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| 1 | 晚期非小细胞肺癌免疫检查点抑制剂新型生物标志物:血液PD-L1动态检测显示文摘背景免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)具有良好疗效已成为恶性肿瘤治疗领域备受瞩目的翘楚。然而,仅有小部分患者获得长期临床获益。如何选择生物标志物来筛查ICIs治疗优势人群仍是一大热点。方法收集51例晚期恶性肿瘤患者的肿瘤组织和配对血样本,进行PD-L1表达的相关性分析。40例晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者接受ICIs治疗,2个月时检测血液PD-L1(bloodPD-L1,bPD-L1)表达的动态变化,包括PD-L1 mRNA、外泌体PD-L1(exosomalPD-L1,exoPD-L1)蛋白和可溶性PD-L1(solublePD-L1,sPD-L1)。应用R软件计算最佳截断值,用于预测最佳客观缓解(best objective response,b OR)、无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)。结果51例不同恶性肿瘤患者中,组织PD-L1(tissuePD-L1,tPD-L1)表达阳性患者的PD-L1mRNA表达水平显著升高。40例接受ICIs治疗的晚期NSCLC患者中,bPD-L1 mRNA上调≥2.04的患者b OR、PFS和OS更佳;21例接受ICIs治疗的晚期NSCLC患者中,exoPD-L1上调≥1.86的患者临床获益更大。sPD-L1动态变化与ICIs疗效无显著相关性。PD-L1 mRNA和exoPD-L1联合检测更有利于预测ICIs治疗疗效。结论bPD-L1表达与tPD-L1表达存在正相关;晚期NSCLC患者ICIs治疗初期PD-L1 mRNA和(或)exoPD-L1表达升高,可作为评估临床获益的新型生物标志物。 | Qiao YANG Mingjing CHEN Jiaoyang GU Kai NIU Xianlan ZHAO Linpeng ZHENG Zihan XU Yongxin YU Feng LI Lingxin MENG Zhengtang CHEN Wenlei ZHUO Luping ZHANG Jianguo SUN 杨峤(译) 孙建国(译) | 2021 | 中国肺癌杂志2021，24，12： | 10 |
| 2 | Cryo-EM structure of human mTOR complex 2显示文摘 | Xizi Chen Mengjie Liu Yuan Tian Jiabei Li Yilun Qi Dan Zhao Zihan Wu Min Huang Catherine C. L. Wong Hong-Wei Wang Jiawei Wang Huirong Yang Yanhui Xu | 2018 | Cell Research2018，28，5： | 8 |
| 3 | A highly active VOx-MnOx/CeO_(2) for selective catalytic reduction of NO:The balance between redox property and surface acidity显示文摘Excellent catalysts with low-temperature activity and relatively wide temperature window for selective catalytic reduction of NO with ammonia(NH_(3)-SCR) are highly demanded in view of the practical treatment of NO.Herein,we have designed a highly active VOx-MnOx/CeO_(2) material based on the intrinsic requirement of SCR reaction for catalyst,namely redox sites and surface acid sites.The vanadium oxide and manganese oxide are highly dispersed over the ceria mesosphere via simple incipient wetness impregnation.The loading of manganese could introduce acid sites and enhance the redox property remarkably,while the loading of vanadium increases acid sites and weakens redox property.Through tentatively controlling the appropriate loading ratio of the two components,the optimal catalyst achieves a balance between redox property and surface acidity.The work shed light on the development of new SCR catalyst with superior low temperature activity,wide work temperature window and good hydrothermal stability. | Runnong Yang Zihan Gao Ming Sun Guangying Fu Gao Cheng Wuyuan Liu Xiaobo Yang Xiangyun Zhao Lin Yu | 2021 | Journal of Rare Earths2021，39，11： | 3 |
| 4 | A green method for synthesizing novel nanoparticles and their application in flexible conductive patterns显示文摘A general and unified approach to synthesize Ag,Cu and Au nanoparticles(NPs)is developed at room temperature in air atmosphere under ultrasonication in poly(N-vinylpyrrolidone)(PVP)solutions with ascorbic acid and glucose as the reducing and nucleation agents,respectively.XRD,TEM,and HR-TEM analysis of the Ag,Cu,and Au NPs confirm purity and average diameters of 15.5±2.0 nm,50±3.0 nm,and 10±1.0 nm,respectively.An ultrasonic-assisted mechanism,wherein reduction occurs readily and produces anti-oxidation particles,is proposed and discussed.Fast infrared sintering was used to avoid damaging the substrate of conductive patterns whose resistivity at 10 W(~50℃)sintering power for less than 6 min reached up to 10±0.5 μΩ cm,40±3.0 μΩ cm,and 280±5 μΩ cm for Ag,Cu,and Au patterns,respectively.Paper-based electrodes were produced successfully and exhibited excellent flexibility and good conductivity.The potential of this method for large scale production is discussed. | Wei Li Qiongying Cen Wenjiang Li Zihan Zhao Wenlong Yang Yuqian Li Minfang Chen Guang Yang Jinjun Yang | 2020 | Journal of Materiomics2020，6，2： | 2 |
