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| 1 | Slice Data Based Support Generation Algorithm for Fused Deposition Modeling显示文摘This paper presents a robust algorithm to generate support for fused deposition modeling (FDM). Since many flaws appear in most stereo lithography (STL) models, this algorithm utilizes slice data as input. A top-down approach was used to calculate the support slice layer by layer. The generation algorithm was described in detail including the slice grouping, oriental bounding box (OBB) calculation, offsetting, and Boolean operations. Several cases are given to validate the efficiency and robustness of the procedure. The algorithm provides necessary support not only for hanging surface but also for hanging vertexes and edges with O(n) time complexity, where n is the number of layers. The algorithm fully utilizes the parts' self-support ability and reduces support volume to the maximum extent. This slice data based algorithm has the same efficiency as the STL based algorithm but is more stable, which significantly enhances the robustness of the support generation process. | 黄小毛 叶春生 莫健华 刘海涛 | 2009 | Tsinghua Science and Technology2009，14，S1： | 10 |
| 2 | A Study of Melt Flow Analysis of an ABS-Iron Composite in Fused Deposition Modelling Process显示文摘Fused deposition modelling (FDM) is a filament based rapid prototyping system which offers the possibility of introducing new composite material for the FDM process as long as the new material can be made in feedstock filament form. Swinburne has been undertaking extensive research in development of new composite materials involving acrylonitrile-butadiene-styrene (ABS) and other materials including metals. In order to predict the behaviour of new ABS based composite materials in the course of FDM process, it is necessary to investigate the flow of the composite material in liquefier head. No such study is available considering the geometry of the liquefier head. This paper presents 2-D and 3-D numerical analysis of melt flow behaviour of a representative ABS-iron composite through the 90-degree bent tube of the liquefier head of the fused deposition modelling process using ANSYS FLOTRAN and CFX finite element packages. Main flow parameters including temperature, velocity, and pressure drop have been investigated. Filaments of the filled ABS have been fabricated and characterized to verify the possibility of prototyping using the new material on the current FDM machine. Results provide promising information in developing the melt flow modelling of metal-plastic composites and in optimising the FDM parameters for better part quality with such composites. | MOSTAFA Nikzad SYED Hasan Masood IGOR Sbarski ANDREW Groth | 2009 | Tsinghua Science and Technology2009，14，S1： | 6 |
| 3 | A Stepwise Annulation for the Transformation of Cyclic Ketones to Fused 6 and 7-Membered Cyclic Enimines and Enones显示文摘The efficient construction of functionalized polycyclic structures is an imports nt objective in organic synthesis.Herein,we disclose a three-step'[2+n]'annulation method for the transformation of cyclic ketones to fused enimines and enones.The method relies on the Suzuki coupling reaction and the amide reductive alkenylation reaction.A series of fused bicyclic(6/6,6/7,8/7)and tricyclic(6/6/6;6/6/7,6/5/7)ring systems bearing an α,β-enimine or an α,β-enone functionality have been synthetized in good overall yields. | Dong-Ping Wu Qian He Dong-Huang Chen Jian-Liang Ye Pei-Qiang Huang | 2019 | Chinese Journal of Chemistry2019，37，4： | 6 |
| 4 | Complex formulations, simple techniques: Can 3D printing technology be the Midas touch in pharmaceutical industry?显示文摘3 D printing is a method of rapid prototyping and manufacturing in which materials are deposited onto one another in layers to produce a three-dimensional object. Although 3 D printing was developed in the 1980 s and the technology has found widespread industrial applications for production from automotive parts to machine tools,its application in pharmaceutical area is still limited. However,the potential of 3 D printing in the pharmaceutical industry is now being recognized. The ability of 3 D printing to produce medications to exact specifications tailored to the needs of individual patients has indicated the possibility of developing personalized medicines. The technology allows dosage forms to be precisely printed in various shapes,sizes and textures that are difficult to produce using traditional techniques. However,there are various challenges associated with the proper application of3 D printing in the pharmaceutical sector which should be overcome to exploit the scope of this technology. In this review,an overview is provided on the various 3 D printing technologies used in fabrication of complex dosage forms along with their feasibility and limitations. | Shrawani Lamichhane Santosh Bashyal Taekwang Keum Gyubin Noh Jo Eun Seo Rakesh Bastola Jaewoong Choi Dong Hwan Sohn Sangkil Lee | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，5： | 5 |
