Antioxidant and Anti-inflammatory Capacity of Ferulic Acid Released from Wheat Bran by Solid-state Fermentation of Aspergillus niger

查看全文 作　　者：YIN Zhi [1]Na;WU Wen [2]Jia;SUN Chong [3]Zhen;LIU Hui [3]Fan;CHEN Wen [3]Bo;ZHAN Qi [3]Ping;LEI Zhuo [3]Gui;XIN [3]Xuan;MA Juan [3]Juan;YAO [3]Kun;MIN [3]Tian;ZHANG Meng [3]Meng;WU [3]Hui

机构地区：[1]Biotechnology,guangdong polytechnic science and trade;[2]School of Medical Technology and Nursing,Shenzhen Polytechnic;[3]College of Food Science and Engineering, South China University of Technology

出　　处：《Biomedical and Environmental Sciences》索引2019年第32卷第1期,共11页

基　　金：financially supported by the Science and Technology Planning Project of Guangdong Province [Nos.2016A040402020,2016B010121014] 摘　　要：Objective A strain of Aspergillus niger(A. niger), capable of releasing bound phenolic acids from wheat bran, was isolated. This strain was identified by gene sequence identification. The antioxidant and anti-inflammatory capacity of ferulic acid released from wheat bran by this A. niger strain(FA-WB) were evaluated. Methods Molecular identification techniques based on PCR analysis of specific genomic sequences were conducted; antioxidant ability was examined using oxygen radical absorbance capacity(ORAC), cellular antioxidant activity(CAA) assays, and erythrocyte hemolysis assays. RAW264.7 cells were used as a model to detect anti-inflammatory activity. Results The filamentous fungal isolate was identified to be A. niger. ORAC and CAA assay showed that FA-WB had better antioxidant activity than that of the ferulic acid standard. The erythrocyte hemolysis assay results suggested that FA-WB could attenuate AAPH-induced oxidative stress through inhibition of reactive oxy gen species(ROS) generation. FA-WB could significantly restore the AAPH-induced increase in intracellular antioxidant enzyme activities to normal levels as well as inhibit the intracellular malondialdehyde formation. TNF-?, IL-6, and NO levels indicated that FA-WB can inhibit the inflammation induced by lipopolysaccharide(LPS). Conclusion Ferulic acid released from wheat bran by a new strain of A. niger had good anti-inflammatory activity and better antioxidant ability than standard ferulic acid. 关键词：FUNGAL identification Fermentation Ferulic acid ANTIOXIDANT ACTIVITY Oxidative HEMOLYSIS ANTI-INFLAMMATORY activity.

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Antioxidant and Anti-inflammatory Capacity of Ferulic Acid Released from Wheat Bran by Solid-state Fermentation of Aspergillus niger

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