|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Impacts and Utilization of Electric Vehicles Integration Into Power Systems显示文摘 | HUZechun SONG Yonghua XU Zhiwei LUO Zhuowei ZHAN Kaiqiao JIA Long | 2012 | 中国电机工程学报2012，32，4： | 49 |
| 3 | Photovoltaic and Solar Power Forecasting for Smart Grid Energy Management显示文摘Due to the challenge of climate and energy crisis,renewable energy generation including solar generation has experienced significant growth.Increasingly high penetration level of photovoltaic(PV)generation arises in smart grid.Solar power is intermittent and variable,as the solar source at the ground level is highly dependent on cloud cover variability,atmospheric aerosol levels,and other atmosphere parameters.The inherent variability of large-scale solar generation introduces significant challenges to smart grid energy management.Accurate forecasting of solar power/irradiance is critical to secure economic operation of the smart grid.This paper provides a comprehensive review of the theoretical forecasting methodologies for both solar resource and PV power.Applications of solar forecasting in energy management of smart grid are also investigated in detail. | Can Wan Jian Zhao Yonghua Song Zhao Xu Jin Lin Zechun Hu | 2015 | CSEE Journal of Power and Energy Systems2015，1，4： | 29 |
| 4 | Internet of Things to network smart devices for ecosystem monitoring显示文摘Smart, real-time, low-cost, and distributed ecosystem monitoring is essential for understanding and managing rapidly changing ecosystems. However, new techniques in the big data era have rarely been introduced into operational ecosystem monitoring, particularly for fragile ecosystems in remote areas.We introduce the Internet of Things(IoT) techniques to establish a prototype ecosystem monitoring system by developing innovative smart devices and using IoT technologies for ecosystem monitoring in isolated environments. The developed smart devices include four categories: large-scale and nonintrusive instruments to measure evapotranspiration and soil moisture, in situ observing systems for CO2 and d13 C associated with soil respiration, portable and distributed devices for monitoring vegetation variables, and Bi-CMOS cameras and pressure trigger sensors for terrestrial vertebrate monitoring. These new devices outperform conventional devices and are connected to each other via wireless communication networks. The breakthroughs in the ecosystem monitoring IoT include new data loggers and longdistance wireless sensor network technology that supports the rapid transmission of data from devices to wireless networks. The applicability of this ecosystem monitoring IoT is verified in three fragile ecosystems, including a karst rocky desertification area, the National Park for Amur Tigers, and the oasis-desert ecotone in China. By integrating these devices and technologies with an ecosystem monitoring information system, a seamless data acquisition, transmission, processing, and application IoT is created. The establishment of this ecosystem monitoring IoT will serve as a new paradigm for ecosystem monitoring and therefore provide a platform for ecosystem management and decision making in the era of big data. | Xin Li Ning Zhao Rui Jin Shaomin Liu Xiaomin Sun Xuefa Wen Dongxiu Wu Yan Zhou Jianwen Guo Shiping Chen Ziwei Xu Mingguo Ma Tianming Wang Yonghua Qu Xinwei Wang Fangming Wu Yuke Zhou | 2019 | Science Bulletin2019，64，17： | 10 |
| 5 | Features of the fault system and its relationship with migration and accumulation of hydrocarbon in Liaodong Bay显示文摘The fault system of Liaodong Bay developed extensively under the control of the Tanlu Fault.The fault system can be grouped into strike-slip faults of grade I,trunk faults of grade II and branch faults (induced faults) of grade III respectively based on its developmental scale.The faults of grade I and II were deep,early and large while the faults of grade III were shallow,late and small.The formation,evolution and distribution features played a significant role in controlling the migration of oil and gas in both horizontal and vertical directions.The fluid transfer in the fault system occurred in the process of faulting.The strike-slip and trunk faults moved actively forming predominant pathways for oil and gas migration.The branch faults,with weak activity,generally controlled the development of traps