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| 1 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 2 | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer显示文摘胃的癌症是世界范围的最普通的恶意之一;然而,在 tumorigenesis 的分子的机制仍然需要探索。BCL2L11 属于 BCL-2 家庭,并且充当内在的 apoptotic 串联的一个中央管理者并且调停房间 apoptosis。尽管 miRNAs 被报导了涉及癌症开发的每个阶段,在 GC 的 miR-24 的角色还没被报导。在现在的学习,当 BCL2L11 的表示在 GC 的肿瘤纸巾被禁止时, miR-24 被发现起来调整。研究从在 vitro 并且在显示出的 vivo,那 miR-24 调整 BCL2L11 表示由与 mRNA 的 3UTR 直接有约束力,因此支持房间生长,移植当禁止房间 apoptosis 时。因此, miR-24 是能是为未来的潜在的药目标的新奇 onco-miRNA 临床的使用。 | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba | 2016 | Protein & Cell2016，7，2： | 11 |
| 3 | Infiltrating lithium into carbon doth decorated with zinc oxide arrays for dendrite-free lithium metal anode显示文摘Lithium metal anode for batteries has attracted extensive attentions, but its application is restricted by the hazardous dendritic Li growth and dead Li formation. To address these issues, a novel Li anode is developed by infiltrating molten Li metal into conductive carbon cloth decorated with zinc oxide arrays. In carbonate-based electrolyte, the symmetric cell shows no short circuit over 1,500 h at 1 mA·cm^-2, and stable voltage profiles at 3 mA cm^-2 for ~ 300 h cycling. A low overpotential of ~ 243 mV over 350 cycles at a high current density of 10 mA·cm^-2 is achieved, compared to the seriously fluctuated voltage and fast short circuit in the cell using bare Li metal. Meanwhile, the asymmetric cell withstands 1,000 cycles at 10 C (1 C = 167 mAh·g^-1) compared to the 210 cycles for the cell using bare Li anode. The excellent performance is attributed to the well-regulated Li plating/stripping drive n from the formation of LiZn alloy on the wavy carb on fibers, resulting in the suppress!on of dendrite growth and pulverization of the Li electrode during cycling. | Xianshu Wang Zhenghui Pan Yang Wu Xiaoyu Ding Xujia Hong Guoguang Xu Meinan Liu Yuegang Zhang Weishan Li | 2019 | Nano Research2019，12，3： | 8 |
| 4 | Construction of a macromolecular structural model of Chinese lignite and analysis of its low-temperature oxidation behavior显示文摘The aim of this paper is to analyze the change in the active structure of lignite during the process of lowtemperature oxidation by constructing a molecular structure model for lignite. Using quantum computation combined with experimental results of proximate analysis, ultimate analysis, Fourier transform infrared spectroscopy(FTIR) and X-ray photoelectron spectroscopy(XPS), a structural model for the large molecular structure was constructed. By analyzing the bond lengths in the model molecule, the evolution law for the active structure of lignite was predicted for the process of low-temperature oxidation. In low-temperature oxidation,alkanes and hydroxyls are the primary active structures observed in lignite, though ether may also react. These active functional groups react with oxygen to release heat, thereby speeding up the reaction between coal and oxygen. Finally, the content of various functional groups in the process of lignite low-temperature oxidation was analyzed by infrared analysis, and the accuracy of the model was verified. | Xianliang Meng Mingqiang Gao Ruizhi Chu Zhenyong Miao Guoguang Wu Lei Bai Peng Liu Yuanfang Yan Pengcheng Zhang | 2017 | Chinese Journal of Chemical Engineering2017，25，9： | 8 |
