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| 1 | Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice显示文摘最近的研究开始在心脏的肥大和机能障碍的致病揭示了 microRNAs (miRNAs ) 的关键角色。在这研究,我们测试了是否转变生长 factor-β(TGF-β) 调整 miRNA 在心脏的肥大和心失败(HF ) 的发展起了一个枢轴的作用。我们观察到 miR-27b 是在 cardiomyocyte 特定的 Smad4 猛烈老鼠的心的 upregulated,它开发了心脏的肥大。在 vitro,实验证明 miR-27b 表示能被 TGF-β 禁止; 1 并且它的 overexpression 支持了 hypertrophic 房间生长,当 miR-27b 抑制导致了 hypertrophic 房间的抑制时,生长由 phenylephrine (PE ) 引起了处理。而且,有 miR-27b 的 cardiomyocyte 特定的 overexpression 的转基因的老鼠的分析表明 miR-27b overexpression 是足够的导致心脏的肥大和机能障碍。我们验证了 peroxisome 激活 proliferator 的 receptor-γ(PPAR-γ) 作为在 cardiomyocyte 的 miR-27b 的一个直接目标。一致地, miR-27b 转基因的老鼠显著地显示了 PPAR-γ 的底层;比控制鼠标。而且,在用在一只 pressure-overload-induced 老鼠的特定的 antagomir 的 miR-27b 的 vivo silencing, HF 的模型增加了心脏的 PPAR-γ表示,稀释心脏的肥大和机能障碍。我们的学习的结果表明那 TGF-β 1-regulated miR-27b 涉及心脏的肥大的规定,并且为心脏病作为一个有效治疗学的目标验证 miR-27b。 | Jian Wang Yao Song Yan Zhang Han Xiao Qiang Sun Ning Hou Shuilong Guo Youliang Wang Kaiji Fan Dawei Zhan Lagabaiyila Zha Yang Cao Zhenhua Li Xuan Cheng Youyi Zhang Xiao Yang | 2012 | Cell Research2012，22，3： | 36 |
| 2 | Relation between electricity structure of the crust and deformation of crustal blocks on the northeastern margin of Qinghai-Tibet Plateau显示文摘Study on the electricity structure along a magnetotelluric (MT) sounding profile on the northeastern margin of Qinghai-Tibet Plateau indicates that four crustal blocks can be de-termined from southwest to northeast, namely Bayan Har block (BH), Qin-Qi block (QQ), Hai-yuan block (HY) or the North-South seismotectonic belt and Ordos block (OD). The BH, QQ and OD blocks display a similar electricity structure of the crust. The upper crust represents a high- resistivity layer and the upper part of lower crust represents a low-resistivity layer with the resis-tivity increasing gradually with depth from the lower part of lower crust to the upper mantle. The electricity structure of the crust in these three blocks is similar to that in the complete blocks on the southern and eastern margins of the Qinghai-Tibet Plateau and belongs to normal electricity layering of the crust in slightly deformed or complete intracontinental blocks. The crust in HY block as a boundary zone has been significantly deformed, hence its electricity layering was de-stroyed and the structure was complex and the block became a recent tectonically active and great seismo-active region. The contact belts between the blocks on the northeastern margin of Qinghai-Tibet Plateau exhibit both upthrusting outward and strike-slip movement different from those on the southern and eastern margins of the plateau. The genesis of the low-resistivity layer in the crust is analyzed and the thickness of the lithosphere is estimated in the paper. | ZHAO Guoze TANG Ji ZHAN Yan CHEN Xiaobin ZHUO Xianjun WANG Jijun XUAN Fei DENG Qianhui ZHAO Junmeng | 2005 | Science China Earth Sciences2005，48，10： | 20 |
| 3 | Antioxidant and Anti-inflammatory Capacity of Ferulic Acid Released from Wheat Bran by Solid-state Fermentation of Aspergillus niger显示文摘Objective A strain of Aspergillus niger(A. niger), capable of releasing bound phenolic acids from wheat bran, was isolated. This strain was identified by gene sequence identification. The antioxidant and anti-inflammatory capacity of ferulic acid released from wheat bran by this A. niger strain(FA-WB) were evaluated. Methods Molecular identification techniques based on PCR analysis of specific genomic sequences were conducted; antioxidant ability was examined using oxygen radical absorbance capacity(ORAC), cellular antioxidant activity(CAA) assays, and erythrocyte hemolysis assays. RAW264.7 cells were used as a model to detect anti-inflammatory activity. Results The filamentous fungal isolate was identified to be A. niger. ORAC and CAA assay showed that FA-WB had better antioxidant activity than that of the ferulic acid standard. The erythrocyte hemolysis assay results suggested that FA-WB could attenuate