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| 1 | The incidences and mortalities of major cancers in China, 2009显示文摘In 2012, the National Central Cancer Registry (NCCR) of China collected cancer registration information for the year 2009 from local cancer registries and analyzed it to describe the incidences and mortalities of cancers in China. Based on the data quality criteria from NCCR, data from 104 registries covering 85,470,522 people (57,489,009 in urban areas and 27,981,513 in rural areas) were checked and evaluated. The data from 72 registries were qualified and accepted for the cancer registry annual report in 2012. The total cancer incident cases and cancer deaths were 244,366 and 154,310, respectively. The morphologically verified cases accounted for 67.23%, and 3.14% of the incident cases only had information from death certifications. The crude incidence in the Chinese cancer registration areas was 285.91/ 100,000 (317.97/100,000 in males and 253.09/100,000 in females). The age-standardized rates for incidences based on the Chinese standard population (ASRIC) and the world standard population (ASRIW) were 146.87/100,000 and 191.72/100,000, respectively, with a cumulative incidence of 22.08%. The cancer mortality in the Chinese cancer registration areas was 180.54/100,000 (224.20/100,000 in males and 135.85/100,000 in females). The age-standardized rates for mortalities based on the Chinese standard population (ASRMC) and the world standard population (ASRMW) were 85.06/100,000 and 115.65/100,000, respectively, and the cumulative mortality was 12.94% . Lung cancer, gastric cancer, colorectal cancer, liver cancer, esophageal cancer, pancreatic cancer, encephaloma, lymphoma, female breast cancer, and cervical cancer were the most common cancers, accounting for 75% of all cancer cases. Lung cancer, gastric cancer, liver cancer, esophageal cancer, colorectal cancer, pancreatic cancer, breast cancer, encephaloma, leukemia, and lymphoma accounted for 80% of all cancer deaths. The cancer registration's population coverage has been increasing, and its data quality is improving. As the basis of the cancer control program, the cancer registry plays an important role in directing anticancer strategies in the medium and long term. Because cancer burdens are different in urban and rural areas in China, prevention and control efforts should be based on practical situations. | Wanqing Chen Rongshou Zheng Siwei Zhang Ping Zhao Guanglin Li Lingyou Wu Jie He | 2013 | Chinese Journal of Cancer2013，32，3： | 111 |
| 2 | Report of incidence and mortality in China cancer registries, 2009显示文摘Objective: The National Central Cancer Registry (NCCR) collected cancer registration data in 2009 from local cancer registries in 2012, and analyzed to describe cancer incidence and mortality in China. Methods: On basis of the criteria of data quality from NCCR, data submitted from 104 registries were checked and evaluated. There were 72 registries' data qualified and accepted for cancer registry annual report in 2012. Descriptive analysis included incidence and mortality stratified by area (urban/rural), sex, age group and cancer site. The top 10 common cancers in different groups, proportion and cumulative rates were also calculated. Chinese population census in 1982 and Segi's population were used for age-standardized incidence/mortality rates. Results: All 72 cancer registries covered a total of 85,470,522 population (57,489,009 in urban and 27,981,513 in rural areas). The total new cancer incident cases and cancer deaths were 244,366 and 154,310, respectively. The morphology verified cases accounted for 67.23%, and 3.14% of incident cases only had information from death certifications. The crude incidence rate in Chinese cancer registration areas was 285.91/100,000 (males 317.97/100,000, females 253.09/100,000), age-standardized incidence rates by Chinese standard population (ASIRC) and by world standard