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| 1 | Hydrogeochemical and Isotopic Evidence for Flow Paths of Karst Waters Collected in the Heshang Cave,Central China显示文摘Understanding of hydrological processes in caves is important to help us interpret paleoclimate records from speleothems. In this study,we integrated hydrogeological and hydrogeochemical properties to characterize the hydraulic behavior of karst waters in the Heshang Cave,Central China. Using geological and topographical analyses,we identified regional watershed boundaries and hydrogeological connections that were controlled by anticlinal geometry and faults. Water samples were collected from the Heshang Cave and potential recharge sites. Geochemical data of c(Sr2+)/c(Ca2+) and c(Mg2+)/c(Ca2+) ratios suggest that the drainage system in Heshang Cave consists of two flow paths. For vadose waters,including drip water and rimstone pool water,c(Sr2+)/c(Ca2+) ratio ranges from 0.000 6 to 0.001 1,and c(Mg2+)/c(Ca2+) ratio ranges from 0.97 to 1.1,indicating that recharge was mainly from rainfall infiltration through the overlying Cambrian dolomite stratum. In contrast,slope current and underground river waters have higher c(Sr2+)/c(Ca2+) ratios(values from 0.002 2 to 0.002 8),and lower c(Mg2+)/c(Ca2+) ratios(values from 0.50 to 0.64). These waters show homogeneous isotopic composition(δ18O:-7.15‰–-6.95‰; δD:-52.73‰–-51.31‰),implying recharge of allogeneic water from the Xiaoer River via karst conduits that pass through Ordovician limestone and Cambrian dolomite stratum. | Xiang Long Ziyong Sun Aiguo Zhou Deliang Liu | 2015 | Journal of Earth Science2015，26，1： | 18 |
| 2 | Using Landsat data to determine land use changes in Datong basin, China 显示文摘 | Ziyong Sun Rui Ma Yanxin Wang | 2009 | Environ Geol2009，57，： | 1 |
| 3 | The effects of wheat bran composition on the production of biomass-hydrolyzing enzymes by Penicillium decumbens显示文摘 | Sun Xianyun Liu Ziyong Qu Yinbo | 2008 | Applied Biochemistry & Biotechnology2008，146，3： | 1 |
| 4 | Springs Emerging along the Elevation Gradient Indicate Intensive Groundwater-Surface Water Exchange in an Alpine Headwater Catchment, Northwestern China显示文摘Groundwater plays an important role in sustaining the streamflow in cold alpine area, but is poorly understood due to a lack of direct access. About 98 groups of springs are observed at the upper reaches of Heihe River Basin, which provide an opportunity to explore the main aquifers. Springs are clustered in three groups according to locations:(1) springs on the moraine and talus deposits;(2) springs at the end of alluvial plain in lower topography;(3) springs along the river bank. The hydrometric, geochemical and isotopic data of springs in a representative catchment were integrated and used to elucidate the groundwater flow paths. Results indicate the Quaternary porous aquifers in the alpine catchment have a profound influence on the regional groundwater flow paths and the groundwater and surface water(GW-SW) interactions. The aquifer consisting of alluvial-pluvial deposits has a great capacity of groundwater storage and plays a vital role in regulating discharge by attenuating the seasonal variation and maintaining the main stream in cold seasons. This is different from the fast recharge and discharge mode of the moraine and talus deposits. Our work highlights the importance of loose deposits in controlling the GW-SW interactions in the cold alpine area. | Yalu Hu Ziyong Sun Rui Ma | 2023 | Journal of Earth Science2023，34，1： | 1 |
| 5 | Antimicrobial resistance among clinical isolates from the Chinese Meropenem Surveillance Study (CMSS), 2003–2008显示文摘 | Hui Wang Minjun Chen Yuxing Ni Yudong Liu Hongli Sun Yunsong Yu Xiujuan Yu Yaning Mei Min Liu Ziyong Sun Yunzhuo Chu Zhidong Hu Xinhong Huang | 2009 | International Journal of Antimicrobial Agents2009，，： | 1 |
