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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | New omega vortex identification method显示文摘A new vortex identification criterion called W-method is proposed based on the ideas that vorticity overtakes deformation in vortex.The comparison with other vortex identification methods like Q-criterion and λ_2-method is conducted and the advantages of the new method can be summarized as follows:(1) the method is able to capture vortex well and very easy to perform;(2) the physical meaning of W is clear while the interpretations of iso-surface values of Q and λ_2 chosen to visualize vortices are obscure;(3)being different from Q and λ_2 iso-surface visualization which requires wildly various thresholds to capture the vortex structure properly, W is pretty universal and does not need much adjustment in different cases and the iso-surfaces of W=0.52 can always capture the vortices properly in all the cases at different time steps, which we investigated;(4) both strong and weak vortices can be captured well simultaneously while improper Q and λ_2 threshold may lead to strong vortex capture while weak vortices are lost or weak vortices are captured but strong vortices are smeared;(5) W=0.52 is a quantity to approximately define the vortex boundary. Note that, to calculate W, the length and velocity must be used in the non-dimensional form. From our direct numerical simulation, it is found that the vorticity direction is very different from the vortex rotation direction in general 3-D vortical flow,the Helmholtz velocity decomposition is reviewed and vorticity is proposed to be further decomposed to vortical vorticity and non-vortical vorticity. | ChaoQun Liu YiQian Wang Yong Yang ZhiWei Duan | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，8： | 49 |
| 3 | The bHLH Transcription Factor MYC3 Interacts with the Jasmonate ZIM-Domain Proteins to Mediate Jasmonate Response in Arabidopsis显示文摘Arabidopsis Jasmonate ZIM 域蛋白质(JAZ ) 充当复杂的 SCFCOI1 的底层镇压他们的下游地指向,它为调整 JA 的植物开发和防卫是必要的。bHLH 抄写因素 MYC2 被发现 JA 回答包括与 JAZ 交往并且调停 JA 禁止的根生长。这里,我们识别了直接由它的 N 终端区域的优点与 JAZ 交往了调整 JA 回答的另一 bHLH 抄写因素 MYC3。有 MYC3 的 overexpression 的转基因的植物在 JA 禁止的根延伸和幼苗开发展出了超敏性。交往 JAZ 模式和 MYC3 的导致 JA 的表示模式从 MYC2 的那些是可区分的。我们推测那 MYC3, MYC2 可以在 JA 回答的规定有冗余而且可区分的功能。 | Zhiwei Cheng Li Sun Tiancong Qi Bosen Zhang Wen Peng Yule Liu Daoxin Xie | 2011 | Molecular Plant2011，4，2： | 35 |
| 4 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 5 | Validation of clinical significance of examined lymph node count for accurate prognostic evaluation of gastric cancer for the eighth edition of the American Joint Committee on Cancer(AJCC) TNM staging system显示文摘Objective: To validate the necessity of increasing the examined lymph node(ELN) count for enhancing the accuracy of prognostic evaluation of gastric cancer(GC) patients after curative gastrectomy in multiple medical centers of China.Methods: The clinicopathological data of 7,620 patients who underwent the curative resection for GC between2001 and 2011 were included to demonstrate whether the ELN count is indispensable for enhancing the accuracy of prognostic evaluation of GC patients after surgery. After a meticulous stratification by using the cut-point survival analysis, all included 7,620 patients were allocated into three groups as: less than 16(<16), between 16 and30(16-30), and more than 30(>30) ELNs. Survival differences among various subgroups of GC patients were analyzed to assess the impact of the ELN count on the stage migration in