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| 1 | Intestinal Microbiota in Early Life and Its Implications on Childhood Health显示文摘Trillions of microbes reside in the human body and participate in multiple physiological and pathophysiological processes that affect host health throughout the life cycle. The microbiome is hallmarked by distinctive compositional and functional features across different life periods.Accumulating evidence has shown that microbes residing in the human body may play fundamental roles in infant development and the maturation of the immune system. Gut microbes are thought to be essential for the facilitation of infantile and childhood development and immunity by assisting in breaking down food substances to liberate nutrients, protecting against pathogens, stimulating or modulating the immune system, and exerting control over the hypothalamic–pituitary–adrenal axis.This review aims to summarize the current understanding of the colonization and development of the gut microbiota in early life, highlighting the recent findings regarding the role of intestinal microbes in pediatric diseases. Furthermore, we also discuss the microbiota-mediated therapeutics that can reconfigure bacterial communities to treat dysbiosis. | Lu Zhuang Haihua Chen Sheng Zhang Jiahui Zhuang Qiuping Li Zhichun Feng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 16 |
| 2 | The double face of miR-320:cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction显示文摘MicroRNAs(miRNAs)are aberrantly expressed in the pathophysiologic process of heart failure(HF).However,the functions of a certain miRNA in different cardiac cell types during HF are scarcely reported,which might be covered by the globe effects of it on the heart.In the current study,Langendorff system was applied to isolate card io myocytes(CMs)and cardiac fibroblasts(CFs)from transverse aortic constriction(TAC)-induced mice.Slight increase of miR-320 expression was observed in the whole heart tissue of TAC mice.Interestingly,miR-320 was significantly elevated in CMs but decreased in CFs from TAC mice at different time points.Then,recombinant adeno-associated virus 9 with cell-type-specific promoters were used to manipulate miR-320 expressions in vivo.Both in vitro and in vivo experiments showed the miR-320 overexpression in CMs exacerbated cardiac dysfunction,whereas overexpression of miR-320 in CFs alleviated cardiac fibrosis and hypertrophy.Mechanically,downstream signaling pathway analyses revealed that miR-320 might induce various effects via targeting PLEKHM3 and IFITM1 in CMs and CFs,respectively.Moreover,miR-320 mediated effects could be abolished by PLEKHM3 re-expression in CMs or IFITM1 re-expression in CFs.Interestingly,miR-320 treated CFs were able to indirectly affect CMs function,but not vice versa.Meanwhile,upstream signaling pathway analyses showed that miR-320 expression and decay rate were rigorously manipulated by Ago2,which was regulated by a cluster of cell-type-specific TFs distinctively expressed in CMs and CFs,respectively.Together,we demonstrated that miR-320 functioned differently in various cell types of the heart during the progression of HF. | Xudong Zhang Shuai Yuan Huaping Li Jiabing Zhan Feng Wang Jiahui Fan Xiang Nie Yan Wang Zheng Wen Yanghui Chen Chen Chen Dao Wen Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 4 |
| 3 | Dynamical decoupling of electron spins in phosphorus-doped silicon显示文摘Quantum coherence is an important enabling feature underpinning quantum computation. However, because of couplings with its noisy surrounding environment, qubits suffer from the decoherence effects. The dynamical decoupling (DD) technique uses pulse-induced qubit flips to effectively mitigate couplings between qubits and environment. Optimal DD eliminates dephasing up to a given order with the minimum number of pulses. In this paper, we first introduce our recent work on prolonging electron spin coherence in γ-irradiated malonic acid crystals and analyze different decoherence mechanisms in this solid system. Then we focus on electron spin relaxation properties in another system, phosphorous-doped silicon (Si:P) crystals. These properties have been investigated by pulse electron paramagnetic resonance (EPR). We also investigate the performance of the dynamical decoupling technique on this system. Using 8-pulse periodic DD, the coherence time can be extended to 296 μs compared with 112 μs with one-pulse control. | RONG Xing WANG Ya YANG JiaHui ZHU JinXian XU WanJie FENG PengBo WEN XuJie SU JiHu DU JiangFeng | 2011 | Chinese Science Bulletin2011，56，7： | 4 |
