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| 1 | Effect of ginseng polysaccharides and dendritic cells on the balance of Th1/Th2 T helper cells in patients with non-small cell lung cancer显示文摘OBJECTIVE: To investigate the effect of thorascopic administration of ginseng polysaccharides(GPS)plus dendritic cells(DC) on T helper cell type 1/T helper cell type 2(Th1/Th2) balance in patients with non-small cell lung cancer(NSCLC).METHODS: A total of 96 NSCLC patients were divided evenly into two groups. The control group was treated with DCs alone and the treatment group was treated with DCs plus GPS. After DCs and GPS were administered thoracoscopically, once a week,4 times for 30 days, the patients' quality of life was measured with the Functional Assessment of Can-cer Treatment-Lung(FACT-L) questionnaire before and after treatment. Serum interferon-γ(INF-γ), interleukin-4(IL-4), IL-2 and IL-5 were examined before and after treatments.RESULTS: The level of Th1 cytokines(INF-γ, IL-2)and the ratio of Th1/Th2 cytokines(INF-γ/IL-4, IL-2/IL-5) increased in both treatment groups, while Th2cytokines(IL-4, IL-5) and FACT-L scores decreased(P<0.01). Furthermore, after treatment Th1 cytokines(INF-γ, IL-2) and the ratio of Th1/Th2 cytokines(INF-γ/IL-4, IL-2/IL-5) were higher in the DCs +GPS group than in the control group(P<0.05). Conversely, FACT-L scores and Th2 cytokines(IL-4, IL-5)were higher in the control group than in the DCs +GPS group(P<0.05).CONCLUSION: The treatment regime of DCs plus GPS had a greater effect on NSCLC patients' immune function as compared with DCs alone. This was evident by increased expression of Th1 cytokines(INF-γ, IL-2) and the ratio of Th1/Th2(INF-γ/IL-4, IL-2/IL-5), as well as by decreased FACT-L scores and the expression of Th2 cytokines(IL-4,IL-5). | Junjie Ma Huiping Liu Xiaolong Wang | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 41 |
| 2 | Performance of a completely autotrophic nitrogen removal over nitrite process for treating wastewater with different substrates at ambient temperature显示文摘The stability and parameters of a bio-ceramic filter for completely autotrophic nitrogen removal were investigated.The completely autotrophic nitrogen removal over nitrite(CANON) reactor was fed with different concentrations of ammonia(400,300,and 200mg N/L) but constant influent ammonia load.The results showed that the CANON system can achieve good treatment performance at ambient temperature(15-23°C).The average removal rate and removal loading of NH4+-N and TN was 83.90%,1.26kg N/(m3·day),and 70.14%,1.09kg N/(m3·day),respectively.Among the influencing factors like pH,dissolved oxygen and alkalinity,it was indicated that the pH was the key parameter of the performance of the CANON system.Observing the variation of pH would contribute to better control of the CANON system in an intuitive and fast way.Denaturing gradient gel electrophoresis analysis of microorganisms further revealed that there were some significant changes in the community structure of ammonium oxidizing bacteria,which had low diversity in different stages,while the species of anaerobic ammonium oxidizing(anammox) bacteria were fewer and the community composition was relatively stable.These observations showed that anaerobic ammonia oxidation was more stable than the aerobic ammonia oxidation,which could explain that why the CANON system maintained a good removal efficiency under the changing substrate conditions. | Xiaoyan Chang Dong Li Yuhai Liang Zhuo Yang Shaoming Cui Tao Liu Huiping Zeng Jie Zhang | 2013 | Journal of Environmental Sciences2013，25，4： | 12 |