accordance with the overall survival(OS)of GC patients.Results: Survival analyses revealed that the ELN count was positively correlated with the OS(P=0.001) and was an independent prognostic predictor(P<0.01) of 7,620 GC patients. Stratum analysis showed that the accuracy of prognostic evaluation could be enhanced when the ELN count was no less than 16(≥16) for node-negative patients and >30 for node-positive patients. Stage migrations were mainly detected in the various subgroups of patients with specific pN stages as follows: pN0 with 16-30 ELNs(pN0_(16-30)) and pN0 with >30 ELNs(pN0_(>30)), pN0 with <16 ELNs(pN0_(<16)) and pN1_(>30), pN1_(<16) and pN2_(16-30), pN1_(16-30) and pN2_(>30), pN3a_(<16) and pN3b_(16-30), and pN3a_(<16) and pN3b_(>30). These findings indicate that increasing the ELN count is a prerequisite to guarantee precisely prognostic evaluation of GC patients.Conclusions: The ELN count should be proposed to be >30 for acquiring the accurate prognostic evaluation for GC patients, especially for node-positive patients. | Jingyu Deng Jinyuan Liu Wei Wang Zhe Sun Zhenning Wang Zhiwei Zhou Huimian Xu Han Liang | 2018 | Chinese Journal of Cancer Research2018，30，5： | 27 |
| 6 | Preoperative neutrophil-to-lymphocyte ratio plus platelet-to-lymphocyte ratioin predicting survival for patients with stage Ⅰ-Ⅱgastric cancer显示文摘Background:The preoperative neutrophil-to-lymphocyte ratio(NLR) and the platelet-to-lymphocyte ratio(PLR) are associated with poor prognosis of gastric cancer.We aimed to determine whether the combination of NLR and PLR(NLR-PLR) could better predict survival of patients after curative resection for stage Ⅰ-Ⅱ gastric cancer.Methods:We collected data from the medical records of patients with stage Ⅰ-Ⅱ gastric cancer undergoing curative resection between December 2000 and November 2012 at the Sun Yat-sen Cancer Center.The preoperative NLRPLR was calculated as follows:patients with both elevated NLR(≥2.1) and PLR(≥ 120) were given a score of 2,and patients with only one or neither were given a score of 1 or 0,respectively.Results:Kaplan-Meier analysis and log-rank tests revealed significant differences in overall survival(OS) among patients with NLR-PLR scores of 0,1 and 2(P < 0.001).Multivariate analysis showed that OS was independently associated with the NLR-PLR score[hazard ratio(HR) = 1.51,95%confidence interval(CI) 1.02-2.24,P = 0.039]and TNM stage(HR = 1.36,95%CI 1.01-1.83,P= 0.041).However,other systemic inflammation-based prognostic scores,including the modified Glasgow prognostic score,the prognostic nutritional index,and the combination of platelet count and NLR,were not.In TNM stage-stratified analysis,the prognostic significance of NLR-PLR was maintained in patients with stage Ⅰ(P < 0.001) and stage Ⅱ cancers(P= 0.022).In addition,the area under the receiver operating characteristic curve for the NLR-PLR score was higher than those of other systemic inflammation-based prognostic scores(P = 0.001).Conclusion:The preoperative NLR-PLR score is a useful predictor of postoperative survival in the patients with stage l-ll gastric cancer and may help identify high-risk patients for rational therapy and timely follow-up. | Xiaowei Sun Xuechao Liu Jianjun Liu Shangxiang Chen Dazhi Xu Wei Li Youqing Zhan Yuanfang Li Yingbo Chen Zhiwei Zhou | 2016 | Chinese Journal of Cancer2016，35，7： | 25 |