| 5 | Effect of Sb-site nonstoichiometry on the structure and microwave dielectric properties of Li_(3)Mg_(2)Sb_(1-x)O_(6) ceramics显示文摘The non-stoichiometric Li_(3)Mg_(2)Sb_(1-x)O_(6)(0.05≤x≤0.125)compounds have been prepared via the mixed oxide method.The influences of Sb nonstoichiometry on the sintering behavior,microstructure,phase composition along with microwave dielectric performances for Li_(3)Mg_(2)Sb_(1-x)O_(6) ceramics were studied.Combined with X-ray diffraction(XRD)and Raman spectra,it was confirmed that phase composition could not be affected by the Sb nonstoichiometry and almost pure phase Li_(3)Mg_(2)SbO_(6) was formed in all compositions.Appropriate Sb-deficiency in Li_(3)Mg_(2)SbO_(6) not only lowered its sintering temperature but also remarkably improved its Q×f value.In particular,non-stoichiometric Li_(3)Mg_(2)Sb_(0.9)O_(6) ceramics sintered at 1250℃/5 h owned seldom low dielectric constant ε_(r)=10.8,near-zero resonant frequency temperature coefficient τ_(f)=-8.0 ppm/℃,and high quality factor Q×f=86,300 GHz(at 10.4 GHz).This study provides an alternative approach to ameliorate its dielectric performances for Li_(3)Mg_(2)SbO_(6)-based compounds through defect-engineering. | Cuijin PEI Jingjing TAN Yang LI Guoguang YAO Yanmin JIA Zhaoyu REN Peng LIU Huaiwu ZHANG | 2020 | Journal of Advanced Ceramics2020，9，5： | 6 |
| 6 | Systematic study of human long intergenic non-coding RNAs and their impact on cancer显示文摘The functional impact of several long intergenic non-coding RNAs (lincRNAs) has been characterized in previous studies. However, it is difficult to identify lincRNAs on a large-scale and to ascertain their functions or predict their structures in laboratory experiments because of the diversity, lack of knowledge and specificity of expression of lincRNAs. Furthermore, although there are a few well-characterized examples of lincRNAs associated with cancers, these are just the tip of the iceberg owing to the complexity of cancer. Here, by combining RNA-Seq data from several kinds of human cell lines with chromatin-state maps and human expressed sequence tags, we successfully identified more than 3000 human lincRNAs, most of which were new ones. Subsequently, we predicted the functions of 105 lincRNAs based on a coding-non-coding gene co-expression network. Finally, we propose a genetic mediator and key regulator model to unveil the subtle relationships between lincRNAs and lung cancer. Twelve lincRNAs may be principal players in lung tumorigenesis. The present study combines large-scale identification and functional prediction of human lincRNAs, and is a pioneering work in characterizing cancer-associated lincRNAs by bioinformatics. | SUN Liang LUO HaiTao LIAO Qi BU DeChao ZHAO GuoGuang LIU ChangNing LIU YuanNing ZHAO Yi | 2013 | Science China(Life Sciences)2013，56，4： | 6 |
| 7 | PKM2 promotes reductive glutamine metabolism显示文摘Objective:Pyruvate kinases M(PKM),including the PKM1 and PKM2 isoforms,are critical factors in glucose metabolism.PKM2promotes aerobic glycolysis,a phenomenon known as'the Warburg effect'.The purpose of this study was to identify the roles of PKM2 in regulating cellular metabolism.Methods:The CRISPR/Cas9 system was used to generate the PKM-knockout cell model to evaluate the role of PKM in cellular metabolism.Lactate levels were measured by the Vitros LAC slide method on an autoanalyzer and glucose levels were measured by the autoanalyzer AU5800.The metabolism of ^(13)C_6-glucose or ^(13)C_5-glutamine was evaluated by liquid chromatography/mass spectrometry analyses.The effects of PKM on tumor growth were detected in vivo in a tumor-bearing mouse model.Results:We found that both PKM1 and PKM2 enabled aerobic glycolysis,but PKM2 converted glucose to lactate much more efficiently than PKM1.As a result,PKM2 reduced glucose levels reserved for intracellular utilization,particularly for the production of citrate,and thus increased theα-ketoglutarate/citrate ratio to promote the generation of glutamine-derived acetylcoenzyme A through the reductive pathway.Furthermore,reductive glutamine metabolism facilitated cell proliferation under hypoxia conditions,which supports in vivo tumor growth.In addition,PKM-deletion induced a reverse Warburg effect in tumorassociated stromal cells.Conclusions:PKM2 plays a critical role in promoting reductive glutamine metabolism and maintaining proton homeostasis.This study is helpful to increase the understanding of the physiological role of PKM2 in cancer cells. | Miao Liu Yuanyuan Wang Yuxia Ruan Changsen Bai Li Qiu Yanfen Cui Guoguang Ying Binghui Li | 2018 | Cancer Biology & Medicine2018，15，4： | 6 |
