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| 1 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 2 | One-pot synthesis of the highly efficient bifunctional Ni-SAPO-11 catalyst显示文摘Hydro isomerization of linear alkanes to branched isomers is an important petrochemical process for production of gasoline with high octane number.Non-noble metal bifunctional catalysts used in this process always suffer from low metal dispersion and poor metal-acid synergy.Herein,a facile one-pot synthesis method was used to simultaneously regulate metal particle sizes and acidity of the Ni-SAPO-11 hydroisomerization catalyst.The physicochemical properties are investigated using XANES,EXAFS,TEM/STEM,FT-IR,XPS,UV-vis and NH_3-TPD.Apart from the highly dispersed nickel nanoparticles with an average diameter of 8 nm,the framework Ni~(2+)ions are generated via substituting framework Al~(3+)ions of the SAPO-11.The formed NiP-OH structures have lower deprotonation energy(DPE)than the SiAl-OH ones,contributing more and stronger acid sites to the Ni-SAPO-11 catalyst.The great metal-acid synergy including high metal to acid sites ratio(n_(Ni)/n_A)and close intimacy is obtained for the Ni-SAPO-11 catalyst.The Ni-SAPO-11 catalyst outperforms the counterpart prepared by the impregnation method and exhibits comparable activity and isomers selectivity to the Pt/SAPO-11 catalyst in the n-hexane hydroisomerization. | Yuchao Lyu Weilong Zhan Zhumo Yu Xinmei Liu Ye Yang Xiaoxing Wang Chunshan Song Zifeng Yan | 2021 | Journal of Materials Science & Technology2021，，17： | 4 |
| 3 | Deep-blue organic light-emitting diodes based on a doublet d-f transition cerium(Ⅲ) complex with 100% exciton utilization efficiency显示文摘Compared to red and green organic light-emitting diodes(OLEDs),blue OLEDs are still the bottleneck due to the lack of efficient emitters with simultaneous high exciton utilization efficiency(EUE)and short excited-state lifetime.Different from the fluorescence,phosphorescence,thermally activated delayed fluorescence(TADF),and organic radical materials traditionally used in OLEDs,we demonstrate herein a new type of emitter,cerium(Ⅲ)complex Ce-1 with spin-allowed and parity-allowed d-f transition of the centre Ce^(3+) ion.The compound exhibits a high EUE up to 100% in OLEDs and a short excited-state lifetime of 42 ns,which is considerably faster than that achieved in efficient phosphorescence and TADF emitters.The optimized OLEDs show an average maximum external quantum efficiency(EQE)of 12.4% and Commission Internationale de L’Eclairage(CIE)coordinates of(0.146,0.078). | Liding Wang Zifeng Zhao Ge Zhan Huayi Fang Hannan Yang Tianyu Huang Yuewei Zhang Nan Jiang Lian Duan Zhiwei Liu Zuqiang Bian Zhenghong Lu Chunhui Huang | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 4 | Efficient rare earth cerium(Ⅲ)complex with nanosecond d-f emission for blue organic light-emitting diodes显示文摘In the field of RGB diodes,development of a blue organic light-emitting diode(OLED)is a challenge because of the lack of an emitter which simultaneously has a short excited state lifetime and a high theoretical external quantum efficiency(EQE).We demonstrate herein a blue emissive rare earth cerium(III)complex Ce-2 showing a high photoluminescence quantum yield of 95%and a short excited state lifetime of 52.0 ns in doped film,which is considerably faster than that achieved in typical efficient phosphorescence or thermally activated delayed fluorescence emitters(typical lifetimes>1μs).The corresponding OLED shows a maximum EQE up to 20.8%and a still high EQE of 18.2%at 1000 cd m^(-2),as well as an operation lifetime 70 times longer than that of a classic phosphorescence OLED.The excellent performance indicates that cerium(III)complex could be a candidate for efficient and stable blue OLEDs because of its spin-and parity-allowed d-f transition from the Ce^(3+)ion. | Zifeng Zhao Liding Wang Ge Zhan Zhiwei Liu Zuqiang Bian Chunhui Huang | 2021 | National Science Review2021，8，2： | 3 |