| 4 | A shear-thinning,ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis显示文摘Spinal cord injury(SCI)is a serious clinical disease.Due to the deformability and fragility of the spinal cord,overly rigid hydrogels cannot be used to treat SCI.Hence,we used TPA and Laponite to develop a hydrogel with shear-thinning ability.This hydrogel exhibits good deformation,allowing it to match the physical properties of the spinal cord;additionally,this hydrogel scavenges ROS well,allowing it to inhibit the lipid peroxidation caused by ferroptosis.According to the in vivo studies,the TPA@Laponite hydrogel could synergistically inhibit ferroptosis by improving vascular function and regulating iron metabolism.In addition,dental pulp stem cells(DPSCs)were introduced into the TPA@Laponite hydrogel to regulate the ratios of excitatory and inhibitory synapses.It was shown that this combination biomaterial effectively reduced muscle spasms and promoted recovery from SCI. | Yibo Ying Zhiyang Huang Yurong Tu Qiuji Wu Zhaoyu Li Yifan Zhang Huilei Yu Annian Zeng Hanzhi Huang Jiahui Ye Weiyang Ying Min Chen Zhiyi Feng Ziyue Xiang Qingsong Ye Sipin Zhu Zhouguang Wang | 2023 | Bioactive Materials2023，，4： | 2 |
| 5 | Measurements and Characterization for the Vehicle-to-Infrastructure Channel in Urban and Highway Scenarios at 5.92GHz显示文摘In the future smart transportation system, reliable vehicle-to-infrastructure(V2 I) communication is very important to ensure vehicle driving safety and to improve vehicle driving efficiency. In this paper, V2 I channel measurements at 5.92 GHz are conducted in typical urban and highway scenarios.The frequency and bandwidth of transmission, as well as the deployment of the RSU(roadside unit) and the OBU(on board unit), are selected by considering the recommendation proposed by 3 GPP TR 36.885. Then,based on the measured data, the key channel characteristic parameters of the V2 I channel are extracted,including path loss, root-mean-square delay spread,stationarity distance, and Doppler spread, etc. Also,the statistical characteristics of the parameters, including time-varying and Doppler characteristics, are investigated and characterized. The work in this paper helps researchers design technology and communication systems in similar scenarios. | Yuanyuan Fan Yi Feng Liu Liu Shuoshuo Dong Zhaoyang Su Jiahui Qiu Xiaobo Lin | 2022 | China Communications2022，19，4： | 2 |
| 6 | Injectable Self‑Healing Adhesive pH‑Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing显示文摘Endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)are well-established therapeutics for gastrointestinal neoplasias,but complications after EMR/ESD,including bleeding and perforation,result in additional treatment morbidity and even threaten the lives of patients.Thus,designing biomaterials to treat gastric bleeding and wound healing after endoscopic treatment is highly desired and remains a challenge.Herein,a series of injectable pH-responsive selfhealing adhesive hydrogels based on acryloyl-6-aminocaproic acid(AA)and AA-g-N-hydroxysuccinimide(AA-NHS)were developed,and their great potential as endoscopic sprayable bioadhesive materials to efficiently stop hemorrhage and promote the wound healing process was further demonstrated in a swine gastric hemorrhage/wound model.The hydrogels showed a suitable gelation time,an autonomous and efficient self-healing capacity,hemostatic properties,and good biocompatibility.With the introduction of AA-NHS as a micro-cross-linker,the hydrogels exhibited enhanced adhesive strength.A swine gastric hemorrhage in vivo model demonstrated that the hydrogels showed good hemostatic performance by stopping acute arterial bleeding and preventing delayed bleeding.A gastric wound model indicated that the hydrogels showed excellent treatment effects with significantly enhanced wound healing with type I collagen deposition,α-SMA expression,and blood vessel formation.These injectable self-healing adhesive hydrogels exhibited great potential to treat gastric wounds after endoscopic treatment. | Jiahui He Zixi Zhang Yutong Yang Fenggang Ren Jipeng Li Shaojun Zhu Feng Ma Rongqian Wu Yi Lv Gang He Baolin Guo Dake Chu | 2021 | Nano-Micro Letters2021，13，5： | 1 |