| 5 | Palladium-Catalyzed Asymmetric [4+3]-Cyclization Reaction of Fused 1-Azadienes with Amino-trimethylenemethanes: Highly Stereoselective Construction of Chiral Fused Azepines显示文摘Summary of main observation and conclusion A Pd-catalyzed asymmetric aromative[4+3]-cyclization reaction of amino-trimethylenemethanes(TMM,1d,ip3-oles)with fused 1-azadienes has been developed.This method enables access to the synthetically importance and biologically active benzofuran fused azepines and indeno-azepines in excellent efficiency and stereoselectivity(up to 95%yield,99%ee,>19:1 dr). | Prathibha Kumari Weiwei Liu Cheng-Jie Wang Jun Dai Mei-Xin Wang Qi-Qiong Yang Yu-Hua Deng Zhihui Shao | 2020 | Chinese Journal of Chemistry2020，38，2： | 5 |
| 6 | On-machine Precision Preparation and Dressing of Ball-headed Diamond Wheel for the Grinding of Fused Silica显示文摘In the grinding of high quality fused silica parts with complex surface or structure using ball-headed metal bonded diamond wheel with small diameter,the existing dressing methods are not suitable to dress the ball-headed diamond wheel precisely due to that they are either on-line in process dressing which may causes collision problem or without consideration for the effects of the tool setting error and electrode wear.An on-machine precision preparation and dressing method is proposed for ball-headed diamond wheel based on electrical discharge machining.By using this method the cylindrical diamond wheel with small diameter is manufactured to hemispherical-headed form.The obtained ball-headed diamond wheel is dressed after several grinding passes to recover geometrical accuracy and sharpness which is lost due to the wheel wear.A tool setting method based on high precision optical system is presented to reduce the wheel center setting error and dimension error.The effect of electrode tool wear is investigated by electrical dressing experiments,and the electrode tool wear compensation model is established based on the experimental results which show that the value of wear ratio coefficient K' tends to be constant with the increasing of the feed length of electrode and the mean value of K' is 0.156.Grinding experiments of fused silica are carried out on a test bench to evaluate the performance of the preparation and dressing method.The experimental results show that the surface roughness of the finished workpiece is 0.03 μm.The effect of the grinding parameter and dressing frequency on the surface roughness is investigated based on the measurement results of the surface roughness.This research provides an on-machine preparation and dressing method for ball-headed metal bonded diamond wheel used in the grinding of fused silica,which provides a solution to the tool setting method and the effect of electrode tool wear. | CHEN Mingjun LI Ziang YU Bo PENG Hui FANG Zhen | 2013 | Chinese Journal of Mechanical Engineering2013，26，5： | 5 |
| 7 | Selenophene-Flanked Diketopyrrolopyrrole Based Conjugated Polymers for Ambipolar Field-Effect Transistors显示文摘Summary of main observation and conclusion The development of selenophene-flanked DPP(SeDPP)based copolymers,especially for the ambipolar ones,lags behind other aromatic group flanked DPP-based polymers.Herein,we report two new ambipolar SeDPP-based conjugated polymers.One is the alternating polymer PSeDPPFT with normal SeDPP and 3,4-difluorothiophene units.The other is PSeFDFT,in which the electron acceptor unit is replaced by a new SeDPP derivative,referred as to half-fused SeDPP.The more planar structure of half fused SeDPP endows the backbone of PSeFDFT with good rigidity and planarity.Both polymers exhibit ambipolar transporting properties in air.The PSeFDFT based fleld-effect transistors(FETs)display higher and more balanced ambipolar properties with μnave of 0.27 cm2·V-1·s-1,μe ave of 0.18 cm2·V-1·s-1,and μh ave/μeave of 1.5 than those of PSeDPPFT(μhave=0.11cm2·V-1·s-1,μeave=0.042cm2·V-1·s-1,and μh/μe=2.6).This is attributed to the more planar structure,lower LUMO level,higher HOMO level,and better interchain packing orientations of PSeFDFT by comparing with PSeDPPFT.Therefore,a new molecular design strategy to modulate the hole and electron transporting properties is proposed for conjugated D-A polymers. | Dandan Shi Xiaobo Yu Liangliang Chen Daoliang Chen Zitong Liu Xisha Zhang Guanxin Zhang Deqing Zhang | 2020 | Chinese Journal of Chemistry2020，38，10： | 4 |