| 8 | In-situ growth of vertically aligned nickel cobalt sulfide nanowires on carbon nanotube fibers for high capacitance all-solid-state asymmetric fiber-supercapacitors显示文摘Fiber-supercapacitors(FSCs)are promising power sources for miniature portable and wearable electronic devices.However,the development and practical application of these FSCs have been severely hindered by their low volumetric capacitance and narrow operating voltage.In this work,vertically aligned nickel cobalt sulfide(Ni Co2S4)nanowires grown on carbon nanotube(CNT)fibers were achieved through an in-situ two-step hydrothermal reaction method.The as-prepared Ni Co2S4@CNT fiber electrode exhibits a high volumetric capacitance of 2332 F cm-3,benefiting from its superior electric conductivity,large surface area,and rich Faradic redox reaction sites.Furthermore,a Ni Co2S4@CNT//VN@CNT(vanadium nitride nanosheets grown on CNT fibers)asymmetric fiber-supercapacitor(AFSC)was successfully fabricated.The device exhibits an operating voltage up to 1.6 V and a high volumetric energy density of 30.64m Wh cm-3.The device also possesses outstanding flexibility as evidenced by no obvious performance degradation under various bending angles and maintaining high capacitance after 5000 bending cycles.This work promotes the practical application of flexible wearable energy-storage devices. | Na Liu Zhenghui Pan Xiaoyu Ding Jie Yang Guoguang Xu Linge Li Qi Wang Meinan Liu Yuegang Zhang | 2020 | Journal of Energy Chemistry2020，29，2： | 5 |
| 9 | Comparative investigation of three types of ethanol sensor based on NiO-SnO_2 composite nanofibers显示文摘NiO-SnO2 composite nanofibers were synthesized via electrospinning techniques and characterized by X-ray diffraction,scanning electron microscopy,transmission electron microscopy,and X-ray photoelectron spectroscopy.Three types of sensor were applied to investigate the sensing properties of these nanofibers.Sensors A were fabricated by mixing the nanofibers with deionized water,and then grinding and coating them on ceramic tubes to form indirect heated gas sensors.Microsensors B(with an area of 600 μm×200 μm) were formed by spinning nanofibers on Si substrates with Pt signal electrodes and Pt heaters.Sensors C were fabricated by spinning nanofibers on plane ceramic substrates(with a large area of 13.4 mm×7 mm) with Ag-Pd signal electrodes only.The operating temperatures of sensors A and B were controlled by adjusting heater currents,and the operating temperatures of sensors C were controlled by adjusting an external temperature control device.Experimental results show that sensors C possess the highest sensing properties,such as high response values(about 42 to 100 μL/L ethanol),quick response/recovery speeds(the response and recovery times were 4 and 7 s,respectively),and excellent consistencies.These phenomena were explained by the retained fiber morphology and suitable sensor area.The presented results can provide some useful information for the design and optimization of one-dimensional nanomaterial-based gas sensors. | SHEN RenSheng LI XiangPing XIA XiaoChuan LIANG HongWei WU GuoGuang LIU Yang CHENG ChuanHui DU GuoTong | 2012 | Chinese Science Bulletin2012，57，17： | 5 |
