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| 1 | Effect of direct current pulse stimulating acupoints of JiaJi (T10-L3) and Ciliao (BL 32) with Han's Acupoint Nerve Stimulator on labour pain in women: a randomized controlled clinical study显示文摘OBJECTIVE: To assess the clinical effect and safety of direct current(DC) pulse produced by Han's Acupoint Nerve Stimulator in reduction(HANS) of labor pain.METHODS: Totally 120 participants were enrolled in this clinical trial, and were randomly divided into4 groups including: HANS group, patient controlled intravenous analgesia(PCIA) group, patient-controlled epidural analgesia(PCEA) group and control group. The HANS group was treated by stimulating the acupoints of Jia Ji(T10-L3) and Ciliao(BL 32)with DC pulse of 100 Hz and 15-30 m A produced by a portable battery-powered Han's Acupoint Nerve Stimulator for 30 min. The PCIA group was intravenously infused Ondansetron(8 mg) for 5 min,then tramadol injection(1.5 mg/kg) was slowly dripped by using Baxter APⅡ electronic pump with50 m L tramadol(0.70%) + ondansetron(8 mg),background infusion 2 m L/h, PCA dose of 2 m L,lockout interval of 10 min. In PCEA group, women received intrathecal injection ropivacaine(3 mg) in L2-3, and epidural catheter was connected to Baxter APⅡ electronic pump, with 100 m L Ropivacaine(0.1%) and Sufentanil(50 ug), background infusion5 m L, Patient controlled analgesia(PCA) dose of 5m L, lockout interval of 10 min. The control group was not received analgesia. The visual analogue scale(VAS), stage and manner of labor, Apgar score of newborn, neonatal weights, oxytocin dosage,postpartum hemorrhage and side effects were monitored in all groups.RESULTS: The vital signs were all stable in the four analgesic groups. After analgesia, there was statistical difference in VAS score between HANS group and control group, between PCEA group and the control group, between PCIA group and control group. The analgesic effect in the PCEA group was significantly better than that of other two groups.The second stage of labor in the PCEA group was longer than the other three groups, showing significant difference between them. The Apgar score of newborn 1min after birth in the PCIA group was slightly lower than that of the other two groups,showing significant difference between them. The neonatal weights between four groups were not significantly different. The rate of cesarean sectionin the control group was significantly higher than that of the labor analgesia group, there was statistically difference in four groups. The number of PCIA group that used oxytocin was lower than that of other three groups. There was no significant difference in postpartum hemorrhage between four groups. The side effects of the PCEA group were itching, uroschesis and neonatal asphyxia and PCIA group were nausea and vomiting and neonatal asphyxia. However, fewer side effects were observed in the HANS group.CONCLUSION: The DC pulse produced by HANS may be a non-pharmacological alternative to labor pain with fewer side effects. | Liu Ye Xu Mingjun Che Xiangming He Junqin Guo Dandan Zhao Guosheng Zhang Guogang Zhang Shuo Kang Kai Zhang Chunlei Wang Yinan Li Shan Zhang Qinglin Xu Li Zhang Ming Han Bin Jing Yumiao Zhang Ning | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 4 |
| 2 | Hotspots of Independent and Multiple Rounds of LTR-retrotransposon Bursts in Brassica Species显示文摘Long terminal repeat retrotransposons(LTR-RTs) are a predominant group of plant transposable elements(TEs) that are an important component of plant genomes. A large number of LTR-RTs have been annotated in the genomes of the agronomically important oil and vegetable crops of the genus Brassica. Herein, full-length LTR-RTs in the genomes of Brassica and other closely related species were systematically analyzed. The full-length LTR-RT content varied greatly(from 0.43% to 23.4%) between different species, with Gypsy-like LTR-RTs constituting a primary group across these genomes. More importantly, many annotated LTR-RTs(from 10.03% to 33.25% of all detected LTR-RTs) were found to be enriched in localized hotspot regions. Furthermore, all of the analyzed species showed evidence of