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| 1 | Numerical modeling of the anomalous post-rift subsidence in the Baiyun Sag,Pearl River Mouth Basin显示文摘The Baiyun Sag is the deepest sag in the Pearl River Mouth Basin in northern continental margin of South China Sea,with the maximum sediment thickness over 12.5 km above the basement including >6.5 km sediments above the 30 Ma breakup unconformity.According to the theoretical models for the rifted basins,the post-rift subsidence is driven solely by the thermal contraction and can be calculated as the function of the lithospheric stretching factor.A method combining the forward modeling and reverse backstripping was designed to estimate lithospheric stretching factor.Using the 2D forward modeling based on the flexural cantilever model,we simulated the multi-rifting process of the Baiyun Sag with constrain of the backstripped profiles.By doing this the lithospheric stretching factor was obtained,and then the theoretical post-rift subsidence was calculated.The calculated theoretical subsidence was much smaller than the observed subsidence given by backstripping.Along the 1530 line in the Baiyun Sag,the anomalous post-rift subsidence is over 2 km in the sag center,and varies slightly to the north and south edges of the sag.This suggests that the anomalous post-rift subsidence continues beyond the sag both in the continental shelf to the north and in the continental slope to the south.The sensitivity tests in the forward modeling process indicate that only the use of low-angle faults (≤13°) can we simulate the shape of the backstripped profile. | LIAO Jie ZHOU Di ZHAO ZhongXian ZHANG YunFan XU ZiYing | 2011 | Science China Earth Sciences2011，54，8： | 14 |
| 2 | Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome显示文摘The trillions of microorganisms in the gut microbiome have attracted much attention recently owing to their sophisticated and widespread impacts on numerous aspects of host pathophysiology.Remarkable progress in large-scale sequencing and mass spectrometry has increased our understanding of the influence of the microbiome and/or its metabolites on the onset and progression of extraintestinal cancers and the efficacy of cancer immunotherapy.Given the plasticity in microbial composition and function,microbial-based therapeutic interventions,including dietary modulation,prebiotics,and probiotics,as well as fecal microbial transplantation,potentially permit the development of novel strategies for cancer therapy to improve clinical outcomes.Herein,we summarize the latest evidence on the involvement of the gut microbiome in host immunity and metabolism,the effects of the microbiome on extraintestinal cancers and the immune response,and strategies to modulate the gut microbiome,and we discuss ongoing studies and future areas of research that deserve focused research efforts. | Ziying Zhang Haosheng Tang Peng Chen Hui Xie Yongguang Tao | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 11 |
| 3 | Outline of Uranium Resources Characteristics and Metallogenetic Regularity in China显示文摘Uranium,as one of twenty-six kinds of important minerals in China,is strategic resource and energy mineral,which has been thoroughly investigated in the project of National Potential Evaluation of Uranium Resource.During the implementation of this project,the authors summarized the metallogenic regularity of uranium resource in China systematically,through the researches of geological characteristics of uranium resource,uranium deposits type(genetic and prediction type),temporal and spatial distribution,and metallogenic series.Based on the investigation of present situation and progress in uranium exploration,this paper proposes the uranium deposits in China should be divided into 4 classes,9 types,21 subtypes in genetic,and 50 types in prediction;suggests to divide China into 29 uranium metallogenic belts and 20 uranium prospective area,and constructs 20uranium-polymetallic metallogenic series,through summarizing temporal and spatial distribution characteristics and metallogenic regularity of uranium deposits in China.The above research is beneficial to the comprehensive understanding of regional uranium metallogenic regularity,and will direct the uranium exploration in the future. | CAI Yuqi ZHANG Jindai LI Ziying GUO Qingyin SONG Jiye FAN Honghai LIU Wusheng QI Fucheng ZHANG Minglin | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 11 |