| 5 | Oerlikon Manmade Fibers lead you to the future显示文摘With numerous innovations,the Oerlikon Manmade Fibers segment presented itself at the ITMA Asia+CITME between Oc-tober 21 and 25 at the new National Exhibition Center China(NECC)in Shanghai-in line with its leitmotif:From Melt to Yarn,Fibers and Nonwovens.The primary focus was on the innovative Oerlikon Manmade Fibers Industrie 4.0 | Zhao Zihan Xu Haipo | 2016 | China Textile2016，，11： | 1 |
| 6 | Electronic tattoos based on large-area Mo2C grown by chemical vapor deposition for electrophysiology显示文摘Tattoo electronics has attracted intensive interest in recent years due to its comfortable wearing and imperceivable sensing,and has been broadly applied in wearable healthcare and human-machine interface.However,the tattoo electrodes are mostly composed of metal films and conductive polymers.Two-dimensional(2D)materials,which are superior in conductivity and stability,are barely studied for electronic tattoos.Herein,we reported a novel electronic tattoo based on large-area Mo_(2)C film grown by chemical vapor deposition(CVD),and applied it to accurately and imperceivably acquire on-body electrophysiological signals and interface with robotics.High-quality Mo_(2)C film was obtained via optimizing the distribution of gas flow during CVD growth.According to the finite element simulation(FES),bottom surface of Cu foil covers more stable gas flow than the top surface,thus leading to more uniform Mo_(2)C film.The resulting Mo_(2)C film was transferred onto tattoo paper,showing a total thickness of~3μm,sheet resistance of 60-150Ω/sq,and skin-electrode impedance of~5×10^(5)Ω.Such thin Mo_(2)C electronic tattoo(MCET in short)can form conformal contact with skin and accurately record electrophysiological signals,including electromyography(EMG),electrocardiogram(ECG),and electrooculogram(EOG).These body signals collected by MCET can not only reflect the health status but also be transformed to control the robotics for human-machine interface. | Shiyu Wang Xin Wang Weifeng Zhang Xiaohu Shi Dekui Song Yan Zhang Yan Zhao Zihan Zhao Nan Liu | 2023 | Nano Research2023，16，3： | 1 |
| 7 | Evaluation of the chemical profile from four germplasms sources of Pruni Semen using UHPLC-LTQ-Orbitrap-MS and multivariate analyses显示文摘Pruni Semen,the seed of several unique Prunus plants,is a traditional purgative herbal material.To determine the authentic sources of Pruni Semen,46 samples from four species were collected and analyzed.Ten compounds including multiflorin A(Mul A),a notable purative compound,were isolated and identified by chemical separation and nuclear magnetic resonance spectroscopy.Seventy-six communal components were identified by ultra-high performance liquid chromatography with linear ion trap-quadrupole Orbitrap mass spectrometry,and acetyl flavonoid glycosides were recognized as characteristic constituents.The flavonoids were distributed in the seed coat and cyanogenic glycosides in the kernel.Based on this,methods for identifying Pruni Semen from different sources were established using chemical fingerprinting,quantitative analysis of the eight principal compounds,hierarchical cluster analysis,principal component analysis,and orthogonal partial least squares discriminant analysis.The results showed that the samples were divided into two categories:one is the small seeds from Prunus humilis(Ph)and Prunus japonica(Pj),and the other is the big seeds from Prunus pedunculata(Pp)and Prunus triloba(Pt).The average content of Mul A was 3.02,6.93,0.40,and 0.29 mg/g,while the average content of amygdalin was 18.5,17.7,31.5,and 30.9 mg/g in Ph,Pj,Pp,and Pt,respectively.All the above information suggests that small seeds might be superior sources of Pruni Semen.This is the first comprehensive report on the identification of chemical components in Pruni Semen from different species. | Zihan Zhao Yue Liu Yushi Zhang Zeyu Geng Rina Su Lipeng Zhou Chao Han Zhanjun Wang Shuangcheng Ma Weidong Li | 2022 | Journal of Pharmaceutical Analysis2022，12，5： | 1 |