having experienced at least one round of a LTR-RT burst, with Raphanus sativus experiencing three or more. Moreover, these relatively ancient LTR-RT amplifications exhibited a clear expansion at specific time points. To gain a further understanding of this timing, Brassica rapa, B. oleracea, and R. sativus were examined for the presence of syntenic regions, but none were present. These findings indicate that these LTR-RT burst events were not inherited from a common ancestor,but instead were species-specific bursts that occurred after the divergence of Brassica species. This study further exemplifies the complexities of TE amplifications during the evolution of plant genomes and suggests that these LTR-RT bursts play an important role in genome expansion and divergence in Brassica species. | CAI Xu CUI Yinan ZHANG Lei WU Jian LIANG Jianli CHENG Lin WANG Xiaowu CHENG Feng | 2018 | Horticultural Plant Journal2018，4，4： | 3 |
| 3 | Electrospinning in membrane contactor:manufacturing Elec-PVDF/SiO2 superhydrophobic surface for efficient flue gas desulphurization applications显示文摘In membrane contactors,maintaining a high SO_(2)absorption flux and an excellent wetting resistance are crucial for hazardous gas removal.In this study,we adopted an electrospinning strategy to fabricate highly robust superhydrophobic dual-layer Elec-PVDF/SiO_(2)composite membrane contactors used for flue gas desulfurization.The composite membrane contactor consisted of a durable and ultrathin three-dimensional(3D)superhydrophobic surface and a porous supporting layer,where the formulation was optimized by regulating the PVDF concentration,solvent ratio and SiO_(2)particles content in electrospinning solution.The scanning electronic microscopy(SEM),EDS-mapping,water contact angle(WCA)and surface roughness of as-prepared Elec-PVDF/SiO_(2)composite membrane contactors were conducted to explore the physical and chemical structure.The SiO_(2)nanoparticles were uniformly loaded in ElecPVDF/SiO_(2)composite membrane contactor,and constructed micro-nano dual-coarse lotus-leaf-like morphology,which noticeably elevated surface roughness(Ra).The SiO_(2)nanoparticles also functioned as hydrophobic modifiers,which boosted the WAC up to 155.The SO_(2)absorption fluxes and SO_(2)removal efficiencies were investigated.In particular,the membrane contactor doped with 20 wt%SiO_(2)nanoparticles significantly elevated the stability of desulfurization performance.Besides,the membrane mass transfer coefficient(Km)and corresponding membrane mass transfer resistance(H/Km)were explored. | Qingping Xin Kaiqiang Xie Qingqing Liang Xu Li Yinan Zeng Yuhang Zhao Lei Zhang Shaofei Wang Hong Li Yuzhong Zhang | 2021 | Green Chemical Engineering2021，2，1： | 3 |
| 4 | Segmental Translocation Contributed to the Origin of the Brassica S-locus显示文摘Self-incompatibility(SI),which has recurred during the evolution of plants,is one of the most important cross-pollination mating systems.Three S-loci have been reported in Brassicaceae,namely,Arabidopsis lyrata(Al),Brassica(Br),and Leavenworthia alabamica(La)S-loci.Here,through multi-genomic comparative analysis of 20 species,we revealed that the most ancient S-locus was formed prior to the divergence of Brassicaceae lineage I and II.Itwas retained and inherited by Arabidopsis,as the Al S-locus in Brassicaceae lineage I.Furthermore,we found that the Br S-locus,which has been widely used in the breeding of Brassica crops to generate hybrid seeds,was formed through segmental translocation(ST)in the hexaploid ancestor of Brassica in Brassicaceae lineage II.The Br S-locus was evolved through a ST from one of the triplicated ancestral S-locus paralogs in the Brassica hexaploidy ancestor,while the other two S-locus paralogs were lost.Together with the previous discovery that the La S-locus was formed through a secondary origin in Brassicaceae lineage I,we conclude the monophyletic origin of Al and Br S-loci and clarify the evolutionary route of S-loci in the Brassicaceae family.Our findings will contribute to evolutionary studies and breeding applications of the S-locus in Brassicaceae. | Yinan Cui Mu Zhuang Jian Wu Jisheng Liu Yiyue Zhang Lingkui Zhang Yile Huang Xu Cai Jianli Liang Kang Zhang Xiaowu Wang Feng Cheng | 2020 | Horticultural Plant Journal2020，6，3： | 2 |