| 8 | L-Plastin deficiency produces increased trabecular bone due to attenuation of sealing ring formation and osteoclast dysfunction显示文摘Bone resorption requires the formation of complex, actin-rich cytoskeletal structures. During the early phase of sealing ring formation by osteoclasts, L-plastin regulates actin-bundling to form the nascent sealing zones(NSZ). Here, we show that L-plastin knockout mice produce osteoclasts that are deficient in the formation of NSZs, are hyporesorptive, and make superficial resorption pits in vitro. Transduction of TAT-fused full-length L-plastin peptide into osteoclasts from L-plastin knockout mice rescued the formation of nascent sealing zones and sealing rings in a time-dependent manner. This response was not observed with mutated full-length L-plastin(Ser-5 and-7 to Ala-5 and-7) peptide. In contrast to the observed defect in the NSZ, L-plastin deficiency did not affect podosome formation or adhesion of osteoclasts in vitro or in vivo. Histomorphometry analyses in 8-and 12-week-old female L-plastin knockout mice demonstrated a decrease in eroded perimeters and an increase in trabecular bone density, without a change in bone formation by osteoblasts. This decrease in eroded perimeters supports that osteoclast function is attenuated in L-plastin knockouts. Micro-CT analyses confirmed a marked increase in trabecular bone mass. In conclusion, female L-plastin knockout mice had increased trabecular bone density due to impaired bone resorption by osteoclasts. L-plastin could be a potential target for therapeutic interventions to treat trabecular bone loss. | Meenakshi AChellaiah Megan CMoorer Sunipa Majumdar Hanan Aljohani Sharon CMorley Vanessa Yingling Joseph PStains | 2020 | Bone Research2020，8，1： | 4 |
| 9 | 18.69% PCE from organic solar cells显示文摘The exquisite design and persistent development of fused-ring-acceptor-unit-based copolymer donors and Yseries nonfullerene acceptors(NFAs)have pushed the power conversion efficiencies(PCEs)for organic solar cells onto the18%level[1-21].Our group invented copolymer donors D18 and D18-Cl[2,3].D18:Y6,D18-Cl:N3 and D18:N3 solar cells have delivered outstanding PCEs of 18.22%,18.13%and18.56%,respectively[2-4].Ternary solar cells based on a polymer donor,a NFA and a fullerene acceptor show great potential since they combine good light-harvesting capability of NFA and good electron-mobility of fullerene[5]. | Ke Jin Zuo Xiao Liming Ding | 2021 | Journal of Semiconductors2021，42，6： | 4 |
| 10 | Molecular dynamics simulations of LiCl association and NaCl association in water by means of ABEEM/MM显示文摘Constrained molecular dynamics simulations have been used to investigate the LiCl and NaCl ionic association in water in terms of atom-bond electronegativity equalization method fused into molecular mechanics (ABEEM/MM). The simulations make use of the seven-site fluctuating charge and flexible ABEEM-7P water model, based on which an ion-water interaction potential has been constructed. The mean force and the potential of mean force for LiCl and NaCl in water, the charge distributions, as well as the structural and dynamical properties of contact ion pair dissociation have been investigated. The results are reasonable and informative. For LiCl ion pair in water, the solvent-separated ion pair configurations are more stable than contact ion pair configurations. The calculated PMF for NaCl in water indicates that contact ion pair and solvent-separated ion pair configurations are of comparable stability. | LI Xin GONG LiDong YANG ZhongZhi | 2008 | Science China Chemistry2008，51，12： | 4 |
| 11 | Sufu的突变位点对Sonic Hedgehog信号通路调控机制的研究显示文摘目的:研究髓母细胞瘤患者中发现的Supressor of Fused(Sufu)的突变位点与Sonic Hedgehog(Shh)信号通路异常激活之间的联系,从而揭示其与肿瘤生长发展之间的关系。方法:构建Sufu突变位点的表达质粒,通过定量PCR、蛋白免疫印迹实验检测Sufu突变体对Sufu^(-/-)细胞内源性Gli1表达水平的影响;通过免疫共沉淀检测Sufu突变体蛋白与Gli1的结合情况;通过MTT实验检测Sufu突变体对人髓母细胞瘤细胞(DAOY)生长增殖的影响。结果:定量PCR和蛋白免疫印迹实验发现,过表达Sufu的错义突变体(突变位点H87R)的Sufu^(-/-)细胞中内源性Gli1表达水平接近于过表达野生型Sufu的Sufu^(-/-)细胞,而过表达3个截短突变体(突变位点R146X、R299X、W430X)Sufu^(-/-)细胞中内源性Gli1表达水平相比于野生型明显增高。正常情况下野生型Sufu可以和Gli1蛋白结合,免疫共沉淀实验发现Sufu的突变体都不同程度地破坏了与Gli1蛋白的结合;蛋白周转速率实验发现Sufu的突变体可以通过蛋白酶体途径降解;MTT实验发现Sufu突变体失去了抑制DAOY细胞生长增殖的能力。结论:髓母细胞瘤患者身上观测到的Sufu突变位点可以驱动肿瘤的形成和生长,并通过细胞功能实验证实了Sufu通过结合Gli蛋白从而抑制其功能。 | 王美 程雁 | 2018 | 南京医科大学学报(自然科学版)2018，38，4： | 4 |
| 12 | THE REACTION OF BENZOYL SUBSTITUTED HETEROCYCLIC KETENE AMINALS WITH ARYL AZIDES.A FACILE APPROACH TO SYNTHSIZE 1,5-DIARYL-4-(2-IMIDAZOLINYL)-1,2,3-TRIAZOLES显示文摘Heterocyclic ketene aminals 1 react with aryl azides 2 to give thetitled compounds 3,and in some cases also with the formation offused heterocycles 4. | Zhi Tang HUANG Mei Xiang WANG Institute of Chemistry,Academia Sinica,Beijing,PR of China | 1990 | Chinese Chemical Letters1990，1，1： | 3 |
