of time in correct quarter, and memory scores in the second trial was not significantly different among the three groups (P > 0.05). CONCLUSION: Paradoxical sleep deprivation inhibits spatial reference memory, but not working memory. | Chunmin Zhu Xiangrong Yao Weisheng Zhang Yanfeng Song Yiping Hou | 2008 | Neural Regeneration Research2008，3，6： | 4 |
| 14 | Unsteady wakes-secondary flow interactions in a high-lift low-pressure turbine cascade显示文摘Detailed experimental measurements were conducted to study the interactions between incoming wakes and endwall secondary flow in a high-lift Low-Pressure Turbine(LPT)cascade.All of the measurements were conducted in both the presence and absence of incoming wakes,and numerical analysis was performed to elucidate the flow mechanism.With increasing Reynolds number,the influence of the incoming wakes on suppressing the secondary flow gradually increased owing to the greater influence of incoming wakes on reducing the negative incidence angle at higher Reynolds numbers,leading to a lower blade loading near the leading edge and suppression of the Pressure Side(PS)leg of the horseshoe vortex.However,the effect of unsteady wakes on suppressing the profile losses gradually became weaker owing to the reduced size of the Suction Side(SS)separation bubble and increased mixing loss in the free-flow region at high Reynolds numbers.Incoming wakes clearly improved the aerodynamic performance of the low-pressure turbine cascade at low Reynolds numbers of 25,000 and 50,000.In contrast,at the high Reynolds number of 100,000,the profile loss at the midspan and mass-averaged total losses downstream of the cascade were higher in the presence of wakes than in the absence of wakes,and the unsteady wakes exerted a negative influence on the aerodynamic performance of the LPT cascade. | Xiao QU Yanfeng ZHANG Xingen LU Junqiang ZHU | 2020 | Chinese Journal of Aeronautics2020，33，3： | 3 |
| 15 | Evaluation of CT findings for the differentiation of benign from malignant primary retroperitoneal tumors显示文摘 | Zhu Zheng Zhao Xinming Zhao Yanfeng Yang Lei Zhao Jing Dai Jingrui Zhou Chunwu | 2014 | Chinese Medical Journal2014，，1： | 3 |
| 16 | Microstructures and magnetic properties of Ce_(32.15)_Co_(49.36)Cu_(9.84)Fe_(9.65) magnet sintered at different temperatures显示文摘The microstructures and magnetic properties of Ce-32.15Co_49.36Cu_9.84Fe_9.65 magnet sintered at the temperatures ranging from 1005 to 1105 °C were investigated. The results on scanning electron microscopy and X-ray diffraction analysis indicate that the remanence B r of the magnets is mainly influenced by the degree of the easy-axis orientation when sintering temperature is less than 1085 °C, the rapidly increasing amount of the secondly phase (5:19 phase) gives rise to the deterioration of the magnetic properties of the magnet above 1085 °C. Moreover, it is found that intrinsic coercivity H ci is strongly related to the content of copper in the matrix of the sintered magnets. The optimal sintering temperature is located in 1025~1055 °C, the corresponding magnetic properties of the magnets are B_r =0.685T, H_(ci) =350kA·m^-1 , and maximum energy product (BH)_m =85.6 kJ·m 3 . | SUN Wei ZHU Minggang FANG Yikun PAN Wei LI Jiajie LI Yanfeng LI Wei | 2012 | Rare Metals2012，31，5： | 3 |
| 17 | Establishment of Tissue Culture Regeneration System in Bama Hemp (Cannabis sativa L.)显示文摘[Objectives]This study was conducted to establish a tissue culture regeneration system in Bama hemp(Cannabis sativa L.).[Methods]Using hemp seeds as explants,a regeneration system was established through explant sterilization,callus induction,callus differentiation,and rooting culture.[Results]The results showed that the best sterilization effect was achieved when sterilizing with 75%ethanol for 30 s,followed by 0.1%HgCl 2 solution for 9 min,with a contamination rate as low as 11.4%.In presence of 3 mg/L 2,4-D and 0.1 mg/L6-BA,the callus induction effect from hemp seeds was better.The formula for better differentiation of callus was MS+2.0 mg/L 6-BA+0.2 mg/L NAA.IBA had a promoting effect on the rooting of hemp aseptic plantlets.The highest rooting rate reached 80%when MS+0.3 mg/L IBA were used.[Conclusions]This study established a hemp seed regeneration system to provide technical support for the conservation and breeding of hemp germplasm resources. | Yanfeng NONG Desheng ZHU Jian LI | 2019 | Agricultural Biotechnology2019，8，6： | 2 |