| 5 | Studies on QCM-type NO2 Gas Sensor Based on Graphene Composites at Room Temperature显示文摘Synthetic graphene composite was modified on a transducer of quartz crystal microbalance(QCM) tofabricate a gas sensor for low concentration nitrogen dioxide(NO2) detection. The gas sensing properties of the QCMcoated with SnO2-rGO and AgNPs-SnO2-rGO composites were investigated when exposing QCM to low NO2 con-centration(2.05--20.5 mg/m3) atmosphere at room temperature. The sensing performances of ,he QCM withAgNPs-SnO2-rGO composites were enhanced by the introduction of Ag nanoparticles, and the QCM modified withAgNPs-SnO2-rGO composites could detect NO2 at room temperature. | QI Pengjia WANG Ziying WANG Rui XU Yinan ZHANG Tong | 2016 | Chemical Research in Chinese Universities2016，32，6： | 2 |
| 6 | HIV-1 Vif suppresses antiviral immunity by targeting STING显示文摘HIV-1 infection-induced cGAS–STING–TBK1–IRF3 signaling activates innate immunity to produce type I interferon(IFN).The HIV-1 nonstructural protein viral infectivity factor(Vif)is essential in HIV-1 replication,as it degrades the host restriction factor APOBEC3G.However,whether and how it regulates the host immune response remains to be determined.In this study,we found that Vif inhibited the production of type I IFN to promote immune evasion.HIV-1 infection induced the activation of the host tyrosine kinase FRK,which subsequently phosphorylated the immunoreceptor tyrosine-based inhibitory motif(ITIM)of Vif and enhanced the interaction between Vif and the cellular tyrosine phosphatase SHP-1 to inhibit type I IFN.Mechanistically,the association of Vif with SHP-1 facilitated SHP-1 recruitment to STING and inhibited the K63-linked ubiquitination of STING at Lys337 by dephosphorylating STING at Tyr162.However,the FRK inhibitor D-65495 counteracted the phosphorylation of Vif to block the immune evasion of HIV-1 and antagonize infection.These findings reveal a previously unknown mechanism through which HIV-1 evades antiviral immunity via the ITIM-containing protein to inhibit the posttranslational modification of STING.These results provide a molecular basis for the development of new therapeutic strategies to treat HIV-1 infection. | Yu Wang Gui Qian Lingyan Zhu Zhuo Zhao Yinan Liu Wendong Han Xiaokai Zhang Yihua Zhang Tingrong Xiong Hao Zeng Xianghui Yu Xiaofang Yu Xiaoyan Zhang Jianqing Xu Quanming Zou Dapeng Yan | 2022 | Cellular & Molecular Immunology2022，19，1： | 2 |
| 7 | Knowledge-aware path: interpretable graph reasoning in proactive dialogue generation显示文摘Proactive dialogue generates dialogue utterance based on a conversation goal and a given knowledge graph(KG). Existing methods combine knowledge of each turn of dialogue with knowledge triples by hidden variables, resulting in the interpretability of generation results is relatively poor. An interpretable knowledge-aware path(KAP) model was proposed for knowledge reasoning in proactive dialogue generation.KAP model can transform explicit and implicit knowledge of each turn of dialogue into corresponding dialogue state matrix, thus forming the KAP for dialogue history. Based on KAP, the next turn of dialogue state vector can be infered from both the topology and semantic of KG. This vector can indicate knowledge distribution of next sentence, so it enhances the accuracy and interpretability of dialogue generation. Experiments show that KAP model’s dialogue generation is closer to actual conversation than other state-of-the-art proactive dialogue models. | Sun Yinan Xu Yajing Li Si Guo Jun | 2021 | The Journal of China Universities of Posts and Telecommunications2021，28，1： | 2 |