| 3 | Efficacy and safety of trastuzumab combined with chemotherapy for first-line treatment and beyond progression of HER2-overexpressing advanced breast cancer显示文摘Objective: To observe the efficacy and safety of trastuzumab combined with chemotherapy in patients with human epidermal growth factor receptor 2(HER2)-overexpressing advanced breast cancer.Methods: A total of 90 patients with HER2-overexpressing advanced breast cancer were enrolled in this study. All patients were diagnosed with ductal invasive breast cancer by pathological analysis, and were aged between 31–73 years with a median of 51 years. HER2-positivity was defined as 3(+) staining in immunochemistry or amplification of fluorescence in situ hybridization(FISH, ratio ≥2.0). Trastuzumab was administered in combination with chemotherapy as first-line treatment and beyond progression as a secondline, third-line, and above treatment in 90, 34, 14, and 6 patients, respectively. The chemotherapy regimen was given according to normal clinical practice. The response rate was evaluated every two cycles, and the primary endpoints were progression-free survival(PFS) and overall survival(OS). Survival curves were estimated by using Kaplan-Meier graphs and were compared by using log-rank test statistics. Multivariate analysis was done using Cox's proportional hazards regression model, and the level of significance was P<0.05.Results: All 90 patients received at least one dose of trastuzumab, and efficacy could be evaluated in 85 patients. The median follow-up was 50 months. In total, 72(80.00%) patients had visceral metastasis, and 43(47.78%) patients had progressed after one or more extensive chemotherapy regimens for metastatic diseases. The median PFS for first-line trastuzumab was 10 months(range, 2–59 months), and the median OS after metastasis or initially local advanced disease was 22 months(range, 2–116 months).Conclusions: Trastuzumab combined with chemotherapy was active and well-tolerated as a first-line treatment and even beyond progression in HER2-overexpressing advanced breast cancer as a second-line or third-line treatment. However, its efficacy is certainly less beyond this point. | Huiping Li Bin Shao Yin Yan Guohong Song Xiaoran Liu Jing Wang Xu Liang | 2016 | Chinese Journal of Cancer Research2016，28，3： | 11 |
| 4 | The role of microRNAs in colorectal cancerr显示文摘MicroRNAs are small non-coding RNAs which regulate gene expression in a post-transcriptional manner. Although the first study was published about 15 years ago, knowledge about their role in regulation of cell proliferation, differentiation, apoptosis and immunity has been greatly advanced recently. Their association with formation, angiogenesis, metastasis and chemotherapy resistance of tumors has become one of the core issues in epigenetics of cancer. Here, we summarize the latest findings concerning microRNAs involved in dif-ferent signal pathways leading to colorectal cancer, introduce some new potential microRNAs as biomarkers in diagnosis and prognosis, and analyze its application in the treatment of cancer. | Mao Liu Huiping Chen | 2010 | Journal of Genetics and Genomics2010，37，6： | 10 |
| 5 | Coastal seafloor observatory at Xiaoqushan in the East China Sea显示文摘The seafloor observation system is becoming an important infrastructure for marine research because it is transforming oceanic research from temporal investigation to long term observation.The East China Sea coastal seafloor observatory,located between 30°31′44″N,122°15′12″E and 30°31′34″N,122°14′40″E,is constructed near the Xiaoqushan Island outside the Hangzhou Bay on the inner continental shelf of the East China Sea.The observatory is connected by a submarine optical fiber composite power cable that is more than one kilometer long and consists of a special junction box that transmits power and communication signals to different instruments.The special junction box has a variety of waterproof plugs and connects to three different instruments installed in a trawl preventer.The submarine optical fiber composite power cable is landed on the platform by The East China Sea Branch,State Oceanic Administration and the power is continuously supplied by the solar panels and solar battery on the top of the platform.The real time data are directly sent through the cable to the platform and are transmitted by CDMA wireless to the receiver at the State Key Laboratory of Marine Geology of Tongji University.Measurements at the observatory have been taken since April 20,2009 after installation and the results have been interpreted.The characteristics of the near bottom boundary are constrained by a sediment suspension model using portion of the observed