| 18 | SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration显示文摘SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and model animals.However,it remains undear whether and how SARS-CoV-2 crosses the blood-brain barrier(BBB).Herein,SARS-CoV-2 RNA was occasionally detected in the vascular wall and perivascular space,as well as in brain microvascular endothelial cells(BMECs)in the infected K18-hACE2 transgenic mice.Moreover,the permeability of the infected vessel was in creased.Furthermore,disin tegrity of BBB was discovered in the infected hamsters by administration of Evans blue.Interestingly,the expression of claudin5,ZO-1,occludin and the ultrastructure of tight junctions(TJs)showed unchanged,whereas,the basement membrane was disrupted in the infected animals.Using an in vitro BBB model that comprises primary BMECs with astrocytes,SARS-CoV-2 was found to infect and cross through the BMECs.Consistent with in vivo experiments,the expression of MMP9 was increased and collagen IV was decreased while the markers for TJs were not altered in the SARS-CoV-2-infected BMECs.Besides,inflammatory responses including vasculitis,glial activation,and upregulated inflammatory factors occurred after SARS-CoV-2 infection.Overall,our results provide evidence supporting that SARS-CoV-2 can cross the BBB in a transcellular pathway accompanied with basement membrane disrupted without obvious alteration of TJs. | Ling Zhang Li Zhou Linlin Bao Jiangning Liu Hua Zhu Qi Lv Ruixue Liu Wei Chen Wei Tong Qiang Wei Yanfeng Xu Wei Deng-Hong Gao Jing Xue Zhiqi Song Pin Yu Yunlin Han Yu Zhang Xiuping Sun Xuan Yu Chuan Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 2 |
| 19 | Wind Tunnel Experiments and Numerical Study on Performance Characteristics of an H-type Vertical Axis Wind Turbine in the Spanwise Direction显示文摘The aerodynamic forces and vortex characteristics of an H-type Vertical Axis Wind Turbine(VAWT)become complicated because of dynamic stall,particularly in the three-dimensional impact on the blade spanwise direction.This study focused on the evaluation of the aerodynamic performance and vortex characteristics of an H-type VAWT in the spanwise direction by numerical simulations and wind tunnel experiments.Pressure acting on the blade surface was obtained from multiport pressure measurement devices by wind tunnel.Meanwhile,the vortex field around different blade sections was investigated through numerical simulations.The stall behavior was analysed by comparing the results of numerical simulations and experiments.As a result,the tangential force of single blade was mainly contributed at the chordwise position of x/c≤0.4 c and the power of single blade was mainly contributed at the azimuthal angle range of 60°≤θ≤150°in the blade section position region of 0≤z/(H/2)≤0.7.At the section position of z/(H/2)=0.5,the initial flow separation was found at the suction side and progressed forward to the leading edge.With the increase of the tip speed ratios,the decreasing position of the averaged local power coefficient of each section was closer to the middle section of z/(H/2)=0,and the attenuation speed became faster.The power coefficient reductions at the blade section position of z/(H/2)=0.9 were 38.29%,46.78%and 56.42%when the tip speed ratios were 1.38,2.19 and 2.58,respectively.The results of this study provided a better understanding of the development of the performance characteristics and vortex characteristics of H-type VAWT. | ZHANG Yanfeng LI Qing’an ZHU Xinyu SONG Xiaowen CAI Chang GUO Zhiping | 2021 | Journal of Thermal Science2021，30，3： | 2 |
| 20 | Unsteady experimental and numerical investigation of aerodynamic performance in ultra-high-lift LPT显示文摘Detailed experimental and numerical investigations were performed for an ultra-high-lift front-loaded low-pressure turbine cascade (Zw=1.58) with periodic wakes.The interaction mechanisms between the incoming wakes and endwall secondary flow were carefully examined.Wakes were produced by moving upstream rods,and flow field downstream of the cascade was measured using a seven-hole probe.Experimental results revealed that incoming wakes influenced not only the boundary layer development of the blade suction surface but also the complex endwall secondary vortex structures.On the suction surface:Incoming wakes clearly suppressed the suction side separation bubble at a low Reynolds number of 25000.Nevertheless,the effects of different wake passing frequencies were not significantly different at Re=100000,and the profile losses under wake passing were even greater than in the absence of wakes.At the end walls:Incoming wakes more strongly suppressed secondary flow at Re=100000 than at Re=25000,because the lowmomentum fluid inside the incoming wakes clearly increased the endwall cross-passage pressure gradient at Re=25000.The experimental results indicated that periodic wakes decreased the passage vortex and counter vortex core strength by 25% and 30%,respectively,at Re=100000.Instantaneous results also demonstrated that endwall secondary vortices decreased significantly near the position of wakes passing. | Xiao QU Yanfeng ZHANG Xingen LU Junqiang ZHU | 2020 | Chinese Journal of Aeronautics2020，33，5： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员