and were beneficial for the accumulation and preservation of oil and gas.The faults of grade I and II formed the major migration pathways for oil and gas,but their fault activity rates appeared to vary along their strikes.The zones with a relatively low fault activity rate might be favorable for oil and gas accumulation.When the activities of strike-slip,trunk,and branch faults came to a halt,the fault seal behavior had a vitally important effect on the accumulation of oil and gas.The controlling role of the fault over fluid distribution was further analyzed by calculating the fault activity quantitatively. | Xu Guosheng Ma Ruolong Gong Deyu Zhou Donghong Li Jianping Guo Yonghua Yuan Haifeng Wu Changrong | 2011 | Petroleum Science2011，8，3： | 8 |
| 6 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 7 | Experimental investigation of thermal effect on cavitation characteristics in a liquid rocket engine turbopump inducer显示文摘The objective of this paper is to investigate the effect of water temperature on cavitation characteristics in a turbopump inducer,a series of experiments at different temperatures have been conducted in a newly developed visualization test facility.It is found that higher temperature shows little influence on the non-cavitation performance and breakdown characteristic in the investigated range.The relationship between cavitation development and pressure fluctuation has been discussed in detail.Higher temperature displays a remarkable stabilization effect on the cavitation excited pressure.In particular,the inception cavitation numbers of both the super-synchronous rotating cavitation and synchronous rotating cavitation are decreased at higher temperatures,and the corresponding frequencies are not affected,while the amplitudes are distinctly reduced,and the occurrence range of synchronous rotating cavitation is significantly narrowed.A generalized RayleighPlesset equation has been employed to account for the thermal effect on the bubble development,which may provide a deep insight in understanding the experimental results.Thermal effect is found to act as a remarkable dissipation mechanism to suppress the bubble growth,smooth the collapse.In particular,the excited pressure during collapse is smaller at higher temperatures,which may lead to the stabilization effect of high temperature in this study. | Chunmin WANG Le XIANG Yonghua TAN Hui CHEN Kaifu XU | 2021 | Chinese Journal of Aeronautics2021，34，8： | 7 |
| 8 | 中国航天主动力液体火箭发动机技术进展显示文摘Liquid propellant rocket engines for a launch vehicle are an essential aerospace technology, representing the advanced level of hi-tech in a country. In recent years, China’s aerospace industry has made remarkable achievements, and liquid rocket engine technology has also been effectively developed. In this article, the development processes of China’s liquid rocket engines are discussed. Then, the performance features of China’s new generation liquid rocket engines as well as the flight tests of the new-generation launch vehicles are introduced. Finally, the development direction and the most recent progress of the next generation large-thrust liquid rocket engine is presented. | TAN Yonghua ZHAO Jian CHEN Jianhua XU Zhiyu | 2020 | Aerospace China2020，21，2： | 6 |
| 9 | Self-crosslinkable chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted siRNA delivery to treat bladder cancer显示文摘Bladder cancer is one of the concerning malignancies worldwide,which is lacking effective targeted therapy.Gene therapy is a potential approach for bladder cancer treatment.While,a safe and effective targeted gene delivery system is urgently needed for prompting the bladder cancer treatment in vivo.In this study,we confirmed that the bladder cancer had CD44 overexpression and small interfering RNAs(siRNA)with high interfere to Bcl2 oncogene were designed and screened.Then hyaluronic acid dialdehyde(HAD)was prepared in an ethanol-water mixture and covalently conjugated to the chitosan nanoparticles(CS-HAD NPs)to achieve CD44 targeted siRNA delivery.The in vitro and in vivo evaluations indicated that the siRNA-loaded CS-HAD NPs(siRNA@CS-HAD NPs)were approximately 100 nm in size,with improved stability,high siRNA encapsulation efficiency and low cytotoxicity.CS-HAD NPs could target to CD44 receptor and deliver the therapeutic siRNA into T24 bladder cancer cells through a ligand-receptor-mediated targeting mechanism and had a specific accumulation capacity in vivo to interfere the targeted oncogene Bcl2 in bladder cancer.Overall,a CD44 targeted gene delivery system based on natural macromolecules was developed for effective bladder cancer treatment,which could be more conducive to clinical application due to its simple preparation and high biological safety. | Ye Liang Yonghua Wang Liping Wang Zhijuan Liang Dan Li Xiaoyu Xu Yuanbin Chen Xuecheng Yang Hongbo Zhang Haitao Niu | 2021 | Bioactive Materials2021，6，2： | 5 |
