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| 1 | Effectiveness of circumferential endoscopic mucosal resection with a novel tissue-anchoring device显示文摘AIM: To evaluate the efficacy of circumferential endoscopic mucosal resection (EMR) with a tissue-anchoring device in comparison to forceps precut EMR and conventional endoscopic submucosal dissection (ESD). METHODS: The study was designed as a prospective, randomized, ex vivo study. Fresh ex vivo specimens were harvested from adult white Yorkshire pigs weighing 30-50 kg. Seventy-five standardized, artificial lesions measuring 3 cm × 3 cm were created by methy- lene blue tattoo at the greater curvature in fresh ex vivo stomachs using the EASIE-R simulator platform (Endosim LLC, Berlin, MA, United States). The three advanced endoscopists performed the three resection techniques such as circumferential EMR using the tissue-anchoring device (TA-EMR), forceps precut EMR (FP-EMR), and endoscopic submucosal dissection. The endoscopists and the type of cutting methods were determined randomly by grouped randomized selection.The resection bed was grossly inspected to determine whether the lesion was resected 'en-bloc ' (defined as no remaining mucosal tattoo remaining on specimen). The resection bed was also probed for evidence of perforation. The procedural time of circumferential resection, submucosal dissection, and injection frequency were recorded by an independent observer.RESULTS: All 75 created lesions were successfully resected by three advanced endoscopists using the three techniques. The mean ± SD size of resected specimens (long axis) were 39.5 ± 5.6 mm, 36.5 ± 7.3 mm, and 44.6 ± 5.6 mm for TA-EMR, FP-EMR, and ESD respectively. The overall mean dissection time of both the TA- EMR and FP-EMR was significant shorter than ESD (TA- EMR: 5.1 ± 3.3 min, FP-EMR: 3.5 ± 2.0 min vs ESD: 15.8 ± 9.5 min, P < 0.001, P < 0.001). The overall mean total procedure time of both the tissue-anchoring and forceps circumferential EMR was significantly shorter than ESD (TA-EMR: 17.5 ± 6.0 min, FP-EMR: 16.6 ± 6.6 min vs ESD: 28.6 ± 13.9 min, P < 0.001, P < 0.001). The en-bloc resection rate of ESD was 100% (25/25) and the en-bloc resection rate of the TA-EMR (84.0%, 21/25) was higher than for the FP-EMR (60.0%, 15/25), yet not statistically significant (P = 0.18). The perforation rate of each technique was 8.0% (2/25). CONCLUSION: TA-EMR appears to be quicker than ESD, and there was a trend towards improved en bloc resection rate with the TA-EMR when compared to the FP-EMR. | Yunho Jung Masayuki Kato Jongchan Lee Mark A Gromski Ram Chuttani Kai Matthes | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，6： | 3 |
| 2 | Influence of non‐alcoholic fatty liver disease on the development of diabetes mellitus显示文摘 | Anuradhani Kasturiratne Sanjaya Weerasinghe Anuradha S Dassanayake Shaman Rajindrajith Arjuna P Silva Norihiro Kato A Rajitha Wickremasinghe H Janaka Silva | 2012 | J Gastroenterol Hepatol2012，，1： | 2 |
| 3 | Xylan isolated from the stalk of Nicotiana tabacum显示文摘 | Eda S Ohnishi A Kato K | 1976 | Agric Biol Chem1976，40，： | 2 |
| 4 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 5 | 显示文摘 | Kato K Tsuzuki A Torii Y | 1995 | J Mat Sci1995，30，： | 2 |
| 6 | Cell cycle protein expression in proliferating microglia and astrocytes following transient global cerebral ischemia in the rat显示文摘 | Kato H Takahashi A Itoyama Y | 2003 | Brain Res Bul2003，60，： | 2 |
| 7 | Enhanced biodegradation of aromatic pollutants in cocultures of anaerobic and aerobic bacterial consortia 显示文摘 | FELDJ A STAMS A J M KATO M | 1995 | Antonievall Leeuwenhoek1995，67，： | 1 |
| 8 | Relationship between serum pre-B cell colony-enhancing factor/visfatin and atherosclerotic parameters in chronic hemodialysis patients显示文摘 | Kato A Odamaki M Ishida J | 2009 | Am J Ment Retard2009，29，1： | 1 |
| 9 | Visible-Light-Induced H -2 Evolution from an Aqueous Solution Containing Sulfide and Sulfite over a ZnS- CuInS2 - AgInS2 Solid-Solution Photocatalyst 显示文摘 | Tsuji I Kato H Kudo A | 2005 | Angewandte Chemie-International Edition2005，44，23： | 1 |
| 10 | Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo显示文摘 | K D Bowman A M Harrington | 1995 | J Natl Cancer Inst1995，87，： | 1 |
| 11 | (+)-Nortrachelogenin, a new pharmacologically active lignan from Wikstroemia indica 显示文摘 | Hashimoto Y | 1976 | J Nat Prod1976，15，11： | 1 |
| 12 | Effect of sulfidation temperature on the intrinsic activity of Co-MoS2 and Co-WS2 hydrodesulfurization catalysts显示文摘 | Okamoto Y Kato A Usman | 2009 | Journal of Catalysis2009，265，： | 1 |
| 13 | Effect of soybean soluble polysaccharides on the stability of milk protein under acidic condition 显示文摘 | NAKAMURA A FURUTA H KATO M | 2003 | Food Hydrocollids2003，17，： | 1 |
| 14 | Photocatalytic O2 evolution under visible light irradiation on BiVO4 in aqueous AgNO3 solution 显示文摘 | Kudo A Ueda K Kato H Mikami I | 1998 | Catal Lett1998，，53： | 1 |
| 15 | Silk protein, sericin, inhibits lipid peroxidation and tyrosinase activity 显示文摘 | Kato N Sato S Yamanaka A | 1998 | Bioseienee Biotechnology and Biochemistry1998，62，1： | 1 |
| 16 | Matrix metalloproteinas- es 2 and 9 in oral squamous cell carcinomas: manifesta- tion and localization of their activity显示文摘 | Kato K Hara A Kuno T | 2005 | J Cancer Res Clin Oncol2005，131，6： | 1 |
| 17 | Angiomyolipoma of kidney involving the inferior vena cava显示文摘 | Islam A H Ehara T Kato H | 2004 | Int J Urol2004，11，： | 1 |
| 18 | Androgen - insensitivity syndrome as a possible coactivator disease显示文摘 | Adachi M TR Tomura A Imasaki K Kato S Goto K Yanase T Ikuyama S Nawata H | 2000 | N Engl J Med2000，343，： | 1 |
| 19 | Finite element analysis of compressive deformation of bulk metallic glasses显示文摘 | KIM H S KATO H INOUE A | 2004 | Aeta Materialia2004，52，： | 1 |
| 20 | 显示文摘 | Kato H Kudo A | 1999 | Catal Lett1999，58，： | 1 |
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