| 7 | pH and H2O2 dual-responsive carbon dots for biocatalytic transformation monitoring显示文摘Development of sensitive biosensors for biocatalytic transformations monitoring is in high demand but remains a great challenge. It is ascribed to the current strategies that focused on the single metabolite detection, which may bring about the relatively low sensitivity and false diagnosis result. Herein, we report the design and fabrication of novel carbon dots(CDs) with strong orange light emission, pH and H2O2 dual-responsive characteristics. The fluorescence quenching of CDs by H+and H2O2 enables the highly sensitive detection of H+/H2O2-generating biocatalytic transformations. This is exemplified by the glucose oxidase-mediated catalytic oxidation reaction on glucose, in which H+and H2O2 would be formed. As compared to the case in which glucose is present, significant fluorescence reduction is detected, and the fluorescence intensity is negatively proportional to glucose concentration. Thus, highly sensitive detection of glucose was readily achieved with a detection limit down to 10.18 nmol/L. The prepared CDs not only realize the highly sensitive detection of glucose, but also allows the probing other substances by changing the enzymes, thus providing a versatile platform, and demonstrating good potential to be used for biocatalytic transformations effective monitoring. | Wenxin Lv Xin Wang Jiahui Wu Haiyin Li Feng Li | 2019 | Chinese Chemical Letters2019，30，9： | 1 |
| 8 | Dual-site fluorescent probe for highly selective and sensitive detection of sulfite and biothiols显示文摘A dual-site fluorescent probe with double bond and aldehyde as reactive sites, was designed for the selective detection of sulfite and biothiols. Sulfite reacts with conjugate bond selectively, while Cys responses with aldehyde and GSH occurs substitution reaction. Different interactions cause different absorption and fluorescence responses. Moreover, it could be further applied in imaging in living cells. | Mengyang Li Pengcheng Cui Kun Li Jiahui Feng Mingming Zou Xiaoqi Yu | 2018 | Chinese Chemical Letters2018，29，6： | 1 |
| 9 | The effect of subgrade inhomogeneity induced by freeze-thaw on the dynamic response of track-subgrade system显示文摘The developed vertical coupling model of Vehicle-Track-Subgrade which considered subgrade layer vibration is presented. The equations of motion for the ballast, top and bottom subgrade layers are presented in detail. Through inputting different coefficients, the dynamic response of track-subgrade system in a seasonal frozen region in different seasons is obtained by the developed model and the uneven freeze-thaw action of subgrade soil is presented in this model. The effect of subgrade inhomogeneity induced by uneven freeze-thaw on the dynamic response of track-subgrade system was studied and the conclusions are as follows. The force at the interface of ballast and top subgrade layer and the deformation of ballast induced by a passing train changed sharply at the stiffness mutation zone. The force and deformation decreased with increasing stiffness ratio with the same amplitude of irregularities as the excitation source. The force and deformation were larger with larger amplitudes of irregularities. There was an obvious effect of uneven deformation and stiffness of subgrade on the dynamic response of track-subgrade system. | QiongLin Li XianZhang Ling Feng Zhang JiaHui Wang | 2013 | Research in Cold and Arid Regions2013，5，5： | 1 |
