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| 1 | Molecular Recognition of Nucleotodes by the Guanidinium Unit at the Surface of Aqueous Micelles and Bilayers显示文摘 | Mitsuhiko Onda Kanami Yoshihara Hiroshi Koyano Katsuhiko Ariga Toyoki Kunitake | 1996 | J Am Chem Soc1996，118，： | 1 |
| 2 | Opposite regulation of epithelial-to-mesenchymal transition and cellinvasiveness by periostin between prostate and bladder cancer cells显示文摘 | Chul Kim Kanami Sakamoto Yukihiro Tambe Hirokazu Inoue | 2011 | International Journal of Oncology2011，，6： | 1 |
| 3 | Fruit rot of Strawberry pear(pitaya)caused by Bipolaris cactivora显示文摘 | Satoshi taba Nao miyahira Kanami nasu l | 2007 | Journal of General Plant Pathology2007，73，5： | 1 |
| 4 | A simple and efficient method of chromosome preparation using larvae of the barfin flounder verasper moseri(Osteichthyes,Pleurone ctiformes)显示文摘 | Okumura S Mizuho S kanami O | | 0，，： | 1 |
| 5 | Fruit rot of strawberry pear (pitaya) caused by Bipolaris cactivora 显示文摘 | SATOSHI T NAO M KANAMI N | 2007 | J Gen Plant Pathol2007，73，： | 1 |
| 6 | Lipopolysaccharide promotes the survival of osteoclasts via Toll-like receptor 4, but cytokine production of osteoclasts in response to lipopo- lysaccharide is different from that of macrophages 显示文摘 | Kanami I Nobuyuki U Kanichiro K | 2003 | J Immunol2003，170，7： | 1 |
| 7 | Job Demands,Job Resources,and Work Engagement of Japanese Employees:A Prospective Cohort Study显示文摘 | Akiomi Inoue Norito Kawakami Kanami Tsuno | 2013 | International Archives of Occupational and Environmental Health2013，86，4： | 1 |
| 8 | Degradation rates and products of fluticasone propionate in alkaline solutions显示文摘The apparent degradation rate constant of fluticasone propionate(FLT) in 0.1 M NaOH:methanol=1:1 at 37 °C was previously reported to be 0.169 ± 0.003 h^(-1), and four degradation products(products 1–4) were observed in the solution. The aims of the present study were to assess the degradation rates of FLT in other alkaline solutions and clarify the chemical structures of the four degradation products in order to obtain basic data for designing an enema for inflammatory bowel disease. The apparent degradation rate constants in 0.05 M NaOH and 0.1 M NaOH:CH_3CN=1:1 were 0.472 ± 0.013 h^(-1) and 0.154 ± 0.000 h^(-1)(n=3), respectively. The chemical structures of products 1–4 in 0.1 M NaOH:methanol=1:1 were revealed by nuclear magnetic resonance(NMR)and mass spectrometry data. The chemical structure of products 2 was that the 17-position of the thioester moiety of FLT was substituted by a carboxylic acid. The degradation product in 0.1 M NaOH:CH_3CN=1:1 was found to be product 2 based on ~1H NMR data. The degradation product in 0.05 M NaOH was considered to be product 2 based on the retention time of HPLC. These results are useful for detecting the degradation products of FLT by enzymes of the intestinal bacterial flora in the large intestine after dosing FLT as an enema. | Tadakazu Tokumura Naoko Yoshida Kanami Mori-Yasumoto Osamu Shirota Takuro Kurita | 2017 | Journal of Pharmaceutical Analysis2017，7，5： | 1 |
| 9 | A study of the antibacterial mechanism of catechins:Isolation and identification of Escherichia colicell surface proteins that interact with epigallocatechin gallate显示文摘 | MOTOKAZU N KANAMI S TADAHIRO O | 2013 | Food Control2013，33，2： | 1 |
| 10 | Opposite regulation of epithelial-to-mesenchymal transition and cellinvasiveness by periostin between prostate and bladder cancer cells显示文摘 | Chul Kim Kanami Sakamoto Yukihiro Tambe Hirokazu Inoue | 2011 | International Journal of Oncology2011，，6： | 1 |
| 11 | Fruit rot of Strawberry pear (pitaya) caused by Bipolaris cactivora 显示文摘 | Satoshi Taba Nao Miyahira Kanami Nasu | 2007 | Journal of General Plant Pahtology2007，73，5： | 1 |
| 12 | Adrenomedullin can protect against pulmonary vascular remodeling induced by hypoxia 显示文摘 | Hiromitsu M Tatsuo S Kanami I | 2004 | Circulation2004，109，： | 1 |
| 13 | Identification of a dihydroorotate dehydrogenase inhibitor thatinhibits cancer cell growth by proteomic profiling显示文摘Dihydroorotate dehydrogenase(DHODH)is a central enzyme of the de novo pyrimidine biosynthesis pathway and is a promising drug target for the treatment of cancer and autoimmune diseases.This study presents the identification of a potent DHODH inhibitor by proteomic profiling.Cell-based screening revealed that NPD723,which is reduced to H-006 in cells,strongly induces myeloid differentiation and inhibits cell growth in HL-60 cells.H-006 also suppressed the growth of various cancer cells.Proteomic profiling of NPD723-treated cells in ChemProteoBase showed that NPD723 was clustered with DHODH inhibitors.H-006 potently inhibited human DHODH activity in vitro,whereas NPD723 was approximately 400 times less active than H-006.H-006-induced cell death was rescued by the addition of the DHODH product orotic acid.Moreover,metabolome analysis revealed that H-006 treatment promotes marked accumulation of the DHODH substrate dihydroorotic acid.These results suggest that NPD723 is reduced in cells to its active metabolite H-006,which then targets DHODH and suppresses cancer cell growth.Thus,H-006-related drugs represent a potentially powerful treatment for cancer and other diseases. | MAKOTO KAWATANI HARUMI AONO SAYOKO HIRANUMA TAKESHI SHIMIZU MAKOTO MUROI TOSHIHIKO NOGAWA TOMOKAZU OHISHI SHUN-ICHI OHBA MANABU KAWADA KANAMI YAMAZAKI SHINGO DAN NAOSHI DOHMAE HIROYUKI OSADA | 2023 | Oncology Research2023，31，6： | 0 |
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