| 10 | Robust adaptive control of hypersonic vehicle considering inlet unstart显示文摘In this paper,a model reference adaptive control(MRAC)augmentation method of a linear controller is proposed for air-breathing hypersonic vehicle(AHV)during inlet unstart.With the development of hypersonic flight technology,hypersonic vehicles have been gradually moving to the stage of weaponization.During the maneuvers,changes of attitude,Mach number and the back pressure can cause the inlet unstart phenomenon of scramjet.Inlet unstart causes significant changes in the aerodynamics of AHV,which may lead to deterioration of the tracking performance or instability of the control system.Therefore,we firstly establish the model of hypersonic vehicle considering inlet unstart,in which the changes of aerodynamics caused by inlet unstart is described as nonlinear uncertainty.Then,an MRAC augmentation method of a linear controller is proposed and the radial basis function(RBF)neural network is used to schedule the adaptive parameters of MRAC.Furthermore,the Lyapunov function is constructed to prove the stability of the proposed method.Finally,numerical simulations show that compared with the linear control method,the proposed method can stabilize the attitude of the hypersonic vehicle more quickly after the inlet unstart,which provides favorable conditions for inlet restart,thus verifying the effectiveness of the augmentation method proposed in the paper. | WANG Fan FAN Pengfei FAN Yonghua XU Bin YAN Jie | 2022 | Journal of Systems Engineering and Electronics2022，33，1： | 4 |
| 11 | Fuzzy Torque Control of the Bionic Flexible Manipulator Actuated by Pneumatic Muscle Actuators显示文摘A bionic flexible manipulator driven by pneumatic muscle actuator(PMA)can better reflect the flexibility of the mechanism.Current research on PMA mainly focuses on the modeling and control strategy of the pneumatic manipulator system.Compared with traditional electro-hydraulic actuators,the structure of PMA is simple but possesses strong nonlinearity and flexibility,which leads to the difficulty in improving the control accuracy.In this paper,the configuration design of a bionic flexible manipulator is performed by human physiological map,the kinematic model of the mechanism is established,and the dynamics is analyzed by Lagrange method.A fuzzy torque control algorithm is designed based on the computed torque method,where the fuzzy control theory is applied.The hardware experimental system is established.Through the co-simulation contrast test on MATLAB and ADAMS,it is found that the fuzzy torque control algorithm has better tracking performance and higher tracking accuracy than the computed torque method,and is applied to the entity control test.The experimental results show that the fuzzy torque algorithm can better control the trajectory tracking movement of the bionic flexible manipulator.This research proposes a fuzzy torque control algorithm which can compensate the error more effectively,and possesses the preferred trajectory tracking performance. | Kai Liu Yining Chen Jiaqi Xu Yang Wu Yonghua Lu Dongbiao Zhao | 2019 | Chinese Journal of Mechanical Engineering2019，32，5： | 4 |