| 6 | The Effects of Wheat Bran Composition on the Production of Biomass- Hydrolyzing Enzymes by Penicillium Decumbens显示文摘 | Xianyun Sun Ziyong Liu Yinbo Qu etc | 2008 | Biochem Biotechnol2008，146，： | 1 |
| 7 | Systematic evaluation of IgG responses to SARS-CoV-2 spike protein-derived peptides for monitoring COVID-19 patients显示文摘Serological tests play an essential role in monitoring and combating the COVID-19 pandemic.Recombinant spike protein(S protein),especially the S1 protein,is one of the major reagents used for serological tests.However,the high cost of S protein production and possible cross-reactivity with other human coronaviruses pose unavoidable challenges.By taking advantage of a peptide microarray with full spike protein coverage,we analyzed 2,434 sera from 858 COVID-19 patients,63 asymptomatic patients and 610 controls collected from multiple clinical centers.Based on the results,we identified several S protein-derived 12-mer peptides that have high diagnostic performance.In particular,for monitoring the IgG response,one peptide(aa 1148-1159 or S2-78)exhibited a sensitivity(95.5%,95%CI 93.7-96.9%)and specificity(96.7%,95%CI 94.8-98.0%)comparable to those of the S1 protein for the detection of both symptomatic and asymptomatic COVID-19 cases.Furthermore,the diagnostic performance of the S2-78(aa 1148-1159)IgG was successfully validated by ELISA in an independent sample cohort.A panel of four peptides,S1-93(aa 553-564),S1-97(aa 577-588),S1-101(aa 601-612)and S1-105(aa 625-636),that likely will avoid potential cross-reactivity with sera from patients infected by other coronaviruses was constructed.The peptides identified in this study may be applied independently or in combination with the S1 protein for accurate,affordable,and accessible COVID-19 diagnosis. | Yang Li Dan-yun La Qing Lei Zhao-wei Xu Feng Wang Hongyan Hou Lingyun Chen Jiaoxiang Wu Yan Ren Ming-liang Ma Bo Zhang Hong Chen Caizheng Yu Jun-biao Xue Yun-xiao Zheng Xue-ning Wang He-wei Jiang Hai-nan Zhang Huan Qi Shu-juan Guo Yandi Zhang Xiaosong Lin Zongjie Yao Pengfei Pang Dawei Shi Wei Wang Xiao Yang Jie Zhou Huiming Sheng Ziyong Sun Hong Shan Xionglin Fan Sheng-ce Tao | 2021 | Cellular & Molecular Immunology2021，18，3： | 0 |
| 8 | Assessing the Connectivity of a Regional Fractured Aquifer Based on a Hydraulic Conductivity Field Reversed by Multi-Well Pumping Tests and Numerical Groundwater Flow Modeling显示文摘Aquifer connectivity could greatly affect groundwater flow and further control the contaminant transport in fractured medium.However,assessing connectivity of fractured aquifer at regional scales is still a challenge because such connectivity is difficult to be measured directly.This study proposes a framework for assessing connectivity of a fractured aquifer,with Qitaihe area,Heilongjiang Province,northeastern China as an illustrating study area.The 3-D finite difference numerical models were established to interpret the results of three multi-well pumping tests and inversely estimate the distribution of hydraulic conductivity(K)in the fractured aquifer.A static connectivity metric of the minimum hydraulic resistance(MHR)was calculated,based on the optimized K-field,to evaluate the hydraulic connectivity in the aquifer,and the corresponding least resistance paths(LRPs)were identified.The results indicate a better horizontal connectivity in the fractured aquifer in the northeastern and middle parts than in the southwestern part of the study area.The identified LRP indicated that the preferential flow channels at regional scales were controlled mainly by aquifer connectivity instead of local high-K zones.The results of this study can provide a method for aquifer connectivity estimation at regional scales. | Jingjing Lin Rui Ma Ziyong Sun Liansong Tang | 2023 | Journal of Earth Science2023，34，6： | 0 |