| 4 | Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer显示文摘5-methylcytosine (5mC ) 和它的氧化形式 5-hydroxymethylcytosine (5hmC ) 被建议了涉及 tumorigenesis。因为印射方法的广泛地使用的 5mC 的读出,定序的重亚硫酸盐(BS-seq ) ,是 5mC 的和, 5hmC 层次, 5mC/5hmC 模式和这二修正的关系仍然保持糟糕理解。由介绍真实 5mC (BS-seq 由帮助 Tet 的 BS-seq 改正了, TAB-seq ) 并且 5hmC (TAB-seq ) 在单个核苷酸的分辨率同时铺平,我们这里证明与匹配的正常纸巾相比没有在肾肿瘤的 5mC 的全球损失。相反地, 5hmC 全球性被失去在几乎所有肾肿瘤纸巾。在肿瘤纸巾的 5hmC 水平是为肾癌症的一个独立预示的标记,与与更短的全面幸存联系的 5hmC 的底层。而且,我们证明 5hmC 的损失与匹配的正常纸巾相比在肿瘤被连接到 hypermethylation,特别地在基因身体区域。惊人地,基因身体 hypermethylation 显著地与肿瘤相关的基因的 silencing 被联系。IDH1 的 Downregulation 作为在肾癌症位于 5hmC 损失下面的机制被识别。恢复 5hmC 层次稀释了肿瘤房间的侵略能力并且在一个异种皮移植模型压制了肿瘤生长。一起,我们的结果证明 5hmC 的损失在由改变 DNA methylation 模式的肾癌症是一个预示的标记和一个 oncogenic 事件。 | Ke Chen Jing Zhang Zhongqiang Guo Qin Ma Zhengzheng Xu Yuanyuan Zhou Ziying Xu Zhongwu Li Xiongjun- Ye Xuesong Li Bifeng Yuan Yuwen Ke Chuan He Liqun Zhou Jiang Liu WeiminCi | 2016 | Cell Research2016，26，1： | 10 |
| 5 | Long-term trends in fog and boundary layer characteristics in Tianjin,China显示文摘Long-term trends in fog episodes,vertical variations of atmospheric boundary structure,and air pollutant concentrations during two different heavy fog events in the Tianjin area were analyzed.The total amount of fog has increased since 1980 due to the stability of the boundary layer and an increase of pollutant emissions.The variation in the characteristics of the boundary layer and air pollutant concentrations were significantly different between the two fog processes(fog 1 and fog II).The onset of fog I was accompanied by a temperature inversion in the low atmosphere,and the average kinetic energy showed a clear diurnal trend and vertical variation,which increased with height.The dissipation of fog I was mainly due to turbulence.However,the atmospheric stratification was not stable in the lower layer before the onset of fog II.The diurnal and vertical changes in kinetic energy were very small,in which turbulent momentum at each measurement height tended to be zero.In the dissipation process of fog II,wind speed increased significantly.Surface PM_(2.)5 concentrations decreased,but the ratio of PM_(2.5) to PM_(10)increased from 0.66 to 0.82 until fog I dissipated.However,the concentration of PM2.5 did not decrease at the early stage of fog II,but the ratio of PM_(2.5) to PM_(10) PM_(2.5)/PM_(10) decreased to 0.21 when fog II dissipated.This study showed that there was a clear difference in the evolution of pollutant concentration for different pollutants and in different developing stages during the fog events.PM2.5 concentration accumulated faster than those of SO_2 and NO_x,and the PM_(2.5) cumulative rate was greater in the mid-term of the fog process. | Suqin Han Ziying Cai Yufen Zhang Jiao Wang Qing Yao Peiyan Li Xiangjin Li | 2015 | Particuology2015，13，3： | 7 |
| 6 | Effects of erythropoietin on the expression of tumor necrosis factor-alpha and Bax after facial nerve axotomy in rats显示文摘This study sought to evaluate the effect of high-dose erythropoietin (EPO;5 000 IU/kg) on the expression of tumor necrosis factor-alpha (TNF-α) and Bax in the facial nucleus after facial nerve transection in rats.A total of 42 Wistar rats of both genders were used in this study,and 40 rats were randomly divided into 2 groups:EPO group and model group.The EPO group was treated with EPO once a day for 5 days at a dose of 5 000 IU/kg body weight.The model group was treated with saline of the same amount.At day 3 after EPO (or saline) treatment,the right facial nerves of the 40 rats were transected at the level of the stylomastoid foramen,with the left sides untreated.The remaining 2 rats that did not undergo axotomy served as the control group.The surviving motor neurons in operated rats were counted in coronal paraffin sections of the facial nucleus.The expression of TNF-α and Bax in the facial nucleus was detected by immunohistochemical staining at days 3,7,14,21,and 28 after axotomy.At days 14,21,and 28 after facial nerve axotomy,a significantly greater proportion of facial motor neurons survived in the EPO group than in the model group.After axotomy,the expression of TNF-α and Bax increased in motor neurons in both the EPO and the model groups.TNF-α expression reached its peak level at day 14 after axotomy,while Bax expression reached its peak level at day 21.TNF-α expression was much lower in the EPO group than in the model group at all time points.No significant difference in Bax expression was found between the EPO and the model groups.These results indicate that high-dose EPO treatment attenuates the increase in TNF-α expression in the facial nucleus and reduces the loss of motor neurons after facial nerve transection in rats.However,high-dose EPO treatment has little effect on Bax expression. | Wei Zhang Shengyu Lue Ziying Yu Ming Bi Bin Sun | 2011 | Neural Regeneration Research2011，6，6： | 6 |
