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| 1 | Searching for the Nano-Hertz Stochastic Gravitational Wave Background with the Chinese Pulsar Timing Array Data ReleaseⅠ显示文摘Observing and timing a group of millisecond pulsars with high rotational stability enables the direct detection of gravitational waves(GWs).The GW signals can be identified from the spatial correlations encoded in the times-of-arrival of widely spaced pulsar-pairs.The Chinese Pulsar Timing Array(CPTA)is a collaboration aiming at the direct GW detection with observations carried out using Chinese radio telescopes.This short article serves as a“table of contents”for a forthcoming series of papers related to the CPTA Data Release 1(CPTA DR1)which uses observations from the Five-hundred-meter Aperture Spherical radio Telescope.Here,after summarizing the time span and accuracy of CPTA DR1,we report the key results of our statistical inference finding a correlated signal with amplitude logA_(c)=-14.4_(-2.8)^(+1.0)for spectral index in the range ofα∈[-1.8,1.5]assuming a GW background(GWB)induced quadrupolar correlation.The search for the Hellings–Downs(HD)correlation curve is also presented,where some evidence for the HD correlation has been found that a 4.6σstatistical significance is achieved using the discrete frequency method around the frequency of 14 n Hz.We expect that the future International Pulsar Timing Array data analysis and the next CPTA data release will be more sensitive to the n Hz GWB,which could verify the current results. | Heng Xu Siyuan Chen Yanjun Guo Jinchen Jiang Bojun Wang Jiangwei Xu Zihan Xue RNicolas Caballero Jianping Yuan Yonghua Xu Jingbo Wang Longfei Hao Jingtao Luo Kejia Lee Jinlin Han Peng Jiang Zhiqiang Shen Min Wang Na Wang Renxin Xu Xiangping Wu Richard Manchester Lei Qian Xin Guan Menglin Huang Chun Sun Yan Zhu | 2023 | Research in Astronomy and Astrophysics2023，23，7： | 3 |
| 2 | La[N(SiMe3)2]3-Catalyzed Hydroboration of Esters and Other Challenging Unsaturated Groups显示文摘Background and Originality Content Reduction of esters to corresponding alcohols is a fundamental transformation in organic chemistry.111 Conventionally,this transformation is realized by employing hydride sources or hydrogenation mediated by transition metal catalysts.12,31 The major demerit of metal hydride reduction Is the handling of the intrinsically unsafe pyrophoric and moisture sensitive chemical agents,especially at large scale.Moreover,quenching the excessive reactive metal hydrides during workup and the disposal of the effluent generated may pose additional cumbersome environmental bur-den.pal For transition metal mediated hydrogenation,usually harsh conditions with elevated reaction temperature accompanying with high pressure are mandatory. | Xiaojuan Xu Zihan Kang Dandan Yan Mingqiang Xue | 2019 | Chinese Journal of Chemistry2019，37，11： | 2 |
| 3 | Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure显示文摘Peritoneal fibrosis together with increased capillaries is the primary cause of peritoneal dialysis failure.Mesothelial cell loss is an initiating event for peritoneal fibrosis.We find that the elevated glucose concentrations in peritoneal dialysate drive mesothelial cell pyroptosis in a manner dependent on caspase-3 and Gasdermin E,driving downstream inflammatory responses,including the activation of macrophages.Moreover,pyroptosis is associated with elevated vascular endothelial growth factor A and C,two key factors in vascular angiogenesis and lymphatic vessel formation.GSDME deficiency mice are protected from high glucose induced peritoneal fibrosis and ultrafiltration failure.Application of melatonin abrogates mesothelial cell pyroptosis through a MT1R-mediated action,and successfully reduces peritoneal fibrosis and angiogenesis in an animal model while preserving dialysis efficacy.Mechanistically,melatonin treatment maintains mitochondrial integrity in mesothelial cells,meanwhile activating m TOR signaling through an increase in the glycolysis product dihydroxyacetone phosphate.These effects together with quenching free radicals by melatonin help mesothelial cells maintain a relatively stable internal environment in the face of high-glucose stress.Thus,Melatonin treatment holds some promise in preserving mesothelium integrity and in decreasing angiogenesis to protect peritoneum function in patients undergoing peritoneal dialysis. | Hongxia Ruan Xuejuan Li Lina Zhou Zihan Zheng Rulin Hua Xu Wang Yuan Wang Yujie Fan Shuwen Guo Lihua Wang Shafiq ur Rahman Ziwei Wang Yuyuan Wei Shuangyan Yu Rongzhi Zhang Qian Cheng Jie Sheng Xue Li Xiaoyan Liu Ruqiang Yuan Xiaoyan Zhang Lihong Chen Guowang Xu Youfei Guan Jing Nie Hongqiang Qin Feng Zheng | 2024 | Science China(Life Sciences)2024，67，2： | 0 |