| 7 | Geochronology and geochemistry of the Fangcheng Neoproterozoic alkali-syenites in East Qinling orogen and its geodynamic implications显示文摘Finding of Neoproterozoic syenites at Fangcheng in the northern Qinling region of the East Qinling orogen provides an important constraint on timing of tectonic transformation to extensional regime. The alkaline pluton consists mainly of nepheline syenite,aegirine syenite,and alkali-feldspar syenite. The syenites are of intermediate (SiO2=54%―62%),rich in alkali (K2O+Na2O=12%―15%),aluminum (Al2O3=16.81%―23.26%) and large ion lithophile elements (LILE),without any obvious Nb,Ta,Zr,and Hf anoma-lies. The Fangcheng syenites are geochemically characterized by relative enrichment of LREE,minor differentiation of HREE,significant negative Eu anomalies (Eu=0.13―0.23),less negative εNd(t) values of -1.37 to -3.90,young Nd model ages of 1364 to 1569 Ma,and high zircon saturation temperatures of 915 to 1044℃. The syenitic magmas probably originated from small proportion melting of upper mantle in an extensional regime of intraplate-anorogenic tectonic setting,and have been slightly contaminated by crustal materials during ascending and/or emplacement. LA-ICP-MS zircon U-Pb dating yields ages of 844.3±1.6 Ma (MSWD=0.86),suggesting that the Fangcheng alkaline syenites formed in the early Neo-proterozoic. They are the oldest Neoproterozoic alkaline rocks ever recognized in the Qinling orogen as well as in South China. This implies that the tectonic regime of the Qinling region would have transformed from post-collisional stretch to intraplate-anorogenic extension no later than 844 Ma. | BAO ZhiWei WANG Qiang BAI GuoDian ZHAO ZhenHua SONG YaoWu LIU XiaoMing | 2008 | Chinese Science Bulletin2008，53，13： | 22 |
| 8 | Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle显示文摘在到最糟的最高的注意在航线上吸烟以及薄雾侮辱的全球付钱的时间,所有人知道两个外长、显著。然而,包括许多医药人员,人们主要不知道 gastroesophageal 倒流(GER ) 怎么糟糕在我们的自己的航线上侮辱。GER 的症状通常被看作心痛和流回,它能主要被容忍。不管多么起来在它出现的地方,去的胃的内容相对地传递食管然后远侧的咽象苛评一样的鸟喙,用作一张嘴,以便生产众多微粒子并且到达oro鼻的洞并且另外引起的航线过敏鼻炎和气喘的攻击,甚至肺的实质损害。它将减少生活质量或甚至使受危险生活。内长的侮辱在呼吸系统出现,但是从消化的道发源的点不是众所周知的并且经常 undiagnosed 并且不正确地对待。导致的航线挑战是的 GER 一个可对待、预防的实体一旦诊断被做,好消除能通过 radiofrequency 或 fundoplication 借助于张开的贲门的生活方式调整,药,或固定被期望。作者王忠高博士承受了它为长并且症状在反倒流外科以后消失了 8 年。这是王忠高博士和他的队工作的一个演讲并且将引起注意到公众以便认出作为吸烟或薄雾从人的本身,然而并非从外面的环境发生的一个可对待的条件做的这个相对未知的实体。 | Zhonggao Wang Zhiwei Hu Jimin Wu Feng Ji Hongtao Wang Yungang Lai Xiang Gao Yachan Ning Chengchao Zhang Zhitong Li Weitao Liang Jianjun Liu | 2015 | Frontiers of Medicine2015，9，1： | 21 |
| 9 | Identification of coastal wetlands of international importance for waterbirds:a review of China Coastal Waterbird Surveys 2005–2013显示文摘Background:China's coastal wetlands belong to some of the most threatened ecosystems worldwide.The loss and degradation of these wetlands seriously threaten waterbirds that depend on wetlands.Methods:The China Coastal Waterbird Census was organized by volunteer birdwatchers in China's coastal region.Waterbirds were surveyed synchronously once every month at 14 sites,as well as irregularly at a further 18 sites,between September 2005 and December 2013.Results:A total of 75 species of waterbirds met the 1 % population level Ramsar listing criterion at least once at one site.The number of birds of the following species accounted for over 20 % of the total flyway populations at a single site:Mute Swan(Cygnus olor),Siberia Crane(Grus leucogeranus),Far Eastern Oystercatcher(Haematopus osculans),Bar-tailed Godwit(Limosa lapponica),Spotted Greenshank(Tringa guttifer),Great Knot(Calidris tenuirostris),Spoon-billed Sandpiper(Calidris pygmeus),Saunders' s Gull(Larus saundersi),Relict Gull(Larus relictus),Great Cormorant(Phalacrocorax carbo),Eurasian