| 13 | Single-/fused-band dual-mode mid-infrared imaging with colloidal quantum-dot triple-junctions显示文摘Image data acquired with fused multispectral information can be used for effective identification and navigation owing to additional information beyond human vision,including thermal distribution,night vision,and molecular composition.However,the construction of photodetectors with such capabilities is hindered by the structural complexity arising from the integration of multiple semiconductor junctions with distinct energy gaps and lattice constants.In this work,we develop a colloidal quantum-dot dual-mode detector capable of detecting,separating,and fusing photons from various wavelength ranges.Using three vertically stacked colloidal quantum-dot homojunctions with alternating polarity,single-band short-wave infrared imaging and fused-band imaging(short-wave and mid-wave infrared)can be achieved with the same detector by controlling bias polarity and magnitude.The dual-mode detectors show detectivity up to 8×10^(10)Jones at the fused-band mode and 3.1×10^(11)Jones at the single-band mode,respectively.Without image post-processing algorithms,the dual-mode detectors could provide both night vision and thermal information-enhanced night vision imaging capability.To the best of our knowledge,this is the first colloidal quantum-dot detector that can achieve such functionality.The operation mode can be changed at a high frequency up to 1.7 MHz,making it possible to achieve simultaneously dual-mode imaging and remote temperature sensing. | SHUO ZHANG GE MU JIE CAO YUNING LUO QUN HAO MENGLU CHEN YIMEI TAN PENGFEI ZHAO XIN TANG | 2022 | Photonics Research2022，10，8： | 3 |
| 14 | Characterization for elastic constants of fused deposition modelling-fabricated materials based on the virtual fields method and digital image correlation显示文摘Fused deposition modelling(FDM), a widely used rapid prototyping process, is a promising technique in manufacturing engineering. In this work, a method for characterizing elastic constants of FDM-fabricated materials is proposed. First of all, according to the manufacturing process of FDM, orthotropic constitutive model is used to describe the mechanical behavior. Then the virtual fields method(VFM) is applied to characterize all the mechanical parameters(Q_(11), Q_(22), Q_(12), Q_(66)) using the full-field strain,which is measured by digital image correlation(DIC). Since the principal axis of the FDM-fabricated structure is sometimes unknown due to the complexity of the manufacturing process, a disk in diametrical compression is used as the load configuration so that the loading angle can be changed conveniently. To verify the feasibility of the proposed method, finite element method(FEM) simulation is conducted to obtain the strain field of the disk. The simulation results show that higher accuracy can be achieved when the loading angle is close to 30?. Finally, a disk fabricated by FDM was used for the experiment. By rotating the disk, several tests with different loading angles were conducted. To determine the position of the principal axis in each test, two groups of parameters(Q_(11), Q_(22), Q_(12), Q_(66)) are calculated by two different groups of virtual fields. Then the corresponding loading angle can be determined by minimizing the deviation between two groups of the parameters. After that, the four constants(Q_(11), Q_(22), Q_(12), Q_(66)) were determined from the test with an angle of 27?. | Quankun Cao Huimin Xie | 2017 | Acta Mechanica Sinica2017，33，6： | 3 |
| 15 | Design, synthesis and bioactivity of novel ALS inhibitors (V)——Initial model of the herbicidal sulfonylureas and fused heterocyclic sulfonamides binding with receptor显示文摘By means of the X\|ray diffraction method, quantum pharmacology analysis and quantitative structure\|activity relationships (QSAR) analysis, the structure\|activity relationships of the herbicidal sulfonylureas and fused heterocyclic sulfonamides were systematically studied. The results showed that the structure\|activity relationships of these two kinds of herbicides were identical and that the heterocyclic ring and sulfonyl moiety in the molecules were their pharmacophores which likely bind in the same receptor sites of acetolactate synthase (ALS). According to these results, the initial model of these two kinds of herbicides binding with the receptor was put forward. | 杨光富 赵国锋 陆荣健 刘华银 杨华铮 | 1998 | Science China Chemistry1998，41，4： | 2 |