| 5 | Morphology and molecular phylogeny of three black corals(Antipatharia,Schizopathidae)from seamounts in the Western Pacific Ocean,with description of a new species显示文摘Three deep-sea black corals belonging to the family Schizopathidae,are reported from two seamounts on the Caroline Ridge in the tropical Western Pacific:Umbellapathes parva sp.nov.with depth of 1488-1766 m,Telopathes cf.magna MacIsaac&Best,2013 with depth of 937-1016 m,and Stauropathes cf.punctata(Roule,1905)with depth of 942-1353 m.The latter two species are the first records in the Western Pacific Ocean.U.parva sp.nov.is characterized by monopodial corallum,relatively long unpinnulated stalk with complex pinnulated branche s developing from the lowermost primary pinnules and small spine s.It differs from two known congeners by much smaller spine s and the present of secondary pinnules.T.cf.magna MacIsaac&Best,2013 has sparsely branched corallum,relatively long and simple pinnules arranged in subopposite or alternate pairs.S.cf.punctata(Roule,1905)is characterized by the corallum with almost planar pinnulated branches,and pinnules arranged in subopposite pairs.Our results indicate that the corallum size and shape are variable in conspecific specimens particularly those at different growth stages.By contrast,the size of the polypar spines as well as the abpolypar spines have little variation and can be served as a main differing feature for schizopathid species.The phylogenetic analyses using nuclear internal transcribed spacer region(spanning partial 18 S rDNA,ITS 1,5.8 S,ITS2,and partial 28 S rDNA)and two mitochondrial fragments cox3-IGR-coxl(COI)and trnW-IGR-nad2(NAD2)showed Telopathes,Stau ropathes,and Bathypathes had close relationships,and Umbellapathes formed a sister clade with Alternatipathes. | Ting LÜ Zifeng ZHAN Kuidong XU | 2021 | Journal of Oceanology and Limnology2021，39，5： | 1 |
| 6 | Paragorgia papillata sp.nov.,a new bubblegum coral(Octocorallia:Paragorgiidae)from a seamount in the tropical Western Pacific显示文摘A new species of bubblegum coral,Paragorgia papillata sp.nov.,discovered from a seamount located on the Caroline Ridge at the water depth of 858 m,is studied using morphological and molecular approaches.The new gorgonian is white-colored,uniplanar with prominent autozooids,and measures about670-mm high and 690-mm wide.The genetic distance and phylogenetic analysis showed that P.papillata sp.nov.was closely related to P.coralloides Bayer,1993,but the former differs morphologically from the latter by its prominent calyces(diameter 2.0-4.0 mm and height 1.5-3.0 mm vs.both diameter and height about 1 mm),white cortex(vs.pink),regular 8-radiates in surface cortex(vs.mostly 8-radiate derived globular radiates)and highly ornate medullar spindles(length 185-400μm vs.no more than 150μm).P.papillata sp.nov.is the third known white-colored species of the genus,and the fifth species found in the tropical Western Pacific. | Yang LI Zifeng ZHAN Kuidong XU | 2021 | Journal of Oceanology and Limnology2021，39，5： | 1 |
| 7 | Morphology and phylogeny of Chrysogorgia pinniformis sp.nov.and C.varians sp.nov.,two golden corals from the Caroline seamounts in the tropical Western Pacific Ocean显示文摘Two new species of Chrysogorgia Duchassaing&Michelotti,1864 collected from the Caroline seamounts in the tropical Western Pacific Ocean are described.Chrysogorgia pinniformis sp.nov.belongs to Versluys’group C(Squamosae typicae)with only scales in polyp body wall and tentacles.C.pinniformis sp.nov.is characterized by large branches pinnately branched and forming multiple fans with its small branches regularly and quasi-dichotomous branched,and scales and rods present in the polyp mouth area.It is most similar to C.pinnata Cairns,2007 by the pinnate trait,but differs from the latter by its group C pattern(vs.group A,Spiculosae)and having sclerites present in the polyp mouth area(vs.absent).Chrysogorgia varians sp.nov.belongs to the Chrysogorgia group A(Spiculosae)with rods distributed in the polyp body wall and tentacles.It is characterized by warty rods and elongated scales in the tentacles,many warts and ridges on the scales,conspicuously toothed margins at the rounded ends in the pinnules,and small rods with ridge-like warts in the polyp mouth area.This species was frequent and abundant in the Caroline seamounts during our cruises and its morphological variability in growth period was obvious.The phylogenetic analyses based on mtMutS and 28 S rDNA regions supported the assignment of the new species to the genus Chrysogorgia.However,the mtMutS marker showed very limited usefulness for species delimitation and inner relationship inference of Chrysogorgia.In contrast,the 28 S rDNA showed much higher level of genetic variation,and it may be a potential barcode for this genus.In the 28 S rDNA trees,the two new species clustered together.Additionally,compilation of our data showed that 42 of 78(ca.54%)Chrysogorgia species were found in the Indo-West Pacific convergent region,indicating that this area may be a hotspot of deep-water Chrysogorgia species. | Yu XU Zifeng ZHAN Kuidong XU | 2021 | Journal of Oceanology and Limnology2021，39，5： | 1 |