| 12 | Experimental investigation of cavitation instabilities in inducer with different tip clearances显示文摘To investigate the effect of tip clearance size on cavitation characteristics in a turbopump inducer,a series of experiments have been conducted in a newly developed visualization test facility using room temperature water as working fluid.The pressure fluctuations near the tip region were collected,and the cavity structures under various conditions were documented by a high-speed camera.It is found that large tip clearance distinctly reduces both the non-cavitation and cavitation performance.Three cavitation instabilities,super-synchronous rotating cavitation,synchronous rotating cavitation and cavitation surge have been carefully identified through combination of cross-correlation analysis of pressure signals and visualization results.Large tip clearance displays a remarkable stabilization effect on pressure fluctuation,cavitation surge totally disappears,and the range of occurrence of synchronous rotating cavitation becomes smaller for the large tip clearance,whereas super-synchronous rotating cavitation only occurs in the large tip clearance.The cavitation areas are smaller at large tip clearance,while the flow channels are more seriously choked when cavitation occurs heavily in comparison with those at small tip clearance,which may be responsible for the worse cavitation performance. | Le XIANG Yonghua TAN Hui CHEN Kaifu XU | 2021 | Chinese Journal of Aeronautics2021，34，9： | 4 |
| 13 | Assessment of estrogen disrupting potency in animal foodstuffs of China by combined biological and chemical analyses显示文摘Food has been documented as one of major routes for human exposure to environmental estrogens(EEs), but information on the occurrence of EEs in animal foodstuffs is still scarce.This study analyzed estrogenic activity in 16 types of animal foodstuffs(n = 142) collected from four cities(Wuhan, Guangzhou, Wenzhou and Yantai) of China by combined yeast estrogen screen(YES) bioassay and chemical analysis. By bioassay, all samples' extracts were found to induce estrogenic activities and the bioassay-derived 17β-estradiol equivalent(EEQbio) ranged from 8.29 to 118.32 ng/g. In addition, the samples were analyzed by liquid chromatography coupled to tandem mass spectrometry for further chemical analysis. 17β-Estradiol was found in all samples in this survey at levels of 0.44 to 15.04 ng/g.All samples had 33.1% detection rate of 17α-ethinylestradiol(EE2), and the maximum concentration was 2.80 ng/g. Bisphenol A and 4-nonylphenols were detected in 83.8% and83.1% of samples, with concentrations up to 12.56 ng/g and 35.76 ng/g, respectively.However, the concentrations of estrone, diethylstilbestrol and 4-t-octylphenol were found to be below the limit of detection. A comparison of EEQbiomeasured from the YES assay and EEQchemcalculated from chemical analysis showed good correlation(R2= 0.84). Based on the results, the YES assay can be used as a rapid pre-screening method for monitoring the levels of estrogenic activity in large numbers of animal foodstuffs, and chemical analysis used in combination can be used for the identification of specific EEs. | Jun Wang Wei Xia Yonghua Xiao Chenjiang Ying Jia Long Hui Zhang Xi Chen Congda Mao Xiumin Li Lin Wang Shunqing Xu | 2014 | Journal of Environmental Sciences2014，26，10： | 4 |
| 14 | Searching for the Nano-Hertz Stochastic Gravitational Wave Background with the Chinese Pulsar Timing Array Data ReleaseⅠ显示文摘Observing and timing a group of millisecond pulsars with high rotational stability enables the direct detection of gravitational waves(GWs).The GW signals can be identified from the spatial correlations encoded in the times-of-arrival of widely spaced pulsar-pairs.The Chinese Pulsar Timing Array(CPTA)is a collaboration aiming at the direct GW detection with observations carried out using Chinese radio telescopes.This short article serves as a“table of contents”for a forthcoming series of papers related to the CPTA Data Release 1(CPTA DR1)which uses observations from the Five-hundred-meter Aperture Spherical radio Telescope.Here,after summarizing the time span and accuracy of CPTA DR1,we report the key results of our statistical inference finding a correlated signal with amplitude logA_(c)=-14.4_(-2.8)^(+1.0)for spectral index in the range ofα∈[-1.8,1.5]assuming a GW background(GWB)induced quadrupolar correlation.The search for the Hellings–Downs(HD)correlation curve is also presented,where some evidence for the HD correlation has been found that a 4.6σstatistical significance is achieved using the discrete frequency method around the frequency of 14 n Hz.We expect that the future International Pulsar Timing Array data analysis and the next CPTA data release will be more sensitive to the n Hz GWB,which could verify the current results. | Heng Xu Siyuan Chen Yanjun Guo Jinchen Jiang Bojun Wang Jiangwei Xu Zihan Xue RNicolas Caballero Jianping Yuan Yonghua Xu Jingbo Wang Longfei Hao Jingtao Luo Kejia Lee Jinlin Han Peng Jiang Zhiqiang Shen Min Wang Na Wang Renxin Xu Xiangping Wu Richard Manchester Lei Qian Xin Guan Menglin Huang Chun Sun Yan Zhu | 2023 | Research in Astronomy and Astrophysics2023，23，7： | 3 |
