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| 1 | Molecular mechanisms of heavy metal tolerance and evolution in invertebrates显示文摘跟随基因组学革命,我们对应力位于防卫下面的分子的机制的知识极大地被扩展了。在强壮的选择压力下面,许多动物可以发展提高的应力忍耐。这能被改变蛋白质的结构完成(通过在基因的编码区域的变化) 或由改变蛋白质的数量(通过在 transcriptional 的变化规定) 。进化的后者类型能被替换在兴趣(cis 规章的变化) 或由改变 transcriptional 管理者蛋白质(trans 规章的变化) 的结构或数量的基因的倡导者完成。metallothionein 系统是在重金属的上下文的最好学习的压力反应系统之一。Metallothionein 表示被假定被金属抄写因素 1 调整(MTF-1 ) ;然而,直到现在, MTF-1 的参与仅仅为一些脊椎动物和果蝇被证明了。象线虫和蚯蚓那样的无脊椎动物上的数据建议 metallothionein 正式就职的另外的机制可能是在场的。Cd 忍耐的详细研究为土壤生活跳虫的种被做, Orchesella cincta。种类是完了的这的 metallothionein 基因在暴露金属的领域人口表示了。metallothionein 倡导者的分析表明了有功能的意义,出现在简历记者试金的广泛的多型性。在比较 20 张不同人口的研究,高快车的倡导者等位基因的频率断然在土壤与金属的集中被相关,特别 Cd。跳虫学习证明涉及细胞的应力反应的基因的那个 cis 规章的变化可以贡献金属公差的进化。 | Thierry K. S. Janssens Dick Roelofs Nico M. van Straalen | 2009 | Insect Science2009，16，1： | 9 |
| 2 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 3 | Comparative analysis of Solanum stoloniferum responses to probing by the green peach aphid Myzus persicae and the potato aphid Macrosiphum euphorbiae显示文摘抽象植物由种类特定的防卫机制保护自己免于蚜虫攻击。以前,我们证明了茄属 stoloniferum Schlechtd 有抵抗因素到 Myzus persicae Sulzer (Homoptera:Aphididae ) 在 epidermal/mesophyll 水平,那不对 Macrosiphum euphorbiae 托马斯是有效的(Homoptera:Aphididae ) 。这里,我们比较 nymph 的死亡, pre 繁殖的发展时间,和 M 的探查的行为。persicae 和 M。S 上的 euphorbiae。stoloniferum 和茄属 tuberosum L。而且,我们在 S 在基因表示分析变化。stoloniferum 96 个小时由也张贴群袭蚜虫种类。尽管 M。探查蚜虫遇到更多的探查的行为表演的 euphorbiae 在韧皮部 activitieslonger 在 S 上探查和分泌唾液时间上抑制。stoloniferum 比在 S 上。tuberosum,蚜虫成功了在两植物上到达韧皮部树液的持续摄取。由 M 探查。S 上的 persicae。stoloniferum 植物导致了仅仅的有限的喂。M 的幸存。euphorbiae 和 M。persicae 在年轻叶子,然而并非在 S 的衰老的叶子被影响。stoloniferum。由 M 的群袭。euphorbiae 比 M 改变了更多的基因的表示。persicae 做了。在全身的水平,两个蚜虫得到了弱回答。S 的群袭。有很多 M 的 stoloniferum 植物。persicae 在叶子导致了词法变化,导致被破坏脉管的实质引起并且包围织物的色点的发展。相反,由 M 的群袭。euphorbiae 没有词法效果。两个都,植物种类能为 M 被认为是好主人。euphorbiae,而仅仅 S。tuberosum 是为 M 的一位好主人。persicae 和 S。stoloniferum 不是。S 的群袭。由 M 的 stoloniferum。persicae 或 M。euphorbiae 象一套普通基因一样改变了为每蚜虫特定的一套植物基因的表示。 | Adriana E. Alvarez Viviana G. Broglia Anahi M. Alberti D'Amato Doret Wouters Edwin van der Vossen Elisa Garzo W. Fred Tjallingii Marcel Dicke Ben Vosman | 2013 | Insect Science2013，20，2： | 5 |
| 4 | The Social Identity Approach to Effective Leadership: An Overview and Some Ideas on Cross-Cultural Generalizability显示文摘当雇员与这些组和组织一起识别时,他们工作为,这典型地为工作相关的态度和行为有积极含意。现在的纸提供它的跨文化的 generalizability 的领导和一些想法的社会身份途径的集中的概述。到这个目的,我们将首先构画出社会身份途径的基本信条并且与工作相关的变量总结组织上的鉴定的关系。然后,我们将为有效领导讨论社会身份相关的概念的角色。特别地,我们将在下列三个方面上介绍实验研究:(1 ) 领导人鉴定的转移到他们的追随者上,(2 ) 领导人 prototypicality 的角色,并且(3 ) 领导人活跃地管理这些组的身份的方法他们铅。最后,我们将为未来研究提供怎么实现身份管理的原则进实践上的一些建议和提议建议,与中国的一个特殊焦点。 | Rolf van Dick Rudolf Kerschreiter | 2016 | Frontiers of Business Research in China2016，10，3： | 4 |
| 5 | Quanti?cation of Tyrosine Hydroxylase and Erb B4 in the Locus Coeruleus of Mood Disorder Patients Using a Multispectral Method to Prevent Interference with Immunocytochemical Signals by Neuromelanin显示文摘The locus coeruleus(LC) has been studied in major depressive disorder(MDD) and bipolar disorder(BD). A major problem of immunocytochemical studies in the human LC is interference with the staining of the immunocytochemical end-product by the omnipresent natural brown pigment neuromelanin. Here, we used a multispectral method to untangle the two colors: blue immunocytochemical staining and brown neuromelanin.We