data.In particular,discussion is provided on the sea surface height anomaly at Xiaoqushan Island influenced by the tsunami driven by the 2010 Earthquake in Chile.The successful establishment of the coastal seafloor observatory is the first step toward future development of seafloor observation systems in China.It not only accumulates experiences in technology and engineering,but also paves the way for performing important oceanic research using the long term continuous observation platform. | XU HuiPing ZHANG YanWei XU ChangWei LI JianRu LIU Ding QIN RuFu LUO ShenQian FAN DaiDu | 2011 | Chinese Science Bulletin2011，56，26： | 10 |
| 6 | Type Synthesis of 1T2R Parallel Mechanisms Using Structure Coupling-Reducing Method显示文摘Direct kinematics with analytic solutions is critical to the real-time control of parallel mechanisms.Therefore,the type synthesis of a mechanism having explicit form of forward kinematics has become a topic of interest.Based on this purpose,this paper deals with the type synthesis of 1T2R parallel mechanisms by investigating the topological structure coupling-reducing of the 3UPS&UP parallel mechanism.With the aid of the theory of mechanism topology,the analysis of the topological characteristics of the 3UPS&UP parallel mechanism is presented,which shows that there are highly coupled motions and constraints amongst the limbs of the mechanism.Three methods for structure coupling-reducing of the 3UPS&UP parallel mechanism are proposed,resulting in eight new types of 1T2R parallel mechanisms with one or zero coupling degree.One obtained parallel mechanism is taken as an example to demonstrate that a mechanism with zero coupling degree has an explicit form for forward kinematics.The process of type synthesis is in the order of permutation and combination;therefore,there are no omissions.This method is also appli cable to other configurations,and novel topological structures having simple forward kinematics can be obtained from an original mechanism via this method. | Haitao Liu Ke Xu Huiping Shen Xianlei Shan Tingli Yang | 2019 | Chinese Journal of Mechanical Engineering2019，32，5： | 9 |
| 7 | Preliminary analysis on the source properties and seismogenic structure of the 2017 M_s7.0 Jiuzhaigou earthquake显示文摘At GMT time 13:19, August 8, 2017, an Ms7.0 earthquake struck the Jiuzhaigou region in Sichuan Province, China,causing severe damages and casualties. To investigate the source properties, seismogenic structures, and seismic hazards, we systematically analyzed the tectonic environment, crustal velocity structure in the source region, source parameters and rupture process, Coulomb failure stress changes, and 3-D features of the rupture plane of the Jiuzhaigou earthquake. Our results indicate the following:(1) The Jiuzhaigou earthquake occurred on an unmarked fault belonging to the transition zone of the east Kunlun fault system and is located northwest of the Huya fault.(2) Both the mainshock and aftershock rupture zones are located in a region where crustal seismic velocity changes dramatically. Southeast to the source region, shear wave velocity at the middle to lower crust is significantly low, but it rapidly increases northeastward and lies close to the background velocity across the rupture fault.(3) The aftershock zone is narrow and distributes along the northwest-southeast trend, and most aftershocks occur within a depth range of 5–20 km.(4) The focal mechanism of the Jiuzhaigou earthquake indicates a left-lateral strike-slip fault, with strike, dip, and rake angles of 152°, 74° and 8°, respectively. The hypocenter depth measures 20 km, whereas the centroid depth is about 6 km. The co-seismic rupture mainly concentrates at depths of 3–13 km, with a moment magnitude(M_w) of 6.5.(5) The co-seismic rupture also strengthens the Coulomb failure stress at the two ends of the rupture fault and the east segment of the Tazang fault. Aftershocks relocation results together with geological surveys indicate that the causative fault is a near vertical fault with notable spatial variations: dip angle varies within 66°–89° from northwest to southeast and the average dip angle measures ~84°. The results of this work are of fundamental importance for further studies on the source characteristics, tectonic environment, and seismic hazard evaluation of the Jiuzhaigou earthquake. | Zujun XIE Yong ZHENG Huajian YAO Lihua FANG Yong ZHANG Chengli LIU Maomao WANG Bin SHAN Huiping ZHANG Junjie REN Lingyun JI Meiqin SONG | 2018 | Science China Earth Sciences2018，61，3： | 8 |
