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| 1 | Function of apoptosis and expression of the proteins Bcl-2,p53 and C-myc in the development of gastric cancer显示文摘INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer . | An Gao Xu Shao Guang Li Ji Hong Liu Ai Hua Gan Research Laboratory of Digestive Disease,Huizhou Central People’s Hospital,Huizhou 516001,Guangdong Province,ChinaDr.An Gao Xu graduated from Guangdong Medical College in 1984.He is an associate physician-in-chief,specializing in the research and treatment of gastrointestinal and liver tumors.He has published 24 papers and 1 book. | 2001 | World Journal of Gastroenterology2001，7，3： | 91 |
| 2 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 3 | Barometric altimetry system as virtual constellation applied in CAPS显示文摘This work describes the barometric altimetry as virtual constellation applied to the Chinese Area Positioning System (CAPS), which uses the transponders of communication satellites to transfer navigation messages to users. Barometric altimetry depends on the relationship of air pressure varying with altitude in the Earth’s atmosphere. Once the air pressure at a location is measured the site altitude can be found. This method is able to enhance and improve the availability of three-dimensional positioning. The difficulty is that the relation between barometric pressure and altitude is variable in different areas and under various weather conditions. Hence, in order to obtain higher accuracy, we need to acquire the real-time air pressure corresponding to an altimetric region’s reference height. On the other hand, the altimetry method will be applied to satellite navigation system, but the greatest difficulty lies in how to get the real-time air pressure value at the reference height in the broad areas overlaid by satellite navigation. We propose an innovational method to solve this problem. It is to collect the real-time air pressures and temperatures of the 1860 known-altitude weather observatories over China and around via satellite communication and to carry out time extrapolation forecast uniformly. To reduce data quantity, we first partition the data and encode them and then broadcast these information via navigation message to CAPS users’ receivers. Upon the interpolations being done in receivers, the reference air pressure and temperature at the receiver’s nearby place is derived. Lastly, combing with the receiver-observed real air pressure and temperature, the site’s altitude can be determined. The work is presented in the following aspects: the calculation principle, formulae, data collection, encoding, prediction, interpolation method, navigation message transmission together with errors causes and analyses. The advantages and shortcomings of the technique are discussed at the end. | AI GuoXiang SHENG PeiXuan DU JinLin ZHENG YongGuang CAI XianDe WU HaiTao HU YongHui HUA Yu LI XiaoHui | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，3： | 22 |
| 4 | Intense exercise can cause excessive apoptosis and synapse plasticity damage in rat hippocampus through Ca2+ overload and endoplasmic reticulum stress-induced apoptosis pathway显示文摘 | Ding Yi Chang Cunqing Xie Lan Chen Zhimin Ai Hua | 2014 | Chinese Medical Journal2014，，18： | 15 |
| 5 | Up-regulation of visfatin expression in subjects with hyperthyroidism and hypothyroidism is partially relevant to a nonlinear regulation mechanism between visfatin and tri-iodothyronine with various concentrations显示文摘背景 Visfatin ,内脏的导出脂肪的 adipocytokine ,戏在类脂化合物 metabolism.However , visfatin 的精确功能和它由甲状腺荷尔蒙的规定的重要生理的功能仍然是观察的 unknown.This 学习在有在 vivo 的甲状腺机能亢进和甲状腺机能减退的题目的血浆 visfatin 集中,并且作为进一步的 interpretation.Methods 在 vitro 调查了在 visfatin 和 tri-iodothyronine ( T3 )之间的可能的规定机制在 vivo | HAN Jing ZHANG Tian-ou XIAO Wen-hua CHANG Cui-qing AI Hua | 2012 | Chinese Medical Journal2012，，5： | 11 |