| 8 | Establishment of Alloptilella splendida gen.et sp.nov.and resurrection of Scytalium veneris(Thomson&Henderson,1906),two sea pens(Cnidaria:Pennatulacea)from seamounts in the tropical Western Pacific显示文摘Sea pens are a highly specialized and morphologically distinct group of octocorallians,but many taxa were poorly described and their phylogenetic relationships are still poorly known.We describe two species of sea pens collected from the tropical Western Pacific:Alloptilella splendida gen.et sp.nov.and Scytalium veneris(Thomson&Henderson,1906).Alloptilella splendida gen.et sp.nov.accords with the definition of the recently resurrected genus Ptilella Gray,1870 in most characters,but differs from the latter in the arrangement of autozooids and the location of mesozooids.The new species mostly resembles Pennatula naresi K(o|')lliker(1880),but differs by the location of me sozooids and the reddish color of sclerite s surrounding siphonozooids.The generic separation is also well supported by their genetic distances and the molecular phylogenetic trees constructed by the concatenated mtMutS-COI-28 S,where Alloptilella clustered with Scytalium Herklots,1858 and formed a clade with the cluster of Ptilella and Distichoptilum.Scytalium veneris,usually considered as a junior synonym of Scytalium sarsii Herklots,1858,is resurrected by recognizing their distinctive differences.This is the first record of Scytalium veneris outside its type locality,and the phylogenetic analysis indicates that Scytalium is a monophyletic group.Both the families Pennatulidae and Virgulariidae are polyphyletic,and more morphological and molecular data are needed to clarify the phylogenetic positions of pennatulacean families and genera. | Yang LI Zifeng ZHAN Kuidong XU | 2021 | Journal of Oceanology and Limnology2021，39，5： | 1 |
| 9 | Efficacy and safety of the combination of Liushen capsules and Arbidol in the treatment of COVID-19:protocol for a randomized,multi-center pilot study显示文摘Background:From early experience,some Traditional Chinese Medicine and Arbidol had effects of against COVID-19,infer that the combination of Liushen capsules and Arbidol may further increase the therapeutic.Methods/Design:We conducted a randomized,blank parallel-controlled,open-label,multi-center,basal therapy-loaded design clinical trial.A total of 40 patients are going to be recruited after satisfying the criteria.Participants will be allocated randomly into the treatment group with the combination of Arbidol and Liushen capsules and the control group with the basic therapy.Each group will receive treatment at least 7-days or until the virus becomes negative,and visits after drug administration at day 3(visit 1),the day when the virus becomes negative(visit 2),day 7(visit 3),the day before discharge(visit 4)and day 28(visit 5),to collect their survival status and disease prognosis so that the efficacy and safety of a combination of Arbidol and Liushen capsule will be evaluated.Discussion:We described the protocol of the first clinical trial for treatment COVID-19 by using a combination of Arbidol and Liushen capsules.The results of this study will provide a basis for the design and sample size estimate of subsequent large-scale clinical trials.Trial registration:This study has been registered at Chinese clinical trial Registry(chictr.org.cn):ChiCTR2000029993. | Yangqing Zhan Zhengtu Li Jiayang He Shaoqiang Li Ye Lin Jingyi Liang Jie Zhou Yanmei Wu Xuandan Su Feng Ye Zifeng Yang | 2020 | TMR Modern Herbal Medicine2020，3，4： | 0 |