population (ASIRW) were 146.87/100,000 and 191.72/100,000 with the cumulative incidence rate (0-74 age years old) of 22.08%. The cancer incidence and ASIRC were 303.39/100,000 and 150.31/100,000 in urban areas whereas in rural areas, they were 249.98/100,000 and 139.68/100,000, respectively. The cancer mortality in Chinese cancer registration areas was 180.54/100,000 (224.20/100,000 in males and 135.85/100,000 in females), age-standardized mortality rates by Chinese standard population (ASMRC) and by world standard population (ASMRW) were 85.06/100,000 and 115.65/100,000, and the cumulative incidence rate (0-74 age years old) was 12.94%. The cancer mortality and ASMRC were 181.86/100,000 and 80.86/100,000 in urban areas, whereas in rural areas, they were 177.83/100,000 and 94.40/100,000 respectively. Lung cancer, gastric cancer, colorectal cancer, liver cancer, esophageal cancer, pancreas cancer, encephaloma, lymphoma, female breast cancer and cervical cancer, were the most common cancers, accounting for 75% of all cancer cases in urban and rural areas. Lung cancer, gastric cancer, liver cancer, esophageal cancer, colorectal cancer, pancreatic cancer, breast cancer, encephaloma, leukemia and lymphoma accounted for 80% of all cancer deaths. The cancer spectrum showed difference between urban and rural areas, males and females. The main cancers in rural areas were cancers of the stomach, followed by esophageal cancer, lung cancer, liver cancer and colorectal cancer, whereas the main cancer in urban areas was lung cancer, followed by liver cancer, gastric cancer and colorectal cancer. Conclusions: The coverage of cancer registration population has been increasing and data quality is improving. As the basis of cancer control program, cancer registry plays an important role in making anticancer strategy in medium and long term. As cancer burdens are different between urban and rural areas in China, prevention and control should be implemented based on practical situation. | Wanqing Chen Rongshou Zheng Siwei Zhang Ping Zhao Guanglin Li Lingyou Wu Jie He | 2013 | Chinese Journal of Cancer Research2013，25，1： | 202 |
| 3 | A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study显示文摘Fulminant myocarditis(FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen(LSBCTR), a completely novel treatment regimen, for FM. A total of 169 FM patients recruited from January 2008 to December 2018 were divided into two groups: patients receiving LSBCTR(81 cases),which includes(i) mechanical life support(positive pressure respiration, intra-aortic balloon pump with or without extracorporeal membrane oxygenation),(ii) immunomodulation therapy using sufficient doses of glucocorticoids and immunoglobulins, and(iii) application of neuraminidase inhibitors, and those receiving conventional treatment(88 cases). The endpoints were in-hospital death and heart-transplantation. Of all the population, 44 patients(26.0%) died in hospitals. Inhospital mortality was 3.7%(3/81) for LSBCTR group and 46.6%(41/88) for traditional treatment(P<0.001). Early application of LSBCTR, mechanical life support, neuraminidase inhibitors, and immunomodulation therapy significantly contributed to reduction in in-hospital mortality. This study describes a novel treatment regimen for FM patients that dramatically reduces inhospital mortality. Its generalization and clinical application will efficiently save lives although further optimization is needed.This study offers an insight that virus infection induced inflammatory waterfall results in cardiac injury and cardiogenic shock and is the therapeutic target. | Sheng Li Shengyong Xu Chenze Li Xiao Ran Guanglin Cui Mengying He Kun Miao Chunxia Zhao Jiangtao Yan Rutai Hui Ning Zhou Yan Wang Jiangang Jiang Jing Zhang Daowen Wang | 2019 | Science China(Life Sciences)2019，62，3： | 43 |
