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| 1 | Degradation of lipid droplets by chimeric autophagy-tethering compounds显示文摘Degrading pathogenic proteins by degrader technologies such as PROTACs(proteolysis-targeting chimeras)provides promising therapeutic strategies,but selective degradation of non-protein pathogenic biomolecules has been challenging. | Yuhua Fu Ningxie Chen Ziying Wang Shouqing Luo Yu Ding Boxun Lu | 2021 | Cell Research2021，31，9： | 5 |
| 2 | Functional hair follicle regeneration:an updated review显示文摘The hair follicle(HF)is a highly conserved sensory organ associated with the immune response against pathogens,thermoregulation,sebum production,angiogenesis,neurogenesis and wound healing.Although recent advances in lineage-tracing techniques and the ability to profile gene expression in small populations of cells have increased the understanding of how stem cells operate during hair growth and regeneration,the construction of functional follicles with cycling activity is still a great challenge for the hair research field and for translational and clinical applications.Given that hair formation and cycling rely on tightly coordinated epithelial-mesenchymal interactions,we thus review potential cell sources with HF-inducive capacities and summarize current bioengineering strategies for HF regeneration with functional restoration. | Shuaifei Ji Ziying Zhu Xiaoyan Sun Xiaobing Fu | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 2 |
| 3 | Chitosan/LiCl composite scaffolds promote skin regeneration in full-thickness loss显示文摘Small molecules loaded into biological materials present a promising strategy for stimulating endogenous repair mechanisms for in situ skin regeneration.Lithium can modulate various biologic processes,promoting proliferation,angiogenesis,and decreasing inflammation.However,its role in skin repair is rarely reported.In this study,we loaded lithium chloride(LiCl)into the chitosan(CHI)hydrogel and develop a sterile and biocompatible sponge scaffold through freeze-drying.In-vitro assessment demonstrated that the CHI-LiCl composite scaffolds(CLiS)possessed favorable cytocompatibility,swelling and biodegradation.We created full-thickness skin wounds in male C57BL/c mice to evaluate the healing capacity of CLiS.Compared with the wounds of control and CHI scaffold(CS)groups,the wounds in the CLiS-treated group showed reduced inflammation,improved angiogenesis,accelerated re-epithelialization,sustained high expression ofβ-catenin with a small amount of regenerated hair follicles.Therefore,CLiS may be a promising therapeutic dressing for skin wound repair and regeneration. | Jifang Yuan Qian Hou Deyun Chen Lingzhi Zhong Xin Dai Ziying Zhu Meirong Li Xiaobing Fu | 2020 | Science China(Life Sciences)2020，63，4： | 1 |
| 4 | Synchronization transition of a modular neural network containing subnetworks of different scales显示文摘Time delay and coupling strength are important factors that affect the synchronization of neural networks.In this study,a modular neural network containing subnetworks of different scales was constructed using the Hodgkin–Huxley(HH)neural model;i.e.,a small-scale random network was unidirectionally connected to a large-scale small-world network through chemical synapses.Time delays were found to induce multiple synchronization transitions in the network.An increase in coupling strength also promoted synchronization of the network when the time delay was an integer multiple of the firing period of a single neuron.Considering that time delays at different locations in a modular network may have different effects,we explored the influence of time delays within each subnetwork and between two subnetworks on the synchronization of modular networks.We found that when the subnetworks were well synchronized internally,an increase in the time delay within both subnetworks induced multiple synchronization transitions of their own.In addition,the synchronization state of the small-scale network affected the synchronization of the large-scale network.It was surprising to find that an increase in the time delay between the two subnetworks caused the synchronization factor of the modular network to vary periodically,but it had essentially no effect on the synchronization within the receiving subnetwork.By analyzing the phase difference between the two subnetworks,we found that the mechanism of the periodic variation of the synchronization factor of the modular network was the periodic variation of the phase difference.Finally,the generality of the results was demonstrated by investigating modular networks at different scales. | Weifang HUANG Lijian YANG Xuan ZHAN Ziying FU Ya JIA | 2023 | Frontiers of Information Technology & Electronic Engineering2023，24，10： | 0 |
| 5 | A Lotus in Its Prime--Celebrating the 20th Annivereary of Macao’s Return lo the Motherland显示文摘On December 20,1999,the Chinese government resumed its exercise of sovereignty over Macao,established the Macao Special Administrative Region(SAR),and implemented“one country,two systems”and the policies of Macao being ruled by its own citizens and enjoying a high degree of autonomy,ushering in a new chapter in the historical development of Macao.The year 2019 marks the 20th anniversary of Macao s return to China. | Fu Ziying | 2020 | Qiu Shi2020，12，2： | 0 |
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