| 6 | Water relations and an expression analysis of plasma membrane intrinsic proteins in sensitive and tolerant rice during chilling and recovery显示文摘寒心的损害的症状是在射击的水赤字的开发,源于水运输和蒸发的不平衡。在这个工作,二个米饭变化(Oryza sativa L。var。Wasetoitsu 和 Somewake ) 幼苗是在 7 度 C 的 chilled,在 28 度 C 由恢复列在后面。基于生长显型和电解质漏测试, Somewake 被显示是一个寒心容忍的变化,和 Wasetoitsu 寒心敏感的。寒心的压力显著地减少了叶子,积聚的蒸发和渗透的根的相对的水内容(RWC ) 在两个变化的水力的电导率(Lp ) 。但是当回到了 28 度 C 时, Somewake 的水关系平衡更好恢复了。所有 11 血浆膜的 mRNA 表示侧面内在的蛋白质(果仁) , aquaporins 的亚群,被有 TaqMan 次要的林子文件夹(MGB ) 的 -PCR 探查的即时反向的抄写(RT ) 随后决定源于米饭 var。Nipponbare 在寒心的处理和恢复期间。大多数 PIP 基因在低温度是下面调整的,并且在温暖的温度恢复了。在 Somewake 和 Wasetoitsu 的一些果仁的相对表示在平行减少了在期间寒心。然而在恢复期间, OsPIP1 的相对表示; 1, OsPIP2; 1, OsPIP2; 7 在射击和 OsPIP1; 1, OsPIP2; 1 比 Wasetoitsu 在 Somewake 在根是显著地更高的。这在在寒心的条件以后重建水平衡支持果仁的角色。我们讨论 aquaporin 果仁亚科的成员在植物起的多样化的作用寒心的忍耐取决于 aquaporin isoforms,植物织物和寒心的持续时间的阶段。 | Xin Yu Yan Hui Peng Min Hua Zhang Yan Jun Shao Wei Ai Su Zhang Cheng Tang | 2006 | Cell Research2006，16，6： | 11 |
| 7 | Effect of heparin on apoptosis in human nasopharyngeal carcinoma CNE2 cells显示文摘In order to study the mechanism of the effect of heparin on apoptosis in carcinoma cells, the nasopharyngeal carcinoma cell line CNE2 was used to identify the effect of heparin on apoptosis associated with the expression of c-myc, bax, bcl-2 proteins by use of Hoechst 33258 staining, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL), agarose gel electrophoresis, and flow cytometry, as well as Western blot analysis. The results showed that heparin induced apoptosis of CNE2 cells including the morphologic changes such as reduction in the volume, and the nuclear chromatin condensation, as well as the “ladder pattern” revealed by agarose gel electrophoresis of DNA in a concentration-dependent manner.The number of TUNEL-positive cells was dramatically increased to 33.6±1.2% from 2.8±0.3% by treat ment with heparin in different concentrations (10~40 kU/L). The apoptotic index was increased to 32.5% from 3.5% by detecting SubG1 peaks on flow cytometry. Western blot analysis showed that levels of bcl-2,bax and c-myc were significantly overexpressed by treatment with the increase of heparin concentrations.These results suggest that heparin induces apoptosis of CNE2 cells, which may be regulated by differential expression of apoptosis-related genes. | LI HONG LIANG , KAI HE YE , HAI WEI ZHANG , YING RU LUO , XIAN DA REN, AI HUA XIONG, RUI SITU Department of Pharmacology ,Pharmacy College, Department of Pathology Medical College, Jinan University, Guangzhou 510632, China | 2001 | Cell Research2001，11，4： | 9 |
| 8 | Relationship between microorganisms in coronary atheromatous plaques and periodontal pathogenic bacteria显示文摘 | ZHANG Yuan-ming ZHONG Liang-jun LIANG Ping LIU Hua MU La-ti AI Si-ka-er | 2008 | Chinese Medical Journal2008，，16： | 9 |
| 9 | Association between Plasma Metal Levels and Diabetes Risk: a Case-control Study in China显示文摘Objective Many metals, some of which have been classified as environmental endocrine disruptors, are used extensively in everyday consumer products and are ubiquitous in our living environment. In the present study, we aimed to explore the associations between the prevalence risk of type 2 diabetes and plasma levels of 20 trace elements as well as those of heavy metals in a Han Chinese population. Methods We conducted a case-control study to