| 9 | Systemically comparing host immunity between survived and deceased COVID-19 patients显示文摘Novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused the disastrous pandemic of Coronavirus Disease-2019(COVID-19).1,2,3 Although the epidemiological,clinical,and immunological characteristics of COVID-19 have been reported,4,5,6 the kinetics of immune responses and their association with clinical outcomes remain poorly understood.Here,we summarize the characteristics of cellular immune responses in a total of 157 COVID-19 patients enrolled in Tongji Hospital between February and March 2020 and compare the properties between 95 survived and 62 deceased patients with different onset time.The demographic and clinical characteristics of these patients are shown in Supplementary Table 1.No significant difference in age,gender,clinical symptoms,and imaging features was recorded between survived and deceased patients. | Feng Wang Hongyan Hou Yin Yao Shiji Wu Min Huang Xiao Ran Hongmin Zhou Zheng Liu Ziyong Sun | 2020 | Cellular & Molecular Immunology2020，17，8： | 0 |
| 10 | COVID-ONE-hi:The One-stop Database for COVID-19-specific Humoral Immunity and Clinical Parameters显示文摘Coronavirus disease 2019(COVID-19),which is caused by SARS-CoV-2,varies with regard to symptoms and mortality rates among populations.Humoral immunity plays critical roles in SARS-CoV-2 infection and recovery from COVID-19.However,differences in immune responses and clinical features among COVID-19 patients remain largely unknown.Here,we report a database for COVID-19-specific IgG/IgM immune responses and clinical parameters(named COVID-ONE-hi).COVID-ONE-hi is based on the data that contain the IgG/IgM responses to 24 full-length/truncated proteins corresponding to 20 of 28 known SARS-CoV-2 proteins and 199 spike protein peptides against 2360 serum samples collected from 783 COVID-19 patients.In addition,96 clinical parameters for the 2360 serum samples and basic information for the 783 patients are integrated into the database.Furthermore,COVID-ONE-hi provides a dashboard for defining samples and a one-click analysis pipeline for a single group or paired groups.A set of samples of interest is easily defined by adjusting the scale bars of a variety of parameters.After the“START”button is clicked,one can readily obtain a comprehensive analysis report for further interpretation.COVID-ONE-hi is freely available at www.COVID-ONE.cn. | Zhaowei Xu Yang Li Qing Lei Likun Huang Dan-yun Lai Shu-juan Guo He-wei Jiang Hongyan Hou Yun-xiao Zheng Xue-ning Wang Jiaoxiang Wu Ming-liang Ma Bo Zhang Hong Chen Caizheng Yu Jun-biao Xue Hai-nan Zhang Huan Qi Siqi Yu Mingxi Lin Yandi Zhang Xiaosong Lin Zongjie Yao Huiming Sheng Ziyong Sun Feng Wang Xionglin Fan Sheng-ce Tao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 0 |
| 11 | Granular Carbides-Assisted Ultrafine-Ferrite Fabrication in the Pearlitic Steel Without Severe Plastic Deformation and Annealing显示文摘The evolution of ferrite grain and cementite lamella during cold rolling in a granular carbide–pearlite steel has been investigated.Particular attention has been given to a quantitative characterization of changes in the ferrite grains.Electron backscattered diff raction and transmission electron microscopy observations show that the ultrafi ne ferrite(~388 nm)can be produced through low equivalent strain cold rolling without severe plastic deformation(SPD)and annealing.The average grain size of ferrite depends on the volume fraction,shape and distribution of granular carbides as well as interlamellar spacing of pearlite.A general explanation of granular carbides-assisted grain refi nement is that the embedded carbides between natural barrier will signifi cantly facilitate dislocation nucleation during cold rolling.Dislocation reaction occurs more drastically and quickly near these granular carbides.Such reactions promote the formation of high-angle grain boundaries.The formation of ultrafi ne ferrite grains and subgrains in steel after cold rolling toε=1.4 strain makes the strength and ductility increased simultaneously compared withε=0.6 cold-rolled steel.The results suggest a new material design strategy to obtain ultrafi ne-grained structure via the granular carbides assistance. | Han Zheng Liming Fu Xinbo Ji Ziyong Li Yanle Sun Sixin Zhao Wei Wang Aidang Shan | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，12： | 0 |