| 7 | s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide显示文摘Hand-foot skin reaction(HFSR),among the most significant adverse effects of sorafenib,has been limiting the clinical benefits of this frontline drug in treating various malignant tumors.The mechanism underlying such toxicity remains poorly understood,hence the absence of effective intervention strategies.In the present study,we show that vascular endothelial cells are the primary cellular target of sorafenib-induced HFSR wherein soluble heparin-binding epidermal growth factor(s-HBEGF)mediates the crosstalk between vascular endothelial cells and keratinocytes.Mechanistically,s-HBEGF released from vascular endothelial cells activates the epidermal growth factor receptor(EGFR)on keratinocytes and promotes the phosphorylation of c-Jun N-terminal kinase 2(JNK2),which stabilizes sirtuin 1(SIRT1),an essential keratinization inducer,and ultimately gives rise to HFSR.The administration of s-HBEGF in vivo could sufficiently induce hyper-keratinization without sorafenib treatment.Furthermore,we report that HBEGF neutralization antibody,Sirtl knockdown,and a classic SIRTI inhibitor nicotinamide could all significantly reduce the sorafenib-induced HFSR in the mouse model.It is noteworthy that nicotinic acid,a prodrug of nicotinamide,could substantially reverse the sorafenib-induced HFSR in ten patients in a preliminary clinical study.Collectively,our findings reveal the mechanism of vascular endothelial cell-promoted keratinization in keratinocytes and provide a potentially promising therapeutic strategy for the treatment of sorafenib-induced HFSR. | Peihua Luo Hao Yan Xueqin Chen Ying Zhang Ziying Zhao Ji Cao Yi Zhu Jiangxia Du Zhifei Xu Xiaochen Zhang Su Zeng Bo Yang Shenglin Ma Qiaojun He | 2020 | Cell Research2020，30，9： | 5 |
| 8 | A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer显示文摘Objective:To compare the efficacy and safety of hyperthermic intravesical chemotherapy(HIVEC)and intravesical chemotherapy(IVEC)in patients with intermediate and high risk nonmuscle-invasive bladder cancer(NMIBC)after transurethral resection.Methods:We included 560 patients diagnosed with primary or recurrent NMIBC between April 2009 and December 2015 at 1 of 6 tertiary centers.We matched 364 intermediate or high risk cases and divided them into 2 groups:the HIVEC+IVEC group[chemohyperthermia(CHT)composed of 3 consecutive sessions followed by intravesical instillation without hyperthermia]and the IVEC group(intravesical instillation without hyperthermia).The data were recorded in the database.The primary endpoint was 2-year recurrence-free survival(RFS)in all NMIBC patients(n=364),whereas the secondary endpoints were the assessment of radical cystectomy(RC)and 5-year overall survival(OS).Results:There was a significant difference in the 2-year RFS between the two groups in all patients(n=364;HIVEC+IVEC:82.42%vs.IVEC:74.18%,P=0.038).Compared with the IVEC group,the HIVEC+IVEC group had a lower incidence of RC(P=0.0274).However,the 5-year OS was the same between the 2 groups(P=0.1434).Adverse events(AEs)occurred in 32.7%of all patients,but none of the events was serious(grades 3–4).No difference in the incidence or severity of AEs between each treatment modality was observed.Conclusions:This retrospective study showed that HIVEC+IVEC had a higher 2-year RFS and a lower incidence of RC than IVEC therapy in intermediate and high risk NMIBC patients.Both treatments were well-tolerated in a similar manner. | Qiang Ruan Degang Ding Bin Wang Chaohong He Xuequn Ren Zhenhua Feng Zhigang Pang Jin Wang Xiangliang Zhang Hongsheng Tang Jiahong Wang Qingjun He Ziying Lei Quanxing Liao Jiali Luo Shuzhong Cui | 2021 | Cancer Biology & Medicine2021，18，1： | 4 |