Spoonbill(Platalea leucorodia),Black-faced Spoonbill(Platalea minor) and Dalmatian Pelican(Pelecanus crispus).A total of 26 sites supported at least one species of which their number met the1 % criterion.Forty-two species met the 1 % criterion in the Yellow River Delta,Shandong;29 at the Cangzhou coast,Hebei and 26 species at the Lianyungang coast,Jiangsu.Conclusions:The results highlight the international importance of China's coastal wetlands for waterbirds.This study also demonstrates that participation of local birdwatchers in waterbird surveys results in data that are invaluable not only for understanding the current status of waterbirds in China's coastal regions but also for waterbird conservation and management. | Qingquan Bai Jianzhong Chen Zhihong Chen Guotai Dong Jiangtian Dong Wenxiao Dong Vivian Wing Kan Fu Yongxiang Han Gang Lu Jing Li Yang Liu Zhi Lin Derong Meng Jonathan Martinez Guanghui Ni Kai Shan Renjie Sun Suixing Tian Fengqin Wang Zhiwei Xu Yat-tung Yu Jin Yang Zhidong Yang Lin Zhang Ming Zhang Xiangwu Zeng | 2015 | Chinese Birds2015，，3： | 20 |
| 10 | Thermal energy storage:Challenges and the role of particle technology显示文摘Thermal energy is at the heart of the whole energy chain providing a main linkage between the primary and secondary energy sources.Thermal energy storage(TES)has a pivotal role to play in the energy chain and hence in future low carbon economy.However,a competitive TES technology requires a number of scientific and technological challenges to be addressed including TES materials,TES components and devices,and integration of TES devices with energy networks and associated dynamic optimization.This paper provides a perspective of TES technology with a focus on TES materials challenges using molten salts based phase change materials for medium and high temperature applications.Two key challenges for the molten salt based TES materials are chemical incompatibility and low thermal conductivity.The use of composite materials provides an avenue to meeting the challenges.Such composite materials consist of a phase change material,a structural supporting material,and a thermal conductivity enhancement material.The properties of the supporting material could determine the dispersion of the thermal conductivity enhancement material in the salt.A right combination of the salt,the structural supporting material,and the thermal conductivity enhancement material could give a hierarchical structure that is able to encapsulate the molten salt and give a substantial enhancement in the thermal conductivity.Understanding of the structure-property relationships for the composite is essential for the formulation design and fabrication of the composite materials.Linking materials properties to the system level performance is recommended as a key future direction of research. | Zhiwei Ge Yongliang Li Dacheng Li Ze Sun Yi Jin Chuanping Liu Chuan Li Guanghui Leng Yulong Ding | 2014 | Particuology2014，12，4： | 20 |
| 11 | Linear Quadratic Differential Game Strategies with Two-pursuit Versus Single-evader显示文摘In order to intercept the future targets that are characterized by high maneuverability, multiple interceptors may be launched and aimed at single target. The scenario of two missiles P and Q intercepting a single target is modeled as a two-pursuit single-evader non-zero-sum linear quadratic differential game. The intercept space is decomposed into three subspaces which are mutually disjoint and their union covers the entire intercept space. The effect of adding the