AAPH-induced oxidative stress through inhibition of reactive oxy gen species(ROS) generation. FA-WB could significantly restore the AAPH-induced increase in intracellular antioxidant enzyme activities to normal levels as well as inhibit the intracellular malondialdehyde formation. TNF-?, IL-6, and NO levels indicated that FA-WB can inhibit the inflammation induced by lipopolysaccharide(LPS). Conclusion Ferulic acid released from wheat bran by a new strain of A. niger had good anti-inflammatory activity and better antioxidant ability than standard ferulic acid. | YIN Zhi Na WU Wen Jia SUN Chong Zhen LIU Hui Fan CHEN Wen Bo ZHAN Qi Ping LEI Zhuo Gui XIN Xuan MA Juan Juan YAO Kun MIN Tian ZHANG Meng Meng WU Hui | 2019 | Biomedical and Environmental Sciences2019，32，1： | 14 |
| 4 | Energy dependence on modes of electric activities of neuron driven by different external mixed signals under electromagnetic induction显示文摘Energy supply and release play an important role in individual neuron and neural network. In this paper, the electrical activities and Hamilton energy of neuron are investigated when external mixed signals(i.e., the periodic stimulus current and the periodic electromagnetic field) are imposed on the neuron under the electromagnetic induction. As a result, the Hamilton energy is much dependent on the mode transition, the multiple electric activity modes and the numerical analysis of Hamilton energy are more complicated under various parameters. When the periodic high-low frequency electromagnetic radiation is imposed in neuron, it is found that the electrical activities are more complex, and the changing of energy is obvious. In addition, the response of electrical activity and Hamilton energy is much dependent on the changing of amplitude A, B when the external high-low frequency signal is imposed on the neuron, meanwhile, the energy of bursting state is lower than the one of spiking state. It can be used for investigation about the energy coding in the neuron even the neuron networks. | LU LuLu JIA Ya XU Ying GE MengYan YANG LiJian ZHAN Xuan | 2019 | Science China(Technological Sciences)2019，62，3： | 8 |
| 5 | Specific HLA-DQB1 alleles associated with risk for development of hepatocellular carcinoma:A meta-analysis显示文摘AIM:To evaluate the association of human leukocyte antigen(HLA)-DQB1 alleles with hepatocellular carcinoma(HCC) through meta-analysis of published data.METHODS:Case-control studies on HLA-DQB1 allele association with HCC published up to January 2010 were included in the analyses.The odds ratios(ORs) of HLADQB1 allele distributions in HCC patients were analyzed and compared with healthy controls.The meta-analysis software REVMAN 5.0 was applied for investigating heterogeneity among individual studies and for summarizing all the studies.A meta-analysis was performed using fixed-effect or random-effect methods,depending on the absence or presence of significant heterogeneity.Seven case-control studies containing 398 cases and 594 controls were included in the final analysis.RESULTS:Among the five family alleles,two(DQB1*02 and DQB1*03) were found to be significantly associated with the risk of HCC.The combined OR for the association of DQB1*02 and DQB1*03 allele with the risk for HCC was 1.78(95% CI:1.05-3.03,P = 0.03) and 0.65(95% CI:0.48-0.89,P = 0.007),respectively.Among the 13 specific alleles,two(DQB1*0502 and DQB1*0602) were significantly associated with risk of HCC.The combined OR for the association of DQB1*0502 and DQB1*0602 allele with the risk for HCC was 1.82(95% CI:1.14-2.92,P = 0.01) and 0.58(95% CI:0.36-0.95,P = 0.03),respectively.No significant association was established for other HLA-DQB1 family alleles and specific alleles.CONCLUSION:Our results support the hypothesis that specific HLA-DQB1 allele families and alleles might influence the susceptibility or resistance to HCC,although it needs further investigations. | Yong-Ning Xin Zhong-Hua Lin Xiang-Jun Jiang Shu-Hui Zhan Quan-Jiang