investigate the associations between plasma concentrations of 20 metals and diabetes in Jiangsu province. A total of 122 newly diagnosed cases of type 2 diabetes and 429 matched controls were recruited from community physical examinations in Suzhou City of Jiangsu Province. Plasma metal levels were measured by inductively-coupled plasma mass spectrometry. Results After adjusting for confounders, plasma vanadium, chromium, manganese, copper, zinc, arsenic, selenium, strontium, palladium, cadmium, cesium, and barium were associated with diabetes risk(P < 0.05). The adjusted OR increased with increasing concentration of vanadium, manganese, copper, zinc, and cesium. Conclusion Many metals, including manganese, copper, zinc, arsenic, selenium, and cadmium in plasma, are associated with the morbidity of diabetes. Monitoring of environmental metal levels and further studies are urgently needed. | LI Xiu Ting YU Peng Fei GAO Yan GUO Wen Hui WANG Jun LIU Xin GU Ai Hua JI Gui Xiang DONG Qiu WANG Bo Shen CAO Ying ZHU Bao Li XIAO Hang | 2017 | Biomedical and Environmental Sciences2017，30，7： | 8 |
| 10 | Molecular Characterization and Correlation with β-lactam Resistance of Streptococcus pneumonia Isolates in Hangzhou,China显示文摘Penicillin-binding proteins(PBPs) are the target of β-lactam antibiotics(the major treatment for Streptococcus pneumoniae infections),and mutations in PBPs are considered as a primary mechanism for the development of β-lactam resistance in S.pneumoniae.This study was conducted to investigate the mutations in the PBPs of clinical S.pneumoniae isolates in Hangzhou,China,in correlation with β-lactam resistance.Results showed that 19 F was the predominant serotype(7/27) and 14 of the S.pneumoniae isolates were resistant to both penicillin G and cephalosporin.Genotyping results suggested that β-lactam-resistant isolates primarily exhibited single-site mutations in both the STMK and SRNVP motifs of pbp1 a in combination with double-site mutations in the STMK motif of pbp2 x,which might be the primary mechanisms underlying the β-lactam resistance of the isolates in this study. | chu mei fen liu xiao xiang zhang shao ni huang yan ying du peng wang li fang ji lei yan jie sun ai hua | 2018 | Biomedical and Environmental Sciences2018，31，5： | 7 |
| 11 | High quality Sb-doped SnO2 electrodes with high oxygen evolution potential prepared by in situ hydrothermal synthesis method显示文摘与 3.0 V 的高氧进化潜力,高质量的做 Sb 的 SnO2 电极成功地在 Ti 底层上被综合由在 situ 热水的合成方法。 | Ai Sheng Huang Guo Hua Zhao Hong Xu Li | 2007 | Chinese Chemical Letters2007，18，8： | 7 |
| 12 | Selfinjective Koszul Algebras of Finite Complexity显示文摘在这篇论文,我们学习有限复杂性的 selfinjective Koszul 代数学。当它是有限的时,我们证明复杂性是一个非否定的整数;并且范畴 Jin 郭云电子邮件:gjy@xtu.edu.cn 全文预览(小,大)src= “ http://gffzz44912ce5e0ca4a84hkcufnqk60qov60wv.ffgz.tsg.suse.edu.cn/jsmaster ” type=text/javascript > type=text/javascript > 如果(ValueLoaded )ValueShowAd() ;language=JavaScript src=... http://gffzz44912ce5e0ca4a84hkcufnqk60qov60wv.ffgz.tsg.suse.edu.cn/cycle ? host=hs0005647&b=pagebuster.183&v=1.2.20&c=00&hcat=M100&kissn=1439-7617&kkeyword=selfinjective Koszul 代数学,复杂性,斜组代数学,平淡的对称的代数学, 16G60, 16G20,有限 complexity&aid=1439-7617&pid=10.1007/s10114-009-6703-0&bso=listed&msizes=468x60&t=js 的 16D50 &kdoi=10.1007/s10114-009-6703-0&ktitle=Selfinjective Koszul 代数学 ...>...