| 8 | Human infection with a further evolved avian H9N2 influenza A virus in Sichuan, China显示文摘Dear Editor,Avian influenza A (H9N2) virus plays a crucial role in interspecies transmission between animals and humans due to its wide host range, adaptation in mammals and the diversified gene reassortments. Since 1990s, two lineages of H9N2 virus, A/Duck/HK/Y280/97 (Y280-like)and A/Quail/HK/G1/97 (G1) have established in domestic poultry in China and are now widespread in the | Jianan Xu Shuang Li Yong Yang Bing Liu Huiping Yang Tiansu Li Lin Zhang Wei Li Xiaohu Luo Liquan Zhang Ming Pan | 2018 | Science China(Life Sciences)2018，61，5： | 7 |
| 9 | Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing显示文摘Objective:To compare the efficacy of platinum-and non-platinum-based regimens as first-line treatment for advanced triple-negative breast cancer(TNBC)and analyze the relationship between their efficacy and BRCA gene status.Methods:Retrospectively analyze clinical data of 220 patients diagnosed pathologically with advanced TNBC and treated at the Department of Breast Oncology,Peking University Cancer Hospital from 2013 to 2018 and evaluate the efficacy of chemotherapy.A total of 114 patients had BRCA1/2 gene tested by next generation sequencing(NGS)using peripheral blood,and we analyzed the correlation between their efficacy and BRCA1/2 gene status.Results:Non-platinum-based chemotherapy(NPCT)was administered to 129 and platinum-based chemotherapy(PBCT)to 91 study patients.The clinical benefit rate(CBR)and median progression-free survival(PFS)were not statistically different between NPCT and PBCT groups.The median overall survival(OS)was 30.0 and 22.5 months for PBCT and NPCT group,respectively[P=0.090,hazard ratios(HR)=0.703].BRCA status was assessed in 114 patients,14 of whom had deleterious germline BRCA1/2(g BRCA)mutations(seven in each group).In PBCT group,the CBR was 85.7%and 35.1%for patients with and without deleterious g BRCA mutations,respectively(P=0.039).The median PFS were 14.9 and 5.3 months and median OS were 26.5 and 15.5 months for patients with and without deleterious g BRCA mutations,respectively(P=0.001,P=0.161,respectively).Patients in PBCT group had significantly greater rates of grade 3-4 anemia(5.5%vs.0%)and thrombocytopenia(8.8%vs.0%),whereas palmar-plantar erythrodysesthesia(12.4%vs.0%)and peripheral neuropathy(8.6%vs.1.1%)occurred more frequently in NPCT group.Conclusions:Platinum-based regimens are more effective in patients with deleterious g BRCA mutations,but no difference in patients without BRCA gene mutations,so non-platinum is an option in patients without BRCA gene mutations considering the toxicity and side effect.And we recommend that patients with advanced TNBC should have BRCA gene test. | Nan Wang Kun Li Wenfa Huang Weiyao Kong Xiaoran Liu Weijie Shi Feng Xie Hanfang Jiang Guohong Song Lijun Di Quanren Wang Jianjun Yu Huiping Li | 2020 | Chinese Journal of Cancer Research2020，32，2： | 7 |
| 10 | Improvement of Ductility of Powder Metallurgy Titanium Alloys by Addition of Rare Earth Element显示文摘Ti-4.5AI-6.0Mo-1.5Fe, Ti-6AI-1Mo-1Fe 和 Ti-6AI-4V 合金被混合元素的粉末冶金学(下午) 准备微观结构和机械性质上的 Nd 的过程,和效果被扫描电子显微镜学(SEM ) 调查,传播电子显微镜学(TEM ) 和 X 光检查衍射(XRD ) 。因为液相的小数量发生在 sintering 期间, Nd 的增加由 1% 的最大的增长稍微增加了 sintered 钛合金的密度,这被发现。Nd 的增加在张力的力量的改进上显示出小效果,当延伸显著地被改进时。例如,没有 13percent 的 Nd 的增加, Ti-4.5AI-6.0Mo-1.5Fe 的延伸能在 1.2 wt % 的一个 Nd 内容从 1% 被增加。 | Yong LIU Lifang CHEN Weifeng WEI Huiping TANG Bin LIU Baiyun HUANG | 2006 | Journal of Materials Science & Technology2006，22，4： | 7 |