| 8 | Systematical analysis of sludge treatment and disposal technologies for carbon footprint reduction显示文摘This study aims to comprehensively analyze the Greenhouse Gases(GHGs)emissions from current sewage sludge treatment and disposal technologies(buildingmaterial,landfill,land spreading,anaerobic digestion,and thermochemical processes)based on the database of Science Citation Index(SCI)and Social Science Citation Index(SSCI)from 1998 to 2020.The general patterns,spatial distribution,and hotspotswere provided by bibliometric analysis.A comparative quantitative analysis based on life cycle assessment(LCA)put forward the current emission situation and the key influencing factors of different technologies.The effective GHG emissions reduction methods were proposed to mitigate climate change.Results showed that incineration or building materials manufacturing of highly dewatered sludge,and land spreading after anaerobic digestion have the best GHG emissions reduction benefits.Biological treatment technologies and thermochemical processes have great potential for reducing GHGs.Enhancement of pretreatment effect,co-digestion,and newtechnologies(e.g.,injection of carbon dioxide,directional acidification)are major approaches to facilitate substitution emissions in sludge anaerobic digestion.The relationship between the quality and efficiency of secondary energy in thermochemical process and GHGs emission still needs further study.Solid sludge products generated by bio-stabilization or thermochemical processes are considered to have a certain carbon sequestration value and can improve the soil environment to control GHG emissions.The findings are useful for future development and processes selection of sludge treatment and disposal facing carbon footprint reduction. | Yingxin Zhao Zhifan Yang Jiaojiao Niu Zihan Du Conti Federica Zhe Zhu Kaichao Yang Yan Li Baofeng Zhao Thomas Helmer Pedersen Chunguang Liu Mutabazi Emmanuel | 2023 | Journal of Environmental Sciences2023，，6： | 1 |
| 9 | Energy-Saving & Emission-Reduction and Green Economy in Chemical Fiber Industry显示文摘In terms of external requirements,it has been one of China's basic national policy for the enterprises to promote green,low-carbon and recycling economy,which is also a need for transformation of economic growth mode and construction of a resource-saving and environment-friendly society.Chemical fiber enterprises thus have greater obligation to comply with national policy,fulfill social esponsibilities and establish a sound social image. | Zhao Zihan | 2013 | China Textile2013，，12： | 1 |
| 10 | KRAS mutation-induced EndMT of brain arteriovenous malformation is mediated through the TGF-β/BMP-SMAD4 pathway显示文摘Objective Somatic KRAS mutations have been identified in the majority of brain arteriovenous malformations(bAVMs),and subsequent in vivo experiments have confirmed that KRAS mutation in endothelial cells(ECs)causes AVMs in mouse and zebrafish models.Our previous study demonstrated that the KRASG12D mutant independently induced the endothelial-mesenchymal transition(EndMT),which was reversed by treatment with the lipid-lowering drug lovastatin.However,the underlying mechanisms of action were unclear.Methods We used human umbilical vein ECs(HUVECs)overexpressing the KRASG12D mutant for Western blotting,quantitative real-time PCR,and immunofluorescence and wound healing assays to evaluate the EndMT and determine the activation of downstream pathways.Knockdown