> var 闪光名字 ... “ ... ”;var altImgName = “ http://gffzz44677b9a174d4e8dhkcufnqk60qov60wv.ffgz.tsg.suse.edu.cn/hg/0120/a0120602/Springer_TOC_Alerts.gif ”;var xmlfile = “ http://gffzz44677b9a174d4e8dhkcufnqk60qov60wv.ffgz.tsg.suse.edu.cn/hg/0120/a0120602/sgwIssnJournalMapping.xml ”;var minFlashVer = 5;var 宽度 = 468;var 高度 = 60;var 按标签 = “ http://gffzz44912ce5e0ca4a84hkcufnqk60qov60wv.ffgz.tsg.suse.edu.cn/redirect ? host=h0005647; size=468x60; t=js; c=00; target_id=0; hcat=M100; aid=1439-7617; pid=10.1007/s10114-009-6703-0; banner=a0120602; vcurlpreserve= ”;var gifclickTAG = “ http://gffzz44912ce5e0ca4a84hkcufnqk60qov60wv.ffgz.tsg.suse.edu.cn/redirect ? host=h0005647; size=468x60; t=js; c=00; target_id=0; hcat=M100; aid=1439-7617; pid=10.1007/s10114-009-6703-0; banner=a0120602; vcurlpreserve= ”;var 插件 = 0;var d = 文件;如果(navigator.mimeTypes && navigator.mimeTypes [“ application/x-shockwave-flash ”]&& navigator.mimeTypes [“ application/x-shockwave-flash ”].enabledPlugin ){ 如果(navigator.plugins && navigator.plugins [“冲击波闪光”]) var swver =(navigator.plugins [“冲击波闪光”].description.split (''))[2 ] ;如果(swver >= minFlashVer ) 插件 = 1;} 另外如果(navigator.userAgent && navigator.userAgent.indexOf (“ MSIE ”)>=0 &&(navigator.userAgent.indexOf (“ Windows ”)>=0 )){ d.write (“”) ;d.write (“下次在错误上恢复”) ;d.write (unescape (“ %0A')) ;d.write (“如果(minFlashVer = 3 ) 那么插件 =(IsObject (CreateObject (” ShockwaveFlash.ShockwaveFlash.3 “))) ”) ;d.write (unescape (“ %0A')) ;d.write (“如果((minFlashVer ”) ;} 如果(插件){ d.write (“) ;d.write (“”) ;d.write (“”) ;d.write (“”) ;d.write (“”) ;} 另外如果(!(navigator.appName && navigator.appName.indexOf (“ Netscape ”)>=0 && navigator.appVersion.indexOf (“ 2 ” .)>=0 )){ d.write (“) ;d.write (“) ;} var EOLASloaded = 0;功能 loadEOLAS(){ 如果(EOLASloaded == 1 ){ vc_obj_refresh (“ vc-15416-1262103222-20160 ”) ;} 另外 { 集合超时(“ loadEOLAS() ;”, 5 ) ;}}loadEOLAS() ;language=VBScript > 如果,下次在错误上恢复(minFlashVer = 3 ) 那么插件 =(IsObject (CreateObject (“ ShockwaveFlash.ShockwaveFlash.3 ”))) 如果((minFlashVer src= “ http://gffzz44912ce5e0ca4a84hkcufnqk60qov60wv.ffgz.tsg.suse.edu.cn/js/eolas_fix ” > 固定到订户的引用。 | Jin Yun GUO Ai Hua LI Qiu Xian WU | 2009 | Acta Mathematica Sinica,English Series2009，25，12： | 6 |
| 13 | Clinical efficacy of gemcitabine and cisplatin-based transcatheter arterial chemoembolization combined with radiotherapy in hilar cholangiocarcinoma显示文摘BACKGROUND Radical surgical resection is regarded as the best treatment for hepatic hilar cholangiocarcinoma. However, 60%-70% of patients have lost the chance of surgery at the time of diagnosis. Simple biliary stent or drainage tube placement may fail in a short time due to tumor invasion or overgrowth, bile accumulation, or biofilm formation. Effective palliative treatments to extend the effective drainage time are of great significance for improving the quality of life of patients and changing the prognosis of patients. AIM To investigate the clinical efficacy of gemcitabine and cisplatin-based transcatheter arterial chemoembolization (TACE) combined with radiotherapy in hilar cholangiocarcinoma.METHODS A retrospective analysis was conducted on patients clinically diagnosed with hilar cholangiocarcinoma from June 2014 to January 2017 at the Liaoning Provincial Cancer Hospital. Patients were evaluated by specialists, and those who were not suitable for surgery or unwilling to undergo surgery and met the inclusion criteria were included in the study. There were a total of 72 patients (34 males and 38 females) with an average age of 59.9 years (range, 40-72 years). According to percutaneous transhepatic biliary angiography and the patients’ wishes, stent implantation or biliary drainage tube implantation was used to relieve biliary obstruction. The patients were divided into either a control group or a combined treatment group according to their follow-up treatment. The control group consisted of a total of 35 patients who received