found significantly increased tyrosine hydroxylase(TH) in the LC of MDD patients—thus validating the method—but not in BD patients, and we did not find significant changes in the receptor tyrosine-protein kinase ErbB4 in the LC in MDD or BD patients. We observed clear co-localization of ErbB4, TH, and neuromelanin in the LC neurons. The different stress-related molecular changes in the LC may contribute to the different clinical symptoms in MDD and BD. | Lei Guo Jochem StormmesAND Zheng Fang Qingbin Zhu Rawien Balesar Joop van Heerikhuize Arja Sluiter Dick Swaab Ai-Min Bao | 2019 | Neuroscience Bulletin2019，35，2： | 2 |
| 6 | Minimization of excess sludge production for biological wastewater treatment显示文摘 | Yuansong Wei Renze T. Van Houten Arjan R. Borger Dick H. Eikelboom Yaobo Fan | 2003 | Water Research2003，，18： | 2 |
| 7 | Misdiagnosis of tuberculosis and the clinical relevance of nontuberculous mycobacteria in Zambia显示文摘Objective:To determine the accuracy of TB diagnosis of TB in Zambia in the era of increasing HIV prevalence.Methods:Sputum of the clinically diagnosed TB cases was additionally subjected to liquid culture and molecular identification.This study distinguished between TB cases confirmed by positive Mycobacterium tuberculosis(M.tuberculosis) cultures and mycobacterial disease caused by non-tuberculous mycobacteria(NTM).Results:Only 49% of the 173 presumptively diagnosed TB cases was M.tuberculosis cultured,while in 13% (22) cases,a combination of M.tuberculosis and NTM was found.In 18% of the patients only NTM were cultured.In 28% ,no mycobacteria was cultivable.HIV positive status was correlated with the isolation of NTM(P<0.05).Conclusions:The diagnosis of tuberculosis based on symptoms, sputum smear and/or chest X-ray leads to significant numbers of false-positive TB cases in Zambia,most likely due to the increased prevalence of HIV.The role of NTM in tuberculosislike disease also seems relevant to the false diagnosis of TB in Zambia. | Patricia CAM Buijtels Michael D Iseman Shelagh Parkinson Cas S de Graaff Henri A Verbrugh Pieter LC Petit Dick van Soolingen | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，5： | 2 |
| 8 | Differences in the population of genetics of Mycobacterium tuberculosis between urban migrants and local residents in Beijing, China显示文摘 | Dai Guang-ming Zhang Zhi-guo Ding Peng-ju Zhang Qian Wang Li Wang Li-xia van Soolingen, Dick Huang Hai-rong Li Wei-min Li Chuan-you | 2013 | Chinese Medical Journal2013，，21： | 2 |
| 9 | Attraction of Colorado Potato Beetle to Herbivore-Damaged Plants During Herbivory and After Its Termination显示文摘 | Caroline J. Bolter Marcel Dicke Joop J. A. Van Loon J. H. Visser Maarten A. Posthumus | 1997 | Journal of Chemical Ecology1997，，4： | 2 |
| 10 | Quantitative resistance against Bemisia tabaci in Solanum pennellii:Genetics and metabolomics显示文摘The whitefly Bemisia tabaci is a serious threat in tomato cultivation worldwide as all varieties grown today are highly susceptible to this devastating herbivorous insect.Many accessions of the tomato wild relative Solanum pennellii show a high resistance towards B. tabaci. A mapping approach was used to elucidate the genetic background of whiteflyresistance related traits and associated biochemical traits in this species. Minor quantitative trait loci(QTLs) for whitefly adult