second interceptor arises in the intercept space of both P and Q (PQ-intercept space). A guidance law is derived from the Nash equilibrium strategy set (NESS) of the game. Simulation studies are focused on the PQ-intercept space. It is indicated that 1) increasing the target's maneuverability will enlarge PQ-intercept space; 2) the handover conditions will be released if the initial zero-effort-miss (ZEM) of both interceptors has opposite sign; 3) overvaluation of the target's maneuverability by choosing a small weight coefficient will generate robust performance with respect to the target maneuvering command switch time and decrease the fuel requirement; and 4) cooperation between interceptors increases the interception probability. | LIU Yanfang QI Naiming TANG Zhiwei | 2012 | Chinese Journal of Aeronautics2012，25，6： | 19 |
| 12 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 13 | Ground settlement of Chek Lap Kok Airport,Hong Kong,detected by satellite synthetic aperture radar interferometry显示文摘Satellite synthetic aperture radar (SAR) inter-ferometry is used to investigate the slowly accumulating ground settlement at the new Chek Lap Kok Airport in Hong Kong. Most of the land occupied by the airport was reclaimed from the sea and therefore certain ground settlement in the area has been expected. A pair of ERS-2 SAR images spanning nearly a year is used in the study. The high spatial resolution (20 m×20 m) ground settlement map derived indicates that the settlement that occurred in the area over the time period is as large as 50 mm. The SAR measurement results agree with the levelling measurements at some benchmarks in the area to well within 1 cm(rms error),and the overall correlation between the two types of results is 0.89. The paper presents some brief background of inter-ferometric SAR, and outlines the data processing methods and results. | LIU Guoxiang DING Xiaoli CHEN Yongqi LI Zhilin LI Zhiwei | 2001 | Chinese Science Bulletin2001，46，21： | 16 |
| 14 | Design of integrated radar and communication system based on MIMO-OFDM waveform显示文摘Orthogonal frequency division multiplexing(OFDM)waveform enables radar and communication functions simultaneously, which encounters low angle resolution and poor data rate for traditional single input single output(SISO) systems. To solve these problems, an integrated radar and communication system(IRCS) with multiple input multiple output(MIMO) OFDM waveform is proposed. The different limitations of radar and communication in designing such a system are investigated. Then, an optimization problem is devised to obtain suitable system parameters, including the number of subcarriers, subcarrier spacing, number of symbols,pulse repetition frequency(PRF) and length of cyclic prefix(CP).Finally, to satisfy the requirements of both radar and communication, the IRCS parameters are derived in three typical cases.Several numerical results are presented to illustrate the demands of radar and communication, inconsistent or consistent, for the IRCS parameters and the superiority of the proposed system. | Yongjun Liu Guisheng Liao Zhiwei Yang Jingwei Xu | 2017 | Journal of Systems Engineering and Electronics2017，28，4： | 16 |
