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| 1 | LINC00891 regulated by miR-128-3p/GATA2 axis impedes lung cancer cell proliferation,invasion and EMT by inhibiting RhoA pathway显示文摘Long non-coding RNA(lncRNA)LINC00891 knockdown is associated with poor prognosis of lung adenocarcinoma,but the underlying mechanism remains to be further explored.Here,we found that LINC00891 expression is downregulated in lung cancer tissues and cell lines compared with that in adjacent normal tissues and normal lung epithelial cells.LINC00891 overexpression impedes cell proliferation,invasion,migration and epithelial-to-me-senchymal transition(EMT)process in lung cancer cells.Mechanistic research showed that GATA2 directly binds to LINC00891 promoter and transcriptionally regulates LINC00891 expression.Meanwhile,GATA2 was identified as a target of miR-128-3p,and it is negatively regulated by miR-128-3p.Moreover,overexpression of GATA2 suppresses lung cancer cell proliferation,invasion,migration,and EMT process.Furthermore,LINC00891 restrains the RhoA pathway activity,and treatment with CCG-1423(a specific RhoA pathway inhibitor)antagonizes the promoting effect of LINC00891 knockdown on cell malignant behaviors.Additionally,silencing of LINC00891 promotes xenograft tumor growth,which can be reversed by administration with CCG-1423.In summary,LINC00891 regulated by the miR-128-3p/GATA2 axis restrains lung cancer cell malignant progression and hinders xenograft tumor growth by suppressing the RhoA pathway. | Yunfeng Zhang Dingli Song Ziyang Peng Rui Wang Kai Li Hong Ren Xin Sun Ning Du Shou-Ching Tang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，3： | 2 |
| 2 | Distributed finite-time attitude containment control for multiple rigid bodies显示文摘 | MENG Ziyang REN Wei YOU Zheng | 2010 | Automatica2010，46，12： | 1 |
| 3 | Decentralized finite-time sliding mode estimators and their applications in decentralized finite-time formation tracking显示文摘 | Yongcan Cao Wei Ren Ziyang Meng | 2010 | Systems & Control Letters2010，，9： | 1 |
| 4 | Healthy Lifestyles and Chronic Pain with New-Onset Metabolic-Related Multimorbidity among Older Adults—China,2011–2018显示文摘Summary What is already known about this topic?Chronic pain has been identified as a risk factor for cardiovascular diseases.Evidence shows that adopting a healthy lifestyle can help reduce the cardiometabolic risks associated with chronic pain.What is added by this report?Results from this cohort study suggest a positive association between chronic pain and the development of new-onset metabolic-related multimorbidity,specifically metabolic multimorbidity and cardiometabolic comorbidity,within middle-aged and older Chinese adults.Furthermore,adopting healthy lifestyles can potentially mitigate or even reverse these associations.What are the implications for public health practice?The results of our study emphasize the importance of promoting healthy lifestyles among older Chinese adults as a preventative measure against the medical burdens and cardiometabolic risks associated with chronic pain. | Ziyang Ren Yihao Zhao Guanyu Niu Xinyao Lian Xiaoying Zheng Shiyong Wu Jufen Liu | 2023 | China CDC weekly2023，5，16： | 0 |
| 5 | Adverse childhood experiences from family and society contribute to increased risk of depressive symptoms and cognitive impairment:a cross-sectional study显示文摘Background Family environments can shape children’s personalities and social networks,rendering distinguishing adverse childhood experiences(ACEs)from family and society essential,but related evidence remains limited.Aims This cross-sectional study aimed to investigate the correlations between intrafamilial and social ACEs,their associations with depressive symptoms and cognitive impairment and the(education-moderated)mediating role of social ACEs.Methods Data for this cross-sectional study were from the China Health and Retirement Longitudinal Study.Nine intrafamilial(0,1,2,3,and 4 or more)and three social(0,1,and 2 or more)ACEs were identified.Depressive symptoms were assessed using the 10-item Center for Epidemiological Studies Depression Scale.Global cognition,including episodic memory and mental intactness,was calculated as z scores.Binary and ordered logistic regressions,generalised linear models with Gaussian family and identity link,and mediation analysis