|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation显示文摘Mechanistic target of rapamycin mTOR complex 1 (mTORC1)plays a key role in the integration of various environmental signals to regulate cell growth and metabolism,mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase.However,the regulatory mechanism of Rheb activity remains largely unknown.Here,we show that ubiquitination governs the nucleotide-bound status of Rheb.Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex.EGF enhances the deubiquitination of Rheb through AKT-dependent USP4 phosphorylation,leading to the release of Rheb from the TSC complex.Functionally,ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth.Thus,we propose a mechanistic model whereby Rheb-mediated mTORC1 activation is dictated by a dynamic opposing act between Rheb ubiquitination and deubiquitination that are catalyzed by RNF152 and USP4 respectively. | Lu Deng Lei Chen Linlin Zhao Yan Xu Xiaoping Peng Xinbo Wang Lin Ding Jiali Jin Hongqi Teng Yanming Wang Weijuan Pan Fei Yu Lujian Liao Li Li Xin Ge Ping Wang | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Genotypic Characterization of Methicillin-resistant Staphylococcus aureus Isolated from Pigs and Retail Foods in China显示文摘Objective To investigate the genotypic diversity of Methicillin-resistant Staphylococcus aureus(MRSA) isolated from pigs and retail foods from different geographical areas in China and further to study the routes and rates of transmission of this pathogen from animals to food. Methods Seventy-one MRSA isolates were obtained from pigs and retail foods and then characterized by multi-locus sequencing typing(MLST), spa typing, multiple-locus variable number of tandem repeat analysis(MLVA), pulsed-field gel electrophoresis(PFGE), and antimicrobial susceptibility testing. Results All isolated MRSA exhibited multi-drug resistance(MDR). Greater diversity was found in food-associated MRSA(7 STs, 8 spa types, and 10 MLVA patterns) compared to pig-associated MRSA(3 STs, 1 spa type, and 6 MLVA patterns). PFGE patterns were more diverse for pig-associated MRSA than those of food-associated isolates(40 vs. 11 pulse types). Among the pig-associated isolates, CC9-ST9-t899-MC2236 was the most prevalent clone(96.4%), and CC9-ST9-t437-MC621(20.0%) was the predominant clone among the food-associated isolates. The CC9-ST9 isolates showed significantly higher antimicrobial resistance than other clones. Interestingly, CC398-ST398-t034 clone was identified from both pig-and food-associated isolates. Of note, some community-and hospital-associated MRSA strains(t030, t172, t1244, and t4549) were also identified as food-associated isolates. Conclusion CC9-ST9-t899-MC2236-MDR was the most predominant clone in pigs, but significant genetic diversity was observed in food-associated MRSA. Our results demonstrate the great need for improved surveillance of MRSA in livestock and food and effective prevention strategies to limit MDR-MRSA infections in China. | WANG Wei LIU Feng ZULQARNAIN Baloch ZHANG Cun Shan MA Ke PENG Zi Xin YAN Shao Fei HU Yu Jie GAN Xin DONG Yin Ping BAI Yao LI Feng Qin YAN Xiao Mei MA Ai Guo XU Jin | 2017 | Biomedical and Environmental Sciences2017，30，8： | 13 |
| 3 | Multidrug-resistant Tuberculosis Burden among the New Tuberculosis Patients in Zhejiang Province: An Observational Study, 2009-2013显示文摘 | Ying Peng Song-Hua Chen Le Zhang Bin Chen Ming-Wu Zhang Tie-Niu He Fei Wang Cheng-Liang Chai Lin Zhou Yu Zhang Xiao-Meng Wang Zhongwei Jia | 2017 | Chinese Medical Journal2017，，17： | 13 |