of SMAD4 by RNA interference was performed to explore the role of SMAD4 in regulating the EndMT.BAVM ECs expressing the KRASG12D mutant were obtained to verify the SMAD4 function.Finally,we performed a coimmunoprecipitation assay to probe the mechanism by which lovastatin affects SMAD4.Results HUVECs infected with KRASG12D adenovirus underwent the EndMT.Transforming growth factor beta(TGF-β)and bone morphogenetic protein(BMP)signalling pathways were activated in the KRASG12D-mutant HUVECs and ECs in bAVM tissue.Knocking down SMAD4 expression in both KRASG12D-mutant HUVECs and ECs in bAVM tissues inhibited the EndMT.Lovastatin attenuated the EndMT by downregulating p-SMAD2/3,p-SMAD1/5 and acetylated SMAD4 expression in KRASG12D-mutant HUVECs.Conclusions Our findings suggest that the KRASG12D mutant induces the EndMT by activating the ERK-TGF-β/BMP-SMAD4 signalling pathway and that lovastatin inhibits the EndMT by suppressing TGF-β/BMP pathway activation and SMAD4 acetylation. | Hongyuan Xu Ran Huo Hao Li Yuming Jiao Jiancong Weng Jie Wang Zihan Yan Junze Zhang Shaozhi Zhao Qiheng He Yingfan Sun Shuo Wang Yong Cao | 2023 | Stroke & Vascular Neurology2023，8，3： | 1 |
| 11 | A brief introduction to the operation of domestic cocoon silk industry in 2017显示文摘In 2017,fueled by domestic consumption and export demand,the cocoon and silk industry continued to make a turnaround.There was an increasing volume of purchase and rising prices in silkworm cocoons throughout the country.The incomes of silkworm raisers hit a new high;the prices of cocoon silks maintained an upward trend;and the enterprise benefits of the silk industry were increased as well. | Zhao Zihan | 2018 | China Textile2018，，5： | 1 |
| 12 | Dancing Fashion with intelligent manufacturing——The 19th Ningbo International Fashion Fair kicked off this October显示文摘The 19th Ningbo International Fashion Fair (Hereafter referred to as the 19th IFFAIR), themed on 'Fashion Ningbo, Oriental Fashion', drew to a close on October 25th, 2015, covering an area of 40,000 square meters by 330 brands from seven countries and regions, and featured by five professional trade forums, three thematic promotion-activity days as well as 19 fashion shows. During the four days, | Zhao Zihan | 2015 | China Textile2015，，12： | 1 |
| 13 | Alteration of gut microbiota in type 2 diabetes complicated with cholelithiasis patients显示文摘To the Editor:Type 2 diabetes(T2D)and cholelithiasis are both common diseases with a high,prevalence.In China,the,prevalence of T2D,is.0.90% and that offadult cholelithiasis is 6.83%. | Jiajia Chen Linlin Yan Xingfan Ma Ping Yuan Fan Zhao Zihan Han Jingshan Liu Wenbo Wang Donghai Zhou Hongyu Zhao Nan Feng Dandan Huang Shoukui Hu Jin Gui | 2022 | Chinese Medical Journal2022，135，17： | 1 |
| 14 | Oct4 regulates the miR-302 cluster in P19 mouse embryonic carcinoma cells 显示文摘 | Liu Haiying Deng Suo Zhao Zihan | 2011 | Mol Biol Rep2011，38，3： | 1 |
| 15 | Compact logic operator utilizing a single-layer metasurface显示文摘In this paper, we design and demonstrate a compact logic operator based on a single-layer metasurface at microwave frequency. By mapping the nodes in the trained fully connected neural network(FCNN) to the specific unit cells with phase control function of the metasurface, a logic operator with only one hidden layer is physically realized. When the incident wave illuminates specific operating regions of the metasurface, corresponding unit cells are activated and can scatter the incident wave to two designated zones containing logical information in the output layer. The proposed metasurface logic operator is experimentally verified to achieve three basic logic operations(NOT, OR, and AND) under different input signals. Our design shows great application potential in compact optical systems, low-power consumption information transmission, and ultrafast wave-based full signal processing. | Zihan Zhao Yue Wang Xumin Ding Haoyu Li Jiahui Fu Kuang Zhang Shah Nawaz Burokur Qun Wu | 2022 | Photonics Research2022，10，2： | 1 |