| 11 | Regulation and functions of integrin a2 in cell adhesion and disease显示文摘Integrins are cell adhesion molecules that are composed of an alpha(a)subunit and a beta(b)subunit with affinity for different extracellular membrane components.The integrin family includes 24 known members that actively regulate cellular growth,differentiation,and apoptosis.Each integrin heterodimer has a particular function in defined contexts as well as some partially overlapping features with other members in the family.As many reviews have covered the general integrin family in molecular and cellular studies in life science,this review will focus on the specific regulation,function,and signaling of integrin a2 subunit(CD49b,VLA-2;encoded by the gene ITGA2)in partnership with b1(CD29)subunit in normal and cancer cells.Its roles in cell adhesion,cell motility,angiogenesis,stemness,and immune/blood cell regulations are discussed.The pivotal role of integrin a2 in many diseases such as cancer suggests its potential to be used as a novel therapeutic target. | Valery Adorno-Cruz Huiping Liu | 2019 | Genes & Diseases2019，6，1： | 6 |
| 12 | Single phase A2B7-type La-Mg-Ni alloy with improved electrochemical properties prepared by melt-spinning and annealing显示文摘La-Mg-Ni alloys were prepared by melt-spinning with different cooling rates and followed by annealing.Elevation of the cooling rate leads to refinement of the grains size and increasing of the abundance of LaNis.Annealing is favorable to formation of the A2 B7-type phase and promotes the discharge capacity,cycling stability and high rate discharge ability of the as-spun alloys.Phase constitution of the annealed alloys is found to be closely related to the microstructure of the as-spun alloys.A single phase A2 B7-type microstructure is obtained in the annealed alloy which is attributed to the lower abundance of the LaNis of the original alloy spun with lower cooling rate.Formation of the single phase A2 B7-type microstructure is also ascribed to the isolated and homogeneous distribution of the morphology of the as-spun alloy.The single phase alloy presents higher discharge capacity and better cycling stability compared with other annealed alloys. | Yiming Li Zhuocheng Liu Guofang Zhang Yanghuan Zhang Huiping Ren | 2019 | Journal of Rare Earths2019，37，12： | 6 |
| 13 | Robust superhydrophobic polyurethane sponge functionalized with perfluorinated graphene oxide for efficient immiscible oil/water mixture, stable emulsion separation and crude oil dehydration显示文摘In recent years, graphene oxide(GO), prepared by the modified Hummers’ method, and its derivatives have become a focus of research owing to their outstanding physical and chemical properties and low cost. Drawing inspiration from the mussel protein,a facile and environmentally-friendly method was employed to fabricate superhydrophobic/superoleophilic reduced graphene oxide(rGO) derivative. The preparation comprises two steps: coating GO nanosheets with polydopamine(PDA) and subsequent reaction with 1H,1H,2H,2H-perfluorodecanethiol. Due to the excellent adhesive ability of PDA, the resulting f PDA modified rGO nanosheets(rGO-f PDA) were firmly immobilized onto polyurethane(PU) sponge skeleton by a simple drop-coating method. The as-prepared rGO-f PDA functionalized sponge exhibited superhydrophobic behavior with a water contact angle of 162°±2°, high organic adsorption capacity, recyclability and stable oil/water separation behavior under different acidic/alkaline conditions. Due to its facile fabrication technique and outstanding properties, the superhydrophobic-superoleophilic PU-rGOf PDA sponge holds great promise as an oil adsorbent for cleaning up large-scale pollution of oil and organic solvents, and dehydrating crude oil. | CAO Ning GUO JingYu BOUKHERROUB Rabah SHAO QingGuo ZANG XiaoBei LI Jin LIN XueQiang JU Hong LIU EnYang ZHOU ChaoFan LI HuiPing | 2019 | Science China(Technological Sciences)2019，62，9： | 6 |