| 15 | The development of a new real-time subsurface mooring显示文摘Subsurface mooring allows researchers to measure the ocean properties such as water temperature,salinity,and velocity at several depths of the water column for a long period.Traditional subsurface mooring can release data only after recovered,which constrains the usage of the subsurface and deep layer data in the ocean and climate predictions.Recently,we developed a new real-time subsurface mooring(RTSM).Velocity profiles over upper 1000 m depth and layered data from sensors up to 5000 m depth can be realtime transmitted to the small surface buoy through underwater acoustic communication and then to the office through Beidou or Iridium satellite.To verify and refine their design and data transmission process,we deployed more than 30 sets of RTSMs in the western Pacific to do a 1-year continuous run during 2016–2018.The continuous running period of RTSM in a 1-year cycle can reach more than 260 days on average,and more than 95%of observed data can be successfully transmitted back to the office.Compared to the widely-used inductive coupling communication,wireless acoustic communication has been shown more applicable to the underwater sensor network with large depth intervals and long transmission distance to the surface. | WANG Fan WANG Jianing XU Lijun ZHANG Xiangguang YAN Shefeng CHEN Yonghua | 2020 | Journal of Oceanology and Limnology2020，38，4： | 2 |
| 16 | Monoclonal antibody-based enzyme-linked immunosorbent assay for detection of total malachite green and crystal violet residues in fishery products显示文摘 | Hengyi Xu Xuelan Chen Liang Guo Jianwen Zhang Weihua Lai ZoraidaP. Aguilar Hua Wei Yonghua Xiong | 2013 | International Journal of Environmental Analytical Chemistry2013，，9： | 2 |
| 17 | Optimization of Enzymatic Clarification of Green Asparagus Juice Using Response Surface Methodology显示文摘 | Xuehong Chen Feng Xu Weidong Qin Lihua Ma Yonghua Zheng | 2012 | Journal of Food Science2012，，6： | 2 |
| 18 | Effect of ethanol treatment on quality and antioxidant activity in postharvest broccoli florets显示文摘 | Feng Xu Xuehong Chen Peng Jin Xiaoli Wang Jing Wang Yonghua Zheng | 2012 | European Food Research and Technology2012，，5： | 2 |
| 19 | Tailoring spin mixtures by ion-enhanced Maxwell magnetic coupling in colortunable organic electroluminescent devices显示文摘In this work,we show that the spin dynamics of excitons can be dramatically altered by Maxwell magnetic field coupling,together with an ion-enhanced,low-internal-splitting-energy organic semiconducting emitter.By employing a unique,alternating current(AC)-driven organic electroluminescent(OEL)device architecture that optimizes this magnetic field coupling,almost complete control over the singlet-to-triplet ratio(from fluorescent to phosphorescent emission in a single device)is realized.We attribute this spin population control to magnetically sensitive polaron–spin pair intersystem crossings(ISCs)that can be directly manipulated through external driving conditions.As an illustration of the utility of this approach to spin-tailoring,we demonstrate a simple hybrid(double-layer)fluorescence–phosphorescence(F–P)device using a polyfluorene-based emitter with a strong external Zeeman effect and ion-induced long carrier diffusion.Remarkable control over de-excitation pathways is achieved by controlling the device-driving frequency,resulting in complete emission blue–red color tunability.Picosecond photoluminescence(PL)spectroscopy directly confirms that this color control derives from the magnetic manipulation of the singlet-totriplet ratios.These results may pave the way to far more exotic organic devices with magnetic-field-coupled organic systems that are poised to usher in an era of dynamic spintronics at room temperature. | Junwei Xu Yue Cui Gregory M.Smith Peiyun Li Chaochao Dun Linqi Shao Yang Guo Hongzhi Wang Yonghua Chen David L.Carroll | 2018 | Light(Science & Applications)2018，7，1： | 2 |
| 20 | SJES14110700111350显示文摘 | Kesheng Wu Liang Guo Wei Xu Hengyi Xu Zoraida P. Aguilar Guomao Xu Weihua Lai Yonghua Xiong Yiqun Wan | 2014 | Talanta2014，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员