simple biliary drainage tube placement and biliary stent implantation (7 patients with bilateral stents and 6 with a unilateral stent) and 22 patients receiving biliary drainage tube placement alone. The combined treatment group received TACE and extracorporeal radiotherapy after biliary drainage or biliary stent implantation and consisted of a total of 37 patients, including 21 patients receiving combined treatment after biliary stent placement (14 patients with bilateral stents and 7 with a unilateral stent) and 16 undergoing combined therapy after implanting the biliary drainage tube. In the combination treatment group, the TACE chemotherapy regimen employed gemcitabine and cisplatin, and the embolic agent was iodized oil. A particular dose was determined according to the patient's body surface area and the tumor staining indicated by DSA. In vitro radiotherapy was performed with intensity-modulated radiotherapy or threedimensional conformal radiotherapy at an average dose of 48.3 Gy. Both groups were followed from stent implantation or drainage tube implantation until the patient quitted or died. The median length of follow-up observation was 13 mo. The differences in overall survival time and the effect of different jaundice reducing methods (single stent, double stent, or biliary drainage) on the patency time and survival time of biliary stents were compared between the two groups;the related factors affecting overall survival time were analyzed. RESULTS The median survival time of the control group was 10.5 mo;the median survival time of patients with biliary stent implantation and those with percutaneous biliary drainage was 9.6 mo and 11.4 mo, respectively, and there was no statistically significant difference between them. The median survival time of the combined treatment group was 20.0 mo, which was significantly higher than that of the control group (P < 0.05). Among patients in the combined treatment group, the median survival time of patients who underwent biliary stent implantation and those who accepted percutaneous biliary drainage before the combination therapy was 19.5 mo and 20.1 mo, respectively, and there was no significant difference between them. In the combination treatment group, the mean time of median stent patency was 15.6 mo, which was significantly higher than that of the control group (7.0 mo;P < 0.05). The independent factors affecting survival time included age, whether to receive combination therapy, percutaneous biliary drainage tube implantation, and Bismuth-Corlette classification as type IV. CONCLUSION Gemcitabine and cisplatin-based TACE combined with radiotherapy can prolong the survival of patients with hilar cholangiocarcinoma. Independent predictors of survival include selection of combination therapy, Bismuth-Corlette classification as type IV, selection of percutaneous biliary drainage tube implantation, and age. | Wen-Heng Zheng Tao Yu Ya-Hong Luo Ying Wang Ye-Fu Liu Xiang-Dong Hua Jie Lin Zuo-Hong Ma Fu-Lu Ai Tian-Lu Wang | 2019 | World Journal of Gastrointestinal Oncology2019，11，6： | 6 |