| 10 | Structural insights into SUN-KASH complexes across the nuclear envelope显示文摘nucleoskeleton 和细胞骨架(LINC ) 的连接器建筑群由阳光和 KASH 包含域的蛋白质组成并且衔接原子信封的内部、外部的膜。LINC 建筑群在原子放,房间极化和细胞的僵硬起关键作用。以前,我们报导了人的 SUN2 的 homotrimeric 结构。我们现在决定了人的 SUN2-KASH 建筑群的水晶结构。在复杂结构, SUN 领域 homotrimer 绑在三独立 “ hook”相似 KASH 肽。在建筑群的 SUN 领域的全面符合构造非常处于它的 apo 状态类似于 SUN 领域。一个主要 conformational 变化包含 KASH 固定的阳光领域的 AA'-loop,它重排形成微型 β与 KASH 肽交往的表。KASH 领域的磅主题在 SUN 领域的 homotrimeric 接口上紧适合进一个恐水病的衣袋,我们它称为双性人衣袋。而且, SUN 领域 homotrimer 三明治的二邻近的 protomers 由结合的恐水病的相互作用和氢的 KASH 领域。这些有约束力的地点的变化在 vitro 破坏或减少在 SUN 和 KASH 域之间的协会。另外, transfection 野类型,然而并非变异, SUN2 在 Ovcar-3 房间支持房间移植。这些结果提供 LINC 建筑群的一个结构的模型,它为另外的学习是必要的物理、功能在细胞质和核质之间联合。 | Wenjia Wang Zhubing Shi Shi Jiao Cuicui Chen Huizhen Wang Guoguang Liu Qiang Wang Yun Zhao Mark I Greene Zhaocai Zhou | 2012 | Cell Research2012，22，10： | 3 |
| 11 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 12 | Determination of glucose deficiency-induced cell death by mitochondrial ATP generation-driven proton homeostasis显示文摘 | Yanfen Cui Yuanyuan Wang Miao Liu Li Qiu Pan Xing Xin Wang Guoguang Ying Binghui Li | 2017 | Journal of Molecular Cell Biology2017，9，5： | 3 |
| 13 | Exosomal miR-155 from gastric cancer induces cancerassociated cachexia by suppressing adipogenesis and promoting brown adipose differentiation via C/EPBβ显示文摘Objective:The aim of this research was to identify whether exosomes were involved in impairing adipogenesis in cancer-associated cachexia(CAC)by detecting the adipodifferentiation capacity and the expressions of adipogenic proteins in gastric cancer(GC)-associated adipocytes.Methods:Western blotting and RT-PCR were used to investigate the expressions of C/EPBβ,C/EPBα,PPARγ,and UCP1 in adipose mesenchymal stem cells(A-MSCs)to evaluate the function of exosomal miR-155.BALB/c nude mice were intravenously injected in vivo with GC exosomes with different levels of miR-155 to determine changes in adipodifferentiation of A-MSCs.Results:Exosomes derived from GC cells suppressed adipogenesis in A-MSCs as characterized by decreased lipid droplets.Similarly,A-MSCs co-cultured with GC exosomes exhibited increased ATP production through brown adipose differentiation characterized by highly dense mitochondria and enhanced UCP1 expression(P<0.05).Mechanistically,exosomal miR-155 secreted from GC cells suppressed adipogenesis and promoted brown adipose differentiation by targeting C/EPBβ,accompanied by downregulated C/EPBαand PPARγand upregulated UCP1(P<0.05).Moreover,overexpression of miR-155 in GC exosomes improved CAC in vivo,which was characterized by fat loss,suppressed expressions of C/EPBβ,C/EPBα,and PPARγin A-MSCs,and high expression of UCP1(P<0.05).Decreasing the level of miR-155 in injected GC exosomes abrogated the improved CAC effects.Conclusions:GC exosomal miR-155 suppressed adipogenesis and enhanced brown adipose differentiation in A-MSCs by targeting C/EPBβof A-MSCs,which played a crucial role in CAC. | Ying Liu Meng Wang Ting Deng Rui Liu Tao Ning Ming Bai Guoguang Ying Haiyang Zhang Yi Ba | 2022 | Cancer Biology & Medicine2022，19，9： | 3 |
| 14 | Structural analysis of receptor-like kinase SOBIR1 reveals mechanisms that regulate its phosphorylation-dependent activation显示文摘Plant leucine-rich repeat(LRR)receptor-like kinases(RLKs)and LRR receptor-like proteins(RLPs)comprise a large family of cell surface receptors that play critical roles in signal perception and transduction.Both LRR-RLKs and LRR-RLPs rely on regulatory LRR-RLKs to initiate downstream signaling pathways.BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1/SOMATIC EMBRYOGENESIS RECEPTOR KINASE 3(BAK1/SERK3)and SUPPRESSOR OF BIR1-1(SOBIR1)are important and extensively studied regulatory LRR-RLKs with distinct functions.Although the regulatory mechanism of BAK1 activation has been studied in detail,the activation mechanism of SOBIR1 remains poorly understood.Here,the crystal structures of the catalytically inactive kinase domain of