| 4 | Comparative Analysis of JmjC Domain-containing Proteins Reveals the Potential Histone Demethylases in Arabidopsis and Rice显示文摘Histone methylation homeostasis is achieved by controlling the balance between methylation and demethylation to maintain chromatin function and developmental regulation. In animals, a conserved Jumonji C (JmjC) domain was found in a large group of histone demethylases. However, it is still unclear whether plants also contain the JmjC domaincontaining active histone demethylases. Here we performed genome-wide screen and phylogenetic analysis of JmjC domain-containing proteins in the dicot plant, Arabidopsis, and monocot plant rice, and found 21 and 20 JmjC domaincontaining, respectively. We also examined the expression of JmjC domain-containing proteins and compared them to human JmjC counterparts for potential enzymatic activity. The spatial expression patterns of the Arabidopsis JmjC domaincontaining genes revealed that they are all actively transcribed genes. These active plant JmjC domaincontaining genes could possibly function in epigenetic regulation to antagonize the activity of the large number of putative SET domaincontaining histone methyltransferase activity to dynamically regulate histone methylation homeostasis. | Falong Lu Guanglin Li Xia Cui Chunyan Liu Xiu-Jie Wang Xiaofeng Cao | 2008 | Journal of Integrative Plant Biology2008，50，7： | 24 |
| 5 | Chinese expert consensus statement on the diagnosis and treatment of fulminant myocarditis显示文摘Fulminant myocarditis is primarily caused by infection with any number of a variety of viruses. It arises quickly, progresses rapidly, and may lead to severe heart failure or circulatory failure presenting as rapid-onset hypotension and cardiogenic shock,with mortality rates as high as 50%–70%. Most importantly, there are no treatment options, guidelines or an expert consensus statement. Here, we provide the first expert consensus, the Chinese Society of Cardiology Expert Consensus Statement on the Diagnosis and Treatment of Fulminant Myocarditis, based on data from our recent clinical trial(NCT03268642). In this statement, we describe the clinical features and diagnostic criteria of fulminant myocarditis, and importantly, for the first time,we describe a new treatment regimen termed life support-based comprehensive treatment regimen. The core content of this treatment regimen includes(i) mechanical life support(applications of mechanical respirators and circulatory support systems,including intraaortic balloon pump and extracorporeal membrane oxygenation),(ii) immunological modulation by using sufficient doses of glucocorticoid, immunoglobulin and(iii) antiviral reagents using neuraminidase inhibitor. The proper application of this treatment regimen may and has helped to save the lives of many patients with fulminant myocarditis. | Daowen Wang Sheng Li Jiangang Jiang Jiangtao Yan Chunxia Zhao Yan Wang Yexin Ma Hesong Zeng Xiaomei Guo Hong Wang Jiarong Tang Houjuan Zuo Li Lin Guanglin Cui Section of Precision Medicine Group of Chinese Society of Cardiology,Editorial Board of Chinese Journal of Cardiology &Working Group of Adult Fulminant Myocarditis | 2019 | Science China(Life Sciences)2019，62，2： | 18 |
| 6 | Efficacy of open reduction and internal fixation with a miniplate and hollow screw in the treatment of Lisfranc injury显示文摘 | Baoliang Li Wenbo Zhao Lei Liu Fuguo Huang Guanglin Wang Yue Fang | 2015 | Chinese Journal of Traumatology2015，18，1： | 17 |
| 7 | Internal fixation with headless compression screws and back buttress plate for treatment of old Hoffa fracture显示文摘Hoffa 破裂的早临床、 X 光线照相术的结果用无头的压缩螺丝钉由开的减小和内部固定的一个标准协议对待的 ObjectiveTo 分析在 8 中国 patients.MethodsOpen 减小的一个连续系列与背撑墙板结合了,内部固定在所有病人上被执行。破裂被 K 电线解剖地暂时减少并且成立。如果破裂的结束是衰退的,从 ipsilateral 的自体同源的骨头接枝肠骨的冠在结束之间被包装。然后,破裂碎片与 AO 6.5 被修理;公里无头的压缩 cannulated 螺丝钉。至少二个螺丝钉被用来提供旋转稳定性。一个轮廓 pre 的重建盘子作为背撑墙 plate.ResultsAll posteromedially 或 posterolaterally 被放在 nonarticular 表面上病人被跟随在上面为至少 12 个月(范围 12-25 月) 。所有破裂完成了解剖减小并且临床上并且 X 光线照相术地愈合了。在最近的后续,吝啬的屈曲学位是 120.6 °
( 范围 110 °-135°) ,吝啬的延期学位是 2.5 °