| 4 | Incidence and risk factors of tuberculosis among the elderly population in China:a prospective cohort study显示文摘Background:China is facing challenges of the shifting presentation of tuberculosis(TB)from younger to elderly due to an ageing population,longer life expectancy and reactivation disease.However,the burden of elderly TB and influence factors are not yet clear.To fill the gap,we generated a cohort study to measure the magnitude of TB incidence and associated factors among the elderly population aged 65 years and above in China.Methods:In this cohort established in 2013 through a prevalence survey conducted in selected sites,a total of 34076 elderlies without TB were enrolled into two-year follow-up.We used both active and passive case findings to find out all TB patients among them.The person-year(PY)incidence rates for both bacteriologically positive TB and active TB were calculated.Cox proportional regression model was performed to test effect of risk factors,and the population attributable fraction(PAF)of each risk factor contributing to incident TB among elderlies was calculated.Results:Over the two-year follow-up period,a total of 215 incident active TB were identified,62 of which were bacteriologically positive.The incidence rates for active TB and bacteriologically positive TB were 481.8 per 100000 PY(95%CI:417.4–546.2 per 100000 PY)and 138.9 per 100000 PY(95%CI:104.4–173.5 per 100000 PY),respectively.Incident cases detected by active case finding were significantly higher(P<0.001).Male,non-Han nationality,previously treated TB,ex/current smoker and body mass index(BMI)<18.5 presented as independent predictors for developing TB disease.For developing bacteriologically positive TB,the biggest contribution was from self-reported ex or current smoker(18.06%).And,for developing active TB,the biggest contribution was from non-Han nationality(35.40%),followed by male(26.80%)and age at 75 years and above(10.85%).Conclusions:Ageing population in China had a high TB incidence rate and risk to develop TB disease,implying that National TB Program(NTP)needs to prioritize for elderly.Active case finding should be applied capture more active TB cases among this particular population,especially for male,non-Han nationality,and those with identified risk factors. | Jun Cheng Yan-Ni Sun Can-You Zhang Yan-Ling Yu Li-Hong Tang Hong Peng Ying Peng Yu-Xia Yao Shuang-Yi Hou Jian-Wei Li Jin-Ming Zhao Lan Xia Lin Xu Yin-Yin Xia Fei Zhao Li-Xia Wang Hui Zhang | 2020 | Infectious Diseases of Poverty2020，9，1： | 10 |
| 5 | Association between Plasma Metal Levels and Diabetes Risk: a Case-control Study in China显示文摘Objective Many metals, some of which have been classified as environmental endocrine disruptors, are used extensively in everyday consumer products and are ubiquitous in our living environment. In the present study, we aimed to explore the associations between the prevalence risk of type 2 diabetes and plasma levels of 20 trace elements as well as those of heavy metals in a Han Chinese population. Methods We conducted a case-control study to investigate the associations between plasma concentrations of 20 metals and diabetes in Jiangsu province. A total of 122 newly diagnosed cases of type 2 diabetes and 429 matched controls were recruited from community physical examinations in Suzhou City of Jiangsu Province. Plasma metal levels were measured by inductively-coupled plasma mass spectrometry. Results After adjusting for confounders, plasma vanadium, chromium, manganese, copper, zinc, arsenic, selenium, strontium, palladium, cadmium, cesium, and barium were associated with diabetes risk(P < 0.05). The adjusted OR increased with increasing concentration of vanadium, manganese, copper, zinc, and cesium. Conclusion Many metals, including manganese, copper, zinc, arsenic, selenium, and cadmium in plasma, are associated with the morbidity of diabetes. Monitoring of environmental metal levels and further studies are urgently needed. | LI Xiu Ting YU Peng Fei GAO Yan GUO Wen Hui WANG Jun LIU Xin GU Ai Hua JI Gui Xiang DONG Qiu WANG Bo Shen CAO Ying ZHU Bao Li XIAO Hang | 2017 | Biomedical and Environmental Sciences2017，30，7： | 8 |