| 4 | Multi-chambered,carbon-coated Ni_(0.4)Fe_(2.6)O_(4) nanoparticle superlattice microspheres for boosting water oxidation reaction显示文摘Developing active and robust non-noble-metal-based electrocatalysts for the oxygen evolution reaction(OER)is of vital practical significance for accelerating the kinetics of water splitting.Here,a novel double emulsion template method is proposed to design and prepare hierarchically multichambered,carbon-coated Ni_(0.4)Fe_(2.6)O_(4) nanoparticle superlattice microspheres(M-NFO@C-NSMs)for the highly efficient oxygen evolution.The high-temperature calcination under inert gas enables an improved electrochemical property by rationally transforming the long-chain organic capping ligands into partially graphitized uniform carbon coatings.More importantly,benefiting from the unique hierarchical superstructure with macro-/meso-/microporosities and three-dimensional continuous conductive carbon frameworks,M-NFO@C-NSMs exhibit comprehensively enhanced OER activity in a dilute alkaline electrolyte as compared to their solid counterparts and most spinelbased electrocatalysts reported to date.Notably,the collective property of supraparticles endowed M-NFO@C-NSMs with superior long-term cyclic stability.This work sheds light on the sophisticated design of functionalized supraparticles for efficient water splitting. | Mingzhong Li Yuwei Deng Guanhong Wu Shuqing Xue Yancui Yan Zihan Liu Jinxiang Zou Dong Yang Angang Dong | 2021 | Aggregate2021，2，2： | 0 |
| 5 | Generalized assembly of sandwich-like 0D/2D/0D heterostructures with highly exposed surfaces toward superior electrochemical performances显示文摘Heterostructures composed of two-dimensional(2D)nanosheets and zero-dimensional(0D)nanoparticles(NPs)have attracted increasing attention because of the synergy arising from the coupling interactions between the two mixed-dimensional components.Despite recent advances,it remains a challenge to fabricate 2D/0D heterostructures with clean and accessible surfaces,which is highly desirable for the diversity of catalytic,sensing,and energy storage applications.Herein,we report a generalized methodology that enables the facile assembly of sandwich-like 0D/2D/0D heterostructures with facilitated mass-transport channels and exposed surface active sites.A ligand-exchange strategy with HBF4 is employed to strip off the surface-coating ligands of colloidal NPs,rendering them positively charged and dispersible in polar solvents.This allows subsequent electrostatic assembly of NPs with oppositely charged 2D nanosheets to afford sandwich-like 0D/2D/0D heterostructures.The barely covered surfaces and the advantageous architectures of such sandwich-like 0D/2D/0D heterostructures induce the desired synergistic effect,making them particularly suitable for electrochemical energy storage and conversion.We demonstrate this by employing MXene/NiFe_(2)O_(4) and MXene/Fe3O4 heterostructures for high-performance electrocatalytic oxygen evolution and supercapacitors,respectively. | Shuqing Xue Guanhong Wu Mingzhong Li Zihan Liu Yuwei Deng Wenqian Han Xuanyu Lv Siyu Wan Xiangyun Xi Dong Yang Angang Dong | 2022 | Nano Research2022，15，1： | 0 |
| 6 | Combining cisplatin and a STING agonist into one molecule for metalloimmunotherapy of cancer显示文摘Mounting evidence suggests that strategies combining DNA-damaging agents and stimulator of interferon genes(STING) agonists are promising cancer therapeutic regimens because they can amplify STING activation and remodel the immunosuppressive tumor microenvironment. However, a single molecular entity comprising both agents has not yet been developed. Herein, we designed two PtIV-MSA-2 conjugates(Ⅰand Ⅱ) containing the DNA-damaging chemotherapeutic drug cisplatin and the innate immuneactivating STING agonist MSA-2;these conjugates showed great potential as multispecific small-molecule drugs against pancreatic cancer. Mechanistic studies revealed that conjugate Ⅰ upregulated the expression of transcripts associated with innate immunity and metabolism in cancer cells, significantly differing from cisplatin and MSA-2. An analysis of the tumor microenvironment demonstrated that conjugate I could enhance the infiltration of natural killer(NK) cells into tumors and promote the activation of T cells, NK cells and dendritic cells in tumor tissues. These findings indicated that conjugate I, which was created by incorporating a Pt chemotherapeutic drug and STING agonist into one molecule, is a promising and potent anticancer drug candidate, opening new avenues for small-molecule-based cancer metalloimmunotherapy. | Shuren Zhang Dongfan Song Wenhao Yu Ji Li Xiaoyu Wang Yachao Li Zihan Zhao Qi Xue Jing Zhao Jie P.Li Zijian Guo | 2024 | National Science Review2024，11，1： | 0 |