were used.Results 13435 participants aged 59.0(51.0–66.0)were included.Compared with participants with no intrafamilial ACEs,those with 1,2,3,and 4 or more intrafamilial ACEs tended to develop more social ACEs,with odds ratios(ORs)of 1.55(95%confidence interval(CI):1.36 to 1.76),2.36(95%CI:2.08 to 2.68),3.46(95%CI:3.02 to 3.96)and 6.10(95%CI:5.30 to 7.02),respectively.Both intrafamilial and social ACEs were associated with depressive symptoms(OR>3 for four or more intrafamilial ACEs and two or more social ACEs)and global cognition(β=−0.26 for four or more intrafamilial ACEs andβ=−0.29 for two or more social ACEs).Social ACEs mediated the associations of intrafamilial ACEs with depressive symptoms and global cognition by 12.3%and 13.1%,respectively.Furthermore,as education levels increased,the impact of intrafamilial ACEs on depressive symptoms was increasingly mediated through social ACEs,while the mediating role of social ACEs between intrafamilial ACEs and cognitive impairment gradually diminished.Conclusions Improving children’s social environments and elevating general education can prevent later-life depressive symptoms and cognitive impairment attributed to ACEs in China. | Ziyang Ren Yanan Luo Xiaoying Zheng Jufen Liu | 2023 | General Psychiatry2023，36，4： | 0 |
| 6 | Effect modifications of BMI transition and trajectory in the associations of adverse childhood experiences with new-onset dementia and its subtypes in older US adults显示文摘Background Adverse childhood experiences(ACEs)and dementia are associated and comorbid with obesity.However,according to emerging research,the role of obesity in the association between ACEs and dementia seems controversial.Aims This analysis aimed to explore the associations between ACEs and different dementia subtypes and the effect modification of long-term body mass index(BMI).Methods Data were obtained from the US Health and Retirement Study.Six ACEs were categorised as 0,1 and 2 or more.All-cause dementia,Alzheimer’s disease(AD)and other dementias were defined by self-reported or proxy-reported physician diagnosis.Cox proportional hazards regression was used to explore the associations of ACEs with new-onset all-cause dementia,AD and other dementias from 2010 to 2020.Effect modification of BMI in 2010 and BMI transition and trajectory(fitted by group-based trajectory modelling)from 2004 to 2010 were assessed.Results 15282 participants with a mean age of 67.0 years(58.0–75.0)were included in the 2010 data analysis.Significant interactions of ACEs with baseline BMI,BMI transition and BMI trajectory in their associations with new-onset all-cause dementia and AD were observed(all p<0.05).For instance,positive associations of two or more ACEs(vs none)with all-cause dementia and AD were found in those with a BMI trajectory of maintaining≥30 kg/m2(maintain obesity)rather than a decline to or maintaining<25 kg/m2(decline to or maintain normal weight),with hazard ratios(HRs)of 1.87(95%confidence interval(CI):1.45 to 2.42)and 1.85(95%CI:1.22 to 2.80),respectively.Conclusions ACEs were associated with dementia and AD in US adults with long-term abnormally elevated BMI but not with long-term normal or decreasing BMI.Integrated weight management throughout life could prevent dementia among those with childhood adversity. | Ziyang Ren Binbin Su Yushan Du Tianjing Zhou Xiaoying Zheng Jufen Liu | 2023 | General Psychiatry2023，36，4： | 0 |
| 7 | Structure and Catalytic Behaviour of Saponite and Its Cross-Linking Product显示文摘Synthetic saponites have been intercalated with hydroxyl aluminium oligomers and characterized with several techniques. The basal 001 peak of the pillared saponite (PS) is 1. 8 nm. The amount of the aluminium in the tctrahedral sheet is correlative with cross-linking density. The sheet-to-pillar linkage mode may be Si-O-AlpⅥ. The acid sites in pillared saponite may locate either at surface of clay or at that of pillar. The cumene conversion is relative to accessible acid sites on the surface of PS. The pillar density in the PS has an effect on the pore structure which is correlative with shape selectivity during the reaction between ethanol and ammonia. | Jiang Dazhen, Liu Ziyang, Sun Tie and Ren Beiyuan (Department of Chemistry, Jilin University, Changchun)Min Enze and He Mingyuan (Research Institute of Petroleum Processing, Beijing) | 1991 | Chemical Research in Chinese Universities1991，7，3： | 0 |
