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| 1 | A Fuzzy Clustering Algorithm Based on Multipath Component Trajectory for Millimeter Wave Radio Channels显示文摘Time-varying channel modeling plays an important role for many applications in time-variant scenarios,while most clustering algorithms focus on static channels and cannot accurately model the channel time-evolution properties.In this paper,a fuzzy clustering algorithm based on multipath component(MPC)trajectory is proposed.Firstly,both the distance and velocity similarities of the MPCs in different snapshots are taken into account to track the MPC trajectory,in which the fuzzy scheme and a kernel function are used to calculate the distance and velocity similarities,respectively.Secondly,a fuzzy MPC trajectory clustering algorithm is proposed to cluster the MPCs in multiple snapshots.The MPCs in a snapshot are clustered according to the membership,which is defined as the probability that a MPC belongs to different clusters.Finally,time-varying channels at 28 GHz are simulated to validate the performance of our proposed algorithm.The results show that our proposed algorithm is able to accurately identify the clusters in time-varying channels compared with the existing clustering algorithms. | Fei Du Yu Zhang Qingliang Li Xinyue Zhang Bo Zhu Zihao Fu Suiyan Geng Xiongwen Zhao | 2022 | China Communications2022，19，11： | 0 |
| 2 | Determination of Double Beta Decay Half-Life of 136Xe with the PandaX-4T Natural Xenon Detector显示文摘Precise measurement of two-neutrino double beta decay(DBD)half-life is an important step for the searches of Majorana neutrinos with neutrinoless double beta decay.We report the measurement of DBD half-life of 136xe using the Pandax-4T dual-phase Time Projection Chamber(TPC)with 3.7-tonne natural xenon and the first 94.9-day physics data release. | Lin Si Zhaokan Cheng Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Jinrong He Di Huang Yanlin Huang Zhou Huang Ruquan Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu Xiaoying Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yujun Mao Yue Meng Nasir Shaheed Xiaofeng Shang Xuyang Ning Ningchun Qi Zhicheng Qian Xiangxiang Ren Changsong Shang Guofang Shen Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Zhe Yuan Dan Zhang Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou | 2023 | Research2023，，2： | 0 |
| 3 | The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3-SRF axis显示文摘Coronary restenosis is an important cause of poor long-term prognosis in patients with coronary heart disease.Here,we show that lysine methyltransferase SMYD2 expression in the nucleus is significantly elevated in serum-and PDGF-BB-induced vascular smooth muscle cells(VSMCs),and in tissues of carotid artery injury-induced neointimal hyperplasia.Smyd2 overexpression in VSMCs(Smyd2-vTg)facilitates,but treatment with its specific inhibitor LLY-507 or SMYD2 knockdown significantly inhibits VSMC phenotypic switching and carotid artery injury-induced neointima formation in mice.Transcriptome sequencing revealed that SMYD2 knockdown represses the expression of serum response factor(SRF)target genes and that SRF overexpression largely reverses the inhibitory effect of SMYD2 knockdown on VSMC proliferation.HDAC3 directly interacts with and deacetylates SRF,which enhances SRF transcriptional activity in VSMCs.Moreover,SMYD2 promotes HDAC3 expression via tri-methylation of H3K36 at its promoter.RGFP966,a specific inhibitor of HDAC3,not only counteracts the pro-proliferation effect of SMYD2 overexpression on VSMCs,but also inhibits carotid artery injury-induced neointima formation in mice.HDAC3 partially abolishes the inhibitory effect of SMYD2 knockdown on VSMC proliferation in a deacetylase activity-dependent manner.Our results reveal that the SMYD2-HDAC3-SRF axis constitutes a novel and critical epigenetic mechanism that regulates VSMC phenotypic switching and neointimal hyperplasia. | Xiaoxuan Zhong Xiang Wei Yan Xu Xuehai Zhu Bo Huo Xian Guo Gaoke Feng Zihao Zhang Xin Feng Zemin Fang Yuxuan Luo Xin Yi Ding-Sheng Jiang | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 4 | Nanoengineered polypeptides from tetraphenylethylene-functionalized N-carboxyanhydride: Synthesis, self-assembly and intrinsic aggregation-induced emission显示文摘Ring-opening polymerization of N-carboxyanhydrides(NCAs)bearing pendant groups creates functional polypeptides.In this paper,we report the design,synthesis and polymerization of tetraphenylethylene(TPE)-modified NCA,which is used to incorporate aggregation-induced emission(AIE)-active segments into polypeptides.Specifically,we attempted the synthesis of amphiphilic methoxy poly(ethyleneglycol)-block-poly(γ-benzyl-L-glutamate)-block-poly(γ-4-(1,2,2-triphenylvinyl)benzyl-L-glutamate)(PEG-PBLG-PTPELG),which had well-controlled molecular weight and narrow polydispersity.The hydrophilic PEG and hydrophobic PBLG-PTPELG assembled into micelles in aqueous solution with diameter around 70 nm,displaying AIE at 480 nm.Our work demonstrates that the TPE-modified NCA is applicable for the preparation of the AIE-active polypeptides,integrating the AIE luminogens into the polypeptides which may offer unique opportunities for tuning AIE properties by adjusting the composition and conformation of polypeptides.We preliminarily explored the use of the amphiphilic polypeptides for the formulation of doxorubicin-containing micelles that can potentially be used for real-time monitoring of the nanomedicine distribution. | Xu Wang Zihao Zhao Tianrui Xue Zhengzhong Tan Ziyuan Song Shiqi Wei Yang Bo Ying Wang Jianjun Cheng | 2021 | Progress in Natural Science:Materials International2021，31，4： | 0 |
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