| 8 | Solubility determination and thermodynamic modeling of bis-2-hydroxyethyl terephthalate(BHET)in different solvents显示文摘Studies on the degradation process of waste polyethylene terephthalate(PET)have become increasingly mature,but there are relatively few studies on the separation of degradation products.The products contain many components and the separation of which is difficult.Therefore,the study on phase equilibrium thermodynamics of bis-2-hydroxyethyl terephthalate(BHET)is of great theoretical significance and practical value to provide basic data for the BHET crystallization separation.In this work,the degraded products were purified and characterized.The solubility of BHET in methanol,ethanol,ethylene glycol,water and the mixture of ethylene glycol+water were determined by static method.The experimental results were correlated with different models,such as ideal solution(IS)model,λh equation,Apelblat equation and NRTL model.Based on the van’t Hoff equation,the mixing Gibbs energy,enthalpy and entropy were calculated.From this work,the basic data which can be used to guide the crystallization process of BHET were obtained,including solubility data,correlation model and thermodynamic properties. | Haoyu Yao Dongxia Yan Xingmei Lu Qing Zhou Yinan Bao Junli Xu | 2022 | Chinese Journal of Chemical Engineering2022，35，5： | 1 |
| 9 | Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation显示文摘One major strategy to generate genetically modified mouse models is gene targeting in mouse embryonic stem(ES)cells,which is used to produce gene-targeted mice for wide applications in biomedicine.However,a major bottleneck in this approach is that the robustness of germiine transmission of gene-targeted ES cells can be significantly reduced by their genetic and epigenetic instability after long-term culturing,which impairs the efficiency and robustness of mouse model generation.Recently,we have established a new type of pluripotent cells termed extended pluripotent stem(EPS)cells,which have superior developmental potency and robust germline competence compared to conventional mouse ES cells.In this study,we demonstrate that mouse EPS cells well maintain developmental potency and genetic stability after long-term passage.Based on gene targeting in mouse EPS cells,we established a new approach to directly and rapidly generate gene-targeted mouse models through tetraploid complementation,Haibo Li and Chaoran Zhao contributed equally to this work.Electronic supplementary material The online version of this article(http://gffzzd3cc09b8251d45dfs9x66qc0wobxx6opu.ffgz.tsg.suse.edu.cn/10.1007/s13238-018-0556-1)contains supplementary material,which is available to authorized users.which could be accomplished in approximately 2 months.Importantly,using this approach,we successfully constructed mouse models in which the human interleukin 3(IL3)or interleukin 6(IL6)gene was knocked into its corresponding locus in the mouse genome.Our study demonstrates the feasibility of using mouse EPS cells to rapidly generate mouse models by gene targeting,which have great application potential in biomedical research. | Haibo Li Chaoran Zhao Jun Xu Yaxing Xu Chunmei Cheng Yinan Liu Ting Wang Yaqin Du Liangfu Xie Jingru Zhao Yanchuang Han Xiaobao Wang Yun Bai Hongkui Deng | 2019 | Protein & Cell2019，10，1： | 1 |
| 10 | Saponins from Platycodi Radix ameliorate high fat diet-induced obesity in Mice 显示文摘 | Han Likun Zheng Yinan Xu Baojun | 2002 | J Nutr2002，132，： | 1 |
| 11 | Derivation of totipotent-like stem cells with blastocyst-like structure forming potential显示文摘It is challenging to derive totipotent stem cells in vitro that functionally and molecularly resemble cells from totipotent embryos.Here,we report that a chemical cocktail enables the derivation of totipotent-like stem cells,designated as totipotent potential stem(TPS)cells,from 2-cell mouse embryos and extended pluripotent stem cells,and that these TPS cells can be stably maintained long term in vitro.TPS cells shared features with 2-cell mouse embryos in terms of totipotency markers,transcriptome,chromatin accessibility and DNA methylation patterns.In vivo chimera formation assays show that these cells have embryonic and extraembryonic developmental potentials at the single-cell level.Moreover,TPS cells can be induced into blastocyst-like structures resembling preimplantation mouse blastocysts.Mechanistically,inhibition of HDAC1/2 and DOT1L activity and activation of RARγsignaling are important for inducing and maintaining totipotent features of TPS cells.Our study opens up a new path toward fully capturing totipotent stem cells in vitro. | Yaxing Xu Jingru Zhao Yixuan Ren Xuyang Wang Yulin Lyu Bingqing Xie Yiming Sun Xiandun Yuan Haiyin Liu Weifeng Yang Yenan Fu Yu Yu Yinan Liu Rong Mu Cheng Li Jun Xu Hongkui Deng | 2022 | Cell Research2022，32，6： | 1 |