| 6 | Survey on Key Technology Development and Application in Trusted Computing显示文摘Trusted computing,which can effectively increase the credibility of information system,has made great achievements and is in continuous development. For country who is going to strengthen network construction like China,it is an important fundamental supporting technology worth researching. China is in the international forefront in the field of trusted computing. This paper gives comprehensive introductions to the new development and application of key technologies in trusted computing,such as various trusted platform modules(TPM、TCM、TPCM),TCG Software Stack(TSS),trusted cloud server and Trusted Execution Environment(TEE). We illustrate the progressing and application extension of these technologies and also point out some key problems worth studying in the future. | Juan Wang Yuan Shi Guojun Peng Huanguo Zhang Bo Zhao Fei Yan Fajiang Yu Liqiang Zhang | 2016 | China Communications2016，13，11： | 7 |
| 7 | Triglycerides and ratio of triglycerides to high-density lipoprotein cholesterol are better than liver enzymes to identify insulin resistance in urban middle-aged and older non-obese Chinese without diabetes显示文摘 | Sun Yu Li Wenjuan Hou Xinguo Wang Chuan Li Chengqiao Zhang Xiuping Yang Weifang Ma Zeqiang Wang Weiqing Ning Guang Zheng Huizhen Ma Aixia Song Jun Lin Peng Liang Kai Liu Fuqiang Gong Lei Wang Meijian Xiao Juan Yan Fei Yang Junpeng Wang Lingshu Tian Meng Liu Jidong Zhao Ruxing Zhu Ping Chen Li | 2014 | Chinese Medical Journal2014，，10： | 7 |
| 8 | Subvoxel light-sheet microscopy for high-resolution high-throughput volumetric imaging of large biomedical specimens显示文摘A key challenge when imaging whole biomedical specimens is how to quickly obtain massive cellular information over a large field of view(FOV).We report a subvoxel light-sheet microscopy(SLSM)method enabling high-throughput volumetric imaging of mesoscale specimens at cellular resolution.A nonaxial,continuous scanning strategy is developed to rapidly acquire a stack of large-FOV images with three-dimensional(3-D)nanoscale shifts encoded.Then,by adopting a subvoxel-resolving procedure,the SLSM method models these low-resolution,cross-correlated images in the spatial domain and can iteratively recover a 3-D image with improved resolution throughout the sample.This technique can surpass the optical limit of a conventional light-sheet microscope by more than three times,with high acquisition speeds of gigavoxels per minute.By fast reconstruction of 3-D cultured cells,intact organs,and live embryos,SLSM method presents a convenient way to circumvent the trade-off between mapping large-scale tissue(>100 mm3)and observing single cell(∼1-μm resolution).It also eliminates the need of complicated mechanical stitching or modulated illumination,using a simple light-sheet setup and fast graphics processing unit-based computation to achieve high-throughput,high-resolution 3-D microscopy,which could be tailored for a wide range of biomedical applications in pathology,histology,neuroscience,etc. | Peng Fei Jun Nie Juhyun Lee Yichen Ding Shuoran Li Hao Zhang Masaya Hagiwara Tingting Yu Tatiana Segura Chih-Ming Ho Dan Zhu Tzung KHsiaic | 2019 | Advanced Photonics2019，1，1： | 6 |
| 9 | A Lunar-based Soft X-ray Imager(LSXI)for the Earth's magnetosphere显示文摘We propose to use the Moon as a platform to obtain a global view of Earth's magnetosphere by a Lunar-based Soft X-ray Imager(LSXI).LSXI is a wide field-of-view Soft X-ray telescope,which can obtain X-ray images of Earth's magnetosphere based on the solar wind charge exchange(SWCX)X-ray emission.Global perspective is crucial to understand the overall interaction of the solar wind with magnetosphere.LSXI is capable of continuously monitoring the evolution of geospace conditions under the impact of the solar wind by simultaneous observation of the bow shock,magnetosheath,magnetopause and cusps for the first time.This proposal is answering the call for the Chinese Lunar Exploration Program Phase IV. | Yihong GUO Chi WANG Fei WEI Tianran SUN Xizheng YU Songwu PENG Graziella BRANDUARDI-RAYMONT Steven SEMBAY | 2021 | Science China Earth Sciences2021，64，7： | 5 |