Dong Qing Wang Shi-Ying Xuan | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 6 | Lung-protective Ventilation in Patients with Brain Injury: A Multicenter Cross-sectional Study and Questionnaire Survey in China显示文摘 | Xu-Ying Luo Ying-Hong Hu Xiang-Yuan Cao Yan Kang Li-Ping Liu Shou-Hong Wang Rong-Guo Yu Xiang-You Yu Xia Zhang Bao-Shan Li Zeng-Xiang Ma Yi-Bing Weng Heng Zhang De-Chang Chen Wei Chen Wen-Jin Chen Xiu-Mei Chen Bin Du Mei-Li Duan Jin Hu Yun-Feng Hoang Gui-Jun Jia Li-Hong Li Yu-Min Liang Bing-Yu Qin Xian-Dong Wang Jian Xiong Li-Mei Yan Zheng-Ping Yang Chen-Ming Dong Dong-Xin Wang Qing-Yuan Zhan Shuang-Lin FU Lin Zhao Qi-Bing Huang Ying-Guang Xie Xiao-Bo Huang Guo-Bin Zhang Wang-Bin Xu Yuan Xu YaLing Liu He-Ling Zhao Rong-Qing Sun Ming Sun Qing-Hong Cheng Xin Qu Xiao-Feng Yang Ming Xu Zhong-Hua Shi Han Chen Xuan He Yan-Lin Yang Guang-Qiang Chen Xiu-Mei Sun Jian-Xin Zhou | 2016 | Chinese Medical Journal2016，，14： | 6 |
| 7 | Ordovician integrative stratigraphy and timescale of China显示文摘In this chapter, starting with a brief review of the research history and current status in the studies of the Ordovician chronostratigraphy in China, the subdivision of the Ordovician System, definition and recognition of its series and stage boundaries, and possible stratigraphic gaps are discussed in details in order to establish a multidisciplinary stratigraphic correlation through an integrated approach including lithostratigraphy, biostratigraphy, radiometric dating, chemostratigraphy and magnetostratigraphy. Being internationally accepted, the Ordovician System is now subdivided into three series and seven stages, in ascending order, Lower(Tremadocian, Floian), Middle(Dapingian, Darriwilian) and Upper series(Sandbian, Katian,Hirnantian). Three of the seven 'Golden Spikes' defining the bases of the Ordovician stages, which were established in 1997–2007, are located in China. As a regionally applied chronostratigraphy, the Ordovician System was subdivided in China into Lower(Xinchangian, Yiyangian), Middle(Dapingian, Darriwilian) and Upper series(Neichiashanian, Chientangkiangian,Hirnantian). This scheme agrees largely with the standard international classification, which can actually be directly applied to China, except for some special circumstances where the Neichiashanian and Chientangkiangian stages of the Upper Ordovician are used. Based on the new studies in recent years and distinctions and differences recognized in the development of the Ordovician System in the constituent terranes of China, a new framework for correlation among the major Chinese palaeoplates or terranes, e.g. South China, North China(including Tarim and Qaidam) and Xizang(Tibet)-western Yunnan, has been established. However, it has been recognized herein that uncertainties still remain on defining the base of the Tremadocian,Dapingian and Katian, and on the correlation between different mega-facies. More specifically, for the Tremadocian, the precise correlation of its base will depend on the better-defined conodont taxonomy, while for the Dapingian and Katian, on the correlation between different mega-facies. It is worthwhile to note that the chemostratigraphic studies of the Ordovician System in China produced the carbonate δ13 C curves for the Darriwilian(Middle Ordovician) and Katian(Upper Ordovician), which show significant differences from the composite global curve. Record of the Ordovician isotopic dating is relatively rare in China, with only three reliable ages from zircons that are all from the upper Katian to Hirnantian of the Upper Ordovician.Abundant bentonite beds in the Upper Ordovician of South China will also provide unique opportunities to advance the isotopic dating and related researches. Studies on the Ordovician magnetostratigraphy need to be significantly enhanced in China, as currently all the available results are restricted to the Lower Ordovician of North China, although they can be correlated with those known from other parts of the world. The analysis of the durational unevenness of the seven stages in the Ordovician supports the possibility to further subdivide the long-durational Tremadocian, Darriwilian and Katian stages, each into two substages. | Yuandong ZHANG Renbin ZHAN Yongyi ZHEN Zhihao WANG Wenwei YUAN Xiang FANG Xuan MA Junpeng ZHANG | 2019 | Science China Earth Sciences2019，62，1： | 6 |