( 范围 0 °-5°) 。平均视觉类似物规模分数是 1.6 个点(范围 0-3 ) 。六个病人作为优秀被估计并且 2 作为根据为特殊外科膝 20 系统的医院好。没有表面或深的感染,或硬件破裂。没有病人让了膝让路或锁住,尽管一些有断断续续的疼痛并且在奋发的锻练以后胀大。损害机制在功能的结果上有重要影响(P = 0.046 ) 与背撑墙板或自体同源的骨头 grafting 相结合对待旧 Hoffa 的 .ConclusionHeadless 压缩螺丝钉断裂是有效措施之一。它将对不仅骨折愈合而且早锻练和功能的恢复导致。 | Min Li Tu Chongqi Wang Guanglin Fang Yue Duan Hong Liu Lei Zhang Hui | 2014 | Chinese Journal of Traumatology2014，17，2： | 7 |
| 8 | Study of the tolerance of Hippochaete ramosissimum to Cu stress显示文摘We investigated the tolerance of Hippochaete ramosissimum and the changes in physiological metabolism following exposure to copper using pot experiments and analyzing plant physiology and biochemistry. The results showed that Cu tolerance in Hippochaete ramosissimum varied significantly between different populations; the tolerance of plants living in Cu polluted areas for extended periods of time exceeded that of plants living in unpolluted areas.SOD and POD activities in highly Cu tolerant plants increased noticeably following exposure to Cu. This indicates that maintaining and increasing the two kinds of protective enzyme activities are the primary foundations of plant tolerance. However, no change in CAT activity was demonstrated following Cu exposure. In summary, there existed considerable differences in physiological metabolism between different populations of Hippochaete ramosissimum following exposure to Cu. | LIU Dengyi, LI Ying, CHU Ling, WANG Guanglin & WANG Lilong Biodiversity Research Center, Anhui Normal University, Wuhu 241000, China The Provincial Key Laboratory of Conservation and Exploitation of Biological Resources in Anhui, Wuhu 241000, China | 2005 | Science China(Life Sciences)2005，48，z1： | 7 |
| 9 | Sequence and epitope analysis of surface proteins of avian influenza H5N1 viruses from Asian patients显示文摘Increasing cases of human infections with the high pathogenic avian influenza virus H5N1 have raised great concern on potential human flu pandemics caused by H5N1. The two viral surface glycoproteins, the hemagglutinin (HA) and the neuraminidase (NA) proteins, are major antigens o H5N1. Introducing new mutations on these two pro teins is the major strategy used by H5N1 to expand host range and to avoid the recognition of host im mune systems. We analyzed the two surface proteins of H5N1 from Asian human patients and identified many new mutation sites, including a few that were unique to certain lethal strains. We also analyzed the distribution of mutations on different epitopes of the two surface proteins. A receptor-binding site tha might involve in the determination of host specificity of H5N1 was also found. Results reported here pro vided information for better understanding of the evolution trend of H5N1 genome in human. | LI Guanglin TAO Shiheng WANG Xiujie | 2006 | Chinese Science Bulletin2006，51，20： | 6 |
| 10 | LUBRICATION FILM FORMATION MECHANISM OF SLIPPER PAIRS IN LOW SPEED HIGH TORQUE HYDRAULIC MOTORS显示文摘Pressure-flow analytical formulas of lubrication film of slipper pairs on camshaft connect- ing rod type low speed high torque (LSHT) hydraulic motors are put forward. The bottom surface of slipper pairs is rectangle, and the effect of squeeze flow and pressure differential flow is considered. The dynamic process of lubrication film formation through squeezing is numerically studied by com- puter simulation. Effects of supply pressure, initial lubrication film thickness, velocity damping coef- ficient, loading impact and gravity, etc are studied. Advantages of novel slipper pairs with large oil cavity area are pointed out. | LI Yong SHI Guanglin CHEN Zhaoneng | 2007 | Chinese Journal of Mechanical Engineering2007，20，1： | 5 |