| 16 | The kinase p38αfunctions in dendritic cells to regulate Th2-cell differentiation and allergic inflammation显示文摘Dendritic cells(DCs)play a critical role in controlling T helper 2(Th2)cell-dependent diseases,but the signaling mechanism that triggers this function is not fully understood.We showed that p38αactivity in DCs was decreased upon HDM stimulation and dynamically regulated by both extrinsic signals and Th2-instructive cytokines.p38α-specific deletion in cDC1s but not in cDC2s or macrophages promoted Th2 responses under HDM stimulation.Further study showed that p38αin cDC1s regulated Th2-cell differentiation by modulating the MK2−c-FOS−IL-12 axis.Importantly,crosstalk between p38α-dependent DCs and Th2 cells occurred during the sensitization phase,not the effector phase,and was conserved between mice and humans.Our results identify p38αsignaling as a central pathway in DCs that integrates allergic and parasitic instructive signals with Th2-instructive cytokines from the microenvironment to regulate Th2-cell differentiation and function,and this finding may offer a novel strategy for the treatment of allergic diseases and parasitic infection. | Miaomiao Han Jingyu Ma Suidong Ouyang Yanyan Wang Tingting Zheng Peishan Lu Zihan Zheng Weiheng Zhao Hongjin Li Yun Wu Baohua Zhang Ran Hu Kinya Otsu Xinguang Liu Ying Wan Huabin Li Gonghua Huang | 2022 | Cellular & Molecular Immunology2022，19，7： | 1 |
| 17 | Biotechnology Rewrites Chemical Fiber Genes Bio-based Fiber Reduces Oil Dependence显示文摘Bio-based fiber, though emerged a little late in China, is enjoying a relatively rapid development, since currently such bio-based fibers as PTT, alginate, PLA, and PHA have make breakthroughs in key technologies. Bio-based fiber, an important part of biomass fibers, is encouraged by the national policy to develop further to conform to the trend of the industry. | Zhao Zihan | 2013 | China Textile2013，，5： | 1 |
| 18 | Save Cotton?Save Textile? Only Emphasizing Cotton Price Di erences Obscures Many Contradictions显示文摘The long-term serious cotton price inversion endangered the cotton growers'interests,and inflicted heavy losses on cotton textile exports,which not only weakened the competitiveness of Chinese textile industry, but also affected the domestic employment.and apparel total exports during the first eight months reached 162 billion yuan with a decreasing of 0.7% year on | Zhao Zihan | 2012 | China Textile2012，，11： | 0 |
| 19 | Indonesia Shows:To shine in April显示文摘INATEX,INDO INTER TEX and TECHNITEX 2015,scheduled to take place from 23–25 April 2015 at Jakarta International Expo(JIEXPO)Jakarta–Indonesia,are to meet with mills and manufacturers from Indonesia and around the world showcasing their collections.These three binding exhibitions,with theme,'The Only Trade Platform to Meet ASEAN Garment Industry',will set as an exclusive business platform for domestic and international quality supplier of Textile and Garment Industries. | Zhao Zihan | 2015 | China Textile2015，，4： | 0 |
| 20 | New Prospects for Chemical Fiber industry显示文摘The 12th five years’ planning is thoroughly implemented this year, chemical fiber industry in our country including the standardization work, fast and efficiently developing, and achieving a number of significant gains, which contribute significantly to the prosperity of economic in nation, industry and location, as well as the economic revival of the global industrial chain. | Zhao Zihan | 2012 | China Textile2012，，11： | 0 |
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