| 8 | Research and application of mineral resources assessment by weights of evidence model based on SIG显示文摘Geological data are usually of the characteristics of multi-source, large amount and multi-scale. The construction of Spatial Information Grid overcomes the shortages of personal computers when dealing with geological data. The authors introduce the definition, architecture and flow of mineral resources assessment by weights of evidence model based on Spatial Information Grid (SIG). Meanwhile, a case study on the prediction of copper mineral occurrence in the Middle-Lower Yangtze metallogenic belt is given. The results show that mineral resources assessement based on SIG is an effective new method which provides a way of sharing and integrating distributed geospatial information and improves the efficiency greatly. | Yuanyuan Chuai Keyan Xiao Yihua Xuan Shaobin Zhan | 2006 | Global Geology2006，9，1： | 3 |
| 9 | Relatedness of Helicobacter pylori populations to gastric carcinogenesis显示文摘Helicobacter pylori(H.pylori) is a Gram-negative bacterium that infects half of the human population.The infection is associated with chronic inflammation of the gastric mucosa and peptic ulcers.It is also a major risk factor for gastric cancer.Phylogenetic analysis of global strains reveals there are seven populations of H.pylori,including hpAfrica1,hpAfrica2,hpEastAsia,hpEurope,hpNEAfrica,hpAsia2 and hpSahul.These populations are consistent with their geographical origins,and possibly result from geographical separation of the bacterium leading to reduced bacterial recombination in some populations.For each population,H.pylori has evolved to possess genomic contents distinguishable from others.The hpEurope population is distinct in that it has the largest genome of 1.65 mbp on average,and the highest number of coding sequences.This confers its competitive advantage over other populations but at the cost of a lower infection rate.The large genomic size could be a cause of the frequent occurrence of the deletion of the cag pathogenicity island in H.pylori strains from hpEurope.The incidence of gastric cancer varies among different geographical regions.This can be attributed in part to different rates of infection of H.pylori.Recent studies found that different populations of H.pylori vary in their carcinogenic potential and contribute to the variation in incidence of gastric cancer among geographical regions.This could be related to the ancestral origin of H.pylori.Further studies are indicated to investigate the bacterial factors contributing to differential virulence and their influence on the clinical features in infected individuals. | Quan-Jiang Dong Shu-Hui Zhan Li-Li Wang Yong-Ning Xin Man Jiang Shi-Ying Xuan | 2012 | World Journal of Gastroenterology2012，18，45： | 3 |
| 10 | The machine protection system for CSNS显示文摘Background The China Spallation Neutron Source(CSNS)accelerator consists of an 80 MeV H-LINAC,a 1.6 GeV rapid cycling synchrotron(RCS)and two beam transport lines.The uncontrolled beam may permanently damage the components or lead to very high residual radiation dose along the beam line.So the equipment protection must be deliberately designed and implemented.Purpose The machine protection system(MPS)protects components from being damaged by the beam.The response time requirement for the CSNS MPS is less than 20 ms,so the PLC(programmable logic controller)was adopted to implement the interlock logic.Methods The MPS was implemented as a two-tier architecture system,and developed through utilizing PLC and Experimental Physics