| 11 | One-step uniform growth of magnesium hydride nanoparticles on graphene显示文摘A simple solvent-free method to synthesize MgH_2 nanoparticles(MgH_2NPs) uniformly grown on graphene nanosheets(GNs) has been reported in this paper. Based on the formation of MgH_2 by di-n-butylmagnesium((C_4H_9)_2Mg) thermal decomposition under hydrogen pressure, the GNs were added as matrix to hinder the agglomeration and growing of MgH_2NPs. The fabricated MgH_2/GNs nanocomposites, in which MgH_2 NPs were homogenously growing in the graphene matrix, have been synthesized by the favorable adsorption energy between(C_4H_9)_2Mg and GNs. Resulting from the one-step solvent-free route, the generated MgH_2 NPs shows high hydrogen capacity and steady hydriding and dehydriding properties, without the interference of the synthetic medium. At the same time, the size of the fabricated MgH_2NPs can be controlled by adjusting the mass ratio of MgH_2 to graphene, the various hydrogen pressure and temperature. Attributed to smaller size effect, well uniform distribution of high density MgH_2NPs, and the agglomeration blocking ability of graphene,the MgH_2/GNs-40 wt% exhibits the favorite hydrogen storage performance. | Yuqin Huang Guanglin Xia Jie Chen Baoping Zhang Qian Li Xuebin Yu | 2017 | Progress in Natural Science:Materials International2017，27，1： | 5 |
| 12 | Characterization of particle size distribution of mainstream cigarette smoke generated by smoking machine with an electrical low pressure impactor显示文摘Cigarette smoking is a particle-related exposure. Studying the characteristics of the particle size distribution of cigarette smoke can aid in providing knowledge of smoke aerosol attributes. We used an electrical low pressure impactor(ELPI) to measure the particle size distribution of mainstream cigarette smoke generated by a smoking machine and provided a continuum of particle sizes of cigarette smoke from a whole cigarette. The results showed that the aerodynamic diameters(D, geometric mean of a channel) of particles ranged from 0.021 to 1.956 μm, and the number concentrations were on the order of 105–109cm-3for different sizes of particles. The particle number of the size category below 0.1 μm approximated that of the category 0.1–2.0 μm, and the particles in the size category of 0.1–2.0 μm contributed extremely heavily to total particulate mass. In addition, the results with small samples indicated that the tar yields normalized per milligram of nicotine showed an approximately linear increase with increasing concentration of total particles. | Xiang Li Haohui Kong Xinying Zhang Bin Peng Cong Nie Guanglin Shen Huimin Liu | 2014 | Journal of Environmental Sciences2014，26，4： | 4 |
| 13 | Phantom motion intent decoding for transhumeral prosthesis control with fused neuromuscular and brain wave signals显示文摘In recent years,the electroencephalography(EEG)brain-computer interface(BCI)has been researched in the area of upper-limb prosthesis control due to the promise of being able to record neurological signals which follow activation patterns in the cortex directly from the brain with non-invasive electrodes.This is seen as a way of bypassing the limitation posed by acquiring neuromuscular signals predominantly with electromyography(EMG)directly from the stump,which possesses residual limb anatomy post-amputation.In this study,the sequential forward selection algorithm to form a 10-optimal-channel representation,alongside an extended signal feature vector was applied,to investigate the motion intent decoding performance of EMG-only,EEG-only,and a fused EMG-EEG sensing configuration for four transhumeral amputees with varying stump lengths.The results showed a considerable improvement for the EMG-only configuration with the advanced feature vector,but only a small increase for the EEG-only,and thus a marginal improvement when information from both signals was fused together.This is likely due to the EEG requiring a greater number of channels spread across the skull to provide a reliable intent decoding.Further work will now involve optimisation studies to find a greater representation of electrode representation and parsimony,to minimise the number of channels while boosting motion intent decoding accuracy. | Ejay Nsugbe Oluwarotimi Williams Samuel Mojisola Grace Asogbon Guanglin Li | 2021 | IET Cyber-Systems and Robotics2021，3，1： | 2 |