| 12 | Phase I study of icotinib hydrochloride (BPI-2009H), an oral EGFR tyrosine kinase inhibitor, in patients with advanced NSCLC and other solid tumors显示文摘 | Qiong Zhao Jianzhong Shentu Nong Xu Jianya Zhou Guangdie Yang Yinan Yao Fenlai Tan Dongyang Liu Yingxiang Wang Jianying Zhou | 2010 | Lung Cancer2010，，2： | 1 |
| 13 | Integrative Analysis of Genome,3D Genome,and Transcriptome Alterations of Clinical Lung Cancer Samples显示文摘Genomic studies of cancer cell alterations,such as mutations,copy number variations(CNVs),and translocations,greatly promote our understanding of the genesis and development of cancers.However,the 3D genome architecture of cancers remains less studied due to the complexity of cancer genomes and technical difficulties.To explore the 3D genome structure in clinical lung cancer,we performed Hi-C experiments using paired normal and tumor cells harvested from patients with lung cancer,combining with RNA sequenceing analysis.We demonstrated the feasibility of studying 3D genome of clinical lung cancer samples with a small number of cells(1×10^(4)),compared the genome architecture between clinical samples and cell lines of lung cancer,and identified conserved and changed spatial chromatin structures between normal and cancer samples.We also showed that Hi-C data can be used to infer CNVs and point mutations in cancer.By integrating those different types of cancer alterations,we showed significant associations between CNVs,3D genome,and gene expression.We propose that 3D genome mediates the effects of cancer genomic alterations on gene expression through altering regulatory chromatin structures.Our study highlights the importance of analyzing 3D genomes of clinical cancer samples in addition to cancer cell lines and provides an integrative genomic analysis pipeline for future larger-scale studies in lung cancer and other cancers. | Tingting Li Ruifeng Li Xuan Dong Lin Shi Miao Lin Ting Peng Pengze Wu Yuting Liu Xiaoting Li Xuheng He Xu Han Bin Kang Yinan Wang Zhiheng Liu Qing Chen Yue Shen Mingxiang Feng Xiangdong Wang Duojiao Wu Jian Wang Cheng Li | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 1 |
| 14 | Inverse design and realization of an optical cavity-based displacement transducer with arbitrary responses显示文摘Optical cavity has long been critical for a variety of applications ranging from precise measurement to spectral analysis.A number of theories and methods have been successful in describing the optical response of a stratified optical cavity,while the inverse problem,especially the inverse design of a displacement sensitive cavity,remains a significant challenge due to the cost of computation and comprehensive performance requirements.This paper reports a novel inverse design methodology combining the characteristic matrix method,mixed-discrete variables optimization algorithm,and Monte Carlo method-based tolerance analysis.The material characteristics are indexed to enable the mixed-discrete variables optimization,which yields considerable speed and efficiency improvements.This method allows arbitrary response adjustment with technical feasibility and gives a glimpse into the analytical characterization of the optical response.Two entirely different light-displacement responses,including an asymmetric sawtooth-like response and a highly symmetric response,are dug out and experimentally achieved,which fully confirms the validity of the method.The compact Fabry-Perot cavities have a good balance between performance and feasibility,making them promising candidates for displacement transducers.More importantly,the proposed inverse design paves the way for a universal design of optical cavities,or even nanophotonic devices. | Qianbo Lu Qingxiong Xiao Chengxiu Liu Yinan Wang Qixuan Zhu Manzhang Xu Xuewen Wang Xiaoxu Wang Wei Huang | 2023 | Opto-Electronic Advances2023，6，3： | 0 |