| 15 | Preparation and Characterization of Three Monoclonal Antibodies against HIV-1 p24 Capsid Protein显示文摘HIV-1 p24 detection provides a means to aid the early diagnosis of HIV-1 infection, track the progression of disease and assess the efficacy of antiretroviral therapy. In the present study, three monoclonal antibodies (mAbs) p3JB9, p5F1 and p6F4 against HIV-1 p24 were generated. All mAbs could detect p24 of HIV-1IIIB, HIV-1Ada-M, HIV-174V mAbs p5F1 and p6F4 could detect HIV-1KM018, while p3JB9 could not. Three mAbs did not react with HIV-2ROD, HIV-2CBL-20 and SIVagmTYO-1. The recognized epitope of p5F1 was located on the Gag amino acid region DCKTILKALGPAATLEEMMTAC. The p5F1 was used to establish a modified sandwich ELISA with rabbit anti-p24 serum and showed good specificity and high sensitivity, which has been used to measure HIV-1 p24 antigen levels in research. | Guangjie Liu Jianping Wang Jianchun Xiao Zhiwei Zhao Yongtang Zheng | 2007 | Cellular & Molecular Immunology2007，4，3： | 14 |
| 16 | Integration of micro-supercapacitors with triboelectric nanogenerators for a flexible self-charging power unit显示文摘便携式、便携的电子设备的快速的发展为灵活、有效的精力收获和存储单位增加了需求。通常,这些作为分离部件独立被造并且使用。此处,我们建议雕刻的简单、划算的激光为制作一个灵活自我控告的 micro-supercapacitor 力量单位(SCMPU ) 的技术,由集成摩擦电, nanogenerator (TENG ) 和 micro-supercapacitor (MSC ) 穿进一台单个设备。SCMPU 能被周围的机械运动直接控告。我们表明 SCMPU 的能力连续地驱动轻射出的二极管和商业温湿计。这调查可以支持持续自我动力的系统的开发并且为 supercapacitors 提供一个有希望的新研究应用程序。 | Jianjun Luo Feng Ru Fan Tao Jiang Zhiwei Wang Wei Tang Cuiping Zhang Mengmeng Liu Guozhong Cao Zhong Lin Wang | 2015 | Nano Research2015，8，12： | 14 |
| 17 | Fluvial diversity in relation to valley setting in the source region of the Yangtze and Yellow Rivers显示文摘山谷设定的空间分发(旁边地自由,部分限制,或限制) 并且在 Yangtze 和黄河的来源区域的河的形态学被对比并且分析。长江的来源区域被划分成 3 宽广的节(我, II 和 III )基于山谷设定和隧道坡度,与被描绘由的在上游、下游的节限制(一些活动范围部分限制)山谷,当中间的节被描绘与时宽、浅,旁边地自由的山谷。峡在节是突出的我和 III,当编织隧道模式统治节 II 时。由对比,黄河的来源区域基于山谷特征和隧道坡度被划分成 5 宽广的节(节 IV ) 。节我, II 和 IV 是冲积活动范围与主要旁边地自由(一些短活动范围部分限制) 山谷。节 III 和 V 主要被限制或部分限制。更大的词法差异在相对上面的长江的黄河的来源区域是明显的。这包括编织, anabranching,吻合,蜿蜒地流并且笔直地冲积的模式,与在限制活动范围的峡。这个区域的宏消除(举起,坡度,方面,山谷排列和监禁) ,直接连接了到 Qinghai 西藏高原的构造运动,系住到气候, hydrologic 和关於生命的考虑,是在在这个区域的河差异的模式之上的主要控制。 | YU Guo-an LIU Le LI Zhiwei LI Yanfu HUANG Heqing Gary BRIERLEY Brendon BLUE WANG Zhaoyin PAN Baozhu | 2013 | Journal of Geographical Sciences2013，23，5： | 14 |
| 18 | Prognostic factors of primary gastrointestinal stromal tumors: a cohort study based on high-volume centers显示文摘Objective: We aimed to evaluate the clinicopathologic characteristics, immunohistochemical expression and prognostic factors of patients with primary gastrointestinal stromal tumors(GISTs).Methods: Data from 2,570 consecutive GIST patients from four medical centers in China(January2001–December 2015) were reviewed. Survival curves were constructed by the Kaplan-Meier method, and Cox regression models were used to identify independent prognostic factors.Results: Of the included patients, 1,375(53.5%) were male, and the patient age range was 18 to 95(median, 58)years. The tumors were mostly found in the stomach(64.5%), small intestine(25.1%) and colorectal region(5.1%).At the time of diagnosis, the median tumor size was 4.0(range: 0.1–55.0) cm, and the median mitotic index per 50 high power fields(HPFs) was 3(range: 0–254). Of the 2,168 resected patients, 2,009(92.7%) received curative resection. According to the modified National Institutes of Health(NIH) classification, 21.9%, 28.9%, 14.1% and35.1% were very low-, low-, intermediate-and high-risk tumors, respectively. The rate of positivity was 96.4% for c-Kit, 87.1% for CD34, 96.9% for delay of germination 1(DOG-1), 8.0% for S-100, 31.0% for smooth muscle actin(SMA) and 5.1% for desmin. However, the prognostic value of each was limited. Multivariate analysis showed that age, tumor size, mitotic index, tumor site, occurrence of curative resection and postoperative