and Industrial Control System(EPICS)software toolkits.The application logic was taken into careful consideration during the implementation stage.An embedded CPU module can function as an IOC accessing PLC I/O modules through the sequence CPU,with an embedded Linux operation system.Results The interlock logic and heartbeat functions were tested with all functions ok.Time consumption has been measured thoroughly since the important requirement,which is around 15 ms to stop the beam.Conclusions MPS was completed in Sep.2017 and then put into operation.It has been operating smoothly for more than 3 years.MPS has played an important role in every stage of CSNS’s commissioning and operation and achieved high reliability during the user’s experiment operation.The accelerator recently runs stably with low equipment failure. | Kang Mingtao Zhang Yuliang Jin Dapeng He Yongcheng Zhan Mingchuan Zhu Peng Wu Xuan Guo Fengqin Wang Lin | 2021 | Radiation Detection Technology and Methods2021，5，2： | 1 |
| 11 | Mechanism of lead adsorption from aqueous solutions using an adsorbent synthesized from natural condensed tannin 显示文摘 | Xin - Min Zhan Xuan Zhao | 2003 | Water Research2003，37，： | 1 |
| 12 | K-Domain Splicing Factor OsMADS1 Regulates Open Hull Male Sterility in Rice显示文摘We identified the rice floral organ development mutant, termed as open hull and male sterile 1(ohms1), from the progeny of the indica restorer line Zhonghui 8015 treated with 60 Co γ-ray irradiation. The ohms1 mutant exhibited an open hull and lemma- and palea-like structure conversion between the anthers and stigma, which resulted in the ohms1 mutant spikelet showing ‘tridentate lemma'. The ohms1 mutant was entirely sterile but had 60%–70% fertile pollen. Genetic analysis and gene mapping showed that ohms1 was controlled by a single recessive gene, and the mutant gene was fine-mapped to a 42-kb interval on the short arm of chromosome 3 between markers KY2 and KY29. Sequence analysis of the four open reading frames in this region revealed that the mutant carried a single nucleotide transformation(A to G) at the last base of the fifth intron, which was likely corresponded to ohms1 phynotype, in an MIKC type MADS-box gene OsMADS1(LOC_Os03g11614). Enzyme digestion and c DNA sequencing further indicated that the variable splicing was responsible for the deletion of the sixth exon in ohms1, but no structural changes in the MADS domain or amino acid frame shifts appeared. Additionally, real-time fluorescent quantitative PCR analysis showed that the OsMADS1 expression level decreased significantly in the ohms1 mutant. The expression levels of rice flowering factors and floral glume development-related genes also changed significantly. These results demonstrate that OsMADS1 may play an important role in rice floral organ development, particularly in floral glume development and floret primordium differentiation. | SUN Lian-ping ZHANG Ying-xin ZHANG Pei-pei YANG Zheng-fu ZHAN Xiao-deng SHEN Xi-hong ZHANG Zhen-hua HU Xia XUAN Dan-dan WU Wei-xun LI Zi-he CAO Li-yong CHENG Shi-hua | 2015 | Rice science2015，22，5： | 1 |
| 13 | Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils显示文摘Inhibitory immune receptors set thresholds for immune cell activation,and their deficiency predisposes a person to autoimmune responses.However,the agonists of inhibitory immune receptors remain largely unknown,representing untapped sources of treatments for autoimmune diseases.Here,we show that V-set and transmembrane domain-containing 1(VSTM1)is an inhibitory receptor and that its binding by the competent ligand soluble galectin-1(Gal1)is essential for maintaining neutrophil viability mediated by downregulated reactive oxygen species production.However,in patients with systemic lupus erythematosus(SLE),circulating Gal1 is oxidized and cannot be recognized by VSTM1,leading to increased intracellular reactive oxygen species levels and reduced neutrophil viability.Dysregulated neutrophil function