| 8 | Natural variations of OsAUX5,a target gene of OsWRKY78,control the neutral essential amino acid content in rice grains显示文摘Grain essential amino acid(EAA)levels contribute to rice nutritional quality.However,the molecular mechanisms underlying EAA accumulation and natural variation in rice grains remain unclear.Here we report the identification of a previously unrecognized auxin influx carrier subfamily gene,OsAUX5,which encodes an amino acid transporter that functions in uptake of multiple amino acids.We identified an elite haplotype of Pro::OsAUX5^(Hap2) that enhances grain EAA accumulation without an apparent negative effect on agronomic traits.Natural variations of OsAUX5 occur in the cis elements of its promoter,which are differentially activated because of the different binding affinity between OsWRKY78 and the W-box,contributing to grain EAA variation among rice varieties.The two distinct haplotypes were shown to have originated from different Oryza rufipogon progenitors,which contributed to the divergence between japonica and indica.Introduction of the indica-type Pro::OsAUX5^(Hap2) genotype into japonica could significantly increase EAA levels,indicating that indica-type Pro::OsAUX5^(Hap2) can be utilized to increase grain EAAs of japonica varieties.Collectively,our study uncovers an WRKY78–OsAUX5-based regulatory mechanism controlling grain EAA accumulation and provides a potential target for breeding EAA-rich rice. | Yuheng Shi Yuanyuan Zhang Yangyang Sun Ziyang Xie Yu Luo Qiyuan Long Jiahui Feng Xueqing Liu Bi Wang Dujun He Junxia Ren Peizhen Guo Junwei Xing Liqiang He Alisdair RFernie Wei Chen Xianqing Liu Yuehua Luo Cheng Jin Jie Luo | 2023 | Molecular Plant2023，16，2： | 0 |
| 9 | Periconceptional Folic Acid Only Versus Multiple Micronutrients Containing Folic Acid and Association with Gestational Diabetes Mellitus-Beijing Municipality,China,2017-2021显示文摘Summary What is already known about this topic?Inconsistent results have been reported on the association between periconceptional folic acid only(FAO)or multiple micronutrients containing folic acid(MMFA)supplementation and the risk of gestational diabetes mellitus(GDM)in previous research.What is added by this report?In a prospective cohort study conducted among pregnant women in Haidian District,Beijing Municipality,it was observed that those who took MMFA demonstrated a higher likelihood of developing GDM in comparison to those who consumed FAO periconceptionally.Interestingly,the increased risk for GDM in pregnant women supplemented with MMFA compared to FAO was primarily due to changes in fasting plasma glucose.What are the implications for public health practice?It is highly recommended that women prioritize the use of FAO in order to yield potential benefits in the prevention of GDM. | Shuangbo Xia Yushan Du Ziyang Ren Jinjuan Zhang Suhong Gao Jiamei Wang Zhiwen Li Xiaohong Liu Jufen Liu | 2023 | China CDC weekly2023，5，23： | 0 |
| 10 | Co-alteration of Myc and RTK-RAS pathways defines a liver-metastatic propensity and immune-cold subgroup of pancreatic adenocarcinoma显示文摘Co-altered pathways refer to the phenomenon where multiple biological pathways exhibit aberrant changes simultaneously within the same tumor sample.This phenomenon can facilitate a better understanding of the mechanism and evolution of tumors and serve as a biological marker for diagnosing,classifying,and treating tumors.1 However,the nature of alteration occurrence and the impact on pancreatic adenocarcinoma(PAAD)remain elusive.The SELECT algorithm was originally designed to systematically assess the evolutionary dependencies and their impact between altered genes in cancer for anticipating drug resistance and proposing alternative strategies.Here,to better characterize the etiology of PAAD and develop an improved risk assessment strategy,2 by utilizing SELECT,we identified a co-altered pathway subgroup of PAAD that demonstrated an elevated risk for unfavorable prognosis,a propensity for liver metastasis,and an immunologically cold microenvironment. | Yuyuan Zhang Ziyang Zu Hui Xu Siyuan Weng Yuqing Ren Quan Cheng Peng Luo Jian Zhang Zaoqu Liu Xinwei Han | 2024 | Genes & Diseases2024，11，3： | 0 |
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