| 15 | The Novel Instance Segmentation Method Based on Multi-Level Features and Joint Attention显示文摘Instance segmentation is an important task in computer vision.In order to enhance the multi-level features expression ability of the segmentation networks,a novel module is proposed in this paper.Firstly,we design a weighted bi-directional feature fusion way by computing the weight distribution function of bi-directional feature pyramid network.Secondly,we propose a joint attention mechanism to effectively filter different levels of feature information by adopting serial and parallel ways to combine the channel attention and spatial attention modules.At the same time,the module uses dynamic convolution to stabilize the calculation speed while improve the 6.7%mean average precision of segmentation.The experiments on the COCO dataset demonstrate that the module can effectively improve the performance of the existing instance segmentation networks. | XU Bowen LU Yinan WU Tieru GUO Xiaoxin | 2023 | Chinese Journal of Electronics2023，32，5： | 0 |
| 16 | Impacts of tropical cyclones and anthropogenic activities on marine vanadium: A unique perspective from high resolution Porites coral record显示文摘As a typical contaminant in fossil fuels,vanadium has undergone dramatically increase due to the impacts from human activities.The excessive anthropogenic vanadium emissions have altered natural geochemical processes.However,research on vanadium geochemistry in the ocean,which is the major sink for vanadium mobilized on land,has lagged much behind relative to those of other contaminants.Here we reconstruct historical patterns of vanadium in surface seawater utilizing a high-resolution temporal record(1984–2015 CE)of geochemical proxies(vanadium/calcium(V/Ca),δ^(18)O,δ^(13)C,etc.)in a Porites coral colony from an offshore non-estuarine island in the northern South China Sea(SCS).We find a close association between the surface winds and the temporal patterns of coral V/Ca ratios,revealing great potential for documenting prehistoric changes in tropical cyclones.Moreover,the coral V/Ca record remarkably captured the temporal patterns of anthropogenic activities,offering a valuable and novel tool for testing the efficacy of specific legislation on pollution prevention.Combined with the other reported coral vanadium data,we recovered the historical changes in vanadium emissions in the northern SCS and identified that changing industrial practices should be responsible for the differences in anthropogenic vanadium emissions at each stage.Our results demonstrated that the coral V/Ca ratio at a high temporal resolution has great potential as a new and direct geochemical proxy for tropical cyclones after removing artificial disturbances in the ocean. | Wei JIANG Xingyuan WU Kefu YU Haodan YANG Shendong XU Ning WANG Yangyang YONG Yinan SUN Chaoshuai WEI Yinghui WANG | 2022 | Science China Earth Sciences2022，65，12： | 0 |
| 17 | Molecular Switches and Multiple Logic Gates Based on 4-(2-Pyridylazo)resorcinol显示文摘一个简单结构的 4-(2-pyridylazo ) 树脂分(同等) 系统介绍有趣的性质与双荧光灯产量。由答案 pH 调制了二种可逆开关行为,“开关”和“在离开上”,与 PAR 系统被认识到。由外部刺激的不同联合刺激了,例如金属离子,紫外照耀和解决方案 pH,同等系统能包括三输入执行多重逻辑函数并且,二输入禁止并且在平行的组合“也不 / 并且”。设计系统的操作与高度很简单、检测敏感荧光灯信号。 | Zhanhui Tao Yinan Qin Yaqing Liu Lei Xu Erkang Wang | 2013 | Chinese Journal of Chemistry2013，31，6： | 0 |
| 18 | Epidemiology and characteristics of identified early mpox cases in Guangdong Province,China:Implications for prevention and control显示文摘In June 2023,the 2022 global mpox(monkeypox)outbreak began to affect Guangdong Province,one of the first regions in China's Mainland to report mpox cases.By July 10,2023,93 mpox cases had been reported in Guangdong Province.This study describes the epidemiological characteristics of these patients by collecting and analyzing data on demographics,sexual behavior,medical history,travel history,clinical symptoms,and diagnostic pathways and processes.The 93 mpox cases were all men aged 20-48 years,95.70%were men who have sex with men(MSM),and 48.39%were HIV-positive.A few cases were married(to women)or living with children.The rash was present in almost all cases(98.91%),with the most common sites being the genital and perianal areas(70.33%).Intimate sexual contact was suspected to be the main route of infection,with a median incubation period of 8.5 days(IQR 