| 9 | Microbial electro-fermentation for synthesis of chemicals and biofuels driven by bi-directional extracellular electron transfer显示文摘Electroactive bacteria could perform bi-directional extracellular electron transfer(EET)to exchange electrons and energy with extracellular environments,thus playing a central role in microbial electro-fermentation(EF)process.Unbalanced fermentation and microbial electrosynthesis are the main pathways to produce value-added chemicals and biofuels.However,the low efficiency of the bi-directional EET is a dominating bottleneck in these processes.In this review,we firstly demonstrate the main bi-directional EET mechanisms during EF,including the direct EET and the shuttle-mediated EET.Then,we review representative milestones and progresses in unbalanced fermentation via anode outward EET and microbial electrosynthesis via inward EET based on these two EET mechanisms in detail.Furthermore,we summarize the main synthetic biology strategies in improving the bi-directional EET and target products synthesis,thus to enhance the efficiencies in unbalanced fermentation and microbial electrosynthesis.Lastly,a perspective on the applications of microbial electro-fermentation is provided. | Ziying Gong Huan Yu Junqi Zhang Feng Li Hao Song | 2020 | Synthetic and Systems Biotechnology2020，5，4： | 4 |
| 10 | Uranium Metallogenic Regionalization and Resource Potential in China显示文摘This paper is comprehensively involved in main types of uranium deposits and their general metallogenic characteristics, metallogenic fields, provinces, regions and belts, and uranium resources potential evaluation. Generally speaking, there are favorable conditions and good uranium resources potential for uranium mineralization in China. | LI Ziying ZHANG Jindai JIAN Xiaofei CAI Yuqi GUO Qingyin ZHU Pengfei | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 4 |
| 11 | Genetic relationships among Chinese and American isolates of Phytophthora sojaeassessed by RAPD markers显示文摘The genetic diversity of three geo- graphic populations of Phytophthora sojae from China and the United States was determined using random amplified polymorphic DNA (RAPD). The purpose was to explore genetic relationships among Chinese and American isolates of the organism. 21 random primers were selected among 200 random primers screened. A total of 223 reproducible RAPD fragments were scored among 111 individuals, of which 199 (89.23%) were polymorphic. Analysis of genetic variation showed that there existed higher genetic variation in the United States population in comparison to the Chinese populations. Nei’s genetic identity and principal component analysis indicated that the populations of Fujian and United States are closer to each other than to Heilongjiang populations. Shannon-Wiener diversity index revealed that the United States populations have a higher genetic di- versity than that of Chinese populations. These data are in support of the hypothesis that P. sojae in the United States might not have been introduced from China. | WANG Ziying WANG Yuanchao ZHANG Zhengguang ZHENG Xiaobuo | 2006 | Chinese Science Bulletin2006，51，17： | 4 |
| 12 | Variation of dependence of the cusp location at different altitude on the dipole tilt显示文摘Using the Cluster cusp crossings data,dependence of the cusp location at the mid-altitude on the geomagnetic dipole tilt during northward IMF is studied.The results show that the cusp center moves 0.051°Invariant Latitude(ILAT)upon the increase of 1°in the dipole tilt angle at the average altitude of 5.8 RE(Earth radius).According to the present results obtained at the altitude of the Cluster orbit and previous results obtained at other altitudes of other satellite orbits,it is found that the higher the altitude in the cusp region is,the bigger the dependence of cusp location on the dipole tilt angle will be.If the altitude increases by 1 RE in the cusp region,the dependence will increase by 0.012°ILAT upon the increase of 1°in the dipole tilt angle.Some possible physical mechanisms are discussed and it shows that the cusp location will be more sensitive to the solar wind dynamic pressure if the altitude is high. | GUO JianGuang SHI JianKui CHENG ZhengWei ZHANG ZiYing WANG Zheng ZHANG TieLong LIU ZhenXing DUNLOP Malcolm | 2013 | Chinese Science Bulletin2013，58，28： | 3 |