| 10 | Ground-layer adaptive optics for the New Vacuum Solar Telescope:Instrument description and first results显示文摘Ground-layer adaptive optics(GLAO)has shown its potential for use in solar observation owing to its wide field-of-view(FOV)correction.A high-order GLAO system that consists of a multiple direction Shack-Hartmann wavefront sensor(WFS),a realtime controller with a multi-CPU processor,and a 151-element deformable mirror was developed for the 1-m New Vacuum Solar Telescope at Yunnan Observatories,Chinese Academy of Sciences.A hexagonal microlens with 9×8 subapertures is employed in the WFS.The detection FOV is 42′′×37′′,in which 9(3×3)guide regions are extracted for multiple direction wavefront sensing with a frame rate of up to 2200 Hz.To our knowledge,this is the first professional solar GLAO system used as a regularly operating instrument for scientific observations.Its installation and adjustment were performed in the summer of 2021.In this article,a detailed account of the GLAO system and its first light results and a comprehensive analysis of the performance of the GLAO system are provided.The results show that this system can effectively improve the imaging quality after compensating for the wavefront aberration due to ground-layer turbulence. | Lanqiang Zhang Hua Bao Xuejun Rao Youming Guo Libo Zhong Xian Ran Nanfei Yan Jinsheng Yang Cheng Wang Jiahui Zhou Ying Yang Yunyao Long Xinlong Fan Zhongyi Feng Donghong Chen Changhui Rao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，6： | 1 |
| 11 | Large-area flexible and transparent UV photodetector based on cross-linked Ag NW@ZnO NRs with high performance显示文摘A series of large-area,flexible and transparent ultraviolet(UV)photodetectors(PDs)based on Ag nanowire(NW)@ZnO nanorods(NRs)are fabricated by an inexpensive,facile and effective approach.These Ag NW@ZnO NRs are successfully synthesized using a two-step method in an oil bath with a high surface-to-volume ratio and good crystallinity.The PDs are fabricated by drop-coating with different drop-coating times on the surface of polyethylene terephthalate(PET)coupled with Au electrodes.By optimizing the cross-linked network of Ag NW@ZnO NRs,PD2 with a size greater than 25 mm exhibits excellent photoresponse under UV light illumination of 365 nm(1.3 m W cm^(-2))with a bias of 5 V:a high sensitivity of over 10^(3),and a much shorter rise/decay time of 2.6 s/2.3 s.Simultaneously,the detector exhibits an average transmittance of more than 70%in the visible light region,as well as good flexibility and excellent mechanical stability under a bending angle of 120°over 1000 circles bending.These integral advantages have significant potential for practical applications and mass production. | Lin Zhang Nuomei Li Qiuchen Ma Jiahui Ding Chuang Chen Zhaocheng Hu Weiwei Zhao Yufeng Li Huanhuan Feng Mingyu Li Hongjun Ji | 2022 | Journal of Materials Science & Technology2022，，15： | 1 |
| 12 | Te-mediated electro-driven oxygen evolution reaction显示文摘In the 21^(st)century,the rapid development of human society has made people’s demand for green energy more and more urgent.The high-energy-density hydrogen energy obtained by fully splitting water is not only environmentally friendly,but also is expected to solve the problems caused by the intermittent nature of new energy.However,the slow kinetics and large overpotential of the oxygen evolution reaction(OER)limit its application.The introduction of Te element is expected to bring new breakthroughs.With the least electronegativity among the chalcogens,the Te element has many special properties,such as multivalent states,strong covalentity,and high electrical conductivity,which make it a promising candidate in electrocatalytic OER.In this review,we introduce the peculiarities of Te element,summarize Te doping and the extraordinary performance of its compounds in OER,with emphasis on the scientific mechanism behind Te element promoting the OER kinetic process.Finally,challenges and development prospects of the applications of Te element in OER are presented. | Feng Gao Jiaqing He Haowei Wang Jiahui Lin Ruixin Chen Kai Yi Feng Huang Zhang Lin Mengye Wang | 2022 | Nano Research Energy2022，1，3： | 1 |