5.0–11.8).The number of cases increased rapidly,and most patients had no history of international travel,suggesting sustained community transmission within the MSM population in Guangdong Province.In addition,93.55%of cases were detected by medical institutions,and more than half of these patients had two or more hospital visits before being diagnosed as an mpox case,indicating that clinicians need further training to increase their sensitivity to mpox.Targeted interventions should prioritize MSM while remaining vigilant for transmission to other populations,such as women and children. | Yinan Zong Yuwei Yang Dongfeng Kong Jianxiong Xu Zimian Liang Fengxiang Shi Jianhua Huang Min Kang Haojie Zhong Wenjia Liang Yan Li | 2023 | Biosafety and Health2023，5，6： | 0 |
| 19 | Risk factors for anastomotic leakage after gastrectomy for Siewert type Ⅱ/Ⅲ adenocarcinoma of the esophagogastric junction:a retrospective case-control study显示文摘Objective:To identify risk factors for anastomotic leakage after gastrectomy in patients with Siewert type II/III adenocarcinoma(AEG)of the esophagogastric junction.Methods:This was a retrospective case-control study of 903 patients with Siewert type II/III AEG treated from January 2012 to January 2015 at the Shanxi Cancer Hospital in China.All patients underwent gastrectomy,and their clinical characteristics were analyzed to identify associations with anastomotic leakage.Independent risk factors were identified by binary logistic regression.The 2-year disease-free survival was calculated and compared between patients with anastomotic leakage and control patients.The study was approved by the Institutional Review Board of Shanxi Medical University(approval No.2014-09-39)on September 19,2014.Results:Out of the 903 patients were included in the study,80(8.86%,80/903)experienced anastomotic leakage.The mortality rate attributed to anastomotic leakage was 8.75%(7/80).Logistic regression analysis revealed that preoperative hypoalbuminemia(odds ratio(OR)=3.249,95%confidence interval(CI):1.569-6.725,P=0.002),type of reconstruction(OR=1.795,95%CI:1.026-3.142,P=0.040),and combined organ resection(OR=1.807,95%CI:1.069-3.055,P=0.027)were independent risk factors for anastomotic leakage.Conclusion:Preoperative hypoalbuminemia,type of reconstruction,and combined organ resection were identified as risk factors for anastomotic leakage in patients undergoing gastrectomy for Siewert type Ⅱ/Ⅲ AEG. | Yibo Li Yinan Shi Jun You Wenqing Hu Yingying Xu Haotang Wei Masanobu Abe Jiajia Cheng Liang Zong Jianhong Dong | 2021 | Journal of Bio-X Research2021，4，2： | 0 |
| 20 | Linking ecosystem services and economic development for optimizing land use change in the poverty areas显示文摘For the sustainable development of human beings and society,it is important to conserve the ecosystems and alleviate poverty in the low agricultural productivity or ecologically vulnerable areas.To avoid the decrease in ecosystem services(ES)under the effects associated with reducing poverty,we need to carefully consider the relationship between land use changes and the economic development in economically poor areas.We selected the Lingqiu County as our study area,which is a national impoverished county in China,and analyzed the impact of poverty alleviation efforts on the ecological and economic sustainability in the region through ES evaluation.The results showed that land use change in the Lingqiu County has not changed the ES significantly during 2007-2016.The gross domestic product(GDP)growth rate(15.81%)during 2001-2016,indicates the effectiveness of the poverty alleviation efforts implemented.The rise in the index of ecological and economic relationship during 2001-2016(from 0.2389 to 0.3629)maintains in a harmonious coordination situation.Presently,the value of ES has not been converted to market-based benefits,and therefore,it is indispensable to find a marketplace for ES(in an innovative way)to promote the high-quality sustainable development of a local economy. | Yinan Xu Jianing Wei Zhijun Li Yingxing Zhao Xinyu Lei Peng Sui Yuanquan Chen | 2021 | Ecosystem Health and Sustainability2021，7，1： | 0 |
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