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| 1 | Fluvial terraces and their implications for Weihe River valley evolution in the Sanyangchuan Basin显示文摘Fluvial terraces are important geomorphic markers for modern valley development.When coupled with numeric ages,terraces can provide abundant information about tectonic,climatic,paleohydrological and the paleoenvironmental changes.On the basis of the paleomagnetic,electron spin resonance(ESR) and optically stimulated luminescence(OSL) dating,in addition to an investigation of local loess-paleosol sequences,we confirmed that 13 fluvial terraces were formed,and then preserved,along the course of the Upper Weihe River in the Sanyangchuan Basin over the past 1.2 Ma.Analyses of the characteristics and genesis of these terraces indicate that they resulted from the response of this particular river system to climate change over an orbital scale.These changes can further be placed within the context of local and regional tectonic uplift,and represent an alternation between lateral migration and vertical incision,dependent upon the predominance of climatic and tectonic controls during different periods.Most of the terraces are strikingly similar in that they have several meters of paleosols which have developed directly on top of fluvial deposits located on the terrace treads,suggesting that the abandonment of terraces due to river incision occurred during the transitions from glacial to interglacial climates.The temporal and spatial differences in the distribution patterns of terraces located on either side of the river valley indicate that a tectonic inversion occurred in Sanyangchuan Basin at-0.62 Ma,and that this was characterized by a transition from overall uplift to depression induced by fault activity.Synthesized studies of the Basin's terraces indicate that formation of the modern valley of the Upper Weihe River may have begun in the late Early Pleistocene between1.4-1.2 Ma. | GAO HongShan LI ZongMeng LIU XiaoFeng PAN BaoTian WU YaJie LIU FenLiang | 2017 | Science China Earth Sciences2017，60，3： | 9 |
| 2 | Quantitative analysis of planation surfaces of the upper Yangtze River in the Sichuan-Yunnan Region, Southwest China显示文摘Identification of the planation surfaces (PSs)is key for utilizing them as a reference in studying the long- term geomorphological evolution of the Upper Yangtze River Basin in the Sichuan-Yurman region,Southwest China.Using a combined method of DEM-based fuzzy logic and topographic and fiver profiles analysis and based on a comprehensive analysis of four morphometfic parameters:slope,curvature,terrain raggedness index, and relative height,we established the relevant fuzzy membership functions,and then calculated the membership degree (MD)of the study area.Results show that patches with a MD>80% and an area>0.4 km^2 correspond well to the results of Google Earth and field investigation,representing the PS remnants.They consist of 1764 patches with an altitude,area,mean slope,and relief of mostly 2000-2500 m above sea level (asl),0-10 km^2,4°-9°,0-500 m,respectively,covering 9.2% of the study area's landscape,dipping to southeast,decreasing progressively from northwest to southeast in altitude,and with no clear relation between each patch's altitude and slope,or relief.All these results indicate that they are remnants of once regionally continuous PSs which were deformed by both the lower crust flow and the faults in upper crust,and dissected by the network of Upper Yangtze River.Additionally,topographic and river profiles analysis show that three PSs (PS1-PS3)well developed along the main valleys in the Yongren-Huili region, indicating several phases of uplift then planation during the Late Cenozoic era.Based on the incision amount deduced from projection of relict river profiles on PSs, together with erosion rates,breakup times of the PS 1,PS2,and PS3 were estimated to be 3.47 Ma,2.19 Ma,and 1.45 Ma,respectively,indicating appearance of modem Upper Yangtze River valley started between the Pliocene to early Pleistocene. | Fenliang LIU Hongshan GAO Baotian PAN Zongmeng LI Huai SU | 2019 | Frontiers of Earth Science2019，13，1： | 7 |
| 3 | Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARγ pathway显示文摘 | Cheng Huang Yuebo Zhang Zhenwei Gong Xiaoyan Sheng Zongmeng Li Wei Zhang Ying Qin | 2006 | Biochemical and Biophysical Research Communications2006，，2： | 1 |
| 4 | The cure behavior of tetraglycidyl diaminodiphenyl methane with diaminodiphenyl sulfone显示文摘 | Gao Jiawu Shen Kui Gao Zongmeng | 2000 | Thermochimica Acta2000，，： | 1 |