SOBIR1(SOBIR1-KD)from Arabidopsis thaliana were determined in complexes with AMP-PNP and Mg^(2+).The results show that SOBIR1-KD contains a uniquely long β3-αC loop and adopts an Src-like inactive conformation with an unusual architecture at the activation segment,which comprises three helices.Biochemical studies revealed that SOBIR1 is transphosphorylated by BAK1 following its autophosphorylation via an intermolecular mechanism,and the phosphorylation of Thr529 in the activation segment and the β3-αC loop are critical for SOBIR1 phosphorylation.Further functional analysis confirmed the importance of Thr529 and the β3-αC loop for the SOBIR1-induced cell death response in Nicotiana benthamiana.Taken together,these findings provide a structural basis for the regulatory mechanism of SOBIR1 and reveal the important elements and phosphorylation events in the special stepwise activation of SOBIR1-KD,the first such processes found in regulatory LRR-RLKs. | Xue Wei Yulu Wang Su Zhang Tianyi Gu Gabryel Steinmetz Haiyan Yu Guoguang Guo Xin Liu Shilong Fan Fengzhong Wang Yangnan Gu Fengjiao Xin | 2022 | Plant Communications2022，3，2： | 2 |
| 15 | Stable and realistic crack pattern generation using a cracking node method显示文摘 | Juan ZHANG Fuqing DUAN Mingquan ZHOU Dongcan JIANG Xuesong WANG Zhongke WU Youliang HUANG Guoguang DU Shaolong LIU Pengbo ZHOU Xiangang SHANG | 2018 | Frontiers of Computer Science2018，12，4： | 1 |
| 16 | Microwave-assisted extraction of tea polyphenols and tea caffeine from green tea leaves显示文摘 | Pan Xuejun Niu Guoguang Liu Huizhou | 2003 | Chemical Engineering and Processing2003，42，2： | 1 |
| 17 | Microwave-assisted extraction of tea polyphenols and tea caffeine from green tea leaves 显示文摘 | Xuejun Pan Guoguang Niu Huizhou Liu | 2003 | Chemical Engineering and Processing2003，42，： | 1 |
| 18 | Optical study on the vision correction and supernormal vision based on the wave-front aberrations of human eye显示文摘In this paper we present the recent research results in the field of vision correction and supernormal vision according to the actual measurements of the wave-front aberrations and the corneal surface topography,the clinical detection of the visual function and the laser corneal refractive surgery,and the optimization of the optical system. These include the features of the aberrations of human eye with different pupil sizes,different fields of view and temporal accommodation,the influence of the polychromatic illumination of the visible wavelength on the supernormal vision,and the effect of the existing laser corneal refractive surgery on the wave-front ab-errations of the eye. It is shown that the wave-front aberration of human eye is of temporal variation and of synthesis with multi impact factors. To achieve super-normal vision,an optimum engineering data for the customized laser corneal sur-gery should be firstly acquired,which may involve the dynamic free-form optical surface. Although the myopia can be corrected by the laser in situ keratomileusis(LASIK) in a certain degree,it brings about negative effects under scotopic condi-tions. | MU GuoGuang WANG ZhaoQi LIU YongJi QUAN Wei WANG Yang WANG Wei | 2007 | Science China(Technological Sciences)2007，50，3： | 1 |
| 19 | Simple and sensitive fluorimetric method for determination of environmental hormone bisphenol A based on its inhibitory effect on the redox reaction between peroxyl radical and rhodamine 6G 显示文摘 | Fan Jing Guo Huiqin Liu Guoguang | 2007 | Analytiea Chimiea Aeta2007，585，1： | 1 |
| 20 | Role of aquaporin-4 in the regulation of migration and invasion of humanglioma cells显示文摘 | Ting Ding Yongjie Ma Wenliang Li Xiaoli Liu Guoguang Ying Li Fu Feng Gu | 2011 | International Journal of Oncology2011，，6： | 1 |
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