or death contributes significantly to the pathogenesis of SLE by providing danger molecules and autoantigens that drive the production of inflammatory cytokines and the activation of autoreactive lymphocytes.Interestingly,serum levels of glutathione,an antioxidant able to convert oxidized Gal1 to its reduced form,were negatively correlated with SLE disease activity.Taken together,our findings reveal failed inhibitory Gal1/VSTM1 pathway activation in patients with SLE and provide important insights for the development of effective targeted therapies. | Xu Jiang Xinyue Xiao Hao Li Yiyi Gong Min Wang Huaxia Yang Lidan Zhao Ying Jiang Yanping Wei Chongchong Zhao Jin Li Yuling Chen Shan Feng Haiteng Deng Shiliang Ma Yue Xu Yudong Liu George C.Tsokos Minghong Jiang Xuan Zhan | 2023 | Cellular & Molecular Immunology2023，20，11： | 1 |
| 14 | Preparation of Low Cost Activated Carbon from Deactivated Resin Catalyst for Methyl Tert-Butyl Ether Synthesis and Its Application in Dimethyl Sulfide Adsorption with Transition Metal Impregnation显示文摘In this paper, a low-cost activated carbon(AC) was prepared from deactivated resin catalyst(DRC) for methyl tert-butyl ether(MTBE) synthesis through carbonization and subsequent steam activation treatment. The activated carbon was characterized in detail. After loading various transition metals, including Cu^(2+), Ag+, Co^(2+), Ni^(2+), Zn^(2+), and Fe^(3+) via the ultrasonic-assisted impregnation method, a series of metal-loaded adsorbents(xM-AC) were obtained and their dimethyl sulfide(DMS) adsorption performance was investigated in a batch system. Among these adsorbents, 15Cu-AC presented a superior DMS adsorption capacity equating to 58.986 mg/g due to the formation of S-M(σ) bonds between Cu^(2+) and sulfur atoms of DMS as confirmed by the Raman spectra and kinetic study. | Yu Zhan Shi Li Meng Xuan | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，2： | 1 |
| 15 | Astudy on flooding scenario simulation of future extreme precipitation in Shanghai显示文摘In the context of climate warming and urbanization,predictions and inundation simulations for future extreme precipitation have become highly active research topics.In this paper,using daily precipitation recorded at 10 meteorological stations in Shanghai for the period 1961-2010,the daily precipitation of each station during the period 2011-2099was simulated by the statistical downscaling model (SDSM).And we examined the varying tendencies of future precipitation by the Mann- Kendall test.Further,the Soil Conservation Service (SCS) model and Pearson-III distribution curve were used to simulate the waterlogging duration and depth of future extreme precipitation in different scenarios with 3-,5-,10-, 20-,50-,and 100-year return periods.The results show that:1)Precipitation in Shanghai before the 2050s shows a trend of increasing and decreasing alternations,followed by a trend of decreasing and a marked decrease in about the 2070s.2)In the 21st century,the waterlogging duration with retum periods of 3,5,and 10years in Shanghai is predicted to last for less than 30 minutes,while the return periods of 20,50,and 100years last for less than 45 minutes.From the spatial distribution,the waterlogging duration to the east and south of the Huangpu River is predicted to be shorter than that of the west and north. 3)With the increase of the return periods,the depth of waterlogging is predicted to increase.The deepest inundated areas are Jinshan to the south-west of Shanghai, the east side of the Huangpu River,and Chongming Island. | Xiaoting WANG Zhan'e YIN Xuan WANG Pengfei TIAN Yonghua HUANG | 2018 | Frontiers of Earth Science2018，12，4： | 1 |