| 14 | Preliminary Discussion on the Relationship Between EM Wave Propagation Characteristics and Medium Parameters in Anisotropic Medium显示文摘The reflection and transmission characteristics of an anisotropic half-space medium normally illuminated by aplane wave are analyzed by kDB coordination. The general formula of reflection coefficient at the air-medium interface isgiven, and its validity is also discussed. The possible propagating modes in different mediums and the effect of medium pa-rameters on these modes are emphatically studied. This work provides the theoretical preparations for the parameter recon-struction of an anisotropic material. | Guo Huiping & Liu Xueguan Dept. of Communication and Electronics, Suzhou University, Suzhou 215021, P. R. ChinaYin Hongcheng & Huang Peikang National Electromagnetic Scattering Laboratory, Beijing 100854, P. R. China | 2002 | Journal of Systems Engineering and Electronics2002，13，4： | 6 |
| 15 | Arsenic in Drinking Water and Its Removal显示文摘Superfluous arsenic in drinking water can do harm to human health. In this paper, a broad overview of the available technologies for arsenic removal has been presented on the basis of literature survey. The main treatment methods included coagulation-sedimentation, adsorption separation and ion exchange, membrane technique, which have both advantages and disadvantages. It concluded that the selection of treatment process should be site specific and prevailing conditions and no process can serve the purpose under diverse conditions as each technology has its own limitations. In order to gain good results, some methods should be improved. | Liu Zhenzhong Deng Huiping Zhan Jian | 2007 | Chinese Journal of Population,Resources and Environment2007，5，3： | 6 |
| 16 | 肿瘤浸润髓系细胞上表达的共抑制分子B7S1抑制抗肿瘤CD8 T细胞的功能显示文摘文章简介近年来,肿瘤免疫治疗蓬勃发展,为人类战胜癌症带来了一线曙光。阻断PD-1/PD-L1通路的抗体药物可以提高CD8 T细胞的抗肿瘤活性,疗效显著优于传统治疗手段。然而,只有小部分实体瘤病人可以对PD-1/PD-L1免疫治疗产生应答. | 黎静 Younghee Lee Yanjian Li Yu Jiang Huiping Lu Wenjuan Zang Xiaohong Zhao Liguo Liu Yang Chen Haidong Tan 杨志英 Michael Q Zhang Tak W.Mak Ling Ni 董晨 | 2019 | 科学新闻2019，0，2： | 6 |
| 17 | Advances in DCC Process and Catalyst for Propylene Production from Heavy Oils显示文摘In the past several decades,SINOPEC has devoted continuously great efforts to the development of DCC technology,the only commercial process using heavy feeds aiming at propylene production.Recently,a series of research breakthroughs have been achieved in molecular refining.Based on the detailed analysis on the complex DCC reaction network,an innovative catalyst technology has been developed to Optimize Catalysis Kinetics (OCK in brief).The deep-cracking process can be improved with optimizing the availability of the active sites.The updated MFI and beta zeolites are used to boost the propylene selectivity.The latest generation catalyst DMMC-1 has been applied commercially.Compared with the best historical records in the past,the propylene yield upon application of the catalyst DMMC-1 increases by 2.4 m% coupled with an improved distribution of products.The DCC technology continues to assume a leading position for manufacturing propylene from heavy feedstocks. | Liu Yujian Long Jun Tian Huiping Xu Yun Zhao Liuzhou (Research Institute of Petroleum Processing,SINOPEC,Beijing 100083) | 2011 | China Petroleum Processing & Petrochemical Technology2011，13，1： | 5 |
| 18 | Urinary donor-derived cell-free DNA as a non-invasive biomarker for BK polyomavirus-associated nephropathy显示文摘BK polyomavirus-associated nephropathy(BKPyVAN)is a common cause of allograft failure.However,differentiation between BKPyVAN and type I T cell-mediated rejection(TCMR)is challenging when simian virus 40(SV40)staining is negative,because of the similarities in histopathology.This study investigated whether donor-derived cell-free DNA(ddcfDNA)can be used to differentiate BKPyVAN.Target region capture sequencing was applied to detect the ddcfDNAs of 12 recipients with stable graft function,22 with type I TCMR,21 with proven BKPy VAN,and 5 with possible Py VAN.We found that urinary ddcfDNA levels were upregulated in recipients with graft injury,whereas plasma ddcfDNA levels were comparable for all groups.The median urinary concentrations and fractions of ddcfDNA in proven BKPyVAN recipients were significantly higher than those in type I TCMR recipients(10.4 vs.6.1 ng/mL,P<0.001 and 68.4%vs.55.3%,P=0.013,respectively).Urinary ddcfDNA fractions(not concentrations)were higher in the BKPyVAN-pure subgroup than in the BKPyVAN-rejection-like subgroup(81.30%vs.56.64%,P=0.025).With a cut-off value of 7.81 ng/m L,urinary ddcf DNA concentrations distinguished proven BKPyVAN from type I TCMR(area under the curve(AUC)=0.848,95%confidence interval(95%CI):0.734 to 0.963).These findings suggest that urinary ddcf DNA is a non-invasive biomarker which can reliably differentiate BKPy VAN from type I TCMR. | Jia SHEN Luying GUO Wenhua LEI Shuaihui LIU Pengpeng YAN Haitao LIU Jingyi ZHOU Qin ZHOU Feng LIU Tingya JIANG Huiping WANG Jianyong WU Jianghua CHEN Rending WANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 4 |