| 10 | Direct growth of single-walled carbon nanotubes on substrates显示文摘As one of the most promising candidate material for next generation electronic devices,the reliable and controllable synthesis of high quality single-walled carbon nanotubes(SWNTs) has long been an essential and important issue in the field.Direct growth of SWNTs on flat substrates by chemical vapor deposition(CVD) process is the best way to obtain SWNTs because it is immediately ready for building nano-devices.The orientation of the SWNTs has been well controlled by gas flow or substrate lattice during the CVD growth process.The chirality and structure control of SWNTs is still a big challenge.However,the conductivity selective growth has already partially succeeded.New catalysts have been explored to obtain SWNTs of higher quality.Along with the further progress in the study of the SWNT growth,the precise control over the orientation,position and conductivity of SWNTs is expected to meet the requirements of carbon-based nanoelectronics. | PENG Fei LIU Yu CUI RongLi GAO DongLiang YANG Feng LI Yan | 2012 | Chinese Science Bulletin2012，57，2： | 5 |
| 11 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 12 | Acetylglutamate kinase is required for both gametophyte function and embryo development in Arabidopsis thaliana显示文摘The specific functions of the genes encoding arginine biosynthesis enzymes in plants are not well characterized. We report the isolation and characterization of Arabidopsis thaliana N-acetylglutamate kinase(NAGK), which catalyzes the second step of arginine biosynthesis. NAGK is a plastid-localized protein and is expressed during most developmental processes in Arabidopsis. Heterologous expression of the Arabidopsis NAGK gene in a NAGK-deficient Escherichia coli strain fully restores bacterial growth on arginine-deficient medium. nagk mutant pollen tubes grow more slowly than wild type pollen tubes and the phenotype is restored by either specifically through complementation by NAGK in pollen, or exogenous supplementation of arginine. nagk female gametophytes are defective in micropylar pollen tube guidance due to the fact that female gametophyte cell fate specification was specifically affected. Expression of NAGK in synergid cells rescues the defect of nagk female gametophytes. Lossof-function of NAGK results in Arabidopsis embryos not developing beyond the four-celled embryo stage. The embryo-defective phenotype in nagk/NAGK plants cannot be rescued by watering nagk/NAGK plants with arginine or ornithine supplementation. In conclusion,our results reveal a novel role of NAGK and arginine in regulating gametophyte function and embryo development, and provide valuable insights into arginine transport during embryo development. | Jie Huang Dan Chen Hailong Yan Fei Xie Ying Yu Liyao Zhang Mengxiang Sun Xiongbo Peng | 2017 | Journal of Integrative Plant Biology2017，59，9： | 4 |
| 13 | Ninety-four thousand-case retrospective study on antibacterial drug resistance of Helicobacter pylori显示文摘BACKGROUND The resistance rate to antibacterial drugs is the key inhibitor of Helicobacter pylori(H.pylori)eradication treatment.AIM To evaluate the prevalence and drug resistance of H.pylori based on big data.METHODS Gastric mucosal specimens were collected from naive patients undergoing upper gastrointestinal endoscopy for H.pylori culture and antimicrobial susceptibility testing(AST),including clarithromycin,levofloxacin,metronidazole and amoxicillin.Every 10 years of age was grouped as an age group.The H.pylori infection and resistance were explored based on the age group and gender.RESULTS The number of H.pylori-positive specimen was 94509 in 283823 gastric mucosal specimens,with an infection rate of 33.30%.The infection rate increased with age,and males had a higher infection rate than females.The average resistance rate of H.pylori to amoxicillin and metronidazole was 0.21%and 93.72%,which remained stable.The average resistance rate to clarithromycin was 23.99%with an increasing trend from 14.43%to 38.24%.The average resistance rate to levofloxacin was 30.29%,which increased from 17.07%to 39.42%and mostly stabilized after 2017.The resistance rate of H.pylori increased with age,except