| 12 | Spatial and Temporal Dynamics of Lakes in Nam Co Basin, 1991–2011显示文摘Lakes in Tibet Plateau with little effects of human activities serve as important indicators of climate change. This study analysed remote sensing data and long term climate variables to examine the hydrological response of lakes in Nam Co Basin. The area changes of lakes were extracted by Landsat TM/ETM+ and analysed by SRTM 3 DEM. And the ICESat elevation data between 2003 and 2009 were used to observe the lake level of the Nam Co Lake. The results show that the number of new formed glacier lakes increased by 36% and the area of glacier lakes increased by 36.7%(0.97 km^2) from 1991 to 2011. At the same time, the surface area of the Nam Co Lake expanded by 3.71%(72.64 km^2) of the original size in 1991, with a tendency value of 3.63 km^2 per year. The lake level of the Nam Co Lake shows an increase tendency of 0.24 m per year during 2003–2009. These variations appear to be related to an increase in mean annual temperature of 0.06 oC per year, and an increase in annual precipitation of 2.1 mm per year in summer in the last two decades. The increased number of lakes and increased area of glacial lakes reached a peak at an altitude of 5 500–5 600 m a.s.l.. The number of new formed glacier lakes and the area of glacier lakes tend to higher altitudes. Climate change has an important impact on the variation of the glacier lakes and the Nam Co Lake. | Xu Wang Aiguo Zhou Ziyong Sun | 2016 | Journal of Earth Science2016，27，1： | 0 |
| 13 | SARS-CoV-2-specific antibody response characteristics in COVID-19 patients of different ages显示文摘Age has been found to be one of the main risk factors for the severity and outcome of COVID-19.However,differences in SARS-CoV-2 specific antibody responses among COVID-19 patients of different age groups remain largely unknown.In this study,we analyzed the IgG/IgM responses to 21 SARS-CoV-2 proteins and 197 peptides that fully cover the spike protein against 731 sera collected from 731 COVID-19 patients aged from 1 to 92 years.We show that there is no overall difference in SARS-CoV-2 antibody responses in COVID-19 patients in the 4 age groups.By antibody response landscape maps,we find that the IgG response profiles of SARS-CoV-2 proteins are positively correlated with age.The S protein linear epitope map shows that the immunogenicity of the S-protein peptides is related to peptide sequence,disease severity and age of the COVID-19 patients.Furthermore,the enrichment analysis indicates that low S1 IgG responses are enriched in patients aged<50 and high S1 IgG responses are enriched in mild COVID-19 patients aged>60.In addition,high responses of non-structural/accessory proteins are enriched in severe COVID-19 patients aged>70.These results suggest the distinct immune response of IgG/IgM to each SARS-CoV-2 protein in patients of different age,which may facilitate a deeper understanding of the immune responses in COVID-19 patients. | Linfang Lu Siqi Yu Min Liu Yang Li Qing Lei Mingxi Lin Danyun Lai Shujuan Guo Hewei Jiang Hongyan Hou Yunxiao Zheng Xuening Wang Mingliang Ma Bo Zhang Hong Chen Junbiao Xue Hainan Zhang Huan Qi Ziyong Sun Feng Wang Xionglin Fan Zhaowei Xu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，4： | 0 |
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