survival(AS) and oviposition rate(OR) were identified and some were confirmed in an F2BC1 population, where they showed increased percentages of explained variance(more than 30%). Bulked segregant analyses on pools of whiteflyresistant and-susceptible F2 plants enabled the identification of metabolites that correlate either with resistance or susceptibility. Genetic mapping of these metabolites showed that a large number of them co-localize with whiteflyresistance QTLs. Some of these whitefly-resistance QTLs are hotspots for metabolite QTLs. Although a large number of metabolite QTLs correlated to whitefly resistance or susceptibility, most of them are yet unknown compounds and further studies are needed to identify the metabolic pathways and genes involved. The results indicate a direct genetic correlation between biochemical-based resistance characteristics and reduced whitefly incidence in S. pennellii. | Floor van den Oever-van den Elsen Alejandro F.Lucatti Sjaak van Heusden Colette Broekgaarden Roland Mumm Marcel Dicke Ben Vosman | 2016 | Journal of Integrative Plant Biology2016，58，4： | 2 |
| 11 | Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis显示文摘 | Neel R Gandhi Paul Nunn Keertan Dheda H Simon Schaaf Matteo Zignol Dick van Soolingen Paul Jensen Jaime Bayona | 2010 | The Lancet2010，，9728： | 2 |
| 12 | The Multilevel Cycle of Anthropogenic Zinc显示文摘 | Graedel T E Beers Dick van Bertram M | 2005 | Journal of Industrial Ecology2005，9，3： | 1 |
| 13 | Do I hear the whistle? a first at- tempt to measure four forms of employee silence and their correlates 显示文摘 | Knoll M Van Dick R | 2013 | Journal of Business Ethics2013，113，2： | 1 |
| 14 | Attraction of Colorado potato beetle to herbivore-damaged plants during herbivory and after its termination显示文摘 | BOLTER C J DICKE M VAN LOON J J A | 1997 | Chem Eco11997，23，4： | 1 |
| 15 | A Critique On The Theory of Financial Intermediation显示文摘 | Bert Scholtens Dick Van Wensveen | 2000 | Journal of Bank&Finance 242000，，： | 1 |
| 16 | Sampling and quantifying invertebrates form drinking water distribution mains显示文摘 | Hein M van Lieverloo Dick W B Geo L B | 2004 | Water Research2004，38，3： | 1 |
| 17 | In vitro predictions of skin absorption of caffeine, testosterone, and benzoic acid: a multi-centre comparison study显示文摘 | J.J.M. van de Sandt J.A. van Burgsteden S. Cage P.L. Carmichael I. Dick S. Kenyon G. Korinth F. Larese J.C. Limasset W.J.M. Maas L. Montomoli J.B. Nielsen J.-P. Payan E. Robinson P. Sartorelli K.H. Schaller S.C. Wilkinson F.M. Williams | 2004 | Regulatory Toxicology and Pharmacology2004，，3： | 1 |
| 18 | Use of infochemicals in pest management with special reference to the banana weevil, Cosmopolites sordidus (Germar) (Coleoptera: Curculionidae) 显示文摘 | Tinzaara W Dicke M Van Huis A | 2002 | Insect Science and its Application2002，22，4： | 1 |
| 19 | Attraction of colorado potato beetle to herbivore-damaged plants during herbivory and after its termination显示文摘 | Bolter C J Dicke M van Loon J J A | 1997 | J Chem Eeol1997，23，： | 1 |
| 20 | Foci of attachment in organizations: A meta-analytie comparison of the strength and correlates of work- group versus organizational identification and commitment显示文摘 | Riketta M and Van Dick R | 2005 | Journal of Vocational Behavior2005，67，3： | 1 |
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