| 14 | Multifunctional dextran micelles as drug delivery carriers and magnetic resonance imaging probes显示文摘Multifunctional nanoparticles combining diagnostic and therapeutic agents into a single platform make cancer theranostics possible and have attracted wide interests in the field. In this study, a multifunctional nanocomposite based on dextran and superparamagnetic iron oxide nanoparticles(SPIO) was prepared for drug delivery and magnetic resonance imaging(MRI). Amphiphilic dextran was synthesized by grafting stearyl acid onto the carbohydrate backbone, and micelle was formed by the resulted amphiphilic dextran with low critical micelle concentration at 1.8 mg L-1. Doxorubicin(DOX) and a cluster of the manganese-doped iron oxide nanoparticles(Mn-SPIO)nanocrystals were then coencapsulated successfully inside the core of dextran micelles, resulting in nanocomposites with diameter at about 100 nm. Cell culture experiments demonstrated the potential of these Mn-SPIO/DOX nanocomposites as an effective multifunctional nanoplatform for the delivery of anticancer drug DOX with a loading content(DLC) of 16 %. Confocal laser scanning microscopyreveals that the Mn-SPIO/DOX had excellent internalization ability against MCF-7/Adr cells after 2-h labeling compared with free DOXáHCl. Under a 3.0-T MRI scanner, Mn-SPIO/DOX nanocomposite-labeled cells in gelatin phantom show much darker images than the control. Their transverse relaxation(T2) rate is also significantly higher than that of the control cells(33.9 versus 2.3 s-1). Our result offers an effective strategy to treat MCF-7/Adr at optimized low dosages with imaging capability. | Bingbing Lin Hongying Su Rongrong Jin Danyang Li Changqiang Wu Xin Jiang Chunchao Xia Qiyong Gong Bin Song Hua Ai | 2015 | Science Bulletin2015，60，14： | 6 |
| 15 | Amphiphilic dextran/magnetite nanocomposites as magnetic resonance imaging probes显示文摘Superparamagnetic iron oxide (SPIO) nanoparticles are effective contrast agents for enhancement of magnetic resonance imaging at the tissue, cellular or even molecular levels. High quality SPIO nanoparticles can be synthesized in the organic phase but need to be transferred into water before any biomedical applications. In this study, amphiphilic poly(ε-caprolactone) grafted dextran (Dex-g-PCL) was used as carriers for particle encapsulation and stabilization in the aqueous phase. Multiple SPIO nanoparticles were self-assembled together with the help of Dex-g-PCL during phase transfer from chloroform to water, and diameters of Dex-g-PCL/SPIO nanocomposites were (64 ± 22) nm through dynamic light scattering measurement. These nanocomposites were superparamagnetic at 300 K with saturated magnetization of 88 emu/g Fe. In the magnetic field of 1.5 T, Dex-g-PCL/SPIO nanocomposites had a T2 relaxivity of 363 Fe mL·mol-1·s-1. This unique nanocomposite brought significant mouse liver contrast with signal intensity changes of -60% at 5 min after intravenous administration. However, uptake of Dex-g-PCL/SPIO nanocomposites in liver reticuloendothelial cells (Kupffer cells) did not immediately happen at shorter time points (<4 h) as verified by histology studies, and it was evident that more iron staining would be located in Kupffer cells 24 h after contrast agent administration. After 24 h and 10 d, the signal intensities (SI) gradually recovered, and SI changes were -44% and -31%, respectively. From our observation, the time window for enhanced-MRI could last at least 12 days and totally recovered after 16 days. This novel sensitive MRI contrast agent may find potential applications in discovering small liver lesions such as early tumor diagnosis. | WANG QiaoYing SU HongYing XIA ChunChao SUN JiaYu LIU Chen WANG ZhiYong GONG QiYong SONG Bin GAO FaBao AI Hua GU ZhongWei | 2009 | Chinese Science Bulletin2009，54，17： | 5 |