amoxicillin.H.pylori in females are at higher risk of resistance to metronidazole but not to amoxicillin,regardless of the age group.Meanwhile,H.pylori in females are at higher risk of resistance to levofloxacin and clarithromycin in the 21-50 age group.The single,dual,triple and quadruple-drug resistance rate was 54.59%,29.03%,11.71%and 0.11%,respectively.CONCLUSION The resistance of H.pylori in Taizhou city is serious.Guided by the consensus report,individualized treatment based on AST is recommended. | Yu Zhang Fei Meng Jie Jin Jun Wang Bin-Bin Gu Jin-Bang Peng Li-Ping Ye | 2021 | World Journal of Clinical Cases2021，9，35： | 4 |
| 14 | Lycopodine-Type Alkaloids from Lycopodium japonicum显示文摘Three new lycopodine-type alkaloids,4a-hydroxyanhydrolycodoline(1),4a,6a-dihydroxyanhydrolycodoline(2),and 6-epi-8b-acetoxylycoclavine(3),and an artifact,lycoposerramine G nitrate(4),along with seventeen related known compounds,were isolated from the club moss Lycopodium japonicum Thunb.ex Murray(Lycopodiaceae).Their structures were elucidated by extensive spectroscopic methods as well as X-ray analysis.Compounds 1–4 were evaluated for their acetylcholine esterase inhibitory activity. | Juan He Xing-De Wu Fei Liu Yu-Cheng Liu Li-Yan Peng Yu Zhao Xiao Cheng Huai-Rong Luo Qin-Shi Zhao | 2014 | Natural Products and Bioprospecting2014，4，4： | 3 |
| 15 | Wide-field auroral imager onboard the Fengyun satellite显示文摘The newly launched Fengyun-3D(FY-3D)satellite carried a wide-field auroral imager(WAI)that was developed by Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences(CIOMP),which will provide a large field of view(FOV),high spatial resolution,and broadband ultraviolet images of the aurora and the ionosphere by imaging the N2 LBH bands of emissions.The WAI consists of two identical cameras,each with an FOV of 68°in the along-track direction and 10°in the cross-track direction.The two cameras are tilted relative to each other to cover a fan-shaped field of size 130°×10°.Each camera consists of an unobstructed four-mirror anastigmatic optical system,a BaF2 filter,and a photon-counting imaging detector.The spatial resolution of WAI is ~10 km at the nadir point at a reference height of 110 km above the Earth’s surface.The sensitivity is>0.01 counts s^(−1) Rayleigh^(−1) pixel^(−1)(140-180 nm)for both cameras,which is sufficient for mapping the boundaries and the fine structures of the auroral oval during storms/substorms.Based on the tests and calibrations that were conducted prior to launch,the data processing algorithm includes photon signal decoding,geometric distortion correction,photometric correction,flatfield correction,line-of-sight projection and correction,and normalization between the two cameras.Preliminarily processed images are compared with DMSP SSUSI images.The agreement between the images that were captured by two instruments demonstrates that the WAI and the data processing algorithm operate normally and can provide high-quality scientific data for future studies on auroral dynamics. | Xiao-Xin Zhang Bo Chen Fei He Ke-Fei Song Ling-Ping He Shi-Jie Liu Quan-Feng Guo Jia-Wei Li Xiao-Dong Wang Hong-Ji Zhang Hai-Feng Wang Zhen-Wei Han Liang Sun Pei-Jie Zhang Shuang Dai Guang-Xing Ding Li-Heng Chen Zhong-Su Wang Guang-Wei Shi Xin Zhang Chao Yu Zhong-Dong Yang Peng Zhang Jin-Song Wang | 2019 | Light(Science & Applications)2019，8，1： | 3 |
| 16 | Characterization of Avian Influenza A(H7N9) Virus Prevalence in Humans and Poultry in Huai′an,China:Molecular Epidemiology,Phylogenetic,and Dynamics Analyses显示文摘Objective To trace the source of human H7N9 cases in Huai'an and elucidate the genetic characterization of Huai'an strains associated with both humans and birds in live poultry market.Methods An enhanced surveillance was implemented when the first human H7N9 case was confirmed in Huai'an.Clinical specimens,cloacal swabs,and fecal samples were collected and screened by real-time reverse transcription-polymerase chain reaction(RT-PCR) for H7N9 virus.The positive samples were subjected