| 7 | Gradient carbonyl-iron/carbon-fiber reinforced composite metamaterial for ultra-broadband electromagnetic wave absorption by multi-scale integrated design显示文摘The demand of high-end electromagnetic wave absorbing materials puts forward higher requirements on comprehensive performances of small thickness,lightweight,broadband,and strong absorption.Herein,a novel multi-layer stepped metamaterial absorber with gradient electromagnetic properties is proposed.The complex permittivity and permeability of each layer are tailored via the proportion of carbonyliron and carbon-fiber dispersing into the epoxy resin.The proposed metamaterial is further optimized via adjusting the electromagnetic parameters and geometric sizes of each layer.Comparing with the four-layer composite with gradient electromagnetic properties which could only realize reflection loss(RL)of less than−6 dB in 2.0-40 GHz,the optimized stepped metamaterial with the same thickness and electromagnetic properties realizes less than−10 dB in the relevant frequency range.Additionally,the RL of less than−15 dB is achieved in the frequency range of 11.2-21.4 GHz and 28.5-40 GHz.The multiple electromagnetic wave absorption mechanism is discussed based on the experimental and simulation results,which is believed to be attributed to the synergy effect induced by multi-scale structures of the metamaterial.Therefore,combining multi-layer structures and periodic stepped structures into a novel gradient absorbing metamaterial would give new insights into designing microwave absorption devices for broadband electromagnetic protections. | Qian Zhou Tiantian Shi Bei Xue Shengyue Gu Wei Ren Fang Ye Xiaomeng Fan Wenyan Duan Zihan Zhang Lifei Du | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，6： | 0 |
| 8 | Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's disease显示文摘Parkinson’s disease can affect not only motor functions but also cognitive abilities,leading to cognitive impairment.One common issue in Parkinson’s disease with cognitive dysfunction is the difficulty in executive functioning.Executive functions help us plan,organize,and control our actions based on our goals.The brain area responsible for executive functions is called the prefrontal co rtex.It acts as the command center for the brain,especially when it comes to regulating executive functions.The role of the prefrontal cortex in cognitive processes is influenced by a chemical messenger called dopamine.However,little is known about how dopamine affects the cognitive functions of patients with Parkinson’s disease.In this article,the authors review the latest research on this topic.They start by looking at how the dopaminergic syste m,is alte red in Parkinson’s disease with executive dysfunction.Then,they explore how these changes in dopamine impact the synaptic structure,electrical activity,and connection components of the prefrontal cortex.The authors also summarize the relationship between Parkinson’s disease and dopamine-related cognitive issues.This information may offer valuable insights and directions for further research and improvement in the clinical treatment of cognitive impairment in Parkinson’s disease. | Zihang Zhou Yalong Yan Heng Gu Ruiao Sun Zihan Liao Ke Xue Chuanxi Tang | 2024 | Neural Regeneration Research2024，19，8： | 0 |
| 9 | Involvement of PGC7 and UHRF1 in the regulation of DNA methylation of the IG-DMR in the imprinted Dlk1-Dio3 locus显示文摘The gene dosage at the imprinted Dlk1-Dio3 locus is critical for cell growth and development.A relatively high gene expression within the Dlk1-Dio3 region,especially the active expression of Gtl2,has been identified as the only reliable marker for cell pluripotency.The DNA methylation state of the IG-DNA methylated regions(DMR),which is located upstream of the Gtl2 gene,dominantly contributes to the control of gene expression in the Dlk1-Dio3 locus.However,the precise mechanism underlying the regulation of DNA methylation in the IG-DMR remains largely unknown.Here,we use the F9 embryonal carcinoma cell line,a low pluripotent cell model,to identify the mechanism responsible for DNA methylation in the IG-DMR,and find that the interaction of PGC7 with UHRF1 is involved in maintaining DNA methylation and inducing DNA hypermethylation in the IG-DMR region.PGC7 and UHRF1 cooperatively bind in the IG-DMR to regulate the methylation of DNA and histones in this imprinted region.PGC7 promotes the recruitment of DNMT1 by UHRF1 to maintain DNA methylation in the IG-DMR locus.The interaction between PGC7 and UHRF1 strengthens their binding to H3K9me3 and leads to further enrichment of H3K9me3 in the IG-DMR by recruiting the specific histone methyltransferase SETDB1.Consequently,the abundance of H3K9me3 promotes DNMT3A to bind to the IG-DMR and increases DNA methylation level in this region.In summary,we propose a new mechanism of DNA methylation regulation in the IG-DMR locus and provide further insight into the understanding of the difference in Gtl2 expression levels between high and low pluripotent cells. | Mengying Yu Yingxiang Liu Zhuo Han Wei Du Bingxue Chen Lei Zhang Hongni Xue Zihan Zhang Zekun Guo | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 0 |
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