| 5 | Dorsomorphin induces cancer cell apoptosis and sensitizes cancer cells to HSP90 and proteasome inhibitors by reducing nuclear heat shock factor 1 levels显示文摘Objective: Heat shock factor 1(HSF1), a transcriptional regulator of heat shock proteins(HSPs), is an attractive therapeutic target for cancer. However, only a few HSF1 inhibitors have been identified so far.Methods: The mRNA and protein levels of HSF1, HSPs, cleaved PARP, and phosphorylated HSF1 were examined by real-time PCR and Western blot. Forced expression, RNA interference, and immunofluorescence assay were used for mechanistic studies.Cell viability and apoptosis were measured by WST-8 assay and flow cytometry, respectively. Xenograft studies were performed in nude mice to evaluate the effect of dorsomorphin and an HSP90 inhibitor on tumor growth.Results: Dorsomorphin suppressed multiple stimuli-induced and constitutive HSPs expression in cancer cells. Mechanistic studies revealed that dorsomorphin reduced heat-induced HSP expression independent of adenosine monophosphate activated protein kinase. Dorsomorphin reduced heat-stimulated HSF1 Ser320 phosphorylation and nuclear translocation, as well as resting nuclear HSF1 levels in cancer cells. Dorsomorphin induced cancer cell apoptosis by inhibiting HSF1 expression. A structure-activity study revealed that the 4-pyridyl at the 3-site of the pyrazolo [1, 5-a]pyrimidine ring is critical for the anti-HSF1 activities of dorsomorphin. Dorsomorphin sensitized cancer cells to HSP90 and proteasome inhibitors and inhibited HSP70 expression induced by these inhibitors in vitro. In tumor-bearing nude mice, dorsomorphin enhanced HSP90 inhibitor-induced cancer cell apoptosis, tumor growth inhibition, and HSP70 expression.Conclusions: Dorsomorphin is an HSF1 inhibitor. It induces cancer cell apoptosis, sensitizes cancer cells to both HSP90 and proteasome inhibitors, and suppresses HSP upregulation by these drugs, which may prevent the development of drug resistance.Hence, dorsomorphin and its derivates may serve as potential precursors for developing drugs against cancer. | Na Li Ting Wang Zongmeng Li Xiaoli Ye Bo Deng Shu Zhuo Pengle Yao Mengmei Yang Hong Mei Xiaofang Chen Tengfei Zhu Shiting Chen Hui Wang Jiming Wang Yingying Le | 2019 | Cancer Biology & Medicine2019，16，2： | 1 |
| 6 | Low-thermal-budget synthesis of monolayer MoS_(2)显示文摘Two-dimensional(2D)materials,such as MoS_(2),have been considered as a competitive coordinate for future electronics due to their excellent electrostatics and high mobility[1-3].Moreover,the potential integration of 2D materials with silicon circuits can present increased density and multifunction in future heterogeneously integrated circuits[4,5].However,the high thermal-budget during MoS_(2) synthesis exceeds the temperature requirement of direct integration with Si in the back-end-of-line(BEOL)fabrication process[6-8]. | Zongmeng Yang Shibo Fang Jing Lu | 2024 | Science China Materials2024，67，1： | 0 |
| 7 | Salubrinal alleviates traumatic spinal cord injury through suppression of the eIF2α/ATF4 pathway in mouse model显示文摘Spinal cord injury(SCI)remains an intractable clinical challenge of neurosurgery,it can be divided into two stages:uncontrollable primary injury induced by mechanical damage and controllable secondary injury regulated by continuous cell death.The apoptosis was the one of most important events in secondary injury,previous studies revealed that excessive endoplasmic reticulum(ER)stress breaks down the homeostasis and triggers apoptosis in the spinal cord.To deter or alleviate the secondary jury,we screen one of fat-soluble compounds,salubrinal,which was an inhibitor of eIF2αdephosphorylation can repair SCI by inhibiting ER stress in mice after SCI.Administration of salubrinal effectively represses apoptosis,protects neuronal cell,and promotes the restoration of locomotor function in mice SCI models.Furthermore,the level of phosphorylated eIF2αwas raised in the presence of salubrinal,but the protein expression of ATF4 and CHOP was downregulated.Unexpectedly,transcriptional expression of CHOPregulated pro-apoptotic genes was decreased.These data suggest salubrinal suppress ER stress by targeting eIF2α/ATF4 pathways and reduces cell death after SCI.It is suggested that the mitigation of secondary lesion by inhibiting ER stress induced apoptosis in the early phase of SCI is promising treatment strategy. | XINFU FAN JIE CHEN ZONGMENG ZHANG FANGHUI CHEN HAOSEN WANG YAFEI CAI JUN LI | 2022 | BIOCELL2022，46，6： | 0 |
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