| 13 | Insight into sulfur and iron effect of binary nickel-iron sulfide on oxygen evolution reaction显示文摘Nickel-iron sulfide has shown attractive activity in electrocatalytic oxygen evolution reaction(OER).However,the effects of low valence sulfur(S^(2−))and metal species on OER in binary nickel-iron sulfide have rarely been systematically studied.Works based on post-catalysis characterization have led to the assumption that the real active species are nickel-iron oxyhydroxide,and that nickel-iron sulfide acts only as a precatalyst.Therefore,to study the role of S,Ni,and Fe for the development of nickel-iron sulfide catalyst is of self-evident importance.Herein,a facile solvothermal method is used to synthesize acetylene black coated with nickel-iron sulfide nanosheets.Electrochemical tests show that the presence of low valence S species makes the catalyst have faster OER kinetics,larger active area,and intermediate active species adsorption area.Therefore,the present study reveals the enhancing effect of low valence sulfur species(S^(2−))on OER in binary nickel-iron sulfide.In situ Raman spectroscopy shows that the generation ofγ-NiOOH intermediate is essential and Fe does not directly participate in the oxygen production.Density functional theory(DFT)calculation shows that Ni-OH deprotonation is a rate-determining step for both binary nickel-iron sulfide and nickel sulfide.The addition of Fe into NiSx lightly increases the charge transfer of Ni atom to O atom,which makes deprotonation easier and thereby improves the OER performance. | Qikang Wu Songrui Wang Jiahui Guo Xueqing Feng Han Li Shanshan Lv Yan Zhou Zheng Chen | 2022 | Nano Research2022，15，3： | 1 |
| 14 | Straw Segmentation Algorithm Based on Modified UNet in Complex Farmland Environment显示文摘Intelligent straw coverage detection plays an important role in agricultural production and the ecological environment.Traditional pattern recognition has some problems,such as low precision and a long processing time,when segmenting complex farmland,which cannot meet the conditions of embedded equipment deployment.Based on these problems,we proposed a novel deep learning model with high accuracy,small model size and fast running speed named Residual Unet with Attention mechanism using depthwise convolution(RADw–UNet).This algorithm is based on the UNet symmetric codec model.All the feature extraction modules of the network adopt the residual structure,and the whole network only adopts 8 times the downsampling rate to reduce the redundant parameters.To better extract the semantic information of the spatial and channel dimensions,the depthwise convolutional residual block is designed to be used in feature maps with larger depths to reduce the number of parameters while improving the model accuracy.Meanwhile,the multi–level attention mechanism is introduced in the skip connection to effectively integrate the information of the low–level and high–level feature maps.The experimental results showed that the segmentation performance of RADw–UNet outperformed traditional methods and the UNet algorithm.The algorithm achieved an mIoU of 94.9%,the number of trainable parameters was only approximately 0.26 M,and the running time for a single picture was less than 0.03 s. | Yuanyuan Liu Shuo Zhang Haiye Yu Yueyong Wang Yuehan Feng Jiahui Sun Xiaokang Zhou | 2021 | Computers, Materials & Continua2021，，1： | 1 |
| 15 | METTL3-mediated m^(6)A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial-mesenchymal transition显示文摘Subretinal fibrosis is a major cause of the poor visual prognosis for patients with neovascular age-related macular degeneration(nAMD).Myofibroblasts originated from retinal pigment epithelial(RPE)cells through epithelial-mesenchymal transition(EMT)contribute to the fibrosis formation.N^(6)-Methyladenosine(m^(6)A)modification has been implicated in the EMT process and multiple fibrotic diseases.The role of m^(6)A modification in EMT-related subretinal fibrosis has not yet been elucidated.In this study,we found that during subretinal fibrosis in the mouse model of laser-induced choroidal neovascularization,METTL3 was upregulated in RPE cells.Through m^(6)A epitranscriptomic microarray and further verification,high-mobility group AT-hook 2(HMGA2)was identified as thekey downstream target of METTL3,subsequently activating potent EMT-inducing transcription factor SNAIL.Finally,by subretinal injections of adeno-associated virus vectors,we confirmed that METTL3 deficiency in RPE cells could efficiently attenuate subretinal fibrosis in vivo.In conclusion,our present research identified an epigenetic mechanism of METTL3-m^(6)A-HMGA2 in subretinal fibrosis and EMT of RPE cells,providing a novel therapeutic target for subretinal fibrosis secondary to nAMD. | Yuwei Wang Yuhong Chen Jian Liang Mei Jiang Ting Zhang Xiaoling Wan Jiahui Wu Xiaomeng Li Jieqiong Chen Junran Sun Yifan Hu Peirong Huang Jingyang Feng Te Liu Xiaodong Sun | 2023 | Journal of Molecular Cell Biology2023，15，3： | 1 |