| 16 | Night Sleep Duration and Risk of Cognitive Impairment in a Chinese Population: A Cross-sectional Study显示文摘Objective Although sleep is one of the most important health-related behavioral factors,the association between night sleep duration and cognitive impairment has not been fully understood.A cross-sectional study was conducted with a random sample of 2,514 participants(≥40 years of age;46.6% women) in China to examine the association between night sleep duration and cognitive impairment.Methods Night sleep duration was categorized as ≤ 5,6,7,8,or ≥9 h per night.Cognitive function was measured using the Mini-Mental State Examination.A multivariate regression analysis was used to analyze the association of night sleep duration with cognitive impairment.A total of 122 participants were diagnosed with cognitive impairment.Results A U-shaped association between night sleep duration and cognitive impairment was found.The odds ratios(95% confidence intervals) of cognitive impairment(with 7 h of daily sleep being considered as the reference) for individuals reporting ≤ 5,6,8,and ≥9 h were 2.14(1.20-3.83),1.13(0.67-1.89),1.51(0.82-2.79),and 5.37(1.62-17.80),respectively(P≤0.01).Conclusion Short or long night sleep duration was an important sleep-related factor independently associated with cognitive impairment and may be a useful marker for increased risk of cognitive impairment. | SONG Qiao Feng LIU Xiao Xue HU Wan Ning HAN Xiao Chen ZHOU Wen Hua LU Ai Dong WANG Xi Zhu WU Shou Ling | 2017 | Biomedical and Environmental Sciences2017，30，10： | 5 |
| 17 | Different expression pattern of serum soluble intercellular adhesion molecules-1 and neutrophilic expression of CD18 in patients with diabetic retinopathy显示文摘AIM: To investigate the levels of serum soluble intercellular adhesion molecules-1(sICAM-1) and neutrophilic expression of CD18 in patients with various stages of diabetic retinopathy and to determine their different expression pattern in the development of diabetic retinopathy(DR). · METHODS: Levels of serum sICAM-1 and CD18 on the surface of neutrophile were measured in 41 DR patients, they were classified in three subgroups according to the stage of retinopathy as determined by fund's ophthalmoscopy; 10 control subjects were also studied. sICAM-1 were measured by enzyme-linked immunosorbent assay and CD18 by flow cytometry. · RESULTS: The neutrophilic CD18 expression and serum sICAM-1 level were all significantly elevated in all diabetic subgroups compared to control subjects (P <0.01). The differences of CD18 and sICAM-1 among the diabetic subgroups were significant in CD18 but not in sICAM-1. The progression of retinopathy was associated with an increase both in CD18 and in sICAM-1 levels by simple correlation analysis (β=0.74, P <0.001; β=0.38,P <0.01, respectively). But stepwise multiple regression analysis revealed that only CD18 was independent determinant of retinopathy (β=1.04, P <0.01). · CONCLUSION: Our results confirm the contribution of endothelial and neutrophilic activation in the development of DR as indicated by increased levels of CD18 and sICAM-1. However, a direct implication of CD18 and ICAM-1 in the progression of DR can be supported only in the CD18 but not ICAM-1. CD18 and ICAM-1 may play different role in the development of diabetic retinopathy. | Hua Ai Hu-Ping Song | 2012 | International Journal of Ophthalmology(English edition)2012，5，2： | 5 |