| 13 | Studies on QCM-type NO2 Gas Sensor Based on Graphene Composites at Room Temperature显示文摘Synthetic graphene composite was modified on a transducer of quartz crystal microbalance(QCM) tofabricate a gas sensor for low concentration nitrogen dioxide(NO2) detection. The gas sensing properties of the QCMcoated with SnO2-rGO and AgNPs-SnO2-rGO composites were investigated when exposing QCM to low NO2 con-centration(2.05--20.5 mg/m3) atmosphere at room temperature. The sensing performances of ,he QCM withAgNPs-SnO2-rGO composites were enhanced by the introduction of Ag nanoparticles, and the QCM modified withAgNPs-SnO2-rGO composites could detect NO2 at room temperature. | QI Pengjia WANG Ziying WANG Rui XU Yinan ZHANG Tong | 2016 | Chemical Research in Chinese Universities2016，32，6： | 2 |
| 14 | Update Chain-based Approach for Checking Route Oscillation of BGP显示文摘This paper presents a novel approach for checking route oscillation of border gateway protocol(BGP) quickly,by which the privacy of routing policies of autonomous system(AS) can be respected.Firstly,route update chain tag(RUCT) is constructed to track the forwarding of update report,and local routing library is made to record the changing history of update report.Then route oscillation can be identified by analyzing correlative state of RUCT and local routing library.The characteristic of this approach is that an arbitrary AS can check route oscillation alone only by sharing its network ID,which greatly respects the pri-vacy of routing policies for each AS.This paper shows that both looping in RUCT and consecutive positive-negative report in local record are sufficient conditions for route oscillation.Comparative experiments demonstrate the availability and efficiency of the proposed approach. | ZHANG Jun | 2011 | Chinese Journal of Aeronautics2011，24，2： | 2 |
| 15 | Uranium Potential and Regional Metallogeny in China显示文摘这份报纸简短涉及中国的铀 metallogenic 类型,省,区域和带的分布。八个目标区域被指出了值得为铀资源勘探。地区性的铀 metallogeny 被讨论,大铀潜力从许多方面指出了。一般来说,有有利条件让铀矿化作用和好观点为铀资源探索。 | ZHANG Jindai LI Ziying | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 2 |
| 16 | Effects of taurocholic acid on immunoregulation in mice显示文摘 | Caiyun Wang Lei Li Hong Guan Saiyinna Tong Mingqiang Liu Chang Liu Ziying Zhang Chenguang Du Peifeng Li | 2012 | International Immunopharmacology2012，，： | 2 |
| 17 | Some properties of field-aligned electron events in high-altitude polar regions显示文摘Using data from the Cluster spacecraft from January 2003 to December 2004, we perform a statistical study on some properties of the field-aligned electron(FAE) events and interplanetary magnetic field(IMF) By dependence of FAE events with different durations in high-altitude polar regions. A total of 1335 FAE events were observed by the C3 spacecraft. More down-flowing events were observed in the Southern Hemisphere, and more up-flowing events were observed in the Northern Hemisphere. It proves that down-flowing events mainly originate from magnetosphere or solar wind and up-flowing events are mainly derived from ionosphere. Short-lifetime events showed a morning concentration in the magnetic local time distribution, and long-lifetime events were concentrated both before and after noon. For the IMF By dependence of the FAE events, short-lifetime events were much affected by IMF By and resulted in a morning concentration, while the long-lifetime events were almost unaffected by IMF By. With further analysis, we determined that the short-lifetime and long-lifetime events had different sources. | ZHANG ZiYing SHI JianKui ZHOU MingQuan CHENG ZhengWei ZHOU Hua | 2016 | Science China Earth Sciences2016，59，2： | 1 |
| 18 | Eco-efficiency Analysis of Industrial System in China: A Data Envelopment Analysis Approach 显示文摘 | Zhang Bing Bi Jun Fan Ziying | 2008 | Ecological Economics2008，68，1： | 1 |
| 19 | Eco-efficiency analysis of industrial system in China: A data envelopment analysis approach显示文摘 | Bing Zhang Jun Bi Ziying Fan Zengwei Yuan Junjie Ge | 2008 | Ecological Economics2008，，1： | 1 |
| 20 | A microporous platinum counter electrode used in dye-sensitized solar cells显示文摘 | Ziying Tang Jihuai Wu Min Zheng Jinhao Huo Zhang Lan | 2013 | Nano Energy2013，，5： | 1 |
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