| 16 | Effects of CBN content on characteristics of PCBN composites in turning GCr15 hardened steels显示文摘Well-sintered polycrystalline cubic boron nitride(PCBN)composites with different contents of cubic boron nitride(CBN) were obtained using Al and TiN as additives under pressure of 5.5 GPa and temperature of 1450 ℃.The network structure of CBN grains and bonding materials was observed using scanning electron microscope(SEM).With the help of X-ray diffraction(XRD) analysis,TiB2 and AlN could be determined as main products and Al3 Ti also was detected in the Al-rich samples after sintering process.Furthermore,it was shown that Vickers hardness of composites was improved with the increase of CBN contents.However,the lifetime of PCBN composites was in negative correlation with the amount of CBN in turning GCr15 hardened steels,and the surface roughness of workpieces machined by these PCBN composites also showed the same trend.A series of cutting data confirmed that the low CBN content in PCBN composites could enhance the working durability and improve the surface quality in turning hardened steels.The present experiments also indicated that the lowest value of flank wear was not constant for different PCBN composites when they were used to machine several workpieces with different hardness. | GUO Jiahui YAO Feng ZHAO Long LI Binhua FENG Fei XIE Hui FANG Haijiang ZHANG Yingjiu | 2019 | 金刚石与磨料磨具工程2019，39，4： | 1 |
| 17 | Neural stem cell-derived exosomes promote mitochondrial biogenesis and restore abnormal protein distribution in a mouse model of Alzheimer's disease显示文摘Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheimer’s disease affects the entire brain,further research is needed to elucidate alterations in mitochondrial metabolism in the brain as a whole.Here,we investigated the expression of several important mitochondrial biogenesis-related cytokines in multiple brain regions after treatment with neural stem cell-derived exosomes and used a combination of whole brain clearing,immunostaining,and lightsheet imaging to clarify their spatial distribution.Additionally,to clarify whether the sirtuin 1(SIRT1)-related pathway plays a regulatory role in neural stem cell-de rived exosomes interfering with mitochondrial functional changes,we generated a novel nervous system-SIRT1 conditional knoc kout AP P/PS1mouse model.Our findings demonstrate that neural stem cell-de rived exosomes significantly increase SIRT1 levels,enhance the production of mitochondrial biogenesis-related fa ctors,and inhibit astrocyte activation,but do not suppress amyloid-βproduction.Thus,neural stem cell-derived exosomes may be a useful therapeutic strategy for Alzheimer’s disease that activates the SIRT1-PGC1αsignaling pathway and increases NRF1 and COXIV synthesis to improve mitochondrial biogenesis.In addition,we showed that the spatial distribution of mitochondrial biogenesis-related factors is disrupted in Alzheimer’s disease,and that neural stem cell-derived exosome treatment can reverse this effect,indicating that neural stem cell-derived exosomes promote mitochondrial biogenesis. | Bo Li Yujie Chen Yan Zhou Xuanran Feng Guojun Gu Shuang Han Nianhao Cheng Yawen Sun Yiming Zhang Jiahui Cheng Qi Zhang Wei Zhang Jianhui Liu | 2024 | Neural Regeneration Research2024，19，7： | 0 |
| 18 | HQD-RRT^(*):a high-quality path planner for mobile robot in dynamic environment显示文摘Mobile robots have been used for many industrial scenarios which can realize automated manufacturing process instead of human workers. To improve the quality of the optimal rapidly-exploring random tree(RRT^(*)) for planning path in dynamic environment, a high-quality dynamic rapidly-exploring random tree(HQD-RRT^(*)) algorithm is proposed in this paper, which generates a high-quality solution with optimal path length in dynamic environment. This method proceeds in two stages: initial path generation and path re-planning. Firstly, the initial path is generated by an improved smart rapidly-exploring random tree(RRT^(*)-SMART) algorithm, and the state tree information is stored as