imatinib were independent prognostic factors. Furthermore, we found that high-risk patients benefited significantly from postoperative imatinib(P<0.001), whereas intermediate-risk patients did not(P=0.954).Conclusions: Age, tumor size, mitotic index, tumor site, occurrence of curative resection and postoperative imatinib were independent prognostic factors in patients with GISTs. Moreover, determining whether intermediate-risk patients can benefit from adjuvant imatinib would be of considerable interest in future studies. | Xuechao Liu Haibo Qiu Peng Zhang Xingyu Feng Tao Chen Yong Li Kaixiong Tao Guoxin Li Xiaowei Sun Zhiwei Zhou | 2018 | Chinese Journal of Cancer Research2018，30，1： | 14 |
| 19 | Composition, origin and weathering process of surface sediment in Kumtagh Desert, Northwest China显示文摘Kumtagh 沙漠是在中国的八最大的沙漠之一,但是因为存取的困难,以前糟糕调查我们的学科交差的学习。在这份报纸, 33 件代表性的表面沉积样品从在实验室荒芜、分析的 Kumtagh 被收集获得重矿物质部件和 geochemical 元素内容。结果证明重矿物质的各种各样的类型在这些样品是在场的,与绿帘石和角闪石的高水平。Si 和艾尔收起化学作文的大部分。与上面的大陆人外壳(UCC ) 的 geochemical 元素的平均作文相比,除了 Si 和 Ca,所有元素被弄空到某个度;Fe, Mg, Ca, P, Ti 和 Mn 在他们的内容有高关联系数。矿物质和 Kumtagh 荒芜的沉积的 geochemical 作文在 Altyn Tagh 山脉和 Taklamakan 沙漠的附近与 Altyn Tagh 山脉,和冲积/洪水的扇子的表面沉积的岩石的有类似,显示 Kumtagh 荒芜的沉积的一主要来源位于 Altyn Tagh 山脉。在 Aqik 山谷和 Shule 河的更低的活动范围的冲积沉积物和湖沉积是容易的被侵蚀并且搬运由强壮在东北弯屈进 Kumtagh 沙漠,形成沙漠的另一来源扔。一张 A-CN-K 第三的图证明由 Na 和 K 的损失捱过的弱度化学药品发生在这些沉积,而 A-CNK-FM 第三的图建议 Fe 和 Mg 经历了重要化学区别。物理捱过过程为 mafic 矿物质在好粒子引起容易的侵蚀和丰富,这样粗糙的荒芜的沙粒子能相对在 Fe 和 Mg 被弄空。在经历不太化学的捱过的干旱区域的沉积的矿物质和 geochemical 作文被物理捱过主要影响。 | XU Zhiwei LU Huayu ZHAO Cunfa WANG Xianyan SU Zhizhu WANG Zhenting LIU Hongyi WANG Lixin LU Qi | 2011 | Journal of Geographical Sciences2011，21，6： | 13 |
| 20 | PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins显示文摘Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules, such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a pathological hallmark of various neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Protein posttranslational modifications (PTMs) are known to 佗gulate RNP granules. In this study, we investigate the function of poly(ADP-ribosyl)ation (PARylation), an important PTM involved in DNA damage repair and cell death, in RNP granule-related neurodegeneration. We reveal that PARylation levels are a major regulator of the assembly-disassembly dynamics of RNP granules containing disease-related RBPs, hnRNP A1 and TDP-43. We find that hnRNP A1 can both be PARylated and bind to PARylated proteins or poly(ADP-ribose)(PAR). We further uncover that PARylation of hnRNP A1 at K298 controls its nucleocytoplasmic transport, whereas PAR-binding via the PAR-binding motif (PBM) of hnRNP Al regulates its association with stress granules. Moreover, we reveal that PAR not only dramatically enhances the liquid-liquid phase separation of hnRNP A1, but also promotes the co-phase separation of hnRNP A1 and TDP-43 in vitro and their interaction in vivo. Finally, both genetic and pharmacological inhibition of PARP mitigates hnRNP Al- and TDP-43-mediated neurotoxicity in cell and Drosophila models of ALS. Together, our findings suggest a novel and crucial role for PARylation in regulating the dynamics of RNP granules, and that dysregulation in PARylation and PAR levels may con tribute to ALS disease pathoge nesis by promoting protei n aggregation. | Yongjia Duan Aiying Du Jinge Gu Gang Duan Chen Wang Xinrui Gui Zhiwei Ma Beituo Qian Xue Deng Kai Zhang Le Sun Kuili Tian Yaoyang Zhang Hong Jiang Cong Liu Yanshan Fang | 2019 | Cell Research2019，29，3： | 13 |
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