| 10 | Blooms of Prorocentrum donghaiense reduced the species diversity of dinoflagellate community显示文摘Most of reported harmful algal blooms(HABs)of microalgae(75%)have been caused by dinoflagellates.Studies on the negative effects of HABs have generally focused on animals,valuable organisms in particular,and environmental factors such as dissolved oxygen and nutrients,but relatively fewer on community level,particularly that using metagenomic approach.In this study,we reported an investigation on the effects of a HAB caused by the dinoflagellate Prorocentrum donghaiense on the species diversity and community structure of the dinoflagellate sub-community via a pyrosequencing approach for the samples taken before,during,and after the bloom season of P.donghaiense in the East China Sea.We sequenced partial 28S rRNA gene of dinoflagellates for the field samples and evaluated the species richness and diversity indices of the dinoflagellate community,as a sub-community of the total phytoplankton.We obtained 800185 valid sequences(categorized into 560 operational taxonomic units,OTUs)of dinoflagellates from 50 samples and found that the biodiversity of dinoflagellate community was significantly reduced during the blooming period in comparison to that in pre-and after-blooming periods,as reflected in the four diversity indices:the species richness expressed as the number of OTUs,Chao1 index,Shannon index(evenness),and Gini-Simpson index.These four indices were all found to be negatively correlated to the cell density of the bloom species P.donghaiense.Correlation analyses also revealed that the P.donghaiense cell abundance was correlated negatively with NO3--N,and NO2--N,but positively with total nitrogen(TN)and total phosphorus(TP).Principal coordinates analysis(PCoA)showed that the community structure of dinoflagellates was markedly different among the different sampling periods,while the redundancy analysis(RDA)revealed P.donghaiense abundance,salinity,NO3--N,and SiO32-were the most four significant factors shaping the dinoflagellate community structure.Our results together demonstrated that HABs caused by the dinoflagellate P.donghaiense could strongly impact the aquatic ecosystem on the sub-community level which the blooming species belongs to. | Huan Wang Zhangxi Hu Zhaoyang Chai Yunyan Deng Zifeng Zhan Ying Zhong Tang | 2020 | Acta Oceanologica Sinica2020，39，4： | 0 |
| 11 | Four first records of trichodinid (Ciliophora: Peritrichia) ectoparasites from cultured molluscs and fishes in China显示文摘Four species of Trichodina parasitizing the gills of cultured molluscs and fishes in China are described:Trichodina pectenis Stein,1974 from the scallop Mizuhopecten yessoensis;Trichodina jadranica Raabe,1958 from the fishes Mugil cephalus and Anguilla bicolor bicolor;Trichodina acuta Lom,1961 and Trichodina rostrata Kulemina,1968 from the fish Acrossocheilus fasciatus.The description of T.pectenis presented here first includes both live characters and morphometric data obtained from specimens impregnated using the wet silver nitrate and protargol methods.The other species were revealed by the dry silver nitrate method.Intensities of infestation and comparisons with related species and populations are provided for each of the four. | ZHAN Zifeng ZENG Hong LIN Nengfeng XU Kuidong | 2018 | Acta Oceanologica Sinica2018，37，10： | 0 |
| 12 | High-Quality de novo Genome Assembly of Huajingxian 74, a Receptor Parent of Single Segment Substitution Lines显示文摘Rice(Oryza sativa L.)is grown nearly worldwide and provides the staple food for more than half of the global population(Luo et al,2017).The genomes of several cultivated rice varieties including Nipponbare(NPB)(Kawahara et al,2013;Sakai et al,2013),IR64(Tanaka et al,2020),93-11(Zhang et al,2018)and R498(Du et al,2017)at chromosome level,and Minghui 63 and Zhenshan 97(Zhang et al,2016)at scaffold level have been assembled,annotated and released,among which the R498 and NPB genomes are widely used as reference genomes in rice research.However,there are thousands of rice cultivars,landraces and wild rice varieties in the world with dramatically different genetic backgrounds,and the genomes of native rice varieties in South China,which is one of the major rice production areas in China,have not been de novo assembled.Huajingxian 74(HJX74)is an indica rice variety bred in South China Agricultural University,Guangdong Province with widely environmental adaptability and high yield(www.ricedata.cn/variety/varis/602548.htm).HJX74 exhibits significant phenotypic and genetic differences from those varieties whose whole genomes have been properly sequenced and assembled(Fig.1). | LI Fangping GAO Yanhao WU Bingqi CAI Qingpei ZHAN Pengling YANG Weifeng SHI Wanxuan LI Xiaohua YANG Zifeng TAN Quanya LUAN Xin ZHANG Guiquan WANG Shaokui | 2021 | Rice science2021，28，2： | 0 |
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