| 16 | Editorial for special issue on advanced energy storage and materials for the 70th Anniversary of USTB显示文摘1. Foreword Energy storage plays a key role in the transition towards a carbon-neutral economy. By balancing power grids and saving surplus energy, it represents a concrete means of improving energy efficiency and integrating more renewable energy sources into electricity systems. A variety of technologies to store energy are developing at a fast pace and increasingly becomingmoremarketcompetitive,includingtraditional electric energy storage, thermal energy storage, and newly developed hydrogen energy storage, etc. The demand for energy storage system with high power and efficiency boosts the development in the advanced techniques and materials,such as batteries, super-capacitors, molten salts, and catalysts for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). | Xindong Wang Ranbo Yu Chun Zhan Wei Wang Xuan Liu | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，5： | 1 |
| 17 | 查看详情显示文摘 | Zhao G Z Tang J Zhan Y Chen X B Zhuo X J Wang J J Xuan E Deng Q H Zhao J M | | 0，，： | 1 |
| 18 | 查看详情显示文摘 | Tang J Zhan Y Zhao G Z Deng Q H Wang J J Chen X B Zhao 1.M Xuan F | | 0，，： | 1 |
| 19 | Spatio-temporal analysis of human wellbeing and its coupling relationship with ecosystem services in Shandong province, China显示文摘Rapid economic and social change promotes to improve human wellbeing(HW),but poses threats to ecosystems and the environment.Studying the coupling relationship between HW and ecosystem services(ES)is crucial for informing high-quality development.Firstly,we built a comprehensive index system for HW assessment,and evaluated HW for 17 prefecture-level cities in Shandong province,China,from 2000 to 2018.Then,we quantified ES based on land use data.Finally,we assessed the coupling coordination degree and analyzed the relationships between HW and each type of ES value.The results were as follows:(1)HW values increased overall in Shandong,with the highest value in Jinan(0.8034)and the lowest value in Heze(0.4965)in 2018.(2)The total ES values for the 17 cities increased slightly.The ranking of 17 cities according to the ES value per unit area was different from the ranking according to the total ES value.(3)All 17 cities in Shandong were in the coordinated development phase after 2015,with increasing coupling coordination degrees.There were clear positive relationships between HW and ES.General and specific policy recommendations were proposed,providing scientific evidence and a reference for Shandong’s urban management and policy formulation. | WANG Chao WANG Xuan WANG Yifan ZHAN Jinyan CHU Xi TENG Yanmin LIU Wei WANG Huihui | 2023 | Journal of Geographical Sciences2023，33，2： | 1 |
| 20 | Pregnancy Loss in Relation to the Risks of Female-Specific Cancers in a Population-Based Cohort and Mendelian Randomization Study — China, 2004–2017显示文摘Summary What is already known about this topic?Limited evidence exists regarding the relationship between pregnancy loss and female-specific cancers within the Chinese population from prospective cohort studies.What is added by this report?Terminations were associated with a 13%lower risk of endometrial cancer,whereas stillbirths were related to an 18%higher risk of cervical cancer.Rural residents with a history of pregnancy loss experienced a 19%and 38%increased risk of breast and cervical cancers,respectively,compared to their urban counterparts.Moreover,a positive graded relationship between live births and pregnancy loss on cervical cancer was observed.What are the implications for public health practice?This study has significant implications for identifying women at an increased risk for breast and genital cancers and contributes to the development of effective public health strategies for female cancer prevention.Future research on reproductive history,particularly in rural areas,should be given priority in efforts to improve female cancer screening and early detection. | Yongle Zhan Yawen Wang Yimin Qu Lin Zhang Xuan Liu Ruiyi Liu Peng Xue Jiaxu Wang Dongxu Qin Hexin Yue Canqing Yu Jun Lyu Yu Guo Zhengming Chen Yu Jiang Liming Li China Kadoorie Biobank Collaborative Group | 2023 | China CDC weekly2023，5，19： | 0 |
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