| 19 | Combined peripheral natural killer cell and circulating tumor cell enumeration enhance prognostic efficiency in patients with metastatic triple-negative breast cancer显示文摘Objective:Triple-negative breast cancer(TNBC)is a heterogeneous disease with poor prognosis.Circulating tumor cells(CTCs)are a promising predictor for breast cancer prognoses but their reliability regarding progression-free survival(PFS)is controversial.We aim to verify their predictive value in TNBC.Methods:In present prospective cohort study,we used the Pep@MNPs method to enumerate CTCs in baseline blood samples from 75 patients with TNBC(taken at inclusion in this study)and analyzed correlations between CTC numbers and outcomes and other clinical parameters.Results:Median PFS was 6.0(range:1.0–25.0)months for the entire cohort,in whom we found no correlations between baseline CTC status and initial tumor stage(P=0.167),tumor grade(P=0.783)or histological type(P=0.084).However,among those getting first-line treatment,baseline CTC status was positively correlated with ratio of peripheral natural killer(NK)cells(P=0.032),presence of lung metastasis(P=0.034)and number of visceral metastatic site(P=0.037).Baseline CTC status was predictive for PFS in first-line TNBC(P=0.033),but not for the cohort as a whole(P=0.118).This prognostic limitation of CTC could be ameliorated by combining CTC and NK cell enumeration(P=0.049).Conclusions:Baseline CTC status was predictive of lung metastasis,peripheral NK cell ratio and PFS in TNBC patients undergoing first-line treatment.We have developed a combined CTC-NK enumeration strategy that allows us to predict PFS in TNBC without any preconditions. | Xiaoran Liu Ran Ran Bin Shao Hope S.Rugo Yanlian Yang Zhiyuan Hu Zewen Wei Fengling Wan Weiyao Kong Guohong Song Hanfang Jiang Xu Liang Ruyan Zhang Ying Yan Guobing Xu Huiping Li | 2018 | Chinese Journal of Cancer Research2018，30，3： | 4 |
| 20 | Application of waste frying oils in the biosynthesis of biodemulsifier by a demulsifying strain Alcaligenes sp.S-XJ-1显示文摘Exploration of biodemulsifiers has become a new research aspect.Using waste frying oils(WFOs) as carbon source to synthesize biodemulsifiers has a potential prospect to decrease production cost and to improve the application of biodemulsifiers in the oilfield.In this study,a demulsifying strain,Alcaligenes sp.S-XJ-1,was investigated to synthesize a biodemulsifier using waste frying oils as carbon source.It was found that the increase of initial pH of culture medium could increase the biodemulsifier yield but decrease the demulsification ratio compared to that using paraffin as carbon source.In addition,a biodemulsifier produced by waste frying oils and paraffin as mixed carbon source had a lower demulsification capability compared with that produced by paraffin or waste frying oil as sole carbon source.Fed-batch fermentation of biodemulsifier using waste frying oils as supplementary carbon source was found to be a suitable method.Mechanism of waste frying oils utilization was studied by using tripalmitin,olein and tristearin as sole carbon sources to synthesize biodemulsifier.The results showed saturated long-chain fatty acid was diffcult for S-XJ-1 to utilize but could effectively enhance the demulsification ability of the produced biodemulsifier.Moreover,FT-IR result showed that the demulsification capability of biodemulsifiers was associated with the content of C=O group and nitrogen element. | Jia Liu Kaiming Peng Xiangfeng Huang Lijun Lu Hang Cheng Dianhai Yang Qi Zhou Huiping Deng | 2011 | Journal of Environmental Sciences2011，23，6： | 4 |
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