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| 1 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 2 | Green tea and the risk of gastric cancer: Epidemiological evidence显示文摘Gastric cancer (GC) is one of the leading causes of cancer death in the world. Numerous efforts are being made to find chemoprotective agents able to reduce its risk. Amongst these, green tea has been reported to have a protective effect against stomach cancer. This article aims to critically evaluate all epidemiological studies reporting an association between green tea consumption and GC risk. MEDLINE, EBSCOHOST and Google Scholar were used to search for clinical trials of green tea and its correlation to stomach cancer. Studies include cohort and case-control studies. Outcome of interests are inverse association, no association, and positive association. Seventeen epidemiologic studies were reviewed. Eleven studies were conducted in Japan, five in China, and one with Japanese descendent in Hawaii. Ten case-control studies and seven cohortstudies were included. The relative risks or odds ratio of GC for the highest level of green tea consumption was compared. Seven studies suggested no association, eight an inverse association, and one a positive association. One study had shown a significantly lowered GC risk when tea was served warm to cold. Another study also showed a significantly risk with lukewarm tea. All studies that analyzed men and women separately have suggested a reduced risk in women than in men, albeit no significant difference. This review demonstrates that there is insufficient information to support green tea consumption reduces the risk of GC. More studies on the subject matter are warranted. | I-Chun Hou Saral Amarnani Mok T Chong Anupam Bishayee | 2013 | World Journal of Gastroenterology2013，19，24： | 8 |
| 3 | Variations in Wool Growth with Nutrient Supply in Northern China显示文摘Field studies on essessment of nutritional status of the grazing sheep were carried out in each of the three major grassland regions, the eastern Inner Mongolia and beyond grassland, the Inner Mongolia - Ningxia - Gansu grassland and the Xinjiang grassland, in northern China. The results obtained showed that the wool production of fine wool sheep in these regions varied between regions and seasons, with similar seasonal patterns in all regions and that reducing the seasonal variations in nutrient supply would enhance wool production substantially. Nutritional limitations to wool growth of the grazing sheep in these regions were suggested, those were: the shortage of protein supply in winter and early spring; the poor quality of much of the pasture and the hay used as supplements, the low energy intake during winter which probably necessitated the use of body stores to maintain body temperature. | D X Lu,Iner(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)Z C Feng,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)H R Wang,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)R Z Yang,(Xinjiang Institute of Animal Science.Xinjiang Academy of Animal Science.Yiu Hou Road.Urumqi.Xinjiang Uygur Autonomous Region PRC)C T Ma,(Chinese Academy of Agricultural Sciences.Lanzhou.Gansu.PRC)D B Purser,(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)J R Lindsay(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)D W Peter(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014) | 1997 | 畜牧与饲料科学1997，22，S1： | 3 |
| 4 | Cyclic rapid warming on centennial-scale revealed by a 2650-year stalagmite record of warm season temperature 显示文摘 | Tan M Liu T S Hou J | 2003 | Geophysical Research Letters2003，30，： | 2 |
| 5 | 查看详情显示文摘 | Zhao C T Hou J N Zhang X Zhu W.Xu M | | 高分子科学(英文版)0，，： | 2 |
| 6 | A multiscale finite element method for elliptic problems in composite materials and porous media 显示文摘 | Hou T Y Wu X H | 1997 | Journal of Computational Physics1997，134，： | 2 |
| 7 | Convergence of a multiscale finite element method for elliptic problems with rapidly oscillating coefficients显示文摘 | Hou T Y Wu X H Cai Z | 1999 | Mathematics of Computation1999，68，227： | 2 |
| 8 | A Extended Class of Time-Continuous Branching Processes显示文摘 | Zhang H J and Hou Z T | 1999 | Submitted,19991999，1999，： | 1 |
| 9 | Toward secure distributed spectrum sensing in cognitive radio networks 显示文摘 | Chen R Park J M Hou Y T | 2008 | IEEE Commu- nication Magazine2008，4，： | 1 |
| 10 | Tungsten devices in analytical atomic spectrometry显示文摘 | Hou X D Jones B T | 2002 | Spectrochimica Acta Prat B2002，57，6： | 1 |
| 11 | Convergence of a multiscale finite element method for elliptic problems with rapidly oscillating coefficients 显示文摘 | Hou T Y Wu Xiaohui Cai Zhiqiang | 1999 | Mathematics of computation1999，68，227： | 1 |
| 12 | Iron-induced oxidative damage and apoptosis in cerebellar granule cells:attenuation by tetramethylpyrazine and ferulic acid显示文摘 | Zhang Z Wei T Hou J | 2003 | Eur J Pharmacol2003，467，： | 1 |
| 13 | On network bandwidth allocation policies and feedback control algorithms for packet networks显示文摘 | Y T HOU B LI S S PANWAR | 2000 | Computer Networks2000，34，3： | 1 |
| 14 | Eight - year atmospheric exposure of steels in china 显示文摘 | Hou W T Liang C F | 1999 | Corrosion1999，55，1： | 1 |
| 15 | Late paleoproterozoic extension and a paleostress field reconstruction of the North China Craton 显示文摘 | Hou G T Wang C C Li J H | 2006 | Teetonophysics2006，422，14： | 1 |
| 16 | Regioselective anodic mono- and difluorination of flavones显示文摘 | Hou Y Higashiya S Fuchigami T | 1999 | Organic Compounds1999，64，9： | 1 |
| 17 | Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked maerophages:Structure-activity relationship and molecular mechanisms involved显示文摘 | Hou DX Yanagita T Uto T | | 0，，03： | 1 |
| 18 | Interaction between electrical double layers of soil colloids and Fe/Al oxides in suspensions显示文摘 | Hou T Xu R.K Tiwari D Zhao A.Z | | 0，，： | 1 |
| 19 | IrrE, a global regulator of extreme radiation resistance inDeinococcus radiodurans, enhances salt tolerance in Escherichia coli and Brassica napus显示文摘 | Pan J Wang J Zhou Z Yan Y Zhang W Lu W Ping S Dai Q Yuan M Feng B Hou X Zhang Y Ma R Liu T Feng L Wang L Chen M Lin M | 2009 | PloS One2009，4，2： | 1 |
| 20 | The effect of market knowl- edge management competence on business per- formance:A dynamic capabilities perspective显示文摘 | Hou J J Chien Y T | 2010 | International Journal of Electronic Business Man- agement2010，，2： | 1 |
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