prior knowledge. During the process of path execution, a strategy of obstacle avoidance is proposed to avoid moving obstacles. The cost and smoothness of path are considered to re-plan the initial path to improve the path quality in this strategy. Compared with related work, a higher-quality path in dynamic environment can be achieved in this paper. HQD-RRT^(*) algorithm can obtain an optimal path with better stability. Simulations on the static and dynamic environment are conducted to clarify the efficiency of HQD-RRT^(*) in avoiding unknown obstacles. | Li Qinghua Wang Jiahui Li Haiming Feng Chao | 2022 | The Journal of China Universities of Posts and Telecommunications2022，29，3： | 0 |
| 19 | Enhanced photocatalytic ammonia oxidation activity and nitrogen selectivity over Ag/AgCl/N-TiO_(2) photocatalyst显示文摘The removal of ammonia(NH_(3))emitted from agricultural and industrial activities is of great significance to protect human health and ecological environment.Photocatalytic NH_(3)oxidation to N2under mild conditions is a promising strategy.However,developing visible light photocatalysts for NH_(3)oxidation is still in its infancy.Here,we fabricate N-TiO_(2)and Ag/AgCl/N-TiO_(2)photocatalysts by sol-gel and photodeposition methods,respectively.The introduction of N not only endows TiO_(2)with visible light response(absorption edge at460 nm)but also results in the formation of heterophase junction(anatase and rutile).Thus,N-TiO_(2)shows 2.0 and 1.8 times higher than those over anatase TiO_(2)and commercial TiO_(2)for NH_(3)oxidation under full spectrum irradiation.Meanwhile,surface modification of Ag can simultaneously enhance visible light absorption(generating localized surface plasmon resonance effect)and charge separation efficiency.Therefore,the photocatalytic activity of Ag/AgCl/N-TiO_(2)is further improved.Furthermore,the presence of N and Ag also enhances the selectivity of N2product owing to the change of reaction pathway.This work simultaneously regulates photocatalytic conversion efficiency and product selectivity,providing some guidance for developing highly efficient photocatalysts for NH_(3)elimination. | Jiaojiao Guan Daorong Li Jiahui Feng Peng Xu Zhaonian Li Siqi Ge Hongxia Chen Kunfeng Zhang | 2024 | Journal of Environmental Sciences2024，，4： | 0 |
| 20 | Overexpression of HOXA9 upregulates NF-κB signaling to promote human hematopoiesis and alter the hematopoietic differentiation potentials显示文摘Background: The HOX genes are master regulators of embryogenesis that are also involved inhematopoiesis. HOXA9 belongs to a cluster of HOX genes that play extensively studied roles inhematopoiesis and leukemogenesis.Methods: We established HOXA9-inducible human embryonic stem cells (HOXA9/hESCs) with normalpluripotency and potential for hematopoiesis, which could be used to analyze gene function with highaccuracy. HOXA9/hESCs co-cultured with aorta–gonad–mesonephros-derived stromal cells (AGM-S3) wereinduced to overexpress HOXA9 with doxycycline (DOX) at various times after hematopoiesis started andthen subjected to flow cytometry.Results: Induction of HOXA9 from Day 4 (D4) or later notably promoted hematopoiesis and also increasedthe production of CD34+ cells and derived populations. The potential for myelogenesis was significantlyelevated while the potential for erythrogenesis was significantly reduced. At D14, a significant promotion ofS phase was observed in green fluorescent protein positive (GFP+) cells overexpressing HOXA9. NF-κBsignaling was also up-regulated at D14 following induction of HOXA9 on D4. All of these effects could becounteracted by addition of an NF-κB inhibitor or siRNA against NFKB1 along with DOX.Conclusions: Overexpression of HOXA9 starting at D4 or later during hematopoiesis significantly promotedhematopoiesis and the production of myeloid progenitors while reduced the production of erythroidprogenitors, indicating that HOXA9 plays a key role in hematopoiesis and differentiation of hematopoieticlineages. | Jiahui Zeng Danying Yi Wencui Sun Yuanlin Liu Jing Chang Lijiao Zhu Yonggang Zhang Xu Pan Yong Dong Ya Zhou Mowen Lai Guohui Bian Qiongxiu Zhou Jiaxin Liu Bo Chen Feng Ma | 2021 | Cell Regeneration2021，10，1： | 0 |
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