| 18 | Induction of HLA-G expression in a melanoma cell line OCM-1A following the treatment with 5-aza-2'-deoxycytidine显示文摘The non-classical HLA class I antigen HLA-G is an immune modulator which inhibits the functions of T cells, NK cells, and the Dendritic cells (DC). As a result, HLA-G expression in malignant cells may provide them with a mechanism to escape the immune surveillance. In melanoma, HLA-G antigen expression has been found in 30% of surgically removed lesions but in less than 1% of established cell lines. One possible mechanism underlying the differential HLA-G expression in vivo and in vitro is that the HLA-G gene is epigenetically repressed in melanoma cells in vitro. To test this hypothesis, we treated the HLA-G negative melanoma cell line OCM-1A with the DNA methyltransferase inhibitor 5-aza-2’-deoXycytidine (5-AC) and analyzed whether HLA-G expression can be restored. Our data strongly suggest that HLA-G is silenced as a result of CpG hypermethylation within a 5’ regulatory region encompassing 220 bp upstream of the start codon. After treatment, HLA-G mRNA expression was dramatically increased. Western blot and flow cytometry showed that HLA-G protein was induced. Interestingly, HLA-G cell surface expression on the 5-AC treated OCM-1 A cells is much less than that on the HLA-G positive JEG-3 cells while a similar amount of total HLA-G was observed. Possible mechanisms for the difference were analyzed in the study such as cell cold-treatment, peptide loading and antigen processing machinery components (APM) as well as β2 microglobulin (β2-m) expression. Data revealed that the APM component calreticulin might be involved in the lower HLA-G surface expression on OCM-1 A cells. Taken together, our results indicated that DNA methylation is an important epigenetic mechanism by which HLA-G antigen expression is modulated in melanoma cells in vitro. Furthermore, to the first time, we hypothesized that the deficiency of calreticulin might be involved in the low HLA-G surface expression on the 5-AC treated OCM-1 A cells. | Wei Hua YAN Ai Fen LIN Chien Chung CHANG Soldano FERRONE | 2005 | Cell Research2005，15，7： | 5 |
| 19 | Reduction of polyethylenimine-coated iron oxide nanoparticles induced autophagy and cytotoxicity by lactosylation显示文摘Superparamagnetic iron oxide(SPIO)nanoparticles are excellent magnetic resonance contrast agents and surface engineering can expand their applications.When covered with amphiphilic alkyl-polyethyleneimine(PEI),the modified SPIO nanoparticles can be used as MRI visible gene/drug delivery carriers and cell tracking probes.However,the positively charged amines of PEI can also cause cytotoxicity and restricts their further applications.In this study,we used lactose to modify amphiphilic low molecular weight polyethylenimine(C_(12-)PEI_(2K))at different lactosylation degree.It was found that the N-alkyl-PEI-lactobionic acid wrapped SPIO nanocomposites show better cell viability without compromising their labelling efficacy as well as MR imaging capability in RAW 264.7 cells,comparing to the unsubstituted ones.Besides,we found the PEI induced cell autophagy can be reduced via lactose modification,indicating the increased cell viability might rely on down-regulating autophagy.Thus,our findings provide a new approach to overcome the toxicity of PEI wrapped SPIO nanocomposites by lactose modification. | Jiuju Du Wencheng Zhu Li Yang Changqiang Wu Bingbing Lin Jun Wu Rongrong Jin Taipeng Shen Hua Ai | 2016 | Regenerative Biomaterials2016，3，4： | 5 |
| 20 | Two New Antibacterial Flavanones from Sophora flavescens显示文摘Two new lavandulylated flavanones, (2R, 3R)-8-lavandulyl-2’-methoxy-5, 7, 4’-trihydroxy- flavanonol (1) and 8-lavandulyl-5, 7, 4’-trihydroxyflavonol (2), were isolated from the dry roots of Sophara flavescens. Their structures were elucidated on the basis of spectroscopic data. Compounds 1 and 2 exhibited significant antibacterial activities. | Mei Ai CAO Xiao Bai SUN Pei Hua ZHAO Cheng Shan YUAN | 2006 | Chinese Chemical Letters2006，17，8： | 5 |
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