| 16 | Unit dual quaternion-based pose optimisation for visual runway observations显示文摘This study addresses the pose estimation problem of an aircraft runway using visual observations in a landing approach scenario.The authors utilised the fact that the geodetic coordinates of most runways are known precisely with highly visible markers.Thus,the runway observations can increase the level of situational awareness during the landing approach,providing additional redundancy of navigation and less reliance on global positioning system.A novel pose optimisation algorithm is proposed utilising unit dual quaternion for the runway corner observations obtained from a monocular camera.The estimated runway pose is further fused with an inertial navigation system in an extended Kalman filter.An open-source flight simulator is used to collect and process the visual and flight dataset during the landing approach,demonstrating reliable runway pose estimates and the improved inertial navigation solution. | Galen Brambley Jonghyuk Kim | 2020 | IET Cyber-Systems and Robotics2020，2，4： | 2 |
| 17 | Post-sulphuration enhances the performance of a lactone polymer donor显示文摘Remarkable progress has been made in conjugated copoly-mer donors due to the development of novel fused-ring ac-ceptor(FRA)building units[1−15].The copolymers based on FRA units have delivered excellent power conversion efficien-cies(PCEs)up to 18.69%in organic solar cells(OSCs)[16].Fused-ring aromatic lactones are promising FRA units[17−19]. | Yufan Jiang Ke Jin Xiujuan Chen Zuo Xiao Xiaotao Zhang Liming Ding | 2021 | Journal of Semiconductors2021，42，7： | 2 |
| 18 | Advances in heterocyclic ketene aminals显示文摘Recent developments in the study of the reactions of heterocyclic ketene aminals are reviewed with the emphases on regioselective alkylation, acylation and glycosylation reactions, and on the aza-ene reactions with α,β-unsaturated compounds, azo and carbonyl compounds. Reactions with 1,3-dipoles and other reagents to synthesize fused heterocycles are also discussed. | WANG Meixiang and HUANG Zhitang(Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China) | 2002 | Progress in Natural Science:Materials International2002，12，4： | 2 |
| 19 | Phantom motion intent decoding for transhumeral prosthesis control with fused neuromuscular and brain wave signals显示文摘In recent years,the electroencephalography(EEG)brain-computer interface(BCI)has been researched in the area of upper-limb prosthesis control due to the promise of being able to record neurological signals which follow activation patterns in the cortex directly from the brain with non-invasive electrodes.This is seen as a way of bypassing the limitation posed by acquiring neuromuscular signals predominantly with electromyography(EMG)directly from the stump,which possesses residual limb anatomy post-amputation.In this study,the sequential forward selection algorithm to form a 10-optimal-channel representation,alongside an extended signal feature vector was applied,to investigate the motion intent decoding performance of EMG-only,EEG-only,and a fused EMG-EEG sensing configuration for four transhumeral amputees with varying stump lengths.The results showed a considerable improvement for the EMG-only configuration with the advanced feature vector,but only a small increase for the EEG-only,and thus a marginal improvement when information from both signals was fused together.This is likely due to the EEG requiring a greater number of channels spread across the skull to provide a reliable intent decoding.Further work will now involve optimisation studies to find a greater representation of electrode representation and parsimony,to minimise the number of channels while boosting motion intent decoding accuracy. | Ejay Nsugbe Oluwarotimi Williams Samuel Mojisola Grace Asogbon Guanglin Li | 2021 | IET Cyber-Systems and Robotics2021，3，1： | 2 |
| 20 | Kinetics of Carbide Layer Forming on the Surface of Steel in Molten Systems显示文摘A mathematical model of kinetics of carbide layer formed on the surface of steel in fused system was set up with the theory of non-stable diffusion mass transfer and regular solution sub-lattice. This model was analyzed and testified by the experiments in which the VC layers were formed on four kinds of steels as steel 45,4Cr5MoSiV1,T10, and Cr12MoV immersed in the V2O5-Na2O-B2O5 fused system with the reducing agent of silicon.The results showed that there was a good agreement between the model and the experimental results;the growth speed of carbide layer depended on the factors of carbon activity in substrate, treatment temperature,kinds of carbides and its structure etc. | Shuhuan Wang Shengwen Wu Shantong Jin Metallurgy School, UST Beijing, Beijing 100083, China | 1998 | International Journal of Minerals,Metallurgy and Materials1998，12，2： | 2 |
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