| 14 | Identification of novel stress-regulated microRNAs from Oryza sativa L.显示文摘 | Xinyu Jian Lin Zhang Guanglin Li Liang Zhang Xiujie Wang Xiaofeng Cao Xiaohua Fang Fan Chen | 2009 | Genomics2009，，1： | 2 |
| 15 | Real-time remote monitoring system for aquaculture water quality显示文摘A multi-parameters monitoring system based on wireless network was set up to achieve remote real-time monitoring of aquaculture water quality,in order to improve the quality of aquaculture products and solve such problems as being difficult in wiring and high costs in current monitoring system.In the system solar cells and lithium cells were used for power supply.The YCS-2000 dissolved oxygen sensor,pH electrode,Pt1000 temperature sensor and ammonia nitrogen sensor were used to monitor the parameters of aquaculture water quality;STM32F103 chip was used for data processing;Zigbee and GPRS modules were used for data transmission to the remote monitoring center,where the data were stored and displayed.The system was connected with aerator to realize automatic control of dissolved oxygen concentration.The test results showed high confidence level of data transmission with a packet loss rate of 0.43%.Therefore,the system could fulfill the real-time remote monitoring of aquaculture water quality and had great practical significance in reduction of labor intensity,improvement of quality of aquatic products and protection of water environment. | Luo Hongpin Li Guanglin Peng Weifeng Song Jie Bai Qiuwei | 2015 | International Journal of Agricultural and Biological Engineering2015，8，6： | 2 |
| 16 | Simultaneously designing and targeting for networks with multiple resources of different qualities 显示文摘 | LIU Zhiyong LI Yanmei ZHANG Guanglin | 2009 | Chi- nese J Chem Eng2009，17，3： | 1 |
| 17 | Emergency treatment experience of 132 cases of acute left heart failure 显示文摘 | Xiao Li Tan Guanglin Zhuo Yanhua | 2010 | Journal of western medicine2010，22，2： | 1 |
| 18 | Data-centrie naiddleware for con- text-aware pervasive computing显示文摘 | Chen Guanglin Li Ming Kotz D | 2008 | Pervasive and Mobile Compu- ting2008，4，2： | 1 |
| 19 | Changes of immunocytic phenotypes and functions from human colorectal adenomatous stage to cancerous stage: Update显示文摘 | Yanhong Shi Zhenfeng Li Wei Zheng Xia Liu Chenyi Sun Jann-Birger Laugsand Zhanju Liu Guanglin Cui | 2015 | Immunobiology2015，，10： | 1 |
| 20 | Origami meets electrospinning:a new strategy for 3D nanofiber scaffolds显示文摘Inspired by the constitution of things in the natural world,three-dimensional (3D)nanofiber scaffold/cells complex was constructed via the combination of electrospinning technology and origami techniques.The nanofiber boxes prepared by origami provided a limited space for the layer-by-layer nanofiber films,and the human fetal osteoblasts (hFOBs)seeded on the both sides of the nanofiber films were expected to facilitate the bonding,of the adjacent nanofiber films through the secretion of extracellular matrix.Specifically,the hFOBs presented 3D distribution in the nanofiber scaffold,and they can stretch across the gaps between the adjacent nanofiber films,forming the cell layers and filling the whole 3D nanofiber scaffold.Eventually,a 3D block composed of electrospun nanofiber scaffold and cells was obtained',which possesses potential applications in bone tissue engineering.Interestingly,we also created 3D nanofiber structures that range from simple forms to intricate architectures via origami,indicating that the combination of electrospinning technology and origami techniques is a feasible method for the 3D construction of tissue engineering scaffolds. | Juqing Song Guanglin Zhu Huichang Gao Lin Wang Nanying Li Xuetao Shi Yingjun Wang | 2018 | Bio-Design and Manufacturing2018，1，4： | 1 |
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