to further RT-PCR and genome sequencing.The phylodynamic patterns of H7N9 virus within and separated from Huai'an and evolutionary dynamics of the virus were analyzed.Results Six patients with H7N9 infection were previously exposed to live poultry market and presented symptoms such as fever(>38.0 °C) and headaches.Results of this study support the hypothesis that live poultry markets were the source of human H7N9 exposure.Phylogenetic analysis revealed that all novel H7N9 viruses,including Huai'an strains,could be classified into two distinct clades,A and B.Additionally,the diversified H7N9 virus circulated in live poultry markets in Huai'an.Interestingly,the common ancestors of the Huai'an H7N9 virus existed in January 2012.The mean nucleotide substitution rates for each gene segment of the H7N9 virus were(3.09-7.26)×10-3 substitutions/site per year(95% HPD:1.72×10-3 to 1.16×10-2).Conclusion Overall,the source of exposure of human H7N9 cases in Huai'an was live poultry market,and our study highlights the presence of divergent genetic lineage of H7N9 virus in both humans and poultry specimens in Huai'an. | YANG Peng Fei YAN Qing Li LIU Chun Cheng XING Ya Dong ZHANG Min Hui GAO Qiang YU Hao YAO Hai Bo HE Nan Jiang | 2016 | Biomedical and Environmental Sciences2016，29，10： | 3 |
| 17 | Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China显示文摘Objective To study the optimal waist circumference(WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome(MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China. | HOU Xin Guo WANG Chuan MA Ze Qiang YANG Wei Fang WANG Ji Xiang LI Cheng Qiao WANG Yu Lian LIU Shu Min Hu Xiu Ping ZHANG Xiu Ping JIANG Mei WANG Wei Qing NING Guang ZHENG Hui Zhen MA Ai Xia SUN Yu SONG Jun LIN Peng LIANG Kai LIU Fu Qiang LI Wen Juan XIAO Juan GONG Lei WANG Mei Jian LIU Ji Dong YAN Fei YANG Jun Peng WANG Ling Shu TIAN Meng ZHAO Ru Xing JIANG Ling CHEN Li | 2014 | Biomedical and Environmental Sciences2014，27，5： | 3 |
| 18 | Modified Glasgow Prognostic Score, and Neutrophil/lymphocyte and Platelet/lymphocyte Ratios in Different Stages of Silicosis显示文摘Until now, although comprehensive management strategies have improved treatment, there are no treatments to alleviate symptoms and slow disease progression[1]. In the past few decades, there has been increasing evidence that inflammation plays a very important role in silicosis. Injury-induced inflammation is an effective strategy to remove harmful stimuli and initiate a healing process. However, it might be harmful to the organism and result in a permanent disease state if the inflammation is prolonged[2]. | HE La Gu WU Peng Fei PENG Yan Hua FENG Juan ZHONG Dai Ming ZHANG Gui Hua ZENG Lei ZHONG Yu Min WANG Xiao Ye YUAN Hua Min | 2019 | Biomedical and Environmental Sciences2019，32，5： | 3 |
| 19 | Transcription of the putative tumor suppressor gene HCCS1 requires binding of ETS-2 to its consensus near the transcription start site显示文摘hepatocellular 癌压制或 1 (HCCS1 ) 基因被在肝癌症的从杂合现象(17p13.3 ) 的损失的一个占优势的区域的两位置的克隆并且由为在大规模 transfection 试金影响房间增长的基因的功能的屏蔽识别。它的过去在在房间文化的房间增长和在裸体鼠标的肿瘤生长的抑制的表达式结果。理解它的抄写规定,倡导者建筑学详细被把了。抄写的主要开始被对 C 残余的教材扩展印射, ATG 在上游的 177 核苷酸上哄骗。由在短暂 transfection 试金估计最小的倡导者(到 +148 区域的 -60 )的一套扫描连接器的异种的倡导者活动,我们发现 +1 到 40 区域是的+对 HCCS1 基因抄写批评,为抄写因素 NF-kappaB (到 +7 的 -21 和到 +26 的 +40 )的包含的有约束力的地点, p53 (到 +9 的 +29 )和 et (到 +20 的 +4 和到 +39 的 +23 )。生物化学、分子的分析表明 ETS 抄写因素 ETS-2 和 Elf-1 在 situ 绑在二个 et 地点并且显著地作出贡献到抄写结盟 HCCS1 基因的活跃状态,当时 NF-kappaB , p53 和 ETS 家庭( ETS-1 和 NERF2 )的二个另外的成员看起来起很少作用。我们的观察提供卓见进 HCCS1 抄写规定的机械学的方面。房间研究(2006 ) 16:780-796。做 i:10.1038/sj .cr.7310092;出版联机 2006 年 9 月 5 日。 | Jing De Zhu Qi Fei Peng Wang Fei Lan Da Qin Mao Hong Yu Zhang Xue Biao Yao | 2006 | Cell Research2006，16，9： | 3 |
| 20 | Role of tetraspanin CD151–α3/α6 integrin complex: Implication in angiogenesis显示文摘 | Wei-Feng Liu Hou-Juan Zuo Bo-lan Chai Dan Peng Yu-Jie Fei Jing-Yang Lin Xiao-Hui Yu Dao-Wen Wang Zheng-Xiang Liu | 2011 | International Journal of Biochemistry and Cell Biology2011，，4： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员